WO2007029611A1 - Dispositif d’iontophorèse - Google Patents

Dispositif d’iontophorèse Download PDF

Info

Publication number
WO2007029611A1
WO2007029611A1 PCT/JP2006/317321 JP2006317321W WO2007029611A1 WO 2007029611 A1 WO2007029611 A1 WO 2007029611A1 JP 2006317321 W JP2006317321 W JP 2006317321W WO 2007029611 A1 WO2007029611 A1 WO 2007029611A1
Authority
WO
WIPO (PCT)
Prior art keywords
electrode structure
working electrode
suction cup
working
negative pressure
Prior art date
Application number
PCT/JP2006/317321
Other languages
English (en)
Japanese (ja)
Inventor
Kazuma Mitsuguchi
Mitsugu Yamauchi
Mizuo Nakayama
Takehiko Matsumura
Hidero Akiyama
Akihiko Matsumura
Original Assignee
Tti Ellebeau, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tti Ellebeau, Inc. filed Critical Tti Ellebeau, Inc.
Priority to JP2007534372A priority Critical patent/JPWO2007029611A1/ja
Priority to US12/065,851 priority patent/US20100030128A1/en
Publication of WO2007029611A1 publication Critical patent/WO2007029611A1/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/20Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303Constructional details

Definitions

  • the working electrode structure and the non-working electrode structure used for administering an ionic drug by iontophoresis and these working electrodes
  • a direct-current power supply device connected to the structure body and the non-working side electrode structure with different polarities, and the tip surface of each of the working side electrode structure and the non-working side electrode structure is used as a close contact surface for living things such as skin
  • a negative pressure generating device for generating a negative pressure integrally between at least one of the working electrode structure and the non-working electrode structure and the biological interface.
  • the suction cup may be integrally formed with at least one of the working electrode structure and the non-working electrode structure. Thereby, the manufacturing cost can be suppressed.
  • FIG. 1 is a cross-sectional view schematically showing an iontophoresis device according to an example of an embodiment of the present invention.
  • the contact surface 160A of the working electrode structure 120A protrudes inside the suction cup 140A.
  • the suction cup 140A is deeper than the tip portion 141A of the suction cup 140A and can be pushed into the biological interface.
  • the working electrode structure 120A includes one each of the ion exchange membrane and the cation exchange membrane, but is limited to this configuration. Then, only a cation exchange membrane may be used, or a bipolar membrane may be used. Further, the force provided with the buffer solution holding portion 132A In the present invention, this buffer solution The holding part 132A is not an essential component.

Abstract

La présente invention concerne un dispositif d’iontophorèse (110) comprenant une structure d’électrode latérale en fonctionnement (120A) et une structure équivalente ne fonctionnant pas (120B) utilisée pour administrer un médicament ionique par iontophorèse, et une alimentation électrique C.C (112) branchée à la structure d’électrodes latérale en fonctionnement (120A) et à la structure équivalente ne fonctionnant pas (120B) avec des polarités différentes de façon à ce que les faces avant de la structure d’électrodes latérale en fonctionnement (120A) et la structure équivalente ne fonctionnant pas (120B) puissent adhérer étroitement, comme surfaces d’adhésion (160A, 160B) à une interface biologique telle que la peau (150). Au moins une des structures d’électrode (120A) en fonctionnement et la structure d’électrode latérale qui ne fonctionne pas (120B) est intégralement fournie avec un générateur de pression négative (139A) ou (139B) pour générer une pression négative entre au moins une des structures d’électrode latérale en fonctionnement (120A) et la structure d’électrode latérale qui ne fonctionne pas (120B) et l’interface biologique lorsque la surface d’adhésion (160A) et/ou (160B) adhère étroitement à l’interface biologique.
PCT/JP2006/317321 2005-09-06 2006-09-01 Dispositif d’iontophorèse WO2007029611A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2007534372A JPWO2007029611A1 (ja) 2005-09-06 2006-09-01 イオントフォレーシス装置
US12/065,851 US20100030128A1 (en) 2005-09-06 2006-09-01 Iontophoresis device

