WO2009009953A1 - Composition de comprimé pour gargarisme par voie orale et son procédé de préparation - Google Patents

Composition de comprimé pour gargarisme par voie orale et son procédé de préparation Download PDF

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Publication number
WO2009009953A1
WO2009009953A1 PCT/CN2008/001284 CN2008001284W WO2009009953A1 WO 2009009953 A1 WO2009009953 A1 WO 2009009953A1 CN 2008001284 W CN2008001284 W CN 2008001284W WO 2009009953 A1 WO2009009953 A1 WO 2009009953A1
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WO
WIPO (PCT)
Prior art keywords
mouthwash
mixture
tablet
component
sodium
Prior art date
Application number
PCT/CN2008/001284
Other languages
English (en)
Chinese (zh)
Inventor
Waiming Wong
Liangyuan Zheng
Original Assignee
Waiming Wong
Liangyuan Zheng
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Waiming Wong, Liangyuan Zheng filed Critical Waiming Wong
Publication of WO2009009953A1 publication Critical patent/WO2009009953A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216—Solid or semisolid forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/22—Peroxides; Oxygen; Ozone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/38—Percompounds, e.g. peracids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/731—Cellulose; Quaternized cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0063—Periodont
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations

Definitions

  • the present invention relates to the field of oral hygiene and health care products, and relates to an oral rapid collapse mouthwash composition and a preparation method thereof.
  • Oral health is a mirror of human health. At present, most people's concept of oral care only stays in the understanding of "brushing teeth in the morning and evening.” In fact, the method of brushing teeth can only eliminate 50% of dental plaque. "A comprehensive oral care program can't just brush your teeth.” To ensure healthy teeth, a complete oral care regimen must be taken. For places where the toothbrush is difficult to reach, the mouthwash with bactericidal function can penetrate deeply and thoroughly clean the mouth. Targeted application of mouthwash not only ensures a healthy oral environment, but also enhances the public image and enhances the confidence of social activities. Mouthwash with a certain function is increasingly important in people's daily oral care.
  • the mouthwash is a liquid form
  • the package is bulky and inconvenient to carry, and is often restricted to carry when traveling by airplane or the like; it is not convenient for many people to use without a container. Therefore, the invention of a new oral care product with convenient carrying, simple use method and mouthwash effect will be beneficial to open up a new concept of oral health care, satisfying people in modern life, especially office workers, traveling and long time.
  • effervescent tablet types of mouthwashes but effervescent tablets require severe production conditions, high packaging costs, and use of acid-base pairs, which may cause irritation to the oral cavity and are limited in use.
  • the technical solution adopted by the present invention is:
  • the main functional component is a mixture containing one or any two or a mixture of two or more of the following formulas:
  • At least one functional ingredient for whitening teeth At least one functional ingredient for whitening teeth.
  • the above components may also contain:
  • At least one disintegrant to enable rapid disintegration of the tablet in the oral cavity
  • the above components may further comprise:
  • At least one binder for increasing the adhesion between the particles during granulation.
  • the functional component for preventing tooth decay and caries may be one of sodium fluoride (NaF), sodium monofluorophosphate (Na 2 P0 3 F), stannous fluoride (SnF 2 ), two or three compounds.
  • the functional component for inhibiting the growth and aggregation of oral bacteria may be a cationic surfactant cetylpyridinium chloride, a nonionic surfactant triclosan; the functional component of whitening teeth may be hydrogen peroxide, peroxidation Urea.
  • the disintegrant is one or a mixture of two or more of the following: 1 crospovidone 2 croscarmellose sodium 3 sodium carboxymethyl starch 4 microcrystalline cellulose 5 hydroxypropyl cellulose.
  • the soluble filler is one or a mixture of two or three of the following: 1 mannitol 2 xylitol 3 sorbitol; a filler having good disintegration performance may be one of microcrystalline cellulose and hydroxypropyl cellulose.
  • the sweetener is one or a mixture of any two or three of the following: 1 sucralose 2 stevioside 3 aspartame; the cooling agent is one or both of the following or Mixture of three kinds: 1 menthol 2 cool alcohol 3 spearmint; lubricant is one of the following or a mixture of any two or more: 1 stearic acid sodium fumarate sodium thiocyanate
  • decyl sulphate 4 polyethylene glycol 40005 polyethylene glycol 6000; the binder is one of the following or a mixture of any two or three: 1 povidone K30 2 hypromellose 3 carboxylate Methylcellulose.
  • the mouthwash sheet of the present invention has a time to disintegrate in the oral cavity within 30 seconds.
  • the mouthwash tablet of the present invention is a solid tablet which can rapidly disintegrate in the oral cavity and rapidly dissolve the active ingredient.
  • it is only necessary to use a small amount of water to directly contain strontium in the oral cavity, or to dissolve it with a small amount of water and then to contain strontium in the oral cavity.
