WO2008059652A1 - Agent désintégrant, et comprimé et granule contenant chacun celui-ci - Google Patents

Agent désintégrant, et comprimé et granule contenant chacun celui-ci Download PDF

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Publication number
WO2008059652A1
WO2008059652A1 PCT/JP2007/067270 JP2007067270W WO2008059652A1 WO 2008059652 A1 WO2008059652 A1 WO 2008059652A1 JP 2007067270 W JP2007067270 W JP 2007067270W WO 2008059652 A1 WO2008059652 A1 WO 2008059652A1
Authority
WO
WIPO (PCT)
Prior art keywords
tablet
disintegrant
xanthan gum
tablets
instant
Prior art date
Application number
PCT/JP2007/067270
Other languages
English (en)
Japanese (ja)
Inventor
Masaaki Kojima
Takehiko Sakai
Original Assignee
Ina Food Industry Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ina Food Industry Co., Ltd. filed Critical Ina Food Industry Co., Ltd.
Priority to JP2008544086A priority Critical patent/JP4361597B2/ja
Publication of WO2008059652A1 publication Critical patent/WO2008059652A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/30—Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/32—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds
    • A23G1/40—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • A23G3/42—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/269—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of microbial origin, e.g. xanthan or dextran
    • A23L29/27—Xanthan not combined with other microbial gums
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/20—Agglomerating; Granulating; Tabletting
    • A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0033—Xanthan, i.e. D-glucose, D-mannose and D-glucuronic acid units, saubstituted with acetate and pyruvate, with a main chain of (beta-1,4)-D-glucose units; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

