WO2008053942A1 - Composition pour la gorge - Google Patents

Composition pour la gorge Download PDF

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Publication number
WO2008053942A1
WO2008053942A1 PCT/JP2007/071263 JP2007071263W WO2008053942A1 WO 2008053942 A1 WO2008053942 A1 WO 2008053942A1 JP 2007071263 W JP2007071263 W JP 2007071263W WO 2008053942 A1 WO2008053942 A1 WO 2008053942A1
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WO
WIPO (PCT)
Prior art keywords
composition
throat
water
liquid
composition according
Prior art date
Application number
PCT/JP2007/071263
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English (en)
Japanese (ja)
Inventor
Yoshiaki Kato
Takashi Matsuda
Keiko Nagayasu
Akira Katsushima
Atsushi Yokomizo
Original Assignee
San-Ei Gen F.F.I., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by San-Ei Gen F.F.I., Inc. filed Critical San-Ei Gen F.F.I., Inc.
Priority to JP2008542168A priority Critical patent/JPWO2008053942A1/ja
Publication of WO2008053942A1 publication Critical patent/WO2008053942A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders

Definitions

  • the present invention relates to a composition for a throat having a voice improvement effect, particularly a voice disorder prevention effect.
  • the efficacy of pharmaceuticals and functional foods in the existing pharyngeal and laryngeal region is mainly intended for the treatment and prevention of various symptoms such as antibacterial, anti-inflammatory, antitussive and expectorant diseases in the throat.
  • various symptoms such as antibacterial, anti-inflammatory, antitussive and expectorant diseases in the throat.
  • it is easy to utter (improvement of utterance), that is, from the viewpoint of QOL and re, it is fully considered.
  • Non-patent document 1 Clinical and research, 75, No.12, 2625 (1998)
  • Patent Document 1 Japanese Patent Laid-Open No. 2005-120061
  • Patent Document 2 JP 2005-239701 A
  • the present invention is a plant-derived component having a food experience and high safety, specifically, a black bean-derived component.
  • An object of the present invention is to provide a composition for throat which has an excellent ingredient for improving voice production.
  • Another object of the present invention is to provide a throat composition prepared so that it can be taken orally as a food or a favorite product by suppressing the bitterness derived from black beans.
  • the inventors of the present invention have been diligently studying day and night in order to achieve the above-mentioned object. It was found that the composition of the liquid composition was adjusted to have a viscosity of 50 mPa's or more using an agent, and that it was excellent in adhesion to the throat when ingested, and exhibited an excellent voice improvement effect. Further, to adjust the viscosity of the liquid composition in the range of 50 ⁇ 36,000mPa 'S, by suppressing the ratio of the water soluble solids of the black beans 20 wt% or less, that the black beans peculiar bitterness is suppressed As a result, it was confirmed that such a liquid composition was suitable for oral intake for the purpose of improving vocalization.
  • the liquid throat composition of the present invention has been completed based on strength and knowledge.
  • the present invention is a liquid throat composition described in the following (1-1) to (1-14).
  • the enzyme treatment is a treatment using at least one enzyme selected from the group consisting of an enzyme having a proteolytic activity and an enzyme having a saccharide-degrading activity.
  • (1-7) Viscosity imparting power S, locust bean gum, tamarind seed gum, pullulan, xanthan gum, guar gum, tara gum, rhamzan gum, thickening polysaccharide consisting of mannan, inulin and polydextros, and molasses,
  • the liquid throat composition according to (1-6) which is at least one selected from the group consisting of honey, fructose-glucose liquid sugar, reduced maltose starch syrup, reduced starch hydrolyzate and sugar syrup consisting of starch syrup.
  • composition for throat is a dysphonia preventive agent or an dysphonia improving agent.
  • the present inventors have found that the water-soluble solid content of black beans is less than 4 wt%! /, Or even if the viscosity is less than 50 mPa's. It has been found that an excellent voice improvement effect can be obtained by orally ingesting a composition containing a specific amount of potassium. According to the composition, it is prepared into a liquid or semi-solid having an arbitrary viscosity not limited to the above-mentioned predetermined viscosity, or prepared into a solid having an arbitrary form such as a wearable or troche. It was confirmed that it can be provided as an oral composition having various forms. The present invention has been completed based on such findings, and provides the following throat composition.
  • Throat composition (II-l) A composition for throat containing a water-soluble solid content of black beans and a potassium-containing substance in a proportion that satisfies the relationship of the following formula (I):
  • X Potassium ion concentration derived from the potassium-containing material in the composition (wt%)
  • Y Black bean water-soluble solid content concentration in the composition (wt%) (Y ⁇ 0.5 wt ⁇ 1 ⁇ 2)
  • the enzyme treatment is a treatment using at least one enzyme selected from the group consisting of an enzyme having a proteolytic activity and an enzyme having a saccharide-degrading activity ( ⁇ The composition for throat described in 3).
