WO2006116165A1 - Chromane and chromene derivatives and uses thereof - Google Patents

Chromane and chromene derivatives and uses thereof Download PDF

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Publication number
WO2006116165A1
WO2006116165A1 PCT/US2006/015208 US2006015208W WO2006116165A1 WO 2006116165 A1 WO2006116165 A1 WO 2006116165A1 US 2006015208 W US2006015208 W US 2006015208W WO 2006116165 A1 WO2006116165 A1 WO 2006116165A1
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WO
WIPO (PCT)
Prior art keywords
disorder
mmol
methyl
compound
chromen
Prior art date
Application number
PCT/US2006/015208
Other languages
English (en)
French (fr)
Inventor
Gavin David Heffernan
Gary Paul Stack
Jonathan Laird Gross
Dahui Zhou
Hong Gao
Original Assignee
Wyeth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth filed Critical Wyeth
Priority to MX2007013163A priority Critical patent/MX2007013163A/es
Priority to BRPI0610027-9A priority patent/BRPI0610027A2/pt
Priority to JP2008507952A priority patent/JP2008538576A/ja
Priority to EP06758490A priority patent/EP1874756A1/en
Priority to AU2006239937A priority patent/AU2006239937A1/en
Priority to CA002605587A priority patent/CA2605587A1/en
Publication of WO2006116165A1 publication Critical patent/WO2006116165A1/en
Priority to IL186837A priority patent/IL186837A0/en
Priority to NO20075641A priority patent/NO20075641L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
PCT/US2006/015208 2005-04-22 2006-04-21 Chromane and chromene derivatives and uses thereof WO2006116165A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
MX2007013163A MX2007013163A (es) 2005-04-22 2006-04-21 Derivados de cromano y cromeno y usos de los mismos.
BRPI0610027-9A BRPI0610027A2 (pt) 2005-04-22 2006-04-21 derivados de cromano e cromeno e usos dos mesmos
JP2008507952A JP2008538576A (ja) 2005-04-22 2006-04-21 クロマンおよびクロメン誘導体およびその使用
EP06758490A EP1874756A1 (en) 2005-04-22 2006-04-21 Chromane and chromene derivatives and uses thereof
AU2006239937A AU2006239937A1 (en) 2005-04-22 2006-04-21 Chromane and chromene derivatives and uses thereof
CA002605587A CA2605587A1 (en) 2005-04-22 2006-04-21 Chromane and chromene derivatives and uses thereof
IL186837A IL186837A0 (en) 2005-04-22 2007-10-22 Chromane and chromene derivatives and uses thereof
NO20075641A NO20075641L (no) 2005-04-22 2007-11-06 Kroman og kromenderivater og ders anvendelse

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67382005P 2005-04-22 2005-04-22
US60/673,820 2005-04-22

Publications (1)

Publication Number Publication Date
WO2006116165A1 true WO2006116165A1 (en) 2006-11-02

Family

ID=36888961

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/015208 WO2006116165A1 (en) 2005-04-22 2006-04-21 Chromane and chromene derivatives and uses thereof

Country Status (19)

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US (2) US7365095B2 (US20060258714A1-20061116-C00152.png)
EP (1) EP1874756A1 (US20060258714A1-20061116-C00152.png)
JP (1) JP2008538576A (US20060258714A1-20061116-C00152.png)
KR (1) KR20080008378A (US20060258714A1-20061116-C00152.png)
CN (1) CN101203505A (US20060258714A1-20061116-C00152.png)
AR (1) AR056320A1 (US20060258714A1-20061116-C00152.png)
AU (1) AU2006239937A1 (US20060258714A1-20061116-C00152.png)
BR (1) BRPI0610027A2 (US20060258714A1-20061116-C00152.png)
CA (1) CA2605587A1 (US20060258714A1-20061116-C00152.png)
CO (1) CO6321153A2 (US20060258714A1-20061116-C00152.png)
GT (1) GT200600166A (US20060258714A1-20061116-C00152.png)
IL (1) IL186837A0 (US20060258714A1-20061116-C00152.png)
MX (1) MX2007013163A (US20060258714A1-20061116-C00152.png)
NO (1) NO20075641L (US20060258714A1-20061116-C00152.png)
PE (1) PE20061297A1 (US20060258714A1-20061116-C00152.png)
RU (1) RU2007139541A (US20060258714A1-20061116-C00152.png)
TW (1) TW200716595A (US20060258714A1-20061116-C00152.png)
WO (1) WO2006116165A1 (US20060258714A1-20061116-C00152.png)
ZA (1) ZA200709052B (US20060258714A1-20061116-C00152.png)

Cited By (12)