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005-258304 2005-09-06
JP2005258304 2005-09-06

Publications (1)

Publication Number Publication Date
WO2007029611A1 true WO2007029611A1 (fr) 2007-03-15

Family

ID=37835730

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2006/317321 WO2007029611A1 (fr) 2005-09-06 2006-09-01 Dispositif d’iontophorèse

Country Status (3)

Country Link
US (1) US20100030128A1 (fr)
JP (1) JPWO2007029611A1 (fr)
WO (1) WO2007029611A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8062783B2 (en) 2006-12-01 2011-11-22 Tti Ellebeau, Inc. Systems, devices, and methods for powering and/or controlling devices, for instance transdermal delivery devices
WO2012086700A1 (fr) * 2010-12-22 2012-06-28 帝國製薬株式会社 Coussin d'électrode pour ionophorèse
JP2017047184A (ja) * 2015-08-31 2017-03-09 エスディー バイオテクノロジーズ カンパニー リミテッド カスタマイズ型複合刺激が加えられる肌の機能改善用の立体陰圧複合刺激器モジュール
WO2023105861A1 (fr) * 2021-12-08 2023-06-15 酒井医療株式会社 Conducteur pour dispositif d'électrothérapie

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5706288B2 (ja) * 2011-09-29 2015-04-22 株式会社ホーマーイオン研究所 浴用通電装置および電極ユニット

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5545370U (fr) * 1978-09-19 1980-03-25
JP2002282118A (ja) * 2001-03-28 2002-10-02 Aron Kasei Co Ltd 吸 盤
JP3090588U (ja) * 2002-04-25 2002-12-20 功 寺田 持久力強化吸盤及び該吸盤との一体的利用に供する持久力強化吸着補助板
JP2004159673A (ja) * 2002-11-08 2004-06-10 Advance Co Ltd イオントフォレーゼ用デバイス