  • the black bean water-soluble solid content concentration in the composition is 0.5 to 20% by weight ( ⁇ -1) to (II-
  • Potassium ion concentration derived from ([pi-7) containing potassium in the composition is 0.0;! A ⁇ 2 weight 0/0, the (II-1) to ( ⁇ -6) /, deviation A composition for throat as described above.
  • composition for throat according to any one of ( ⁇ -1) to ( ⁇ -7), which is a composition having ⁇ in the oral cavity of 5 to 9.
  • the solid throat composition is a chewable tablet, a troche, or a sputum.
  • X Concentration of strength rium ion derived from the content of strength rium in the composition (wt%)
  • ⁇ Concentration of water soluble solids in black beans in the composition (wt%) (however, ⁇ 0.5 wt ⁇ 1 ⁇ 2)
  • X Potassium ion concentration derived from the potassium-containing material in the composition (wt%)
  • Y Black bean water-soluble solid content concentration in the composition (wt%) (Y ⁇ 0.5 wt ⁇ 1 ⁇ 2)
  • the throat composition of the present invention is characterized by having an excellent voice improvement action, particularly a voice disorder prevention action.
  • the liquid throat composition of the present invention is excellent in adhesion persistence to the throat when ingested orally, and as a result, can act on the throat for a long time.
  • the liquid throat composition of the present invention obtains the above-mentioned excellent speech improvement effect by ingesting before singing, such as singing such as karaoke, presentation, speech, drama and lecture. be able to.
  • the liquid throat composition of the present invention has been devised so that a black bean ingredient with a high safety with eating experience is an active ingredient and the bitter taste derived from the black bean ingredient is not expressed, so that it is only as a pharmaceutical product. Nagu It can be effectively used as a daily ingested food.
  • the throat composition of the present invention comprises a highly safe black bean ingredient with a dietary experience as an effective component, and also exhibits an excellent voice improvement effect without being restricted by viscosity or its shape. Therefore, it can be effectively used not only as a medicine but also as a food that is ingested on a daily basis (for example, beverages, syrups, and sweets such as chewables, troches, and strawberries).
  • the "voice improvement action” as used in the present invention is an action that maintains a normal state (smooth utterance) of a utterance in a voice used in daily conversation or a singing voice used in singing. It means the action of promptly returning speech from an abnormal state to a normal state.
  • “Maintaining utterance in a normal state” means, in other words, “effect of preventing normal utterance to abnormal utterance (speech disorder)” (in the present invention! /
  • the effect of promptly returning the utterance from the abnormal state to the normal state means, in other words, “the effect of improving the abnormal utterance (speech disorder) to the normal utterance” "(In the present invention!
  • the throat composition targeted by the present invention preferably has a ⁇ voice disorder prevention effect '', and more preferably has both a ⁇ voice disorder prevention effect '' and a ⁇ voice disorder improvement effect ''! / What is it.
  • the present invention is a liquid throat composition prepared from black beans as a raw material.
  • the liquid throat composition contains 4 to 20% by weight of a black soybean water-soluble solid and is adjusted to have a viscosity of 50 mPa's or more, preferably 50 to 36,000 mPa's. It is characterized by
  • the water-soluble solid content of black beans is a general term for water-soluble components derived from black beans, and generally includes substances that dissolve in water, such as sugars, salts, soluble proteins, and acids. Used as a content index. Such a water-soluble solid content is generally determined by a force S obtained with a refractometer for sugar.
  • the water-soluble solid content of black beans contained in the liquid throat composition of the present invention may be contained in a proportion of 4 to 20% by weight as described above, preferably 5 to 20% by weight, More preferred is 6 to 20% by weight, still more preferred is 6 to 18% by weight.
  • the liquid throat composition of the present invention contains a processed black bean so that the water-soluble solid content of black beans is in the above-mentioned ratio, as long as the water-soluble solid content of black beans is in the above-mentioned ratio.
  • the type and form of the processed black bean to be blended are not particularly limited.
  • a black bean solvent extract is preferred.
  • Black beans are black seeds (grains) (black soybeans) of a short-day annual plant belonging to the leguminous soybean species Glycine max (Shi) Merrill.
  • the black beans can be seeds of any varieties as long as they have varieties such as Meiko Koguro, Tokachikuro, Iwakuro, Tamadakuro, Tamba Black, Shinano Black, and Goku.
  • Examples of the extraction solvent used for the preparation of the black bean solvent extract include water, a polar organic solvent, or a mixture thereof.
  • Examples of the polar organic solvent include alcohol, acetonitrile, ethyl acetate and the like.
  • water, lower alcohols, or a mixture thereof examples include C1-C4 lower alcohols such as methanol, ethanol, propanol, isopropyl alcohol, and butanol, preferably ethanol.
  • the extraction solvent is preferably water or hydrous alcohol (particularly hydrous ethanol). When water-containing alcohol (especially water-containing ethanol) is used as the solvent, the amount of alcohol (ethanol) contained therein is preferably 40% by volume or less.
