WO2008142862A1 - 血管内皮前駆細胞の移植による抗がん療法 - Google Patents

血管内皮前駆細胞の移植による抗がん療法 Download PDF

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Publication number
WO2008142862A1
WO2008142862A1 PCT/JP2008/001247 JP2008001247W WO2008142862A1 WO 2008142862 A1 WO2008142862 A1 WO 2008142862A1 JP 2008001247 W JP2008001247 W JP 2008001247W WO 2008142862 A1 WO2008142862 A1 WO 2008142862A1
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WIPO (PCT)
Prior art keywords
cells
progenitor cells
vascular
vascular epithelial
epithelial progenitor
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PCT/JP2008/001247
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English (en)
French (fr)
Inventor
Yusuke Mizukami
Yutaka Kohgo
Kazumasa Nakamura
Original Assignee
National University Corporation Asahikawa Medical College
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Publication date
Application filed by National University Corporation Asahikawa Medical College filed Critical National University Corporation Asahikawa Medical College
Priority to US12/600,530 priority Critical patent/US8491887B2/en
Priority to EP08751765A priority patent/EP2163250B1/en
Priority to JP2009515092A priority patent/JP5339533B2/ja
Publication of WO2008142862A1 publication Critical patent/WO2008142862A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

自家細胞等を用いて、がんの退縮あるいは良好なドラックデリバリー効果を有し、腫瘍内低酸素域の縮小ないし解除をもたらす抗がん療法を提供するものである。がん患者に対して、血管内皮前駆細胞を移植（経静脈的に投与）し、腫瘍増殖の抑制、血管密度の増加と血管径の拡大、腫瘍内の低酸素域の縮小を確認する。血管内皮前駆細胞としては、血管内皮前駆細胞を経静脈的に投与したときの拒絶反応を抑制しうる点で、がん患者由来の自家細胞を利用することが好ましく、自家細胞を利用する場合、患者の末梢血や骨髄から単核球を分離し、ＶＥＧＦなどのサイトカインを含む血管内皮分化促進培地を用いて培養後に得られる付着細胞として回収した血管内皮前駆細胞を有利に用いることができる。
PCT/JP2008/001247 2007-05-18 2008-05-19 血管内皮前駆細胞の移植による抗がん療法 WO2008142862A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/600,530 US8491887B2 (en) 2007-05-18 2008-05-19 Anticancer therapy by transplanting vascular endothelial progenitor cells
EP08751765A EP2163250B1 (en) 2007-05-18 2008-05-19 Anticancer therapy by transplanting vascular endothelial progenitor cells
JP2009515092A JP5339533B2 (ja) 2007-05-18 2008-05-19 血管内皮前駆細胞の移植による抗がん療法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-133486 2007-05-18
JP2007133486 2007-05-18

Publications (1)

Publication Number Publication Date
WO2008142862A1 true WO2008142862A1 (ja) 2008-11-27

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ID=40031581

Family Applications (1)

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PCT/JP2008/001247 WO2008142862A1 (ja) 2007-05-18 2008-05-19 血管内皮前駆細胞の移植による抗がん療法

Country Status (4)

Country Link
US (1) US8491887B2 (ja)
EP (1) EP2163250B1 (ja)
JP (1) JP5339533B2 (ja)
WO (1) WO2008142862A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010116665A1 (ja) * 2009-04-07 2010-10-14 国立大学法人旭川医科大学 単核球由来の新規血管再生細胞群及びその分化誘導法
WO2012020566A1 (ja) 2010-08-10 2012-02-16 国立大学法人旭川医科大学 Ape1遺伝子導入による高機能化幹細胞・前駆細胞

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5725489B2 (ja) * 2008-06-27 2015-05-27 公立大学法人大阪市立大学 医療用組成物および医療用キット
WO2011007348A2 (en) 2009-07-13 2011-01-20 Biogencell, Ltd. Method for using directing cells for specific stem/progenitor cell activation and differentiation
JPWO2013031845A1 (ja) 2011-08-31 2015-03-23 ぺんてる株式会社 ボールペン用油性インキ組成物
US8956870B2 (en) 2012-01-19 2015-02-17 Biogencell, Ltd. Method for using directing cells for specific stem/progenitor cell activation and differentiation
CN108823149B (zh) * 2018-07-26 2022-01-04 海南医学院 一种人外周血源性早期内皮祖细胞的培养方法

Citations (3)

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Publication number Priority date Publication date Assignee Title
JP2001231549A (ja) 2000-02-28 2001-08-28 Japan Science & Technology Corp 不死化血管内皮細胞株
JP2003250820A (ja) 2002-03-06 2003-09-09 Toyoaki Murohara 血管の再生方法、そのための細胞の分離回収方法及び装置
JP2007089536A (ja) 2005-09-30 2007-04-12 Tokai Univ Ｎｏｔｃｈリガンドを用いた血管内皮前駆細胞への分化誘導法

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US5980887A (en) * 1996-11-08 1999-11-09 St. Elizabeth's Medical Center Of Boston Methods for enhancing angiogenesis with endothelial progenitor cells
IL161903A0 (en) * 2003-07-17 2005-11-20 Gamida Cell Ltd Ex vivo progenitor and stem cell expansion for usein the treatment of disease of endodermally- deri ved organs
EP1621550A1 (en) * 2004-07-29 2006-02-01 Dompé S.P.A. Tumor-homing cells engineered to produce tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001231549A (ja) 2000-02-28 2001-08-28 Japan Science & Technology Corp 不死化血管内皮細胞株
JP2003250820A (ja) 2002-03-06 2003-09-09 Toyoaki Murohara 血管の再生方法、そのための細胞の分離回収方法及び装置
JP2007089536A (ja) 2005-09-30 2007-04-12 Tokai Univ Ｎｏｔｃｈリガンドを用いた血管内皮前駆細胞への分化誘導法

Non-Patent Citations (11)

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KALKA C. ET AL.: "Endothelial progenitor cells: From bench to bedside", FUTURE CARDIOLOGY, vol. 2, no. 4, 2006, pages 455 - 466, XP008123606 *
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See also references of EP2163250A4

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010116665A1 (ja) * 2009-04-07 2010-10-14 国立大学法人旭川医科大学 単核球由来の新規血管再生細胞群及びその分化誘導法
JPWO2010116665A1 (ja) * 2009-04-07 2012-10-18 国立大学法人旭川医科大学 単核球由来の新規血管再生細胞群及びその分化誘導法
US8951795B2 (en) 2009-04-07 2015-02-10 National University Corporation Asahikawa Medical University Revascularization cells derived from mononuclear cells, and method of inducing differentiation thereof
JP5725509B2 (ja) * 2009-04-07 2015-05-27 国立大学法人旭川医科大学 単核球由来の新規血管再生細胞群及びその分化誘導法
WO2012020566A1 (ja) 2010-08-10 2012-02-16 国立大学法人旭川医科大学 Ape1遺伝子導入による高機能化幹細胞・前駆細胞

Also Published As

Publication number Publication date
US20100143311A1 (en) 2010-06-10
JP5339533B2 (ja) 2013-11-13
JPWO2008142862A1 (ja) 2010-08-05
EP2163250A1 (en) 2010-03-17
US8491887B2 (en) 2013-07-23
EP2163250A4 (en) 2011-01-19
EP2163250B1 (en) 2013-01-09

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