WO2022243214A1 - Comprimés non effervescents à dissolution rapide comprenant de la poudre de cacao - Google Patents

Comprimés non effervescents à dissolution rapide comprenant de la poudre de cacao Download PDF

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Publication number
WO2022243214A1
WO2022243214A1 PCT/EP2022/063123 EP2022063123W WO2022243214A1 WO 2022243214 A1 WO2022243214 A1 WO 2022243214A1 EP 2022063123 W EP2022063123 W EP 2022063123W WO 2022243214 A1 WO2022243214 A1 WO 2022243214A1
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WO
WIPO (PCT)
Prior art keywords
tablet
fast
total weight
fast dissolvable
dissolvable
Prior art date
Application number
PCT/EP2022/063123
Other languages
English (en)
Inventor
Zhenbo Ma
Conroy Clive SALMON
Paulo Henrique SANTOS
Original Assignee
Dsm Ip Assets B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets B.V. filed Critical Dsm Ip Assets B.V.
Publication of WO2022243214A1 publication Critical patent/WO2022243214A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/30—Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/32—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds
    • A23G1/40—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/30—Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/32—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/30—Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/32—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds
    • A23G1/42—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/30—Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/50—Cocoa products, e.g. chocolate; Substitutes therefor characterised by shape, structure or physical form, e.g. products with an inedible support
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/30—Cocoa products, e.g. chocolate; Substitutes therefor
    • A23G1/56—Cocoa products, e.g. chocolate; Substitutes therefor making liquid products, e.g. for making chocolate milk drinks and the products for their preparation, pastes for spreading, milk crumb

Definitions

  • the present invention relates to a new formulation (a tablet) comprising cocoa powder, which dissolves or can be dispersed in water (or water based) liquids fast.
  • a new formulation comprising cocoa powder, which dissolves or can be dispersed in water (or water based) liquids fast.
  • the tablets when dissolved in hot or cold liquid) can be consumed easily by a human.
  • Cocoa drinks comprising cocoa are very popular for a very large part of the human population. They are liked by all age groups. Cocoa drinks are consumed all over the world since thousands of years.
  • cocoa drinks The history of cocoa drinks is very old and it started more than 4000 years in South and Central America., where the cacao tree is native.
  • Cocoa powder the highly processed form, is roasted at a much higher temperature and typically supplemented with additives to cut the bitterness (either an alkalizing chemical solution in the case of Dutch- processed or alkalized cocoa, or with sugar and other additives, as found in milk chocolate and candy chocolate bars).
  • Cacao powder which is often labelled as "Raw Cacao Pow der,” is minimally processed form of the bean that maintains the nutritionally dense prop erties of the cacao seed.
  • cocoa and cacao are used in a synonymic way (when not otherwise stated).
  • Cocoa powder is rich in flavonoids (especially flavan-3-ols), a subset of polyphenols.
  • the amount of flavonoids depends on the amount of processing and manufacturing the cocoa powder undergoes. Alkalization, also known as Dutch processing, causes its content of flavonoids to be substantially reduced, but reduces bitterness and improves solubility.
  • cocoa Due to its natural ingredients cocoa has some very nice healthy properties.
  • Cocoa is most commonly used for heart disease and high blood pressure. As stated above, cocoa contains a variety of chemicals, including antioxidants called fla- vonoids. These compounds might also reduce the activity of chemicals in the body that promote inflammation or blockage of blood vessels.
  • Cocoa drinks are sold i.e. as ready to drink forms (in cans, bottles, carton packages etc), which can be consumed on the spot (or heated when desired).
  • cocoa powders for instants drinks which can be prepared by (hot or cold) water or milk (or other liquids) and then consumed. Such powders are usually sold in cans, bags etc.
  • the goal of the present invention was to find a new an improved formulation for instant cocoa drinks.
  • the formulation must be dissolved or dispersed in a fast way in the (hot or cold liquid). Furthermore, it should be a stable formulation, which is easy to be produced.
  • cocoa in the form of a specific non-efferves- cent fast dissolvable tablet.