  • the extraction solvent is adjusted to be acidic! /!
  • the adjustment to acidity can be carried out using an inorganic acid such as hydrochloric acid, sulfuric acid or phosphoric acid, or an organic acid such as citrate or malic acid so that the pH is in the range of about 2 to 5.5.
  • the extraction method a generally used method can be employed. No limitation, for example, a method of immersing raw or dried black beans (as is, or crude powder, shredded product) in a solvent under low temperature, normal temperature, heating or boiling conditions; low temperature, normal temperature, heating or Examples include extraction with stirring under boiling conditions; supercritical extraction using carbon dioxide or the like; or bar-collation method.
  • the dried black bean is immersed in a solvent under high temperature or boiling conditions, and extracted with stirring as necessary (heat treatment). Extraction method).
  • the black bean extract obtained above is further subjected to an enzyme treatment or / and a molecular weight of 500 00 to 25000. It is also possible to perform any combination of fractionation processes.
  • examples of the enzyme used for the enzyme treatment include an enzyme having an action of degrading a sugar or / and a protein.
  • the former saccharide-degrading enzymes amylases such as Christase Y (manufactured by Yamato Kasei) and Sumiteam S (manufactured by Shinnippon Chemical Co., Ltd.); Cellulase A (manufactured by Amano Enzym), Cellulases such as AC40 (manufactured by HIBI); enzymes having saccharide-degrading activity such as hemicellulase such as sucrase S (manufactured by Sankyo) and Sumiteam X (manufactured by Shin Nippon Kagaku Co., Ltd.) can be used.
  • proteolytic enzymes include acidase proteases such as Neurase A (manufactured by Amano Enzyme) and Protease YP-SS (manufactured by Yakult Pharmaceutical Co., Ltd.); Neutral proteases such as Tokasei Kogyo Co., Ltd .; enzymes having proteolytic activity such as alkaline proteases such as Novozym FM (Novozymes) Nyabioprase SP-4FG (Nagase ChemteX) can be used.
  • acidase proteases such as Neurase A (manufactured by Amano Enzyme) and Protease YP-SS (manufactured by Yakult Pharmaceutical Co., Ltd.); Neutral proteases such as Tokasei Kogyo Co., Ltd .
  • enzymes having proteolytic activity such as alkaline proteases such as Novozym FM (Novozymes) Nyabioprase SP-4FG (Nagase Chemt
  • Such an enzyme having a saccharide-degrading activity and an enzyme having a proteolytic activity can be used singly or in combination.
  • the enzyme to be used may be a single enzyme, but various enzymes may be used in combination.
  • a preferred enzyme is an enzyme having a saccharide-degrading activity, and in particular, an enzyme having an activity of degrading a polysaccharide such as the above-mentioned cellulase, amylase, hemicellulase or the like can be suitably used.
  • the enzyme treatment can be carried out under predetermined conditions suitable for each enzyme used.
  • the temperature conditions for performing the enzyme treatment are not particularly limited, but a range of 30 to 80 ° C can be usually used. Preferably it is 35-60 degreeC.
  • Examples of the fractionation treatment with a molecular weight of 5000 to 25000 include a gel filtration method, a membrane separation method, and an adsorption treatment method.
  • a membrane separation method is preferred.
  • the membrane separation method used here is that the fraction of molecular weight 5000-25000 is extracted from the solvent extract of black beans. There is no particular limitation as long as it can be acquired. Specifically, separation and removal of high molecular weight compounds using membranes with a set molecular weight cut off, for example, in the range of about 20000 to 30000, preferably ⁇ is in the range of about 22000 to 28000, more preferably ⁇ is around 25000. And a method for separating and removing low molecular weight compounds using a membrane in the range of about 1000 to 8000, preferably in the range of about 3000 to 7000, more preferably around 5000. It is preferable to do in combination.
  • an NTU-3150 membrane, an NTU-3250 membrane, an NTU-3550 membrane, an NTU-3800 UF membrane (with the molecular weight cut off within the above range) Cefilt-UF (manufactured by NGK); AHP-2013 membrane, AHP-3013 membrane, AHP-1010 membrane (above, manufactured by Asahi Kasei); etc. be able to.
  • the latter method for separating and removing low molecular weight compounds is specifically NTR-7250 membrane, NTR-7410 membrane, NTR-7430 membrane, NTR-7450 membrane with molecular weight cut off within the above range (above, Nitto Denko), AIP-3013 membrane, ACP-3013 membrane, ACP-2013 membrane, AIP-2013 membrane, AIO-1010 membrane (above, manufactured by Asahi Kasei) and other reverse osmosis (RO) membrane treatment, Or use force S to raise ultrafiltration (UF) membrane treatment.
  • the membrane material used for the force and membrane separation method may be natural, synthetic or semi-synthetic, for example, senorelose, cenololose diacetate or triacetate, polyamide, polysolephone, polystyrene, polyimide, polyacrylonitrile. And so on.
