WO2004076602A1 - Procede permettant d'empecher la deterioration des lipides qui constituent la membrane lipidique et utilisation correspondante - Google Patents
Procede permettant d'empecher la deterioration des lipides qui constituent la membrane lipidique et utilisation correspondante Download PDFInfo
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- WO2004076602A1 WO2004076602A1 PCT/JP2004/002206 JP2004002206W WO2004076602A1 WO 2004076602 A1 WO2004076602 A1 WO 2004076602A1 JP 2004002206 W JP2004002206 W JP 2004002206W WO 2004076602 A1 WO2004076602 A1 WO 2004076602A1
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- WIPO (PCT)
- Prior art keywords
- lipid
- lipid membrane
- trehalose
- decomposition
- mass
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B5/00—Preserving by using additives, e.g. anti-oxidants
- C11B5/0021—Preserving by using additives, e.g. anti-oxidants containing oxygen
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
Definitions
- the present invention relates to a method for suppressing the decomposition of a lipid constituting a lipid membrane and its use, and more particularly, to ⁇ , ⁇ -trehalose and / or ⁇ , -trehalose as a lipid membrane or a lipid.
- a method for suppressing the decomposition of lipids constituting lipid membranes, characterized in that it is contained in raw materials including membranes or intermediate products thereof, and the decomposition of lipids constituting lipid membranes produced using the method is suppressed.
- the present invention relates to a composition and a lipid degradation inhibitor containing ⁇ , ⁇ -trehalose and / or ⁇ ,) 8-trehalose as an active ingredient.
- lipid peroxides For products containing lipid membranes, during storage, the lipids that make up the lipid membrane are degraded by a radical reaction, etc., resulting in an off-odor, discoloration, fading, hardening, decomposition, denaturation, etc. It is well known that the decline occurs.
- the product when the product is a food or drink, a pharmaceutical product, or the like, the lipid constituting the lipid membrane is decomposed.
- the resulting peroxide is present not only in the lipid constituting the lipid membrane but also in the presence of the lipid membrane. It is known that it denatures highly reactive components such as lipids, proteins, peptides and / or amino acids that cause deterioration of the quality and function of the product.
- lipid peroxides have been shown to be associated with various diseases such as lifestyle-related diseases and aging due to their harmful effects on cells and tissues.
- the most widely used means in each field at present is to react with a substance generally called an antioxidant, that is, an oxygen or a radical that already exists.
- an antioxidant that is, an oxygen or a radical that already exists.
- a substance that inhibits or suppresses the reactivity of oxygen or radicals by chemically changing itself is added to a product or its raw material.
- the effect of the antioxidant to suppress radical reactions and the like is not endless, and the safety of the antioxidant itself and the problem that the reaction product of the antioxidant itself deteriorates the quality of the product. There is.
- a, ⁇ -trehalose has a different form of glucose, a, trehalose (also called neotrehalose), as this isomer.
- a, trehalose also called neotrehalose
- the behavior of ⁇ , 3-trehalose and ⁇ , / 3-trehalose for ordinary lipids is completely different.
- Japanese Patent Application Laid-Open Publication No. 2000-124, and WO02 / 24832 ⁇ , ⁇ -trehalose is While mixing directly with normal lipids inhibits the degradation of the lipids, ⁇ , i8-trehalose has no effect on inhibiting the decomposition of the lipids even when mixed directly.
- Patent Document 1 discloses a composition containing a-trehalose
- Japanese Patent Application Laid-Open No. 7-163 886 discloses a composition containing a,; 8-trehalose; — 1 2 3 1 9 4, WO 02/24 832, JP 7-213 2 8 3 and JP 7 16 3 3 8 6 a, a— Roast and / or a, / 3- WINCH Reha opening one scan is not only not what we describe inhibiting the degradation of lipids constituting the lipid membrane, no even the suggestion.
- the present invention provides a method for preserving raw materials containing a lipid membrane, intermediate products thereof, or compositions prepared from the decomposition of lipids constituting the lipid membrane.
- the decomposition products of the generated lipids, and other coexisting lipids, lipids such as proteins, peptides, and amino acids In order to suppress the degradation of product quality and the deterioration of functions due to the reaction with components other than the lipid constituting the membrane, it is necessary to provide a method for suppressing the decomposition of lipid constituting the lipid membrane.
- the first object is to provide a composition in which the decomposition of the fat constituting the lipid membrane produced by this method is suppressed
- the second object is to provide a lipid constituting the lipid membrane.
