WO2006022338A1 - Poudre sèche de tissu de pseudo feuille de plante appartenant au gène asparagus - Google Patents

Poudre sèche de tissu de pseudo feuille de plante appartenant au gène asparagus Download PDF

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Publication number
WO2006022338A1
WO2006022338A1 PCT/JP2005/015449 JP2005015449W WO2006022338A1 WO 2006022338 A1 WO2006022338 A1 WO 2006022338A1 JP 2005015449 W JP2005015449 W JP 2005015449W WO 2006022338 A1 WO2006022338 A1 WO 2006022338A1
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WO
WIPO (PCT)
Prior art keywords
asparagus
rutin
dry powder
drying
leaf tissue
Prior art date
Application number
PCT/JP2005/015449
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English (en)
Japanese (ja)
Inventor
Takashi Suzuki
Tomokazu Inoke
Original Assignee
National University Corporation Hokkaido University
Hokkaido Agricultural Laboratory For Business Development
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National University Corporation Hokkaido University, Hokkaido Agricultural Laboratory For Business Development filed Critical National University Corporation Hokkaido University
Priority to JP2006532588A priority Critical patent/JP4972719B2/ja
Publication of WO2006022338A1 publication Critical patent/WO2006022338A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVING, e.g. BY CANNING, MEAT, FISH, EGGS, FRUIT, VEGETABLES, EDIBLE SEEDS; CHEMICAL RIPENING OF FRUIT OR VEGETABLES; THE PRESERVED, RIPENED, OR CANNED PRODUCTS
    • A23B7/00—Preservation or chemical ripening of fruit or vegetables
    • A23B7/02—Dehydrating; Subsequent reconstitution
    • A23B7/024—Freeze-drying, i.e. cryodessication or lyophilisation
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8965—Asparagus, e.g. garden asparagus or asparagus fern
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Definitions