  • a microfiltration (MF) membrane or the like can also be used as the membrane used for the fractionation treatment.
  • the enzyme treatment and the molecular weight fractionation treatment can be performed alone or in combination with the black bean extract or the treated product. Moreover, when both are performed in combination, the enzyme treatment and the molecular weight fractionation treatment can be performed in any combination continuously or discontinuously.
  • the order of the combination is not particularly limited, and any of the order of molecular weight fractionation after the enzyme treatment and the order of molecular weight fractionation after the molecular weight fractionation may be used, but the former method is preferred.
  • the black bean extract or its treatment product is further subjected to normal purification such as acid treatment, extraction treatment, adsorption treatment, ion exchange treatment or membrane treatment. Can also be used for processing The These treatments can be performed on the black bean extract or the treated product, either alone or in combination of two or more.
  • the solvent extract of black beans obtained in this way has a water-soluble solid content of black beans of 4 to 20% by weight, preferably 5 to 20 using a food solution such as water or ethanol as necessary. % By weight, more preferably 6 to 20% by weight, and even more preferably 6 to 18% by weight.
  • the viscosity is preferably increased by using a viscosity-imparting agent as described later. It is adjusted to be 50 mPa's or more, preferably 50 to 36,000 mPa-s.
  • the viscosity is a BL type rotational viscometer (with a rotor No.
  • viscosity means a viscosity measured under such conditions.
  • Adjustment of the viscosity of the liquid throat composition can usually be performed by blending a viscosity-imparting agent. Further, the above-mentioned food solvents such as water and ethanol may be used in combination with a viscosity-imparting agent.
  • the viscosity imparting agent the viscosity of the liquid composition containing 4 to 20% by weight of the water-soluble solid content of black beans is 50 mPa's or more, preferably 50 to 36,000 mPa's. There is no particular limitation as long as it can be used.
  • gums such as locust bean gum, tamarind seed gum, pullulan, xanthan gum, guar gum, tara gum, rhamzan gum and mannan; starch (hereinafter collectively referred to as “polysaccharide”); glucose, fructose Monosaccharides such as sucrose, lactose, trehalose, etc .; oligosaccharides consisting of trisaccharides or more; polysaccharides such as inulin and polydextrose; chickenpox; Sugar alcohol; molasses, honey, fructose dextrose liquid sugar, reduced maltose starch syrup, reduced starch hydrolyzate, mixture of sugars such as starch syrup (these are also collectively referred to as “saccharides”). These can be used alone or in any combination of two or more.
  • locust bean gum tamarind seed gum, pullulan, guar gum, inu Polysaccharides such as phosphorus and polydextrose; and sugars such as molasses, honey, fructose glucose liquid sugar, reduced maltose starch syrup, reduced starch hydrolyzate and starch syrup, more preferably sugars.
  • the viscosity is not particularly limited as long as it is in the range of 50 to 36000 mPa's, preferably 6 O-lOOOOmPa-s, more preferably ⁇ is 90 to 8000 mPa-s.
  • the liquid throat composition of the present invention is a fragrance, a coloring agent, a refreshing agent, an antioxidant, a sweetener or an antibacterial agent within the range not impairing the above characteristics (water-soluble solid content of black beans, viscosity).
  • Other ingredients such as agents can also be added.
  • a potassium containing material can also be mix
  • the potassium-containing material is not particularly limited as long as it contains a potassium salt.
  • Examples include inorganic compounds such as potassium chloride, potassium carbonate, 2 potassium phosphate, 3 potassium phosphate, potassium darconate, 3 potassium citrate, potassium glutamate, and potassium hydrogen tartrate; and whey salt, seaweed ash extraction Cite, buckwheat ash extract, crude seawater potassium chloride, brine lake water sodium chloride, etc.
  • the pH of the liquid throat composition of the present invention is usually in the range of pH 5 to 9, preferably pH 5 to 8, more preferably ⁇ 5 to 7.5. As shown in the experimental examples, when the pH is 4.8 or less, particularly 4.6 or less, the voice improvement effect tends to decrease.
  • the liquid composition thus obtained is then sterilized to prepare a throat composition (viscosity at cooling (20 ° C); 50 to 36000 mPa's).
  • the sterilization treatment is not particularly limited, but normal heat sterilization can be used.
  • the power greatly fluctuates depending on the contained components or the pH. For example, pasteurization by heating at 62 to 65 ° C for about 30 minutes, sterilization at 72 to 75 ° C for about 15 seconds Sterilization, UHT sterilization that heats at about 150 ° C for about 2 to 3 seconds, and retort sterilization that heats at about 120 ° C for about 4 minutes are known.
  • the liquid throat composition according to the present invention is not particularly limited as long as it does not impair the voicing improvement effect of the active ingredient of black beans, and is not particularly limited as long as it is heat sterilized, usually 80 to; Sterilization, or 115 ⁇ ; preferably, sterilization of retort at 135 ° C for 4-30 minutes.