- the third object is to provide a decomposition inhibitor of the present invention. Disclosure of the invention
- the present inventors have long been conducting research on a method for suppressing the decomposition of lipid constituting a lipid membrane using a saccharide.
- ⁇ , ⁇ -trehalose and / or ⁇ , j6-trehalose can suppress the decomposition of lipid constituting the lipid membrane.
- A, ⁇ -trehalose and / or ⁇ , / 3-trihalose We have established a method for suppressing the decomposition of rehalose from lipids constituting lipid membranes or lipid membranes contained in lipid membrane-containing raw materials or intermediate products thereof, and have developed lipid membranes produced using this method.
- the method for suppressing the decomposition of the lipid constituting the lipid membrane according to the present invention is characterized in that ⁇ , ⁇ -trehalose and / or ⁇ ,) ⁇ -trehalose is converted to a lipid membrane or a raw material containing the lipid membrane or an intermediate product thereof. And by including them in a composition produced using them, the decomposition of lipids constituting the lipid membrane is suppressed, In addition to suppressing the production of highly reactive molecules such as lipid peroxides, conjugated gens, and aldehydes, lipid membranes, such as cells or ribosomes, can encapsulate various components inside.
- the active ingredients When in the form of an endoplasmic reticulum, the active ingredients, ⁇ , a-trehalose and / or ⁇ , 6-trehalose, cause the lipid membrane to change its properties by some mechanism. Not only the lipids that make up the lipid membrane, but also the denaturation of the components encapsulated inside the lipid membrane, which are caused by the decomposition of the lipids that make up the lipid membrane.
- the present invention can be advantageously used not only for the constituent lipids but also as a method for suppressing denaturation of components encapsulated in the lipid membrane.
- lipolysis used in the present invention is not limited to a specific cause.
- Conjugated gens, aldehydes, etc., causing off-flavors or off-flavors, or deterioration of quality or function of raw materials containing lipid membranes or intermediate products thereof, or of compositions manufactured using them It means things.
- the lipid membrane referred to in the present invention is a lipid membrane containing lipid as a constituent component, in which all or a part of the lipid is coordinated in a certain direction to form a membrane structure. Any one of them may be used, and it may be a gel phase or a liquid crystal phase. Further, it may be a simple lipid membrane composed of only fatty acids, or a composite lipid membrane in which components other than lipids such as proteins, carbohydrates, and high molecular polymers such as polyvinyl chloride coexist. . Further, the lipid membrane may be a single layer or a double layer, or may be a multi-layer lipid membrane in which they are further overlapped.
- a lipid membrane containing a surfactant such as a two-chain type
- a surfactant such as a two-chain type
- Specific examples include biological membranes such as chemical sensors and other artificial membranes, monomolecular membranes, black membranes, liposomes, and cell membranes.
- the ribosome referred to in the present invention means at least a closed vesicle having a bilayer membrane structure containing a lipid as a component (for example, Masao Takahashi, “Development of functional cosmetics”, CMC Co., Ltd., (See 1st page, 8 Tono, 135 pages (issued in 2000)).
- biological membrane refers to tissues, organs, cells, eggs, plant tissues and organs of animals including humans such as eyes, nasal cavity, oral cavity, gastrointestinal tract, epidermis and hair roots of animals including humans.
- tissue, organs, cells, eggs, plant tissues and organs of animals including humans such as eyes, nasal cavity, oral cavity, gastrointestinal tract, epidermis and hair roots of animals including humans.
- lipid membranes that make up the cells, tissues and organs removed for organ transplantation, cuts, abrasions, bedsores, burns, ulcers, frostbite, inflammatory reactions caused by infection or surgery, and the generation of radicals It also includes inflammatory lipid membranes in tissues, organs and cells in which the decomposition of the lipids that make up the lipid membrane is progressing.
- tissues such as meat, liver and other organs such as sea urchins, fish and eggs such as myosin and acacia eggs, eggs such as ovaries, and squid salt From animal tissues, such as fish sashimi and fillet, lipid membranes in processed organs, plant leaves, stems, fruits and other tissues, wheat, rice, buckwheat, corn, sesame seeds, soybeans, red beans
- germinated seeds such as wheat, rice, buckwheat, corn, etc., and hypocotyls of beans such as soybeans and red beans, and lipid membranes present in processed products thereof are naturally referred to in the present invention. Included in biological membranes.