Family Cites Families (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2626294C3 (de) * 1976-06-11 1980-01-10 Siemens Ag, 1000 Berlin Und 8000 Muenchen Implantierbare Dosiereinrichtung
US4250878A (en) * 1978-11-22 1981-02-17 Motion Control, Inc. Non-invasive chemical species delivery apparatus and method
US4640689A (en) * 1983-08-18 1987-02-03 Drug Delivery Systems Inc. Transdermal drug applicator and electrodes therefor
US5605536A (en) * 1983-08-18 1997-02-25 Drug Delivery Systems Inc. Transdermal drug applicator and electrodes therefor
US4727881A (en) * 1983-11-14 1988-03-01 Minnesota Mining And Manufacturing Company Biomedical electrode
US4747819A (en) * 1984-10-29 1988-05-31 Medtronic, Inc. Iontophoretic drug delivery
US4744787A (en) * 1984-10-29 1988-05-17 Medtronic, Inc. Iontophoresis apparatus and methods of producing same
US4585652A (en) * 1984-11-19 1986-04-29 Regents Of The University Of Minnesota Electrochemical controlled release drug delivery system
US4722726A (en) * 1986-02-12 1988-02-02 Key Pharmaceuticals, Inc. Method and apparatus for iontophoretic drug delivery
US4752285B1 (en) * 1986-03-19 1995-08-22 Univ Utah Res Found Methods and apparatus for iontophoresis application of medicaments
US4725263A (en) * 1986-07-31 1988-02-16 Medtronic, Inc. Programmable constant current source transdermal drug delivery system
US5746711A (en) * 1987-01-05 1998-05-05 Drug Delivery Systems, Inc. Programmable control and mounting system for transdermal drug applicator
US4731049A (en) * 1987-01-30 1988-03-15 Ionics, Incorporated Cell for electrically controlled transdermal drug delivery
US5080646A (en) * 1988-10-03 1992-01-14 Alza Corporation Membrane for electrotransport transdermal drug delivery
US4931046A (en) * 1987-05-15 1990-06-05 Newman Martin H Iontophoresis drug delivery system
US4927408A (en) * 1988-10-03 1990-05-22 Alza Corporation Electrotransport transdermal system
US5006108A (en) * 1988-11-16 1991-04-09 Noven Pharmaceuticals, Inc. Apparatus for iontophoretic drug delivery
GB8928748D0 (en) * 1989-12-20 1990-02-28 Ici Plc Solid state electrochromic devices
US5084006A (en) * 1990-03-30 1992-01-28 Alza Corporation Iontopheretic delivery device
US5236413B1 (en) * 1990-05-07 1996-06-18 Andrew J Feiring Method and apparatus for inducing the permeation of medication into internal tissue
ES2072134T3 (es) * 1990-10-29 1995-07-01 Alza Corp Electrodo iontoforetico para suministrar farmacos y metodo para su hidratacion.
US5158537A (en) * 1990-10-29 1992-10-27 Alza Corporation Iontophoretic delivery device and method of hydrating same
ZA921736B (en) * 1991-03-11 1992-11-25 Alza Corp Iontophoretic delivery device and method of making same
US5405317A (en) * 1991-05-03 1995-04-11 Alza Corporation Iontophoretic delivery device
US5203768A (en) * 1991-07-24 1993-04-20 Alza Corporation Transdermal delivery device
US5310404A (en) * 1992-06-01 1994-05-10 Alza Corporation Iontophoretic delivery device and method of hydrating same
ES2108282T3 (es) * 1992-06-02 1997-12-16 Alza Corp Aparato para la liberacion iontoforetica de farmacos.
US5312326A (en) * 1992-06-02 1994-05-17 Alza Corporation Iontophoretic drug delivery apparatus
US5380271A (en) * 1992-09-24 1995-01-10 Alza Corporation Electrotransport agent delivery device and method
US5322520A (en) * 1992-11-12 1994-06-21 Implemed, Inc. Iontophoretic structure for medical devices
JP3587537B2 (ja) * 1992-12-09 2004-11-10 株式会社半導体エネルギー研究所 半導体装置
US5298017A (en) * 1992-12-29 1994-03-29 Alza Corporation Layered electrotransport drug delivery system
AU676711B2 (en) * 1992-12-31 1997-03-20 Alza Corporation Electrotransport system having flexible means
US5380272A (en) * 1993-01-28 1995-01-10 Scientific Innovations Ltd. Transcutaneous drug delivery applicator
US5406945A (en) * 1993-05-24 1995-04-18 Ndm Acquisition Corp. Biomedical electrode having a secured one-piece conductive terminal