Definitions

  • Patent Document 1 Japanese Patent Application Laid-Open No. 63-211224
  • the disintegrant according to the present invention and the xanthan gum that has been heat-treated into tablets and granules may be heat-treated in a solvent.
  • the solvent contains water. It's okay.
  • the ratio of xanthan gum and water was heat treated at 1: 0.02 to 4 It is preferable.
  • the water content is too high, there arises a problem that the particles are dissolved.
  • the ratio of water is too small, there arises a problem that the heat treatment time becomes long.
  • the ratio of water to xanthan gum can be arbitrarily set.
  • the tablet includes not only the tablet solidified by tableting but also a solid substance compressed and solidified by a mold or the like.
  • Granules are those in which single particles are aggregated, including fine particles, regardless of particle system or shape.
  • the content of the disintegrant is preferably from 0.5 to 30% by weight, preferably from 0.5 to 20% by weight, more preferably from 1 to 10% by weight.
  • a disintegrant according to Example 1 was prepared by subjecting 1 kg of powdery xanthan gum (Keltrol, CP Kelco) to 90 ° C for 48 hours by calothermal treatment.
  • a seasoning tablet was prepared by the combination shown in Table 6. Tableting is performed by the direct method, and the tableting conditions are the same as in Experimental Example 2 (however, tableting pressure: 800 kg / cm 2 ). Further, as Comparative Example 7, a product using corn starch as a disintegrant instead of the disintegrant according to Example 3 was similarly prepared.
  • tablet-like instant oolong tea was prepared according to the formulation shown in Table 21. Tableting is performed by the direct method, and the conditions are tableting machine: HT-12SS (Hatabeko), 0.8g per tablet, R shape with 12mm diameter, tablet strength 4kg. Further, as shown in Table 21, as Comparative Example 17, a tablet-like instant oolong tea was similarly prepared using agar as a disintegrant.
  • Example 22 using the disintegrant according to Example 1, the tablets according to Example 24 are shown in Table 22.
  • a tablet-like instant oolong tea was prepared by blending. Tableting is performed by the direct method, and the conditions are tableting machine: HT-12SS (Hatabeko), 1. Og per tablet, R shape with 12mm diameter, tablet strength 4kg. Further, as shown in Table 22, as Comparative Example 18, a tablet-like instant oolong tea was similarly prepared using microcrystalline cellulose as a disintegrant.
  • Example 25 As shown in Table 23, the tablet-like instant oolong tea to which the disintegrant according to Example 1 is added has a component that it disintegrates more quickly than those to which a disintegrant other than Example 1 is added. Ru [0079] Example 25
  • Comparative Example 1 9 2 0 As shown in Table 25, it can be seen that the tablet-like instant cocoa to which the disintegrant according to Example 1 was added disintegrates more quickly than that to which carmellose calcium was added as a disintegrant.
  • a tablet-like instant juice was prepared according to the formulation shown in Table 26. Tableting is performed by the direct method, and the conditions are tableting machine: HT-12SS (Hatateko), 1. Og per tablet, R shape with a diameter of 12mm, tablet strength 4kg.
  • HT-12SS Tabletatateko
  • Table 26 Comparative Example 20
  • a tablet-like instant juice using corn starch as a disintegrant was similarly prepared.
  • Granulated sugar Toyo Sugar Co., Ltd.
  • Corn starch Made by Matsutani Chemical Co., Ltd.
  • Example 26 the disintegration time of the tablet-like instant juices according to Example 26 and Comparative Example 20 was measured.
  • the measuring method was carried out by putting tablet-like instant juice in 200 mL of water at 10 ° C and measuring the time until the tablet melts and disappears. The results are shown in Table 27.
  • a tablet-like instant soup was prepared according to the formulation shown in Table 28. Tableting is performed by the direct method, and the conditions are tableting machine: HT-12SS (Hatabeko), 1. Og per tablet, R shape with 12mm diameter, tablet strength 4kg. Further, as shown in Table 28, as Comparative Example 21, a tablet-like instant soup was similarly prepared using L-HPC as a disintegrant.
  • Carmellose calcium manufactured by Gotoku Pharmaceutical
  • Croscarmellose sodium Asahi Kasei Corporation
  • the condyles according to Example 31 were prepared according to the formulation shown in Table 36. After adding water to the aspirin, lactose and the disintegrant according to Example 4 and kneading them together, they are dried at 80 ° C through a 1 mm diameter dies, and then open. 1. Granules are made through an Omm sieve. . Further, as shown in Table 36, as Comparative Example 25, granules were similarly prepared using starch instead of the disintegrant according to Example 4.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Nutrition Science (AREA)
  • Medicinal Preparation (AREA)
  • General Preparation And Processing Of Foods (AREA)

Abstract

L'invention concerne un agent désintégrant qui présente un effet de désintégration satisfaisant. L'invention concerne également un comprimé ou un granule contenant l'agent désintégrant. L'agent désintégrant comprend une gomme xanthane modifiée qui est produite par le traitement thermique d'une gomme xanthane purifiée, tout en maintenant sa forme pulvérulente. Le comprimé ou le granule contient l'agent désintégrant dans une quantité comprise entre 0,1 et 30 % en poids. La gomme xanthane modifiée est de préférence préparée sous une forme insoluble dans l'eau. La gomme xanthane modifiée est de préférence traitée thermiquement à une température se situant dans la plage de 50 à 250 °C compris. Le traitement thermique est de préférence effectué pendant une période de 10 secondes à 1000 heures.
PCT/JP2007/067270 2006-11-13 2007-09-05 Agent désintégrant, et comprimé et granule contenant chacun celui-ci WO2008059652A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008544086A JP4361597B2 (ja) 2006-11-13 2007-09-05 崩壊剤、並びにそれが含まれた錠剤及び顆粒

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2006-306157 2006-11-13
JP2006306157 2006-11-13
JP2007-041200 2007-02-21
JP2007041200 2007-02-21

Publications (1)

Publication Number Publication Date
WO2008059652A1 true WO2008059652A1 (fr) 2008-05-22

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ID=39401464

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/067270 WO2008059652A1 (fr) 2006-11-13 2007-09-05 Agent désintégrant, et comprimé et granule contenant chacun celui-ci

Country Status (2)