  • the present invention relates to a dry powder of artificial leaf tissue of an Asparagus genus plant, which is a natural material, and a rutin-supplemented food or drink containing the powder.
  • Rutin (C H O, molecular weight 610.51) is one of the bioactive flavonoids and has the formula I
  • Rutin has been reported to enter the intestine and be decomposed and absorbed into quercetin and exhibit various physiological activities. For example, rutin reduces mortality due to heart disease in elderly patients (Nnotog et al., Lancet, 1993, 342, 1007-1011), or protein edema (High protein edema ) (U.S. Pat. No. 5,096,887), and further reported to have anticancer and antiviral effects (JP-A-4-234320). Rutin also significantly reduces blood cholesterol levels and only suppresses diseases caused by high blood lipid levels such as hyperlipidemia, arteriosclerosis, angina pectoris, stroke and liver disease. There is also a report that it has the effect of treating. On the other hand, rutin is not much toxic to the living body even when ingested in large quantities and has no side effects on liver function. is there.
  • Rutin is produced by organic synthetic methods (Zemplen, Bognar in Ber., 1043 (1943) and Seka, Prosche, Monatsh., 69, 284 (1936)), and typically sono (ordinary malt, Scientific name F agopyrum esculentum) or Dattanzono (scientific name: Fagopyrum tataricum).
  • the simplest way to enjoy the added value of rutin is to ingest plants such as buckwheat directly as food and drink (Japanese Patent Laid-Open No. 2003-2355).
  • Patent Document 1 US Patent No. 5,096, 887
  • Patent Document 2 Japanese Patent Laid-Open No. 4-234320
  • Patent Document 3 Japanese Patent Laid-Open No. 2003-235507
  • Patent Document 4 Japanese Unexamined Patent Publication No. 2003-299462
  • Patent Document 5 JP-A-11-75743
  • Patent Document 6 Patent Application Publication No. 41-57313
  • Non-Patent Document 1 Hartgue et al., Lancet, 1993, 342, 1007-1011
  • Non-Patent Document 2 Zemplen, Bognar in Ber., 1043 (1943)
  • Non-Patent Document 3 Seka, Prosche, Monatsh., 69, 284 (1936)
  • buckwheat can cause serious allergic reactions, so-called sobaergy, to those who take it, and it is difficult to say that it is a food that can be safely used by everyone.
  • sobaergy the use of tartary buckwheat with low buckwheat allergens as a countermeasure against this buckwheat allergy problem.
  • Tartary buckwheat is also suitable for consumption as it contains a very high amount of bitter ingredients as it is also called “bitter wheat”. I cannot say that.
  • Tartary buckwheat also contains a rutin-degrading enzyme, and in order to inactivate it, it is necessary to perform a wet heat treatment using steam or the like.
  • buckwheat allergens are not completely eliminated.
  • the present invention provides a rutin supplement made from a natural material that contains a large amount of rutin and can be substituted for buckwheat, including tartary buckwheat, without problems such as allergies and bitterness like buckwheat. It is intended to provide a supply.
  • the present inventors have made it safer than buckwheat by processing a pseudo-leaf tissue of an Asparagus genus plant, which has not been considered as a conventional food, into a dry powder under mild conditions.
  • a rutin supplement can be easily provided, the following inventions have been completed.
  • the Asparagus plant is Asparagus officinalis
  • a rutin-supplemented food or drink comprising the dry powder according to any one of 1) to 3).
  • Asparagus plants are lily family plants that are widely distributed in the area such as Yochitsuno, Africa and Asia. What is commonly referred to as “asparagus” and used for food is Asparagus officinalis (Japanese name: Dutch pheasant power), but also A. asparagoides, A. cochinchinensis, A. densiflorus cv. 3 ⁇ 4prenger, Skinonosuke Kazufu, A.falcatus, A.myrioclaaus (Tachibo 1 /), A Used for foliage and traditional Chinese medicine.
  • rutin contains a large amount of rutin.
  • asparagus is an edible ingredient that contains as much as 1.3 lmg or less rutin per average dry weight in the entire early growth of asparagus.
  • the artificial leaf tissue has approximately 12.88 mg of rutin per lg dry weight. As a result, it was confirmed that the content was 9.8 times more than the whole asparagus in the early stage of growth.
  • the pseudoleaf tissue containing a large amount of rutin which is made into a dry powder under relatively mild conditions, does not have a bitter taste like tartary buckwheat and has a light asparagus-like flavor and moderate It was confirmed that it can be used as a food or drink that has a good sweet taste and can be taken orally.
  • the rutin supplement obtained by freeze-drying the pseudoleaf tissue of the genus Asparagus plant can be stored in water at room temperature for 20 minutes or boiled in water at 100 ° C for 5 minutes. Even when acetic acid was added and boiled in water at 100 ° C for 5 minutes, no decomposition of rutin was confirmed. Therefore, the rutin degradation that occurs in buckwheat seeds of tartane is not observed with the rutin supplement of the present invention, and the rutin can be kept stable.
  • Asparagus plants that can be used in the present invention include Asparagus offisinalis.
  • Asparagus officinalis and A. schoberioides.
  • the use of artificial leaves of Asparagus officinalis is preferred from the standpoints of planting area and accumulation of cultivation techniques.
  • the artificial leaf tissue of the Asparagus genus plant can be obtained by growing the plant by a cultivation method widely known to growers of the Asparagus genus plant and collecting the generated pseudo leaves. No special ingenuity is required for the purpose of collection only. Therefore, typically, a method of cultivating Asparagus plants for the purpose of harvesting edible asnogas, or so on. Agricultural personnel who are currently engaged in cultivation like
  • the collected pseudo leaves are dried by a mild method such as freeze drying, microwave vacuum drying, or far infrared vacuum drying, and pulverized with a pulverizer or mortar to be processed into a powder form.
  • a mild method such as freeze drying, microwave vacuum drying, or far infrared vacuum drying
  • pulverized with a pulverizer or mortar to be processed into a powder form.
  • devices other than those exemplified above can be used.
  • the pseudoleaf tissue dry powder dried by such a mild method contains saccharides exceeding lOOmg per lg dry weight together with rutin. Therefore, the dry powder of the present invention is a food and drink excellent in palatability that exhibits a light asparagus fragrance and moderate sweetness, or as a food and drink material that imparts such palatability and rutin replenishment ability. Is available
  • dry powder of pseudoparaffin tissue of Asparagus plants contains a suitable excipient, and if necessary, other active ingredients are further added to form tablets, capsules and other dosage forms.
  • excipients include ratatoose, dextrose, sucrose, sorbitol, mannitol, starch, gum arabic, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methylcellulose, microcrystalline cellulose, Polybulol pyrrolidone, water, methyl hydroxybenzoate, propyl hydroxybenzoate, talc, magnesium stearate and mineral oil, etc.
  • arabic is a filler, anti-flocculating agent, lubricant, wetting agent, fragrance, emulsifier, preservative Etc. can be included.
  • a dry powder of an asparagus plant artificial leaf tissue may be added to a raw material for confectionery, bread, potatoes and other foods to produce foods such as confectionery, and these may be used as a rutin supplement.
  • food include dairy products such as chocolate, snacks, confectionery, pizza, bread, cakes, crackers, cookies, biscuits, potatoes, chewing gum, milk, ice cream, cheese, chocolate, soup, And supplements such as ketchup, sauce or vitamins.
  • flavorings and other food additives can be used according to consumer preference.
  • Isorhamnetin-3-glucoside (IRG) dissolved in 100% ethanol as an internal standard substance was added to 50 mg of the powder product prepared in Example 1.
  • Example 1 Example 2
  • Example 3 Relative Fluke 1 ⁇ 1 s 41 ⁇ 7 ⁇ 0 ⁇ 2 29.7 ⁇ 0.9 42.7 ⁇ 0.8 32.1 ⁇ 0.9 G: 3 ⁇ s 39.5 ⁇ 2.0 18.4 ⁇ 0.6 32.4 ⁇ 0.5 15 ⁇ 9 ⁇ 0.3 Sucrose 60.5 ⁇ 8.2 79.5 ⁇ 0.3 43.5 ⁇ 0.3 28.4 ⁇ 1
  • the dry powders obtained by the methods described in Examples 1 to 3 all contained saccharide in an amount of lOOmgZg dry weight or more.
  • these powders were included in the mouth as they were, it was confirmed that they had an asparagus-like taste and sweetness and an excellent flavor that can be used directly for food.
  • the powder of the comparative example lacked sweetness and had a slightly strong blue odor compared to the dry powder of the present invention.
  • the dry powder of the present invention can be safely ingested by people with buckwheat allergies, and has an unpleasant taste for ingestion, but rather has a light asparagus scent and moderate palatability. It can be used as a food / beverage product, or as a food / beverage material that provides good taste and rutin replenishment ability.