  • Effervescent or carbon tablets are tablets which dissolve in water (or water based liquids) and release carbon dioxide. Such tablets are products of compression of component in gredients in the form of powders into a dense mass, which is packaged in blister pack, or with a hermetically sealed package with incorporated desiccant in the cap. To use them, they are dropped into water (or water-based liquids) to make a solution.
  • Effervescent tablets have some advantages over regular tablets, such as the following:
  • Effervescent tablets are popular due to the fact they can be dissolved in a liquid such as water or fruit juice, meaning that they often taste better than regular tab lets. Conventional tablets dissolve slowly which can result in reduced absorption rates, effervescent tablets, in contrast, dissolve quickly and completely, meaning you get the full benefit from the ingredients.
  • Effervescent tablets provide the nutritional benefits intended, but in addition to this they also increase liquid intake. This can be especially beneficial if you are dehy drated or ill and not ingesting as much fluid as usual. Effervescent tablets can be a fantastic way of rehydrating as well as reaping the benefits you are taking the tablets for whether this is a dietary supplement.
  • effervescent tablets can be a lot easier than having to swallow a tablet.
  • Effervescent tablets are easily dissolved into water or a liquid of your choice and then after a while are consistent, well mixed and ready to drink. Traditional tablets or powders, however, need to be measured and stirred in repeatedly to avoid an inconsistent drink with lumpy bits.
  • effervescent tab lets, such as a complex production process and, very often, the need for special packaging materials for achieving a good storage stability.
  • the primary material used in the manufacture of effervescent tablets is relatively hygro scopic, that is, it absorbs moisture from the air. However, this must be prevented because it will initiate the effervescent reaction.
  • One of the principal strategies used to overcome this problem is a completely closed material handling system during production with very low relative humidity.
  • the tablets need to be packed in such a way that it that moisture cannot harm the tablet during storage before use.
  • the present invention relates to a non-effervescent (water) fast dissolvable tab let (DS) , which can be produced at ambient conditions and comprises
  • the dissolution rate of the tablet according to the present invention is excellent.
  • the tablet according to the present invention dissolves or is dispersed in a water (or water-based liquid such as milk) in similar rate as an effervescent tablet. No additional vigorous shak ing, stirring or other means are necessary to achieve a complete dissolution in an accepta ble time.
  • the size of the tablet according to the present invention can vary.
  • the size is more or less the same as a conventional effervescent tablet.
  • the typical and preferred size is usually chosen that the amount of the cocoa powder and of any other used physiologically active ingredient is enough to cover the daily recommended or any desired amount.
  • the shape of the tablet according to the present invention is not an essential feature. But usually it has a disc-like shape having a diameter of up to 3 cm (preferably 1.5 - 2.6 cm) and a thickness of up to 0.8 cm (preferably 0.3 - 0.6 cm) and it has a weight of up to 5.5 g (preferably 0.2 - 5g).
  • the present invention relates to a fast dissolvable tablet DS1 , which is fast dis solvable tablet DS, wherein the tablet has a disc-like shape.
  • the present invention relates to a fast dissolvable tablet DST, which is fast dis solvable tablet DS1 , wherein the tablet has a diameter of up to 3 cm (preferably 1.5 - 2.6 cm) and a thickness of up to 0.8cm (preferably 0.3 - 0.6cm).
  • the present invention relates to a fast dissolvable tablet DS2, which is fast dis solvable tablet DS, DS1 or DST, wherein the tablet has a weight of up to 5.5 g (preferably 0.2 - 5g).
  • the tablet according to the present invention is dissolved or dispersed in a glass of water or milk (or water based liquid), which is usually between 0.1 - 0.4 liter.
  • the tablets according to the present invention dissolved rapidly. It has similar dissolving properties as a usual effervescent tablets.
  • the dissolving time is less than 5 minutes (or even less than 2 minutes).
  • the tablet according to the present invention is soluble in pure water as well as in water- based solvents. This means the tablet according to the present invention can also be dis solved in any water based liquid (such as fruit juices, milk, smoothies, etc).
  • the liquid can be cold or hot.
  • the liquid can be carbonated or non-carbonated.