* Cited by examiner, † Cited by third party
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WO2007123941A2 (en) * 2006-04-18 2007-11-01 Wyeth Chromane and chromene derivatives and uses thereof
WO2007132841A1 (ja) 2006-05-16 2007-11-22 Takeda Pharmaceutical Company Limited 縮合複素環化合物およびその用途
WO2008052088A1 (en) * 2006-10-25 2008-05-02 Wyeth Chromane derivatives, synthesis thereof, and intermediates thereto
WO2008052087A1 (en) * 2006-10-24 2008-05-02 Wyeth Chromane derivatives and uses thereof
WO2009063992A1 (ja) 2007-11-15 2009-05-22 Takeda Pharmaceutical Company Limited 縮合ピリジン誘導体およびその用途
WO2011071136A1 (ja) 2009-12-11 2011-06-16 アステラス製薬株式会社 線維筋痛症治療剤
US8676322B2 (en) 2008-01-30 2014-03-18 Boston Scientific Neuromodulation Corporation Methods and systems of treating pancreatitis pain
US8914112B2 (en) 2008-01-23 2014-12-16 Boston Scienctific Neuromodulation Corporation Methods and systems of treating pancreatitis pain caused by sphincter of Oddi dysfunction
WO2015066344A1 (en) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use
CN105392786A (zh) * 2013-06-21 2016-03-09 济州大学校产学协力团 新型类黄酮及其用途
US9334212B2 (en) 2010-12-21 2016-05-10 Colgate-Palmolive Company Compounds and compositions
WO2019131902A1 (ja) 2017-12-27 2019-07-04 武田薬品工業株式会社 腹圧性尿失禁および便失禁の治療薬

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GB0210397D0 (en) 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
US7435837B2 (en) * 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US20050261347A1 (en) * 2003-10-24 2005-11-24 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
GT200500296A (es) * 2004-10-21 2006-10-02 Sintesis asimetrica de derivados del dehidrobenzofurano
GT200500297A (es) * 2004-10-21 2006-10-27 Sintesis asimetrica de dehidrobenzofuranos sustituidos
MX2007012883A (es) * 2005-04-22 2007-12-10 Wyeth Corp Derivados de dihidrobenzofurano y usos de los mismos.
EP1871355A1 (en) * 2005-04-22 2008-01-02 Wyeth New therapeutic combianations for the treatment or prevention of depression
EP1871754A1 (en) * 2005-04-22 2008-01-02 Wyeth a Corporation of the State of Delaware Dihydrobenzofuran derivatives and uses thereof
WO2006116151A1 (en) * 2005-04-22 2006-11-02 Wyeth Benzofuranyl alkanamine derivatives and uses thereof as 5-ht2c agonists
CN101203216A (zh) * 2005-04-22 2008-06-18 惠氏公司 二氢苯并呋喃衍生物及其用途
BRPI0610046A2 (pt) * 2005-04-22 2010-05-25 Wyeth Corp derivados de benzodioxano e benzodioxolano e usos destes
BRPI0610028A2 (pt) * 2005-04-22 2010-05-18 Wyeth Corp combinações terapêuticas para o tratamento ou a prevenção de distúrbios psicóticos
JP2008538578A (ja) * 2005-04-22 2008-10-30 ワイス 疼痛の治療
CA2605587A1 (en) * 2005-04-22 2006-11-02 Wyeth Chromane and chromene derivatives and uses thereof
CN101203217A (zh) * 2005-04-24 2008-06-18 惠氏公司 调节膀胱功能的方法
CL2007000775A1 (es) * 2006-03-24 2008-01-25 Wyeth Corp Uso de compuestos derivados de benzofurano para el tratamiento de un desorden cognitivo.
RU2472539C2 (ru) 2007-08-06 2013-01-20 Аллерган, Инк. Способы и устройства для доставки препарата десмопрессина
EP2116618A1 (en) 2008-05-09 2009-11-11 Agency for Science, Technology And Research Diagnosis and treatment of Kawasaki disease
US11963995B2 (en) 2008-05-21 2024-04-23 Ferring B.V. Methods comprising desmopressin
PT3085381T (pt) 2008-05-21 2018-05-18 Ferring Bv Desmopressina orodispersível para aumentar o período inicial de sono não perturbado pela noctúria
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
CN101921252B (zh) * 2010-07-02 2012-05-09 中国科学院上海有机化学研究所 1-氧杂苯并杂环类化合物、合成方法和用途
CN109970533B (zh) * 2012-12-18 2022-06-14 帝斯曼知识产权资产管理有限公司 由(r)-6，10，14-三甲基十五碳-5-烯-2-酮制备的(6r，10r)-6，10，14-三甲基十五烷-2-酮
CN107531674B (zh) 2015-02-11 2020-07-31 赛诺维信制药公司 用于治疗cns障碍的1-杂环基异苯并二氢吡喃基化合物和类似物
EP3490607A4 (en) 2016-07-29 2020-04-08 Sunovion Pharmaceuticals Inc. COMPOUNDS AND COMPOSITIONS, AND USES THEREOF
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US7365095B2 (en) 2008-04-29
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