CA2163550A1 (fr) * 1993-05-25 1994-12-08 Gerald E. Hancock Adjuvants pour les vaccins agissant contre le virus respiratoire syncytial
CA2126487C (fr) * 1993-06-23 2001-05-29 Keiichiro Okabe Dispositif d'iontophorese
US6377847B1 (en) * 1993-09-30 2002-04-23 Vyteris, Inc. Iontophoretic drug delivery device and reservoir and method of making same
WO1996005884A1 (fr) * 1994-08-22 1996-02-29 Iomed, Inc. Dispositif d'administration iontophoretique a element d'hydratation integre
JPH11503043A (ja) * 1995-04-07 1999-03-23 ノバルティス・アクチエンゲゼルシャフト 少なくとも2種の被投与物を投与するためのイオン泳動性経皮システム
US6425892B2 (en) * 1995-06-05 2002-07-30 Alza Corporation Device for transdermal electrotransport delivery of fentanyl and sufentanil
EP1762268A1 (fr) * 1995-09-29 2007-03-14 Vyteris, Inc. Électrodes à prix réduit pour un dispositif iontophoretique
US5738647A (en) * 1996-09-27 1998-04-14 Becton Dickinson And Company User activated iontophoretic device and method for activating same
FR2755372B1 (fr) * 1996-11-07 1998-12-24 Elf Aquitaine Dispositif d'ionophorese comportant au moins un ensemble electrode a membrane, pour l'administration transcutanee de principes actifs a un sujet
US7033598B2 (en) * 1996-11-19 2006-04-25 Intrabrain International N.V. Methods and apparatus for enhanced and controlled delivery of a biologically active agent into the central nervous system of a mammal
US6228206B1 (en) * 1997-07-30 2001-05-08 Drug Delivery Technologies, Inc. Bonding agent composition containing conductive filler and method of bonding electrode to printed conductive trace with same
US6047208A (en) * 1997-08-27 2000-04-04 Becton, Dickinson And Company Iontophoretic controller
JP3998765B2 (ja) * 1997-09-04 2007-10-31 シャープ株式会社 多結晶半導体層の製造方法及び半導体装置の評価方法
US6374136B1 (en) * 1997-12-22 2002-04-16 Alza Corporation Anhydrous drug reservoir for electrolytic transdermal delivery device
JP4262410B2 (ja) * 1998-01-28 2009-05-13 アルザ・コーポレーション 低い初期抵抗を有する電気伝達電極アセンブリ
US6505069B2 (en) * 1998-01-28 2003-01-07 Alza Corporation Electrochemically reactive cathodes for an electrotransport device
EP0970719A3 (fr) * 1998-07-08 2000-08-23 Nitto Denko Corporation Structure d'électrode
EP1109594B1 (fr) * 1998-08-31 2004-10-27 Johnson & Johnson Consumer Companies, Inc. Dispositif d'electrotransport comprenant des lames
JP3620703B2 (ja) * 1998-09-18 2005-02-16 キヤノン株式会社 二次電池用負極電極材、電極構造体、二次電池、及びこれらの製造方法
FR2785544B1 (fr) * 1998-11-09 2001-01-05 Lhd Lab Hygiene Dietetique Electrode de transfert d'un courant electrique traversant la peau d'un patient
US6477410B1 (en) * 2000-05-31 2002-11-05 Biophoretic Therapeutic Systems, Llc Electrokinetic delivery of medicaments
US6553253B1 (en) * 1999-03-12 2003-04-22 Biophoretic Therapeutic Systems, Llc Method and system for electrokinetic delivery of a substance
WO2000062857A1 (fr) * 1999-04-16 2000-10-26 Johnson & Johnson Consumer Companies, Inc. Systeme d'administration par electrotransport a capteurs internes
US6692456B1 (en) * 1999-06-08 2004-02-17 Altea Therapeutics Corporation Apparatus for microporation of biological membranes using thin film tissue interface devices, and method therefor
JP4414517B2 (ja) * 1999-09-01 2010-02-10 久光製薬株式会社 イオントフォレーシス用デバイス構造体
CA2394171A1 (fr) * 1999-12-16 2001-06-21 Alza Corporation Dispositif destine a augmenter le flux transdermique de substances echantillonnees
WO2002019941A1 (fr) * 2000-09-08 2002-03-14 Magnani Thomas J Appareil ionophoretique
US6560483B1 (en) * 2000-10-18 2003-05-06 Minnesota High-Tech Resources, Llc Iontophoretic delivery patch
US6553255B1 (en) * 2000-10-27 2003-04-22 Aciont Inc. Use of background electrolytes to minimize flux variability during iontophoresis
US6731977B2 (en) * 2001-01-22 2004-05-04 Iomed, Inc. Iontophoretic electrode with improved current distribution