- the lipid membrane referred to in the present invention includes, as components other than the lipid constituting the lipid membrane, components normally contained in a cell membrane (biomembrane), such as proteins, carbohydrates, nucleic acids, and complexes thereof. It may be.
- lipid membranes Min fatty alcohol, po Lioxyethylene acyl alcohol, polyglycerol, sorbitan fatty acid ester, ethoxylated sorbitan fatty acid ester, glycol monoester, glyceryl mono or diester propylene glycol stearate, sucrose distearate, glyceryl citrate It may contain one kind or two or more kinds.
- ⁇ -trehalose and / or ⁇ , -trehalose is used as an active ingredient of a lipid decomposition inhibitor forming the lipid membrane.
- the fermentation method, enzyme method, organic synthesis method, etc. may be used regardless of the origin or production method.
- the reaction solution obtained by those methods is ⁇ , ⁇ -trehalose and / or ⁇ 0 -trehalose. It can be used as it is, or as a solution containing a carbohydrate containing it, as it is, partially purified or purified to a high purity.
- a, -trehalose the same applicant has disclosed in Japanese Patent Application Laid-Open No.
- a, 8-trehalose can be produced by, for example, a method of producing a, ⁇ -trehalose directly from starch by an enzymatic method disclosed in Japanese Patent Publication No. A starchy or starch disclosed in Japanese Patent Application Laid-Open No.
- the lipid decomposition inhibitor constituting the lipid membrane of the present invention comprises ⁇ , ⁇ -trehalose and / or / 3-trehalose in an amount of about 1% by mass (hereinafter, unless otherwise specified in the present specification, “ “% By mass” is simply expressed as%.) As described above, those containing 5% or more, more preferably 20% or more, in a liquid, base or solid form are suitable. is there.
- the lipid-degradation inhibitor of the lipid membrane of the present invention is only required to exert the effect of inhibiting the degradation of the lipid constituting the lipid membrane, and the active ingredients, ⁇ -trehalose and / or ⁇ - May be composed of only 8-trehalose, or ⁇ , a-trehalose and / or ⁇ ,; ⁇ —glucose, isomaltose, maltose, ⁇ , ⁇ —coexisting in the process of producing trehalose.
- Rehalose Contains various oligosaccharides, dextrin, cyclodextrin, lactose, lactone, and other carbohydrates other than a, ⁇ -trehalose and / or ⁇ , ⁇ -treno-pulose, such as trehalose. May be. Further, if necessary, as an oligosaccharide, for example, the same applicant may be referred to in the specification of International Publication WO02 / 106361 and the specification of International Publication WO02 / 0725.994.
- ⁇ -maltosyl- ⁇ -darcoside also known as ⁇ _darcosyl a, ⁇ -trehalose
- glucose acts to convert the reducing end of three or more malto-oligosaccharides into a trehalose structure by acting on carbohydrates Saccharides such as glycerol and ⁇ -malt trisyl- ⁇ -gluside (also known as ⁇ -maltosyl ⁇ , ⁇ -trehalose) and saccharides containing it, sorbitol, maltitol, xylitol, erythritol One or more sugar alcohols such as It is also free to use.
- a, ⁇ -trehalose and / or ⁇ , 0-trehalose are stable carbohydrates.
- reducing sugars other than those described above may be used depending on the purpose of use, such as increasing dispersibility or increasing the amount.
- Quality non-reducing Carbohydrates, sugar alcohols, high-intensity sweeteners, water-soluble polysaccharides, organic acids, and organic acid salts. Used in combination with one or more selected from inorganic salts, emulsifiers, antioxidants, and substances with a chelating effect Is also optional.
- one or more known colorants, flavors, preservatives, acidulants, umami, sweeteners, stabilizers, alcohols, and fungicides can be used in appropriate amounts.
- the lipid decomposition inhibitor constituting the lipid membrane obtained in this manner may be any of syrup, paste, mask, powder, solid, granule, tablet, etc.
- the shape may be as follows.
- ⁇ -maltosyl-o; -darcoside ⁇ a—maltotriose is a non-reducing saccharide used in combination with the lipid decomposition inhibitor constituting the lipid membrane of the present invention.
- A a- Trehalose saccharide derivatives such as sil-a-darcoside, and maltitol as a saccharide alcohol are all preferable in that they have an excellent effect of inhibiting the decomposition of lipids.
- Maltosyl-a-darcoside and / or a-maltotriosyl-darcoside are particularly desirable because of their high effect.