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  • Health & Medical Sciences (AREA)
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Abstract

L’invention porte sur une poudre sèche de tissu de pseudo feuille de plante appartenant au gène Asparagus contenant de la rutine et au moins 100 mg/g de poids sec de saccharides, en particulier, une poudre sèche obtenue par séchage micro-onde avec pression réduite, séchage à infrarouge lointain avec pression réduite ou séchage sous vide (lyophilisation) d’un tissu de pseudo feuille de plante appartenant au gène Asparagus. Cette poudre peut s’utiliser comme aliment ou boisson idéal au léger arôme d’asperge, avec une saveur adéquate ou bien comme ingrédient pour aliments et boissons ayant les propriétés préférables ci-dessus et susceptibles de fournir de la rutine.
PCT/JP2005/015449 2004-08-26 2005-08-25 Poudre sèche de tissu de pseudo feuille de plante appartenant au gène asparagus WO2006022338A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2006532588A JP4972719B2 (ja) 2004-08-26 2005-08-25 アスパラガス属植物の擬葉組織の乾燥粉末を製造する方法

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JP2004247304 2004-08-26
JP2004-247304 2004-08-26

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006111583A (ja) * 2004-10-15 2006-04-27 Unitika Ltd γ−アミノ酪酸含有組成物及びその製造方法
JP2009137913A (ja) * 2007-12-10 2009-06-25 S Net:Kk 脂質代謝改善剤
JP4892114B2 (ja) * 2009-10-27 2012-03-07 Ｄｉｃライフテック株式会社 藻類粉体の乾熱殺菌方法
JP2013188163A (ja) * 2012-03-13 2013-09-26 Ottochi Green Station:Kk 電離水素水を用いた抗酸化能力の高い野菜およびその加工方法
KR101332194B1 (ko) 2012-01-18 2013-11-25 강원대학교산학협력단 원적외선 조사를 이용한 케르세틴 함량이 증가된 메밀싹 분말의 제조방법
CN105212020A (zh) * 2015-10-20 2016-01-06 苏州凯灵食品有限公司 干燥机及其工作方法
JP2018154575A (ja) * 2017-03-16 2018-10-04 公益財団法人 佐賀県地域産業支援センター β‐ヘキソサミニダーゼ放出抑制用及び／又はＩｇＥ産生抑制用の組成物
CN110301571A (zh) * 2019-03-08 2019-10-08 刘效全 一种植物纤维素固体饮品及其制备方法
CN114747611A (zh) * 2022-05-11 2022-07-15 成都大学 一种芦笋条及其制备方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102390665B1 (ko) * 2019-12-03 2022-04-25 강윤화 아스파라거스 잎을 이용한 조미료 및 이의 제조방법