  • Preferred embodiments according to the present inventions are fast dissolvable tablets comprises 2 - 30 wt-%, based on the total weight of the fast dissolvable tablet, of cocoa powder. More preferred embodiments according to the present inventions are fast dissolvable tab lets comprises 3 - 20 wt-%, based on the total weight of the fast dissolvable tablet, of cocoa powder.
  • fast dissolvable tablets comprises 3 - 15 wt-%, based on the total weight of the fast dissolvable tablet, of cocoa powder.
  • the present invention relates to a fast dissolvable tablet DS3, which is fast dis solvable tablet DS, DS1 , DST or DS2, wherein the tablet comprises 2 - 30 wt-%, based on the total weight of the fast dissolvable tablet, of cocoa powder.
  • the present invention relates to a fast dissolvable tablet DS3’, which is fast dis solvable tablet DS, DS1 , DST or DS2, wherein the tablet comprises 3 - 20 wt-%, based on the total weight of the fast dissolvable tablet, of cocoa powder.
  • the present invention relates to a fast dissolvable tablet DS3”, which is fast dissolvable tablet DS, DS1, DST or DS2, wherein the tablet comprises 3 - 15 wt-%, based on the total weight of the fast dissolvable tablet, of cocoa powder.
  • Dry cocoa solids are the components of cocoa beans remaining after cocoa butter, the fatty component of the bean, is extracted from chocolate liquor, roasted cocoa beans that have been ground into a liquid state. Cocoa butter is 46% to 57% of the weight of cocoa beans and gives chocolate its characteristic melting properties. Cocoa powder is the pow dered form of the dry solids with a small remaining amount of cocoa butter. As stated above untreated cocoa powder is bitter and acidic. Dutch process cocoa has been treated with an alkaline to neutralize the acid.
  • a typical cocoa powder comprises about 58 wt-% of carbohydrates, about 14 wt- % of fat, about 20 wt-% of protein, and about 3% water. It also contains several minerals in rich content, including manganese, magnesium, phosphorus, potassium, iron, and zinc, while calcium levels are moderate. The powder also contains caffeine and theobromine. Due to the fact that cocoa is natural product the content of the ingredients can vary. It is also possible to add other active ingredient to the tablet according to the present invention (next to the cocoa powder). Such active ingredients are usually used in common effervescent tablets.
  • Such suitable additional active ingredients are vitamins, carotenoids, minerals, human milk oligosaccharides (HMOs) and any other dietary ingredient.
  • HMOs human milk oligosaccharides
  • the present invention relates to a fast dissolvable tablet DS4, which is fast dis solvable tablet DS, DS1 , DST, DS2, DS3, DS3’ or DS3”, wherein the tablet according to the present invention can also comprise at least one additional active ingredient.
  • the present invention relates to a fast dissolvable tablet DS4’, which is fast dis solvable tablet DS4, wherein the additional active ingredient is chosen from the group consisting of vitamins, carotenoids, minerals, human milk oligosaccharides (HMOs) and any other dietary ingredient.
  • the additional active ingredient is chosen from the group consisting of vitamins, carotenoids, minerals, human milk oligosaccharides (HMOs) and any other dietary ingredient.
  • the amount of the additional active ingredient can be up to 25 wt-%, based on the total weight of the fast dissolvable tablet (usually up to 20 wt-%).
  • the active ingredients used in the tablet according to the present invention can be used in pure form as well as in preformulated form (which means that one or more active ingre transient is formulated before used in the production of the tablet according to the present invention).
  • the vitamins according to the present invention can be fat-soluble as well as water-solu ble.
  • the fat-soluble vitamins are selected from the group consisting of vitamin A, D, E and K. These vitamins are usually used as preformulated form in the tablet.
  • the water-soluble vitamins are selected from the group consisting of vitamin B1 (thia mine), vitamin B2 (riboflavin), vitamin B3 (niacin, niacinamide), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine, pyridoxamine, pyridoxal), vitamin B7 (biotin), vitamin B9 (fo lic acid, folinic acid), vitamin B12 (cyanocobalamin, hydroxycobalamin, methylcobalamin), and vitamin C (ascorbic acid).