  • the liquid throat composition of the present invention may be a spray-type, drip-type, or discharge-type throat preparation (including food).
  • Various containers such as bottles, pumps, sprays, and tubes can be used as the containers used for the above-mentioned types of preparations.
  • the liquid composition of the present invention thus prepared has a voice improvement effect, particularly a voice disturbance prevention action. Therefore, the liquid composition can be suitably used as it is as a composition for the throat, and as a dysphonia prevention agent or an utterance improving agent.
  • the throat composition targeted by the present invention is prepared from black beans as a raw material, and additionally contains a potassium-containing material, in the same manner as the liquid throat composition described above.
  • the throat composition is characterized in that it contains a water-soluble solid content of black beans and a potassium-containing material in a proportion that is related to the following formula (I):
  • X Concentration of strength rium ion derived from the content of strength rime in the composition (wt%)
  • Y Concentration of black bean water-soluble solids in the composition (wt%) (Y ⁇ 0.5 wt ⁇ 1 ⁇ 2)
  • the proportion of the water-soluble solid content of black beans contained in the composition is 0.5% by weight or more, and the above formula is used for the potassium ion concentration derived from the power lithium-containing material contained in the composition. If it is a ratio which satisfy
  • the throat composition of the present invention contains a processed black bean product in such a proportion that the water-soluble solid content of the black bean satisfies the above conditions.
  • the type and form of the processed black bean are not particularly limited, but a black bean solvent extract is preferred.
  • the method for preparing the black bean solvent extract is as described above. As described above, the black bean solvent extract is treated with an enzyme or / and a molecular weight of 5000 to remove the unpleasant odor, taste or / and color as described above. ⁇ 25000 fraction processing can be done in any combination! /.
  • the throat composition of the present invention contains a potassium-containing material in such a ratio that the content of potassium ions derived from the potassium-containing material satisfies the above-mentioned conditions.
  • the ratio of the potassium-containing material contained in the throat composition of the present invention is not particularly limited as long as it satisfies the above formula with respect to the water-soluble solid content of black beans! Preferably, 0.0;! To 2% by weight, more preferably 0.01 to;!% By weight, and still more preferably 0.02 to 0.6% by weight.
  • the potassium-containing material is not particularly limited as long as it contains a potassium salt.
  • examples include inorganic compounds such as potassium chloride, potassium carbonate, 2 potassium phosphate, 3 potassium phosphate, potassium dalconate, 3 potassium citrate, potassium glutamate, and potassium hydrogen tartrate; and whey salt, seaweed ash Examples include extracts, buckwheat ash extracts, crude seawater potassium chloride, and saltwater lake water chloride sodium chloride.
  • the throat composition of the present invention includes a fragrance, a colorant, a refreshing agent, an anti-oxidant, and the like within a range that does not impair the above characteristics (water-soluble solid content of black beans and content of potassium ions derived from potassium-containing material).
  • Other ingredients such as oxidizing agents, sweeteners or antibacterial agents can also be included.
  • the throat composition of the present invention is preferably prepared so that it usually has a pH in the range of 5 to 9 in the oral cavity after eating or taking.
  • the pH in the oral cavity is preferably pH 5 to 8, more preferably ⁇ 5 to 7.5. This is because, as shown in the experimental examples, when the pH in the oral cavity is 4.8 or less, particularly 4.6 or less, the voice improvement effect tends to decrease.
  • the throat composition of the present invention is preferably adjusted to be in the range of ⁇ 5 to 8, preferably ⁇ 5.5 to 7.5.
  • the composition of the present invention thus prepared has a voice improvement action, particularly a voice disorder prevention action. Therefore, the composition can be used as it is as a throat composition, and as an agent for preventing or improving speech production.
  • the viscosity and shape of the throat composition of the present invention are not particularly limited as long as it contains the water-soluble solid content of black beans and the potassium-containing material in the above-mentioned proportions.
  • it can be arbitrarily prepared into a liquid composition and a semi-solid or solid composition.
  • the throat composition having a liquid form can be prepared using water (purified water, ionic water, etc.) and a food solvent such as ethanol, and if necessary, the pH can be adjusted using a buffer. It can also adjust so that it may become the said range.
  • These liquid compositions can also be prepared in the form of normal beverages, which can be spray-type, drop-type, or discharge-type throat preparations (including food).
  • As the container used to make each type of the above-mentioned preparations it is necessary to use various containers such as bottles, pumps, sprays, and tubes.
  • the throat composition having a semi-solid or solid form is not particularly limited as long as it has an oral administration (or oral ingestion) form.
  • it can be made into solid preparations for oral administration such as powders, tablets, granules, pills, lozenges, syrups, wearable tablets and dry syrups.
  • you may have a form of a candy, a jelly, a gummi, and gum.