EP1385571B1 (fr) * 2001-04-04 2008-07-30 Alza Corporation Dispositif d'administration transdermique par electrotransport comprenant une composition de reservoir compatible antimicrobienne
DE10140666C2 (de) * 2001-08-24 2003-08-21 Univ Braunschweig Tech Verfahren zur Herstellung eines leitfähigen strukturierten Polymerfilms und Verwendung des Verfahrens
EP1440707A4 (fr) * 2001-10-31 2006-05-24 Transcutaneous Tech Inc Dispositif d'ionophorese
US7349733B2 (en) * 2001-11-02 2008-03-25 Ceramatel, Inc. Iontophoretic drug delivery systems
US7047069B2 (en) * 2002-02-04 2006-05-16 Ceramatec, Inc. Iontophoretic fluid delivery device
US6708050B2 (en) * 2002-03-28 2004-03-16 3M Innovative Properties Company Wireless electrode having activatable power cell
US20060009730A2 (en) * 2002-07-29 2006-01-12 Eemso, Inc. Iontophoretic Transdermal Delivery of One or More Therapeutic Agents
US8224435B2 (en) * 2003-03-31 2012-07-17 Alza Corporation Electrotransport device having a reservoir housing having a flexible conductive element
US8734421B2 (en) * 2003-06-30 2014-05-27 Johnson & Johnson Consumer Companies, Inc. Methods of treating pores on the skin with electricity
MXPA06005509A (es) * 2003-11-13 2007-05-23 Johnson & Johnson Sistema y metodo para distribucion transdermica.
US20060095001A1 (en) * 2004-10-29 2006-05-04 Transcutaneous Technologies Inc. Electrode and iontophoresis device
JP2006346368A (ja) * 2005-06-20 2006-12-28 Transcutaneous Technologies Inc イオントフォレーシス装置及びその製造方法
JP2007000342A (ja) * 2005-06-23 2007-01-11 Transcutaneous Technologies Inc 複数薬剤の投与量および投与時期を制御するイオントフォレーシス装置
US8386030B2 (en) * 2005-08-08 2013-02-26 Tti Ellebeau, Inc. Iontophoresis device
US8295922B2 (en) * 2005-08-08 2012-10-23 Tti Ellebeau, Inc. Iontophoresis device
US20070060860A1 (en) * 2005-08-18 2007-03-15 Transcutaneous Technologies Inc. Iontophoresis device
US20070088332A1 (en) * 2005-08-22 2007-04-19 Transcutaneous Technologies Inc. Iontophoresis device
US20070048362A1 (en) * 2005-08-29 2007-03-01 Transcutaneous Technologies Inc. General purpose electrolyte solution composition for iontophoresis
US20070112294A1 (en) * 2005-09-14 2007-05-17 Transcutaneous Technologies Inc. Iontophoresis device
RU2008114490A (ru) * 2005-09-15 2009-10-20 ТиТиАй ЭЛЛЕБО, ИНК. (JP) Устройство ионтофореза стержневого типа
BRPI0616771A2 (pt) * 2005-09-30 2011-06-28 Tti Ellebeau Inc dispositivo de iontoforese para liberar múltiplos agentes ativos para interfaces biológicas
JP2009509677A (ja) * 2005-09-30 2009-03-12 Tti・エルビュー株式会社 小胞封入活性物質のイオントフォレーシス送達
EP1928539A1 (fr) * 2005-09-30 2008-06-11 Tti Ellebeau, Inc. Systemes, dispositifs et procedes d'apport de medicament transdermique a micro-aiguilles fonctionnalisees
WO2007041115A1 (fr) * 2005-09-30 2007-04-12 Tti Ellebeau Inc. Procede et systeme de detection de dysfonctionnements dans un dispositif de ionophorese qui apporte des agents actifs a des interfaces biologiques
US20070078375A1 (en) * 2005-09-30 2007-04-05 Transcutaneous Technologies Inc. Iontophoretic delivery of active agents conjugated to nanoparticles
WO2007041314A2 (fr) * 2005-09-30 2007-04-12 Tti Ellebeau, Inc. Systemes d'administration transdermique de medicament, dispositifs, et methodes faisant intervenir de nouveaux excipients pharmaceutiques
WO2007079116A1 (fr) * 2005-12-28 2007-07-12 Tti Ellebeau, Inc. Appareil de pompe électroosmotique et procédé pour acheminer des agents actifs à des interfaces biologiques
US20080033398A1 (en) * 2005-12-29 2008-02-07 Transcutaneous Technologies Inc. Device and method for enhancing immune response by electrical stimulation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5545370U (fr) * 1978-09-19 1980-03-25
JP2002282118A (ja) * 2001-03-28 2002-10-02 Aron Kasei Co Ltd 吸 盤
JP3090588U (ja) * 2002-04-25 2002-12-20 功 寺田 持久力強化吸盤及び該吸盤との一体的利用に供する持久力強化吸着補助板
JP2004159673A (ja) * 2002-11-08 2004-06-10 Advance Co Ltd イオントフォレーゼ用デバイス