- the antioxidant referred to in the present invention may be any compound as long as it is a compound used for efficiently suppressing an oxidation reaction, and may be selected depending on the use of the decomposition inhibitor for the lipid constituting the lipid membrane. Any one or two or more are appropriately selected.
- flavonoids such as L-ascorbic acid, L-ascorbic acid derivatives, vitamins such as vitamin B2, vitamin B2 derivatives, hesperidin, rutin and derivatives thereof, polyphenols such as catechin, anthocyanin, and proanthocyanidin; , Dibutylhydroxyltoluene, propyl gallate, diphenylpicrylhydrazyl, galvinoxyl, hydroquinone, hydroquinone derivatives, and the like.
- vitamin A, vitamin E, carotene, Terpenes such as xanthin xanthin and their derivatives, and docosapentae
- Unsaturated compounds such as unsaturated fatty acids typified by acetic acid, docosahexaenoic acid and the like can also be freely used according to the intended use.
- ⁇ -trehalose and / or ⁇ 1-trehalose of the present invention or a lipid decomposition inhibitor comprising a lipid membrane containing the same as an active ingredient, ⁇ , ⁇ ; — Trehalose and / or a;; 8— As long as Trehalose and the target lipid membrane are used so as to be in contact with or coexist, the target lipid membrane is isolated and purified. In addition, the desired function is exhibited even in the form of a composition with another component or a biological membrane existing in a living body.
- the lipid decomposition inhibitor that constitutes the lipid membrane is selected from the raw material stage to the product stage in consideration of the target lipid membrane and the composition and existence state of the lipid membrane. It can be used for any suitable process or product, and the product produced in this way can be used as it is, with, ⁇ -trehalose and / or ⁇ ,; 8-trehalose. It can be used in the same way as normal products that do not contain it. Also, even when the target is a biological membrane existing in a living body, ⁇ , ⁇ -trehalose and ⁇ or ⁇ ,; 8-trehalose have high safety, so that there is no danger of damaging the living body. Can be used in the same way as food and drink.
- the target raw material or its By the time intermediate products or compositions made using them are completed or on finished products, for example, mixing, kneading, dissolving, melting, dispersing, suspending, emulsifying, infiltrating, crystallization, Known methods such as spraying, coating, adhesion, spraying, coating (coating), and injection are appropriately selected.
- a known method such as oral ingestion, tube administration, eye drops, infusion, injection, spraying, application, spraying, adhesion, coating, immersion, and penetration is appropriately selected.
- the amount of o ;, ⁇ -trehalose and / or ⁇ , i8-trehalose in the lipid membrane that can be brought into contact with or coexisting with the lipid membrane should be an amount that can exert the effect of inhibiting the decomposition of the lipid constituting the lipid membrane.
- it is usually anhydrous based on the total weight of the lipid membrane, or a raw material containing the lipid membrane or an intermediate product thereof, or a composition produced using the same.
- ⁇ , ⁇ _trehalose and / or ⁇ , / 3-trehalose is contained as uniformly as possible.
- the concentration of a, ⁇ -trehalose and / or ⁇ , —trehalose is about 0.1% or more with respect to the target lipid membrane surface.
- it should be about 0.1% or more, and more preferably, about 1.0% or more. If the concentration of ⁇ , ⁇ -trehalose and / or ⁇ ,; 6-trehalose becomes higher than the solubility, it will crystallize and solidify, and it will be lost on living organisms such as mucous membranes and plant tissues, organs and cells. When used for an existing lipid membrane, there is a concern that these may be impaired, and therefore, it is desirable to use it in an amorphous form.
- the ⁇ , ⁇ -trehalose and / or ⁇ , -trehalose of the present invention, or the lipid degradation inhibitor comprising the lipid membrane containing the same as an active ingredient constitutes a lipid membrane.
- Various fields that require avoiding chemical changes in lipids such as food (including beverages), agriculture, forestry and fisheries, cosmetics, pharmaceuticals, daily necessities, chemicals, dyes, paints, and building materials Field, fragrance field, chemicals field, synthetic fiber field, dye field, photosensitive dye field, and raw materials used in these fields, or intermediate It is useful in a very wide range of fields, such as the field of manufacturing products.
- a: ⁇ -trehalose and / or ⁇ , ⁇ -trehalose of the present invention suppresses the decomposition of the lipid that constitutes the lipid membrane in raw materials and intermediate products, and can maintain their quality and function for a long period of time.