  • Carotenoids are chosen form the group consisting of beta-carotene, lycopene, lutein, bixin, astaxanthin, apocarotenal, beta-apo-8’-carotenal, beta-apo-12’-carotenal, can- thaxanthin, cryptoxanthin, citranaxanthin and zeaxanthin. These carotenoids are usually used as preformulated form in the tablet.
  • the minerals are chosen from the group consisting of minerals, which are added to the formulation are Sodium, Potassium, Calcium, Iron, Zinc, and Magnesium.
  • a suitable trace element is for example iodine.
  • HMOs Human milk oligosaccharides
  • HMOs are composed of the five monosaccharides glucose (Glc), galactose (Gal), N- acetylglucosamine (GlcNAc), fucose (Fuc) and sialic acid (Sia), with N-acetylneuraminic acid (Neu5Ac) as the predominant if not only form of Sia. More than two hundred different HMOs have been identified so far.
  • the HMOs are chosen from the group consisting of 2'-fucosyllactose (2' FL), lacto-N-ne- otetraose (LNnT), 3-fucosyllactose (3FL), difucosyl-lactose (DFL), Lacto-N-fucopentaose I (LNFP I), 3 ' Sialyllactose Sodium Salt (3'SL), 6 ' Sialyllactose Sodium Salt (6'SL), and Lacto-N-Tetraose (LNT).
  • the present invention relates to a fast dissolvable tablet DS5, which is the fast dissolvable tablet DS4 or DS4’, wherein at least one active ingredient is chosen from the group consisting of vitamins chosen from the group consisting of vitamin A, vitamin D (vitamin D3), vitamin E, vitamin K1, vitamin K2, vitamin B1 , vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B7, vitamin B9, vitamin B12, and vitamin C; and/or from carotenoids chosen from the group consisting of beta-carotene, lycopene, lutein, bixin, astaxanthin, apocarotenal, beta-apo-8’-carotenal, beta-apo-12’-carotenal, canthaxanthin, cryptoxanthin, citranaxanthin and zeaxanthin; and/or from minerals chosen from the group consisting of Sodium, Potassium, Calcium, Iron, Zinc, and Magnesium, and/or HMOs chosen from the group consisting of 2'-f
  • a preferred embodiment of the present invention is as fast dissolvable tablet comprising 25-95 wt-%, based on the total weight of the fast dissolvable tablet, of at least one diluent.
  • a more preferred embodiment of the present invention is as fast dissolvable tablet com prising 30 - 80 wt-%, based on the total weight of the fast dissolvable tablet, of at least one diluent.
  • Suitable diluents are sugar alcohols such as mannitol, sorbitol, xylitol and disaccharides such as sucrose or lactose.
  • the present invention relates to a fast dissolvable tablet DS6, which is fast dis solvable tablet DS, DS1, DST, DS2, DS3, DS3’, DS3”, DS4, DS4’ or DS5, wherein the tablet comprises 25 -95 wt-%, based on the total weight of the fast dissolvable tablet, of at least one diluent.
  • the present invention relates to a fast dissolvable tablet DS6’, which is fast dis solvable tablet DS6, wherein the tablet comprises 30 - 80 wt-%, based on the total weight of the fast dissolvable tablet, of at least one diluent.
  • Suitable diluents are sugar alcohols such as mannitol, sorbitol, xylitol and disaccharides such as sucrose or lactose.
  • the present invention relates to a fast dissolvable tablet DS7, which is fast dis solvable tablet DS, DS1 , DST, DS2, DS3, DS3’, DS3”, DS4, DS4’, DS5, DS6 or DS6’, wherein the least one diluent is chosen from the group consisting of sugar alcohols (such as mannitol, sorbitol and xylitol) and disaccharides (such as sucrose and lactose).
  • sugar alcohols such as mannitol, sorbitol and xylitol
  • disaccharides such as sucrose and lactose
  • a preferred embodiment of the present invention is as fast dissolvable tablet comprising 3 - 45 wt-%, based on the total weight of the fast dissolvable tablet, of at least one disin- tegrant.
  • a more preferred embodiment of the present invention is as fast dissolvable tablet com prising 15 - 40 wt-%, based on the total weight of the fast dissolvable tablet, of at least one disintegrant.