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JP (1) JP4361597B2 (fr)
WO (1) WO2008059652A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013091570A (ja) * 2013-01-15 2013-05-16 Kazuo Hanno 国の全額借金返済と都道府県市町村区の全額借金返済の為の知的所有財産の携帯電話及び携帯無線装置による非常停止非常制御操作出来るエレベーター磁極切り換えインバータ制御レールモーター装置の著作権原本。
JP2018000078A (ja) * 2016-06-30 2018-01-11 味の素株式会社 圧粉体調味料組成物
JP2020130049A (ja) * 2019-02-20 2020-08-31 有限会社富山サプリメント 水溶性固形補水飲料及び補水飲料
JP2021176289A (ja) * 2020-05-08 2021-11-11 森永製菓株式会社 カカオ製品
WO2022085440A1 (fr) * 2020-10-23 2022-04-28 サンヨー食品株式会社 Aliment granulaire et son procédé de production
WO2022243214A1 (fr) * 2021-05-19 2022-11-24 Dsm Ip Assets B.V. Comprimés non effervescents à dissolution rapide comprenant de la poudre de cacao

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63211224A (ja) * 1986-11-27 1988-09-02 ツィマ　ソシエテ　アノニム 水分散性錠剤
JPH01104138A (ja) * 1987-07-21 1989-04-21 Takeda Chem Ind Ltd 調味料製剤およびその製造法
JPH1033125A (ja) * 1996-07-23 1998-02-10 Ina Food Ind Co Ltd キサンタンガムの改質方法及び改質キサンタンガム
JP2000007705A (ja) * 1998-06-19 2000-01-11 Nisshin Oil Mills Ltd:The 湿熱処理キサンタンガムおよびその製造方法
JP2006213867A (ja) * 2005-02-04 2006-08-17 Sanei Gen Ffi Inc キサンタンガムの改質方法及びその応用

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63211224A (ja) * 1986-11-27 1988-09-02 ツィマ　ソシエテ　アノニム 水分散性錠剤
JPH01104138A (ja) * 1987-07-21 1989-04-21 Takeda Chem Ind Ltd 調味料製剤およびその製造法
JPH1033125A (ja) * 1996-07-23 1998-02-10 Ina Food Ind Co Ltd キサンタンガムの改質方法及び改質キサンタンガム
JP2000007705A (ja) * 1998-06-19 2000-01-11 Nisshin Oil Mills Ltd:The 湿熱処理キサンタンガムおよびその製造方法
JP2006213867A (ja) * 2005-02-04 2006-08-17 Sanei Gen Ffi Inc キサンタンガムの改質方法及びその応用

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013091570A (ja) * 2013-01-15 2013-05-16 Kazuo Hanno 国の全額借金返済と都道府県市町村区の全額借金返済の為の知的所有財産の携帯電話及び携帯無線装置による非常停止非常制御操作出来るエレベーター磁極切り換えインバータ制御レールモーター装置の著作権原本。
JP2018000078A (ja) * 2016-06-30 2018-01-11 味の素株式会社 圧粉体調味料組成物
JP2020130049A (ja) * 2019-02-20 2020-08-31 有限会社富山サプリメント 水溶性固形補水飲料及び補水飲料
JP7371880B2 (ja) 2019-02-20 2023-10-31 有限会社富山サプリメント 水溶性固形補水飲料及び補水飲料
JP2021176289A (ja) * 2020-05-08 2021-11-11 森永製菓株式会社 カカオ製品
WO2022085440A1 (fr) * 2020-10-23 2022-04-28 サンヨー食品株式会社 Aliment granulaire et son procédé de production
WO2022243214A1 (fr) * 2021-05-19 2022-11-24 Dsm Ip Assets B.V. Comprimés non effervescents à dissolution rapide comprenant de la poudre de cacao

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Publication number Publication date
JPWO2008059652A1 (ja) 2010-02-25
JP4361597B2 (ja) 2009-11-11

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