- it has low sweetness, and is in harmony with other substances that have other tastes such as sourness, salty taste, astringency, umami, and bitterness, and has high acid resistance and heat resistance. Therefore, it can be used not only as a decomposition inhibitor for lipids constituting the lipid membrane contained in raw materials and intermediate products produced in these fields, but also as a taste improver and a quality improver.
- lipids, proteins, peptides, amino acids, and other reactive components in addition to lipid membranes. Therefore, while suppressing the decomposition of lipids, the lipid peroxide produced by the reaction reacts with other coexisting lipids, proteins and sugars and other highly reactive components,
- the lipid decomposition inhibitor constituting the lipid membrane of the present invention which can suppress the progress of such denaturation, can be used extremely advantageously for maintaining the flavor (quality) of foods and drinks.
- seasonings and sweeteners such as powdered seasonings of mushrooms such as kelp, shiitake mushrooms, reishi, and kazuno-reishi, sweets such as Japanese confectionery, western confectionery, snacks, bread, dried fruits, cut fruits, etc.
- Leafy vegetables such as komatsuna and cabbage, root vegetables such as carrots and burdock, germinated plants such as bean sprouts, broccoli sprout and other processed vegetables, wheat, rice, buckwheat Germ germ of corn, etc.
- bean hypocotyl such as soybean, red bean ⁇ their processed products, processed meat products such as bacon, sausage, processed fish and seafood, prepared food, processed egg products, dairy products,
- processed meat products such as bacon, sausage, processed fish and seafood
- dairy products These frozen products, refrigerated products, It can be advantageously used for various foods such as chilled products, retort products, dried products, freeze-dried products, heat-processed products, and soft drinks.
- the degradation inhibitor of ⁇ , ⁇ ; —trehalose and / or ⁇ , jS—trehalose of the present invention or the lipid constituting the lipid membrane containing the same as an active ingredient is a lipid or the like. Even if the food or drink containing the peroxide is ingested or applied to the lipid membrane, it is present in the biological tissue, the lipid membrane of the cells, and the inside thereof due to the peroxide.
- lipids that constitute lipid membranes can also be used as an inhibitor of the decomposition of lipids that constitute lipid membranes, such as feed for larvae, larvae and adults of domestic animals such as livestock, poultry, and pets, and feed, for the purpose of maintaining their quality. it can.
- artificial seawater, culture solutions, and growth degradation point inhibitors, plant nutrients, liquid fertilizers, remedies for tree treatments, and grafting agents as lipid-degrading inhibitors that make up the lipid membrane of It can suppress the decomposition of lipids constituting the lipid membrane of animals and plants, and can stably maintain its vitality and freshness.
- the ⁇ , ⁇ -trehalose and / or ⁇ ,; 6-trehalose of the present invention, or the lipid degradation inhibitor comprising the lipid membrane containing the same as an active ingredient, is particularly useful in the cell membrane and the like. As it suppresses the decomposition of lipids that constitute the biological membrane, it is used as an inhibitor of the inflammatory reaction associated with the generation of peroxides generated in the body, and is used in diseases such as atopy and allergic diseases.
- Recognized dermatitis, eczema, juniper, insect bites, burns, sunburn, immune reactions It can also be used advantageously for the prevention and treatment of various inflammatory diseases such as inflammatory diseases of the organs such as stomatitis, gingivitis, conjunctivitis, gastritis, colitis, ulcerative colitis and Crohn's disease. It can also be advantageously used as a culture solution for plants and trees, a growth point culture solution, a plant nutrient, a liquid fertilizer, a therapeutic restoration material, a grafting agent, and the like.
- a raw material produced by using the method for suppressing the decomposition of lipid constituting the lipid membrane of the present invention or an intermediate product thereof, or a composition produced by using these materials may be a lipid membrane such as ribosome.
- a closed endoplasmic reticulum consisting of, for example, the components that can be encapsulated therein include various physiologically active substances that easily lose their activity, useful components used in health foods, and active components in cosmetics and pharmaceuticals. .
- the lipid decomposition inhibitor constituting the lipid membrane of the present invention comprises: By acting on the constituent lipids to stabilize the lipid membrane, the decomposition and denaturation of the useful components encapsulated in the lipid membrane structure or inside the lipid membrane are suppressed, and their activities and functions are stabilized over a long period of time. Since it can be retained, it can be advantageously used to maintain the quality of high-quality health foods, cosmetics, pharmaceuticals, reagents, feeds, feeds, etc., which contain closed vesicles of lipid membranes encapsulating them.