  • Suitable disintegrants are starch, crospovidone (cross linked polyvinyl N-pyrrolidone), co processed sugar alcohol with starch, croscarmellose Sodium, and sodium starch glyco- late.
  • the present invention relates to a fast dissolvable tablet DS8, which is fast dis solvable tablet DS, DS1 , DST, DS2, DS3, DS3’, DS3”, DS4, DS4’, DS5, DS6, DS6’ or DS7, wherein the tablet comprises 3 - 45 wt-%, based on the total weight of the fast dissolvable tablet, of at least one disintegrant.
  • the present invention relates to a fast dissolvable tablet DS8’, which is fast dis solvable tablet DS, DS1 , DST, DS2, DS3, DS3’, DS3”, DS4, DS4’, DS5, DS6, DS6’ or DS7, wherein the tablet comprises 15 - 40 wt-%, based on the total weight of the fast dissolvable tablet, of at least one disintegrant.
  • the present invention relates to a fast dissolvable tablet DS9, which is fast dis solvable tablet DS, DS1 , DST, DS2, DS3, DS3’, DS3”, DS4, DS4’, DS5, DS6, DS6’, DS7, DS8 or DS8’, wherein the at least one disintegrant is chosen from the group consisting of starches, crospovidone (cross linked polyvinyl N-pyrrolidone), co-processed sugar alcohol with starch, croscarmellose Sodium, and sodium starch glycolate.
  • crospovidone cross linked polyvinyl N-pyrrolidone
  • co-processed sugar alcohol with starch croscarmellose Sodium
  • sodium starch glycolate sodium starch glycolate
  • the tablet according to the present invention can comprise further ingredients (auxiliary agents), such as flavours, colours, fillers, lubricants, and sweeteners.
  • auxiliary agents such as flavours, colours, fillers, lubricants, and sweeteners.
  • Such ingredients can be present in the tablets according to the present invention in amount of up to 25 wt-%, based on the total weight of the tablet.
  • the present invention relates to a fast dissolvable tablet DS10, which is fast dissolvable tablet DS, DS1 , DST, DS2, DS3, DS3’, DS3”, DS4, DS4’, DS5, DS6, DS6’, DS7, DS8, DS8’ or DS9, wherein the tablet comprises at least one auxiliary agent chosen from the group consisting of, flavours, colours, fillers, lubricants and sweetener.
  • the present invention relates to a fast dissolvable tablet DS10’, which is fast dissolvable tablet DS11 , wherein the tablet comprises 1 - 25 wt-% (preferably 3 - 12 wt- %), based on the total weight of the tablet, of at least one auxiliary agent.
  • a preferred embodiment of the present invention is a tablet, wherein the car bonate content is below 0.5 wt-%, based on the total weight of the tablet.
  • a more preferred embodiment of the present invention is a tablet, wherein the carbonate content is below 0.3 wt-%, based on the total weight of the tablet.
  • Especially preferred embodiment of the present invention is a tablet which is essentially free of any carbonate. This means that the tablet does not comprise any carbonate. This means that no carbonate is added to the tablet.
  • the present invention relates to a fast dissolvable tablet DS11, which is fast dissolvable tablet DS, DS1 , DST, DS2, DS3, DS3’, DS3”, DS4, DS4’, DS5, DS6, DS6’, DS7, DS8, DS8’, DS9, DS10 or DS10’, wherein the tablet comprises less than 0.5 wt-%, based on the total weight of the tablet, of carbonate.
  • the present invention relates to a fast dissolvable tablet DS1 T, which is fast dissolvable tablet DS, DS1 , DST, DS2, DS3, DS3 ⁇ DS3”, DS4, DS4 ⁇ DS5, DS6, DS6 ⁇ DS7, DS8, DS8’, DS9, DS10 or DS10’, wherein the tablet comprises less than 0.3 wt-%, based on the total weight of the tablet, of carbonate.
  • the present invention relates to a fast dissolvable tablet DS11”, which is fast dissolvable tablet DS, DS1 , DST, DS2, DS3, DS3’, DS3”, DS4, DS4’, DS5, DS6, DS6’, DS7, DS8, DS8’, DS9, DS10 or DS10’, wherein the tablet is essentially free of any car bonate.
