WO2006033412A1 - Médicament soulageant les troubles dus aux radiations - Google Patents

Médicament soulageant les troubles dus aux radiations Download PDF

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Publication number
WO2006033412A1
WO2006033412A1 PCT/JP2005/017526 JP2005017526W WO2006033412A1 WO 2006033412 A1 WO2006033412 A1 WO 2006033412A1 JP 2005017526 W JP2005017526 W JP 2005017526W WO 2006033412 A1 WO2006033412 A1 WO 2006033412A1
Authority
WO
WIPO (PCT)
Prior art keywords
parts
radiation damage
weight
mass
ascorbic acid
Prior art date
Application number
PCT/JP2005/017526
Other languages
English (en)
Japanese (ja)
Inventor
Hiroto Chaen
Toshio Miyake
Original Assignee
Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo filed Critical Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
Priority to JP2006536426A priority Critical patent/JPWO2006033412A1/ja
Publication of WO2006033412A1 publication Critical patent/WO2006033412A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/174—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Husbandry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention décrit un médicament soulageant les troubles dus aux radiations qui est sans danger même lorsqu’il est administré à un sujet vivant, ainsi qu'une préparation contenant ledit médicament. Le médicament soulageant les troubles dus aux radiations contient, au titre de composant actif, de l’acide α-D-glucopyranosyl-(1→2)-L-ascorbique.
PCT/JP2005/017526 2004-09-24 2005-09-22 Médicament soulageant les troubles dus aux radiations WO2006033412A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2006536426A JPWO2006033412A1 (ja) 2004-09-24 2005-09-22 放射線障害軽減剤

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004277019 2004-09-24
JP2004-277019 2004-09-24

Publications (1)

Publication Number Publication Date
WO2006033412A1 true WO2006033412A1 (fr) 2006-03-30

Family

ID=36090166

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2005/017526 WO2006033412A1 (fr) 2004-09-24 2005-09-22 Médicament soulageant les troubles dus aux radiations

Country Status (2)

Country Link
JP (2) JPWO2006033412A1 (fr)
WO (1) WO2006033412A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007176879A (ja) * 2005-12-28 2007-07-12 Natl Inst Of Radiological Sciences 酵母を有効成分とする放射線防護剤
EP2301944A1 (fr) 2009-09-03 2011-03-30 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Composition particulaire contenant de l'acide ascorbique 2-O-alpha -D-glucosyl-L cristallin anhydre, son procédé de production et utilisations associées
WO2012033218A1 (fr) 2010-09-07 2012-03-15 株式会社林原生物化学研究所 CRISTAUX HYDRATÉS D'ACIDE 2-O-α-D-GLUCOSYL-L-ASCORBIQUE, POUDRE CONTENANT LES CRISTAUX HYDRATÉS DE L'ACIDE 2-O-α-D-GLUCOSYL-L-ASCORBIQUE, PROCÉDÉ DE PRODUCTION DES CRISTAUX HYDRATÉS, PROCÉDÉ DE PRODUCTION DE LA POUDRE, UTILISATION DES CRISTAUX HYDRATÉS, ET UTILISATION DE LA POUDRE
JP2012121914A (ja) * 2004-09-24 2012-06-28 Hayashibara Biochem Lab Inc 放射線障害軽減剤
WO2012121297A1 (fr) 2011-03-07 2012-09-13 株式会社林原 PROCÉDÉ DE PRODUCTION D'UNE POUDRE CONTENANT DES CRISTAUX ANHYDRES D'ACIDE 2-O-α-D-GLUCOSYL-L-ASCORBIQUE
WO2014017046A1 (fr) 2012-07-23 2014-01-30 国立大学法人東京大学 Agent prophylactique et/ou thérapeutique pour une radiolésion
CN110520108A (zh) * 2017-02-16 2019-11-29 福斯特斯特林研究公司 用于防止辐射损伤和促进组织再生的组合物和方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN2014MN00937A (fr) * 2012-11-22 2015-09-04 Original Biomedicals Co Ltd
JP6310708B2 (ja) * 2014-01-28 2018-04-11 花王株式会社 固形状組成物
JP2018090640A (ja) * 2018-03-16 2018-06-14 花王株式会社 固形状組成物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03139288A (ja) * 1989-05-19 1991-06-13 Hayashibara Biochem Lab Inc α―グリコシル―Ｌ―アスコルビン酸とその製造方法並びに用途
JP2001322990A (ja) * 2000-05-12 2001-11-20 Pola Chem Ind Inc 活性酸素消去剤及びそれを含有する活性酸素消去用の組成物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3082058B2 (ja) * 1992-05-22 2000-08-28 株式会社ホーネンコーポレーション ６−Ｏ−α−Ｄ−ガラクトピラノシル−Ｌ−アスコルビン酸またはその塩およびその製造法並びにその用途
JP2001097888A (ja) * 1999-09-28 2001-04-10 Hiroshi Ikeno 外用組成物
JP4754066B2 (ja) * 2000-12-22 2011-08-24 株式会社林原生物化学研究所 抗関節障害剤
JP4456796B2 (ja) * 2001-09-27 2010-04-28 株式会社林原生物化学研究所 コラーゲン産生増強剤の製造方法とその用途
US7566698B2 (en) * 2001-12-28 2009-07-28 Suntory Holdings Limited 2-O-(β-D-glucopyranosyl) ascorbic acid, process for its production, and foods and cosmetics containing compositions comprising it
WO2006033412A1 (fr) * 2004-09-24 2006-03-30 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Médicament soulageant les troubles dus aux radiations