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8062783B2 (en) 2006-12-01 2011-11-22 Tti Ellebeau, Inc. Systems, devices, and methods for powering and/or controlling devices, for instance transdermal delivery devices
WO2012086700A1 (fr) * 2010-12-22 2012-06-28 帝國製薬株式会社 Coussin d'électrode pour ionophorèse
CN103269748A (zh) * 2010-12-22 2013-08-28 帝国制药株式会社 用于电离子透入疗法治疗的电极垫
JP5870037B2 (ja) * 2010-12-22 2016-02-24 帝國製薬株式会社 イオントフォレシス用の電極パッド
US10342968B2 (en) 2010-12-22 2019-07-09 Teikoku Seiyaku Co., Ltd. Electrode pad used for iontophoresis treatment
JP2017047184A (ja) * 2015-08-31 2017-03-09 エスディー バイオテクノロジーズ カンパニー リミテッド カスタマイズ型複合刺激が加えられる肌の機能改善用の立体陰圧複合刺激器モジュール
WO2023105861A1 (fr) * 2021-12-08 2023-06-15 酒井医療株式会社 Conducteur pour dispositif d'électrothérapie

Also Published As

Publication number Publication date
US20100030128A1 (en) 2010-02-04
JPWO2007029611A1 (ja) 2009-03-19

Similar Documents

Publication Publication Date Title
US8295922B2 (en) Iontophoresis device
JP4793806B2 (ja) イオントフォレーシス装置
US20090254018A1 (en) Electrode assembly for freezing-type iontophoresis device
US20070048362A1 (en) General purpose electrolyte solution composition for iontophoresis
EP1808197A1 (fr) Electrode et appareil de iontophorese
TWI541044B (zh) 離子電滲用貼片
RU2004113374A (ru) Аппарат для ионтофореза
WO2007029611A1 (fr) Dispositif d’iontophorèse
SG161257A1 (en) External preparation, method of applying external preparation, iontophoresis device and transdermal patch
ATE531422T1 (de) Iontophoretisches gerät
JP2006212194A (ja) イオントフォレーシス装置
US20090299264A1 (en) Electrode Assembly for Dry Type Iontophoresis
WO2007026671A1 (fr) Dispositif de iontophorèse permettant de selectionner un medicament a administrer selon les informations provenant d'un capteur
US7734339B2 (en) Iontophoresis apparatus
EP1932562A1 (fr) Appareil d'iontophorèse
CA2618382A1 (fr) Appareil a iontophorese
JP2007037639A (ja) 電極及びイオントフォレーシス装置
WO2007020911A1 (fr) Dispositif d’iontophorèse
WO2007088897A1 (fr) Systeme de iontophorese de type cartouche
EP1844813A1 (fr) Appareil de iontophorese
EP1944058A1 (fr) Appareil d'iontophorèse fixé à une muqueuse
US20090299265A1 (en) Electrode Assembly for Iontophoresis Having Shape-Memory Separator and Iontophoresis Device Using the Same
JP2008073117A (ja) カートリッジ型イオントフォレーシス装置
JP2007135893A (ja) イオントフォレーシス装置および作用側電極ユニット
JP2007054531A (ja) イオントフォレーシス装置

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2007534372

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 06797263

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 12065851

Country of ref document: US