  • a solid composition having a dosage form can be prepared according to conventional methods in the art.
  • the throat composition of the present invention may be formulated with various carriers and additives that are pharmaceutically acceptable for oral administration in order to prepare the oral dosage form and to stabilize the composition.
  • various carriers and additives that are pharmaceutically acceptable for oral administration in order to prepare the oral dosage form and to stabilize the composition.
  • Carriers or additives for oral administration or oral ingestion include lactose, sucrose, glucose, mannitol, sonorebitol, corn starch, partially pregelatinized starch, crystalline senorelose, low-substituted hydroxypropylcellulose, cano Excipients such as remellose sodium, talc; starch, ⁇ -starch, agar, gelatin, gum arabic, dextrin, methylcellulose, ethinoresenorelose, polyvinylinopyrrolidone, hydroxypropinoremethinoresenorelose, hydroxypropyl Binders such as cellulose, carboxymethyl cellulose or salts thereof, crystalline cellulose; calcium carbonate, crospovidone, starch, carboxymethyl cellulose calcium, low-substituted hydroxypropyl cellulose, carboxymethyl starch Disintegrating agents such as: magnesium stearate, talc, polyethylene glycol, anhydrous, such as anhydrous key
  • stabilizers In addition to the above components, as long as the effects of the present invention are not impaired, stabilizers, emulsifiers, dispersants, fluidizing agents, buffering agents, wetting agents, interfaces, which are usually acceptable as additives for pharmaceuticals or foods.
  • Optional components such as activators, thickeners, preservatives, pH adjusters, colorants, solvents, and solubilizing agents can be added as desired.
  • the throat composition of the present invention is prepared in the aforementioned solid, semi-solid or liquid oral form and can be administered or ingested.
  • the method of administration or ingestion and the timing thereof are not limited, but preferably, the water-soluble solid content of black beans is 0.2- It is preferable to administer (ingest) at a rate of 0. 4g.
  • the concentrated extract of black beans prepared in Reference Example 1 water-soluble solid content: 70% by weight
  • locust bean gum as a viscosity-imparting agent were used.
  • a liquid composition (test samples 1 to 18) (see Table 1) was prepared. 6 healthy adult males (26-56) who are aware of their voice disturbances when these liquid compositions are uttered daily. (Year-old) (panelist) ingested and evaluated the voice improvement effect and bitterness.
  • Dilute black bean concentrate (water-soluble solid content 70% by weight) with water to give black beans water-soluble solid content 3, 6, 12, 18 and 24% by weight (test sample;! ⁇ 5) respectively
  • a liquid composition was prepared. This was then sterilized at 90 ° C. for 20 minutes to give a low-viscosity liquid composition (viscosity 2-8 mPa's).
  • the viscosity of the liquid composition is a BL type rotational viscometer (manufactured by Toki Sangyo Co., Ltd.) (uses rotor N0.1 up to a viscosity of 450 mPa's, viscosity greater than S450 mPa's and rotor N0 up to 2250 mPa's.
  • Dilute black bean concentrate (water-soluble solid content 70 wt%) with 1.5 wt% locust bean gum aqueous solution to obtain black beans water-soluble solid content 3, 6, 12, 18 and 24 wt% respectively.
  • a liquid composition containing the test samples 6 to 10 was prepared. Next, this was sterilized at 90 ° C. for 20 minutes to obtain a highly viscous liquid composition (viscosity 3150-7450 mPa's).
  • Diluted black bean concentrate (water-soluble solid content 70% by weight) with various concentrations of locust bean gum aqueous solution so that the water-soluble solid content of black bean is 12% by weight (test sample 11 ⁇ ; 14)
  • a viscous liquid composition was prepared. Next, this was sterilized at 90 ° C. for 20 minutes to obtain a liquid composition having a low to high viscosity (viscosity 11.5-557.5 mPa's).
  • test samples 5 and 10 each of the above-prepared test samples;! To 18 was ingested by the panelists! /, And the voice improvement feeling evaluation test and the bitterness evaluation test described below were conducted.
  • the liquid composition (test samples 5 and 10) with a water-soluble solid content of black beans of 24% by weight is lg, and the water-soluble solid content of black beans is 18%.
  • % Liquid composition (test samples 4 and 9) is 1.3 g, liquid composition (test samples 3, 8, 11-14) containing 12% by weight of black beans in water-soluble solids is 2 ⁇ black water in water Liquid composition (test samples 2, 7, and 15--18) with 6% solids by weight solids, 8g liquid composition (test samples 1 and 6) with 3% by weight of water-soluble solids of black beans It was.
  • the feeling of voicing improvement is the length of the throat tiredness, throat dryness, voice faintness, ease of voice production, and duration after utterance when the test sample is ingested. This was evaluated comprehensively. When it is improved overall, it is judged as improved.
  • the feeling of improvement in utterance and the feeling of bitterness are the sum of the scores of the six panelists. The higher the score, the higher the voicing improvement effect, and the lower the score, the lower the bitterness, the less bitter.