  • the tablets according to the present invention can be produced by using commonly known processes.
  • the pressing can be done by commonly known and used equipment, such as a “D” type rotary press.
  • a suitable and ideal tablet according to the present invention has a hardness of around 3kp to 20kp, preferably 3kp - 15kp.
  • the present invention relates to a fast dissolvable tablet DS12, which is fast dissolvable tablet DS, DS1 , DST, DS2, DS3, DS3’, DS3”, DS4, DS4’, DS5, DS6, DS6’, DS7, DS8, DS8’, DS9, DS10, DS10’, DS11, DS1 T or DS11”, wherein the tablet is essen tially free of any carbonate.
  • the tablet (depending on the choice of active ingredients) can be used as dietary supple ments.
  • the tablets can be packed and sold in any commonly used container for tablet, due to the good storage stability.
  • a tablet can be dissolved in water or milk within 3 mins at room tem perature; a tablet can be dissolved in hot milk within 2 mins.
  • a tablet With gentle mixing, a tablet can be dissolved in water or milk within 3 mins at room tem perature; a tablet can be dissolved in hot milk within 2 mins.

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Inorganic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Nutrition Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne une nouvelle formulation (un comprimé) comprenant de la poudre de cacao, qui se dissout ou peut être dispersée rapidement dans de l'eau ou des liquides (à base d'eau). Les comprimés (lorsqu'ils sont dissous dans un liquide chaud ou froid) peuvent être facilement consommés par un être humain.
PCT/EP2022/063123 2021-05-19 2022-05-16 Comprimés non effervescents à dissolution rapide comprenant de la poudre de cacao WO2022243214A1 (fr)

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US202163190505P 2021-05-19 2021-05-19
US63/190,505 2021-05-19
CH6132021 2021-05-28
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Citations (5)

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Publication number Priority date Publication date Assignee Title
JP2004155781A (ja) * 2002-10-17 2004-06-03 Tokuyuki Namiki 口腔内速崩錠
JP2008073004A (ja) * 2006-09-25 2008-04-03 Unitec Foods Co Ltd ココアタブレット
WO2008059652A1 (fr) * 2006-11-13 2008-05-22 Ina Food Industry Co., Ltd. Agent désintégrant, et comprimé et granule contenant chacun celui-ci
US20080317891A1 (en) * 2007-06-21 2008-12-25 Anderson Brent A Edible Products Having A High Cocoa Polyphenol Content and Improved Flavor and The Milled Cocoa Extracts Used Therein
CN106109512A (zh) * 2016-06-27 2016-11-16 郭迎庆 一种可可多酚咀嚼片的制备方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004155781A (ja) * 2002-10-17 2004-06-03 Tokuyuki Namiki 口腔内速崩錠
JP2008073004A (ja) * 2006-09-25 2008-04-03 Unitec Foods Co Ltd ココアタブレット
WO2008059652A1 (fr) * 2006-11-13 2008-05-22 Ina Food Industry Co., Ltd. Agent désintégrant, et comprimé et granule contenant chacun celui-ci
US20080317891A1 (en) * 2007-06-21 2008-12-25 Anderson Brent A Edible Products Having A High Cocoa Polyphenol Content and Improved Flavor and The Milled Cocoa Extracts Used Therein
CN106109512A (zh) * 2016-06-27 2016-11-16 郭迎庆 一种可可多酚咀嚼片的制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NGUYEN P.T.N. ET AL: "Sugar alcohols - Multifunctional agents in the freeze casting process of foods", JOURNAL OF FOOD ENGINEERING, vol. 153, 1 May 2015 (2015-05-01), AMSTERDAM, NL, pages 1 - 7, XP055953391, ISSN: 0260-8774, Retrieved from the Internet <URL:https://www.sciencedirect.com/science/article/pii/S0260877414005275/pdfft?md5=d0c21379516498f78eaa1d2c29e0bf85&pid=1-s2.0-S0260877414005275-main.pdf> DOI: 10.1016/j.jfoodeng.2014.12.007 *

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