  • compositions of the present invention are, inter alia: sodium fluoride (NaF), cetylpyridinium chloride and urea peroxide; the main components thereof include:
  • Cetylpyridinium chloride ⁇ 0.005% ⁇ 30.0%
  • the mouthwash tablet of the present invention is specifically used by: using a small amount of water to directly contain strontium in the oral cavity, and the tablet disintegrates and disperses in 1 minute to form a suspension having a particle size within a certain range, and the active ingredient is rapidly formed. Dissolve, thoroughly clean the mouth, and play a role in preventing tooth decay and/or inhibiting bacteria and/or whitening teeth. Or first dissolve it with a small amount of water and then contain it in the mouth.
  • the oral rapid collapse mouth piece according to the present invention is a solid tablet containing a mouthwash component, which has the same efficacy as mouthwash, but is superior in some respects:
  • the oral rapid collapse mouth piece according to the present invention is a solid tablet, which is used without a specific container for quantification;
  • the oral rapid collapse mouth piece according to the present invention can be directly contained in the oral cavity only by ordinary drinking water;
  • the active ingredient in the oral rapid collapse mouth piece of the invention is solid form, has good stability, long shelf life, and does not need to add other preservatives;
  • the oral rapid collapse mouth piece according to the present invention is small in size, light in weight, convenient to carry, and can be used by many people, and is particularly suitable for use in working, traveling, and long-term outdoor activities.
  • the oral rapid collapse mouth piece according to the present invention is a non-effervescent system orally disintegrating tablet, which adopts excipients with good disintegration performance and special preparation technology to achieve the purpose of rapid collapse. It also has significant advantages over effervescent tablets:
  • the oral rapid collapse mouth piece according to the present invention has loose production conditions and can be produced under the production conditions of ordinary tablets, compared with the severe production conditions in which the relative humidity of the effervescent tablet is 30% or less and the temperature does not exceed 25 °C. , can greatly reduce production costs;
  • the oral rapid collapse mouth piece according to the present invention is a non-effervescent disintegration system, and the requirements for packaging materials are comparable to those of ordinary tablets, and the packaging cost is relatively low;
  • excipients used in the rapid disintegration mouthparts of the present invention are mild in nature, do not contain acid and alkali, and are non-irritating to the oral cavity;
  • composition 2 sodium fluoride and mannitol were weighed separately, mixed, and the povidone K30 solution was added, stirred, sieved through a 40 mesh sieve, and dried.
  • the above granules were mixed with other raw materials and punched with a 13 mm shallow arc, and the tablet hardness was controlled at 4 kgf.
  • the disintegration time in the mouth is 20 seconds.
  • the preparation method is the same as above.
  • the disintegration time in the mouth was 21 seconds.
  • Example 2 Preparation of sodium fluoride containing sodium and cetylpyridinium chloride valproate tablets Composition 1: Povidone K30 5.6mg
  • Composition 2 is a composition of Composition 2:
  • the preparation method is the same as above.
  • the disintegration time in the mouth was 18 seconds.
  • Composition 3 is a composition of Composition 3:
  • sodium fluoride, hexadecanoylpyridinium chloride and mannitol were weighed separately, mixed, and the povidone K30 solution was added, stirred, sieved through a 40 mesh sieve, and dried.
  • Other materials were dispersed in PROSOLV SMCC 50 and mixed with the above particles.
  • the sheet was punched with a 13 mm shallow arc, and the hardness of the tablet was controlled at 4 kgf.
  • the disintegration time in the mouth is 20 seconds.
  • Composition 2 is a composition of Composition 2:
  • 600.7 mg was prepared as above.
  • the disintegration time in the mouth was 28 seconds.
  • Composition 4 is a composition having Composition 4:
  • sodium fluoride, hexadecanoylpyridinium chloride and mannitol were weighed separately, mixed, and the povidone K30 solution was added, stirred, sieved through a 40 mesh sieve, and dried.
  • the other materials were dispersed in hydroxypropylcellulose and mixed with the above granules. With a 13mm shallow arc punching piece, the tablet hardness is controlled to 25 seconds in a 4kgfo mouth.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Inorganic Chemistry (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention porte sur un comprimé pour gargarisme se désintégrant rapidement par voie orale, qui comprend au moins un composant pour éviter les dents cariées et la carie dentaire, et/ou au moins un composant pour inhiber la croissance et l'agrégation de bactéries buccales et/ou au moins un composant pour blanchir les dents. Le comprimé est capable de se dissoudre à plus de 75 % en trente secondes.
PCT/CN2008/001284 2007-07-16 2008-07-07 Composition de comprimé pour gargarisme par voie orale et son procédé de préparation WO2009009953A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US94990807P 2007-07-16 2007-07-16
US60/949,908 2007-07-16
CNA2007101916246A CN101455620A (zh) 2007-12-13 2007-12-13 一种漱口片组合物及制备方法
CN200710191624.6 2007-12-13