  • a liquid composition (viscosity 31) to which viscosity was imparted with a viscosity-imparting agent as in test samples 6 to 10 50 ⁇ 7450mPa 's) is an oral solution that has excellent voicing improvement and almost no bitterness even if the water-soluble solid content of black beans is 6 ⁇ ; 18% by weight.
  • the water-soluble solid content of black beans was as low as 3% by weight as in the test sample 6, no improvement in vocalization was obtained.
  • Test Sample 5 when the water-soluble solid content of black beans was as high as 24% by weight, bitterness was strongly expressed, which hindered oral intake.
  • a liquid composition having a good voice improvement effect, no strength, no bitter taste, and no obstacle to oral intake has a water-soluble solid content of black beans of 4 to 20% by weight, preferably The viscosity is 5 to 20% by weight, more preferably 6 to 20% by weight, and the viscosity of the liquid composition is considered to be 50 mPa's or more, preferably 60 mPa's or more.
  • Bistop D-3000 (manufactured by San-Ei Gen F / F I Co., Ltd.)
  • Locust bean gum (Bistop D-2050, Saneigen) as a viscosity-imparting agent in 904.4 g of water F.F.I. Co., Ltd.) 8 ⁇ 3g and sweetener (sucralose) 0.3g was added, dissolved by heating and stirring at 80 ° C for 10 minutes, and then the black bean concentrate extract prepared in Reference Example 1 (water-soluble (Solid content 70 wt%) 86 8 was added and stirred until uniform. To this was added perfume lg and autoclaved at 121 ° C for 20 minutes to prepare 1 kg of a liquid throat composition having a viscosity of 114 mPa's.
  • Formulation Example 1 As in Formulation Example 1, each component shown in Table 2 and Table 3 was blended in the proportions described, Formulation Examples 2 and 3 using tamarind seed gum as a viscosity-imparting agent, and pullulan as a viscosity-imparting agent were used. A liquid throat composition of Formulation 4 and Formula 6 using guar gum was prepared. The viscosities of Formulation Examples 2 to 4 and 6 were 121 mPa * s, 149 mPa * s, 97 mPa * s, and 453 mPa * s, respectively.
  • Liquid composition having various water-soluble solid content and potassium ion concentration (test sample) using concentrated black bean extract (water-soluble solid content 70 wt%) prepared in Reference Example 1 and potassium chloride as potassium content 19-55) (see Tables 4-7).
  • test sample was ingested by 6 healthy adult men (26 to 56 years old) (panelists) who were aware of impaired voice when performing daily continuous utterances. The improvement effect was evaluated.
  • Each liquid composition (test samples 19 to 55) was ingested by placing each prepared liquid composition on the back of the tongue and swallowing it at once.
  • Concentrated black bean extract (70% water soluble solids) with water and / or honey , So that the water-soluble solid content of black beans is 0.25, 0.5, 1, 2, 4, 8, 16, 24 and 70% by weight, respectively, and the potassium ion is in the proportion of 0-3.776% by weight
  • a liquid composition (test samples 22 to 55) was prepared.
  • a liquid composition (test samples 19 to 21) containing no concentrated extract of black beans was also prepared. They were then sterilized at 90 ° C for 20 minutes. The viscosity of the liquid composition was measured at 20 ° C. at a rotational speed of 12 rpm using a BL type rotational viscometer (manufactured by Toki Sangyo Co., Ltd.) in the same manner as in Experimental Example 1.
  • test samples 19 to 55 prepared above were ingested by the paneler, and an utterance improvement feeling evaluation test was performed in the same manner as in Experimental Example 1.
  • the liquid composition (test samples 22 and 23) containing 0.25% by weight of water-soluble solids of black beans has 4.0g of water-soluble solids of black beans so that an equivalent amount of black bean extract can be ingested.
  • the liquid composition (test sample 24-30) of 0.5% by weight is 4.0g
  • the liquid composition (test sample 3;!-34) of 1% by weight of black beans is 4.0g.
  • the liquid composition (test sample 35-39) with a solid content of 2% by weight is 4.0g
  • the liquid composition (test sample 40-43) with a water-soluble solid content of 4% by weight is 4.0g.
  • the liquid composition (test sample 44-47) with a solid content of 8% by weight is 4.0g
  • the water-soluble composition of black beans with a water content of 16% by weight is 4.0g, with the water solubility of black beans.
  • the liquid composition (test samples 54 to 55) in which 70 g of the water-soluble solid content of black beans and black beans was 70% by weight was 0.3 g.