- the inhibitor of ⁇ , ⁇ -trehalose and / or ⁇ , 3—trehalose of the present invention or a lipid-degradation inhibitor comprising the lipid membrane containing the same as an active ingredient may be used alone or in addition to the above.
- it can be used to produce turf tea and other agricultural or fruit trees, horticultural crops, or their germinated plants, seedlings and other plants (each part of leaves, stems, roots, flowers, seeds, etc.). Direct spraying or spraying the soil around the plant to suppress the decomposition of the lipids that make up the lipid membrane of these plant tissues, organs, and cells.
- resistance and osmotic pressure resistance protects from dryness, frost damage, salt damage, etc., and as a plant growth promoter, maintains and enhances the vitality of plants, yields of fruits, seeds and grains increase of Any purpose it is possible to use.
- DMPC dimethylstil-phosphatidylcholine
- AVANTI dimethylstil-phosphatidylcholine
- DPPC dipalmity h-phosphatidylcholine
- a, t-trehalose (reagent grade, sold by Hayashibara Biochemical Laboratory), ⁇ , i8-trehalose (reagent grade, sold by Hayashibara Biochemical Laboratory), sucrose (reagent grade)
- a 0.154 M aqueous solution of maltose (reagent grade “Maltose HHH” sold by Hayashibara Biochemical Laboratories, Inc.) or maltose (sold by Wako Pure Chemical Industries, Ltd.).
- maltose reagent grade “Maltose HHH” sold by Hayashibara Biochemical Laboratories, Inc.
- maltose sold by Wako Pure Chemical Industries, Ltd.
- the GLC system is GC-14B (manufactured by Shimadzu Corporation), and the analytical column is a cantilever ram TC-FFAP (inner diameter 0.53 mm x length 30 m, film thickness 1.0 ⁇ m;
- the carrier gas was helium gas with a flow rate of 10 miZmin, the injection temperature was 230 ° C, the column oven temperature was 120 ° C for 2 minutes, and then 5 ° C / 2 3 at min speed
- the temperature was raised to 0 ° C, and detection was performed with a flame ion detector.
- ⁇ , ⁇ -trehalose and / or ⁇ , jS-trehalose can be used to form lipid membranes such as phospholipids such as lecithin, DMPC or DPPC, lipids such as linoleic acid, or lipids such as linoleic acid.
- lipid membranes such as phospholipids such as lecithin, DMPC or DPPC, lipids such as linoleic acid, or lipids such as linoleic acid.
- Lipids such as lecithin, DMPC, or DPPC encapsulated in lipid membranes, and the generation of conjugated gens from lipids such as linoleic acid, such as DPPC, and lipids that constitute lipid membranes and lipids encapsulated in lipid membranes It has been found that the compound has an action of suppressing the decomposition of the compound.
- the mechanism of suppressing the decomposition of the lipid constituting the lipid membrane is based on the mechanism of formation of aggregates when fatty acids and ⁇ , ⁇ -trehalose and / or ⁇ , / 3-trehalose are directly mixed. Was shown to be different.
- the present invention is applied to decompose a, -trehalose and / or a, i8-trehalose into lipids constituting a lipid membrane.
- the lipid membrane is formed by incorporating it into raw materials containing lipid membranes or intermediate products that may cause quality deterioration such as off-odor, discoloration, hardening, decomposition, and denaturation during storage, or function deterioration. It has been found that the decomposition of lipids can be suppressed. Furthermore, although ⁇ , ⁇ -trehalose cannot be inhibited by its direct mixing with fatty acids, its degradation cannot be suppressed, but it interacts with the lipids that make up the lipid membrane to stabilize the lipid membrane. Since the decomposition of the constituent lipids and the lipid encapsulated in the lipid membrane can be suppressed, it has been found that the decomposition or denaturation of various components caused by the decomposition of these lipids can be suppressed.
- ⁇ , ⁇ -trehalose and / or ⁇ , ⁇ -trehalose inhibits the decomposition of lipids constituting the lipid membrane and stabilizes the lipid membrane, thereby lysing cells (including autolysis). And burns, dermatitis, atopic dermatitis, ulcerative colitis, gastritis, enteritis, etc., which are exacerbated by peroxides and radicals generated by the decomposition of lipids, as they inhibit the damage of tissues and tissues. It can also be advantageously used as a prophylactic or therapeutic agent for inflammatory diseases, an organ preservative at the time of transplantation and the like, and an agent for preserving the freshness of animal and plant tissues.