Citations (1)

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JPS63273462A (ja) * 1987-05-01 1988-11-10 Marutomo Kk アスパラガスを原料とした粉末茶並に抽出茶液

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JPS63273462A (ja) * 1987-05-01 1988-11-10 Marutomo Kk アスパラガスを原料とした粉末茶並に抽出茶液

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DATABASE CAPLUS [online] OKONENKO V.U. ET AL: "Phytochemical study of Asparagus officinalis.I.Extraction of flavonoids from the leaves of A.officinalis", XP002999393, accession no. STN Database accession no. 1967:44249, DN.66:44249 *
FARMATSEVTICHNII ZHURNAL, vol. 21, no. 5, 1966, KIEV, pages 44 - 47 *
MAEDA T. ET AL: "Asparagus no Jakukeichu no Rutin Oyobi So-Polyphenol Ganryo no Hinshukan Sai Oyobi Kisetsu Henka", JOURNAL OF THE JAPANESE SOCIETY FOR HORTICULTURAL SCIENCE, vol. 73, no. 1, 3 April 2004 (2004-04-03), pages 124, XP002999396 *
SAKAKIBARA H. ET AL: "Simultaneous Determination of All Polyphenols in Vegetables, Fruits, and Teas", J.AGRIC.FOOD CHEM., vol. 51, no. 3, 2003, pages 571 - 581, XP002999394 *
SUZUKI T. ET AL: "Asparagus Soshiki ni Fukumareru Rutin no MALDI-TOF MS o Mochiita Teiryo", JOURNAL OF THE JAPANESE SOCIETY FOR HORTICULTURAL SCIENCE, vol. 73, no. 2, 25 September 2004 (2004-09-25), pages 434, XP002999391 *
YAMAMOTO H. ET AL: "Kinoko Saibai ni Okeru Asparagus Keiyo Zansa Riyo ni Kansuru Kenkyu", NOUGYOU DENKA, vol. 48, no. 9, 1995, pages 13 - 15, XP002999395 *
YAMAMOTO W. ET AL: "Asparagus no Shiyusei to Shokubutsutai Kaku Bui ni Okeru To Ganryo no Kisetsuteki Henka", JOURNAL OF THE JAPANESE SOCIETY FOR HORTICULTURAL SCIENCE, vol. 70, no. 1, 2001, pages 256, XP002999392 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006111583A (ja) * 2004-10-15 2006-04-27 Unitika Ltd γ−アミノ酪酸含有組成物及びその製造方法
JP2009137913A (ja) * 2007-12-10 2009-06-25 S Net:Kk 脂質代謝改善剤
JP4892114B2 (ja) * 2009-10-27 2012-03-07 Ｄｉｃライフテック株式会社 藻類粉体の乾熱殺菌方法
KR101332194B1 (ko) 2012-01-18 2013-11-25 강원대학교산학협력단 원적외선 조사를 이용한 케르세틴 함량이 증가된 메밀싹 분말의 제조방법
JP2013188163A (ja) * 2012-03-13 2013-09-26 Ottochi Green Station:Kk 電離水素水を用いた抗酸化能力の高い野菜およびその加工方法
CN105212020A (zh) * 2015-10-20 2016-01-06 苏州凯灵食品有限公司 干燥机及其工作方法
JP2018154575A (ja) * 2017-03-16 2018-10-04 公益財団法人 佐賀県地域産業支援センター β‐ヘキソサミニダーゼ放出抑制用及び／又はＩｇＥ産生抑制用の組成物
CN110301571A (zh) * 2019-03-08 2019-10-08 刘效全 一种植物纤维素固体饮品及其制备方法
CN114747611A (zh) * 2022-05-11 2022-07-15 成都大学 一种芦笋条及其制备方法
CN114747611B (zh) * 2022-05-11 2024-01-26 成都大学 一种芦笋条及其制备方法

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