  • the improvement in utterance is the sum of the scores of the six panelists. The higher the score is, the higher the score is! The higher the score, the higher the utterance improvement effect. In addition, based on the total score, we judged as follows:
  • Viscosity (mPa ⁇ s) 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 Voice improvement effect +++ (23)-(0) + (6) ++ (15) ++ + (20)-(0) + (7) ++ (16) +++ (19)-(0)
  • X Potassium ion concentration derived from the potassium-containing material in the composition (wt%)
  • Y Black bean water-soluble solid concentration in the composition (wt%) (Y ⁇ 0.5 wt%)
  • Black beans extract (water-soluble solid content 70%) 57.2kg, K PO 2.1kg, water 939.7kg,
  • the black bean extract FD powder was prepared as follows:
  • a black bean concentrate extract (water-soluble solid content 20%) was prepared, and 140 kg of the extract was freeze-dried at 0.8 ⁇ or lower for 24 hours and crushed into blocks. After that, 30.5 kg of black bean extract FD powder was obtained by passing through a 30 mesh sieve.
  • FIG. 1 is a graph showing the relationship between the black bean water-soluble solid content (% by weight) contained in the throat composition of the present invention and the concentration (% by weight) of potassium ions derived from potassium inclusions. It is a figure when the upper limit of the vertical axis (black bean water-soluble solid content%) is 20% by weight and the upper limit of the horizontal axis (added potassium ion concentration%) is 1% by weight.
  • FIG. 2 is a graph showing the relationship between the black bean water-soluble solid content (% by weight) contained in the throat composition of the present invention and the concentration (% by weight) of potassium ions derived from potassium-containing substances. It is a figure when the upper limit of the vertical axis (black bean water-soluble solid content%) is 70% by weight and the upper limit of the horizontal axis (added potassium ion concentration%) is 2% by weight.

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Abstract

L'invention concerne une composition pour la gorge ayant un effet d'amélioration de la vocalisation, en particulier un effet de prévention des troubles de la voix. La composition pour la gorge de l'invention comprend une composition liquide pour la gorge qui contient un composant solide hydrosoluble de haricots noirs selon un rapport de 4 à 20 % en poids et possède une viscosité de 50 à 36 000 mPa•s, et une composition pour la gorge qui contient un composant solide hydrosoluble de haricots noirs et un matériau contenant du potassium selon un rapport qui satisfait la relation représentée par la formule suivante (I) : Y ≥ 0,6285X-0,7276 (I) X : Concentration (% en poids) d'ion potassium obtenu à partir du matériau contenant du potassium dans la composition Y : Concentration (% en poids) de composant solide hydrosoluble de haricots noirs dans la composition (à condition que Y ≥ 0.5% en poids).
PCT/JP2007/071263 2006-10-31 2007-10-31 Composition pour la gorge WO2008053942A1 (fr)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9609869B2 (en) 2009-12-01 2017-04-04 Syngenta Crop Protection, Llc Insecticidal compounds based on isoxazoline derivatives

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001039866A (ja) * 1999-07-30 2001-02-13 Taisho Pharmaceut Co Ltd 粘膜適用医薬組成物
JP2004222673A (ja) * 2003-01-27 2004-08-12 Sanei Gen Ffi Inc ヨーグルト及びその製造方法
JP2005120061A (ja) * 2003-10-20 2005-05-12 Sanei Gen Ffi Inc 発声向上剤
JP2006034201A (ja) * 2004-07-29 2006-02-09 T Hasegawa Co Ltd 苺果肉加工品
JP2006061035A (ja) * 2004-08-25 2006-03-09 Morinaga Milk Ind Co Ltd プリン状食品およびその製造方法
JP2006083081A (ja) * 2004-09-15 2006-03-30 Taisho Pharmaceut Co Ltd 粘膜適用液剤

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001039866A (ja) * 1999-07-30 2001-02-13 Taisho Pharmaceut Co Ltd 粘膜適用医薬組成物
JP2004222673A (ja) * 2003-01-27 2004-08-12 Sanei Gen Ffi Inc ヨーグルト及びその製造方法
JP2005120061A (ja) * 2003-10-20 2005-05-12 Sanei Gen Ffi Inc 発声向上剤
JP2006034201A (ja) * 2004-07-29 2006-02-09 T Hasegawa Co Ltd 苺果肉加工品
JP2006061035A (ja) * 2004-08-25 2006-03-09 Morinaga Milk Ind Co Ltd プリン状食品およびその製造方法
JP2006083081A (ja) * 2004-09-15 2006-03-30 Taisho Pharmaceut Co Ltd 粘膜適用液剤

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9609869B2 (en) 2009-12-01 2017-04-04 Syngenta Crop Protection, Llc Insecticidal compounds based on isoxazoline derivatives
US10206400B2 (en) 2009-12-01 2019-02-19 Syngenta Participations Ag Insecticidal compounds based on isoxazoline derivatives
US10750745B2 (en) 2009-12-01 2020-08-25 Syngenta Crop Protection, Llc Insecticidal compounds based on isoxazoline derivatives
US11357231B2 (en) 2009-12-01 2022-06-14 Syngenta Crop Protection Llc Insecticidal compounds based on isoxazoline derivatives

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