Publications (1)

Publication Number Publication Date
WO2009009953A1 true WO2009009953A1 (fr) 2009-01-22

Family

ID=40259298

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2008/001284 WO2009009953A1 (fr) 2007-07-16 2008-07-07 Composition de comprimé pour gargarisme par voie orale et son procédé de préparation

Country Status (2)

Country Link
CN (1) CN101455620A (fr)
WO (1) WO2009009953A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101829027B (zh) * 2010-05-11 2012-07-04 李少君 多功能漱口水
CN103083209B (zh) * 2013-01-25 2014-10-01 中山大学 一种漱口液的母片及其制备方法
CN104473822A (zh) * 2014-12-02 2015-04-01 东莞市荷花食品有限公司 一种含有植物提取物漱口片及其制作方法
CN105147612A (zh) * 2015-09-23 2015-12-16 北京水木中天植物科学研究院 一种口腔清新喷剂
CN105853381A (zh) * 2016-05-06 2016-08-17 中国人民解放军第四军医大学 一种具有协同增效作用的防龋漱口片及其制备方法
CN106309148B (zh) * 2016-09-28 2019-04-26 北京瑞济善健康科技有限公司 速释口腔护理漱口清新片及其制备方法和用途
CN106727268B (zh) * 2017-02-22 2020-07-17 云南白药集团股份有限公司 口腔崩解片及其制备方法
CN107510747A (zh) * 2017-08-04 2017-12-26 上海中华药业南通有限公司 一种漱口泡腾片及其制备方法
CN109260033B (zh) * 2018-09-29 2021-04-16 广州艾蓓生物科技有限公司 一种固体漱口粒及其制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1179972A (zh) * 1997-09-29 1998-04-29 杨成玉 多能口洁泡腾片
WO1999033437A1 (fr) * 1997-12-29 1999-07-08 The Procter & Gamble Company Composition de nettoyage des dents sous forme de comprime
US20050244493A1 (en) * 2004-04-30 2005-11-03 Withiam Michael C Rapidly disintegrating tablets comprising calcium carbonate
CN1950055A (zh) * 2004-04-30 2007-04-18 J.M.休伯有限公司 含磷酸钙的口腔护理产品
CN1950068A (zh) * 2004-04-30 2007-04-18 J.M.休伯有限公司 包含二氧化钛的快速崩解片剂

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1179972A (zh) * 1997-09-29 1998-04-29 杨成玉 多能口洁泡腾片
WO1999033437A1 (fr) * 1997-12-29 1999-07-08 The Procter & Gamble Company Composition de nettoyage des dents sous forme de comprime
US20050244493A1 (en) * 2004-04-30 2005-11-03 Withiam Michael C Rapidly disintegrating tablets comprising calcium carbonate
CN1950055A (zh) * 2004-04-30 2007-04-18 J.M.休伯有限公司 含磷酸钙的口腔护理产品
CN1950068A (zh) * 2004-04-30 2007-04-18 J.M.休伯有限公司 包含二氧化钛的快速崩解片剂

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Publication number Publication date
CN101455620A (zh) 2009-06-17

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