- the lipid decomposition inhibitor constituting the lipid membrane containing a, monotrehalose and / or a, / 3-trehalose as an active ingredient of the present invention is a lipid membrane or a lipid membrane. It can contribute significantly to the stabilization of the raw material containing it or its intermediate products, or the compositions produced using these, so that it is industrially industrial in the fields of foods containing lipid membranes, cosmetics, pharmaceuticals, and chemicals. It can be used to great advantage in the production, transportation and storage of products in a wide range of fields such as.
- Example ⁇ Lipids constituting lipid membrane
- Example B An example will be described. However, the present invention is not limited by these examples.
- Example A a carbohydrate containing trehalose and Z or or j8-trehalose, or a lipid decomposition inhibitor comprising a lipid membrane containing the same
- Trehalose (trade name “Treha”, sold by Hayashibara Shoji Co., Ltd.) is dissolved in water to prepare a solution of about 50%, and this 1 part by mass and commercially available DE 43 1.5% by weight of acid saccharified starch syrup (about 80% water) is mixed with about 20% of trehalose per syrup and about 32% of water containing other saccharified carbohydrates and about 30% of DE.
- a trehalose-rich syrup was prepared.
- This product promotes the decomposition of lipids comprising lipid membranes, including processed foods and drinks, cosmetics, quasi-drugs, pharmaceuticals, feed, feed, or raw materials or intermediate products of these It stabilizes the lipid membrane by incorporating it into a lipid membrane or a composition containing a lipid membrane, which is liable to cause quality deterioration or functional deterioration such as generation of an offensive odor, discoloration, hardening, decomposition, and denaturation during storage. It can be advantageously used for a method for suppressing the decomposition of lipids constituting a lipid membrane.
- the product is also suitable as a decomposition inhibitor for lipids constituting a lipid membrane.
- Example A-3 of Japanese Patent Application Laid-Open No. 4-179494 a saccharide containing about 34% of lactone neotrehalose per solid was converted into anhydrous matter.
- an aqueous solution containing about 3 5% was prepared, after adjusting the P H to four. 5
- the mixture was heated to 40 ° C, and 8-galactosidase was added thereto and reacted for 24 hours. This was filtered, decolorized, desalted and concentrated by a conventional method to prepare a syrup containing 75% in concentration and 23.5% per solid, 0 !,; 8-trehalose.
- This product is processed foods and drinks, cosmetics, quasi-drugs, pharmaceuticals, feedstuffs.Feeds, or the raw materials or intermediate products, etc. Stabilizing the lipid membrane by forming it into a lipid membrane or a composition containing a lipid membrane, which is liable to cause quality deterioration and functional deterioration such as generation of off-flavor, fading, hardening, decomposition, denaturation, etc. It can be advantageously used for a method for suppressing the decomposition of lipids.
- the product is also suitable as a decomposition inhibitor for lipids constituting a lipid membrane.
- Example A-2 The syrup prepared in Example A-2 was purified by column chromatography to prepare a nectar-containing crystal powder containing 78% of ⁇ , ⁇ 6_ trehalose.
- the decomposition of lipids constituting the lipid membrane including processed foods and drinks, cosmetics, quasi-drugs, pharmaceuticals, feed, feed, or these raw materials or intermediate products, progresses. Stabilize the lipid membrane by incorporating it into a lipid membrane or a composition containing a lipid membrane, which is liable to cause quality deterioration and functional deterioration such as generation of off-odor, discoloration, hardening, decomposition, and denaturation during storage, and stabilization of the lipid membrane. It can be advantageously used for a method for suppressing the decomposition of constituent lipids.
- the product is suitable as a decomposition inhibitor for lipids constituting a lipid membrane.
- Trehalose hydrated crystal (Reagent grade, sold by Hayashibara Biochemical Laboratory Co., Ltd.) 60 parts by mass of commercially available anhydrous crystal multi-tablet (Hayashibara Shoji Co., Ltd., trade name “Mavit”) ) Is mixed with 40 parts by mass, and the powder mixture Was prepared.
- This product is processed foods and drinks, cosmetics, quasi-drugs, pharmaceuticals, feedstuffs.Feeds, or the raw materials or intermediate products, etc.
- Stabilizing the lipid membrane by forming it into a lipid membrane or a composition containing a lipid membrane, which is liable to cause quality deterioration and functional deterioration such as generation of off-flavor, fading, hardening, decomposition, denaturation, etc. It can be advantageously used for a method for suppressing the decomposition of lipids.