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03139288A (ja) * 1989-05-19 1991-06-13 Hayashibara Biochem Lab Inc α―グリコシル―Ｌ―アスコルビン酸とその製造方法並びに用途
JP2001322990A (ja) * 2000-05-12 2001-11-20 Pola Chem Ind Inc 活性酸素消去剤及びそれを含有する活性酸素消去用の組成物

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EL-NAHAS S.M. ET AL: "Radioprotective effect of vitamins C and E", MUTATION RESEARCH, vol. 301, no. 2, 1993, pages 143 - 147, XP002994921 *
TAKEBAYASHI J. ET AL: "Long-term radical scavenging activity of AA-2G and 6-acyl-AA-2G against 1,1-diphenyl-2-picrylhydrazyl", BIOLOGICAL & PHARMACEUTICAL BULLETIN, vol. 25, no. 11, 2002, pages 1503 - 1505, XP002994922 *

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012121914A (ja) * 2004-09-24 2012-06-28 Hayashibara Biochem Lab Inc 放射線障害軽減剤
JP2007176879A (ja) * 2005-12-28 2007-07-12 Natl Inst Of Radiological Sciences 酵母を有効成分とする放射線防護剤
US9186368B2 (en) 2009-09-03 2015-11-17 Hayashibara Co., Ltd. Process for producing a particulate composition comprising an hydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid
EP2301944A1 (fr) 2009-09-03 2011-03-30 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Composition particulaire contenant de l'acide ascorbique 2-O-alpha -D-glucosyl-L cristallin anhydre, son procédé de production et utilisations associées
US10603333B2 (en) 2009-09-03 2020-03-31 Hayashibara Co., Ltd. Process for producing a particulate composition comprising an hydrous crystalline 2-o-alpha-d-glucosyl-ascorbic acid
US9872872B2 (en) 2009-09-03 2018-01-23 Hayashibara Co., Ltd. Process for producing a particulate composition comprising an hydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid
EP3081573A1 (fr) 2009-09-03 2016-10-19 Hayashibara Co., Ltd. Composition particulaire contenant de l'acide ascorbique 2-o-alpha -d-glucosyl-l cristallin anhydre, son procédé de production et utilisations associées
US9265781B2 (en) 2009-09-03 2016-02-23 Hayashibara Co., Ltd. Process for producing a particulate composition comprising anhydrous crystalline 2-O-alpha-D-glucosyl-L-ascorbic acid
EP2743276A1 (fr) 2009-09-03 2014-06-18 Hayashibara Co., Ltd. Composition particulaire contenant de l'acide ascorbique 2-O-alpha -D-glucosyl-L cristallin anhydre, son procédé de production et utilisations associées
US8765416B2 (en) 2009-09-03 2014-07-01 Hayashibara Co., Ltd. Particulate composition containing anhydrous crystalline 2-O-alpha-D-glucosyl-L-ascorbic acid, process for producing the same, and uses thereof
JP5856963B2 (ja) * 2010-09-07 2016-02-10 株式会社林原 ２−Ｏ−α−Ｄ−グルコシル−Ｌ−アスコルビン酸含水結晶及び２−Ｏ−α−Ｄ−グルコシル−Ｌ−アスコルビン酸含水結晶含有粉末とそれらの製造方法並びに用途
US9206215B2 (en) 2010-09-07 2015-12-08 Hayashibara Co., Ltd. Hydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid, particulate composition comprising the same, their preparation and uses
JPWO2012033218A1 (ja) * 2010-09-07 2014-01-20 株式会社林原 ２−Ｏ−α−Ｄ−グルコシル−Ｌ−アスコルビン酸含水結晶及び２−Ｏ−α−Ｄ−グルコシル−Ｌ−アスコルビン酸含水結晶含有粉末とそれらの製造方法並びに用途
WO2012033218A1 (fr) 2010-09-07 2012-03-15 株式会社林原生物化学研究所 CRISTAUX HYDRATÉS D'ACIDE 2-O-α-D-GLUCOSYL-L-ASCORBIQUE, POUDRE CONTENANT LES CRISTAUX HYDRATÉS DE L'ACIDE 2-O-α-D-GLUCOSYL-L-ASCORBIQUE, PROCÉDÉ DE PRODUCTION DES CRISTAUX HYDRATÉS, PROCÉDÉ DE PRODUCTION DE LA POUDRE, UTILISATION DES CRISTAUX HYDRATÉS, ET UTILISATION DE LA POUDRE
KR20140039177A (ko) 2011-03-07 2014-04-01 가부시기가이샤하야시바라 2-O-α-D-글루코실-L-아스코르빈산 무수결정 함유 분말의 제조방법
WO2012121297A1 (fr) 2011-03-07 2012-09-13 株式会社林原 PROCÉDÉ DE PRODUCTION D'UNE POUDRE CONTENANT DES CRISTAUX ANHYDRES D'ACIDE 2-O-α-D-GLUCOSYL-L-ASCORBIQUE
WO2014017046A1 (fr) 2012-07-23 2014-01-30 国立大学法人東京大学 Agent prophylactique et/ou thérapeutique pour une radiolésion
US9895331B2 (en) 2012-07-23 2018-02-20 The University Of Tokyo Prophylactic and/or therapeutic agent for radiation damage
CN110520108A (zh) * 2017-02-16 2019-11-29 福斯特斯特林研究公司 用于防止辐射损伤和促进组织再生的组合物和方法

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JP2012121914A (ja) 2012-06-28
JP5498521B2 (ja) 2014-05-21
JPWO2006033412A1 (ja) 2008-05-15

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