- the product is also suitable as a decomposition inhibitor for lipids constituting a lipid membrane.
- lipid membrane Stabilize the lipid membrane by forming it into a lipid membrane or a composition containing a lipid membrane that is liable to cause quality deterioration or functional deterioration such as generation of off-odor, discoloration, hardening, decomposition, denaturation, etc. It can be advantageously used for a method for suppressing the decomposition of lipids.
- the product is also suitable as a decomposition inhibitor for lipids constituting a lipid membrane.
- L-ascorbic acid 2-darcoside available from Hayashibara Biochemical Research Laboratories, Inc.
- a, -trahalose available from Hayashibara Shoji Co., Ltd., trademark “Treha”
- enzyme-treated rutin available from Toyo Seika Co., Ltd., trade name “a G rutin”
- This product is processed foods and drinks, cosmetics, quasi-drugs, pharmaceuticals, Degradation of lipids constituting the lipid film, including feed, feed, or these raw materials or intermediate products, progresses, and quality deterioration such as generation of offensive odor, discoloration, hardening, decomposition, and denaturation during storage
- the lipid membrane is stabilized, and can be advantageously used in a method for suppressing the decomposition of lipids constituting the lipid membrane.
- the product is also suitable as a decomposition inhibitor for lipids constituting a lipid membrane.
- L-ascorbic acid 2 -darcoside (70% by mass of crystalline powder containing n-trehalose) prepared according to the method of Example A-3 0; 2 parts by weight) and 2 parts by weight of enzyme-treated rutin (available from Toyo Seika Co., Ltd., trade name: “a G-rutin”) were mixed to prepare a powder mixture.
- enzyme-treated rutin available from Toyo Seika Co., Ltd., trade name: “a G-rutin”
- the lipids that make up the lipid membrane including processed foods and drinks, cosmetics, quasi-drugs, pharmaceuticals, feed, feed, or these raw materials or intermediate products, are being degraded and stored.
- Stabilizing the lipid membrane by forming it into a lipid membrane or a composition containing a lipid membrane, which is liable to cause quality deterioration and functional deterioration such as generation of off-flavor, fading, hardening, decomposition, denaturation, etc. It can be advantageously used for a method for suppressing the decomposition of lipids.
- This product is also suitable as a decomposition inhibitor for lipids forming a lipid membrane.
- Example II Use of a saccharide containing ⁇ , (3 ⁇ 4-trehalose and / or ⁇ , / 3-trehalose or a lipid decomposition inhibitor containing the same as a lipid membrane containing the same
- Example B-3 Dried fruits ⁇ Mixed vegetables
- the saccharide derivatives of, a-trehalose and, ⁇ -trehalose suppress the oxidation of the lipids that make up the lipid membrane of the vegetable peringo cells, and have no stickiness and storage stability.
- Excellent flavored and dried fruit 'mix vegetables Prepare the cookie dough by the usual method, spread it on a wrap to a thickness of about 3 mm, put the dried fruit ⁇ mixed vegetables, roll it into a roll, cut it into 1 cm width Dried fruits in an oven and baked to prepare cookies mixed with mixed vegetables.
- Example B-4 Sprouts
- Soybean sprouts were prepared by the method of Example A-1. Degradation inhibitor for lipids constituting a syrup-like lipid membrane containing 1 trehalose 15 mass parts and 5 mass parts of ethanol were mixed with 80 mass parts of water. And immersed in a solution cooled to 10 ° C for 60 minutes. After draining, storing overnight at 4 ° C, dressing this product and tasting it, the decomposition of lipids constituting the lipid membrane of sprouts is suppressed, and the freshness is maintained well. I was This product is suitable as a raw material for salads and other processed foods.
- Example B-5 Wheat germ processed product
- Example B-6 Western carrot powder
- Example A- A / 3 Trehalose-containing lipid-containing lipid membrane prepared by the method of 3 A, o;-Trehalose and a, — Trehalose after impregnation It was air-dried at 55 ° C for 16 hours.
- This western carrot slice was pulverized with a pulverizer to prepare a dry western carrot powder containing at least 80% of particles having a particle diameter of 100 m or more.
- a, ⁇ -trehalose and ⁇ , / 3-trehalose inhibit the decomposition of the lipids that make up the lipid membrane of carrot powder. Since these nutrients are stably retained for a long period of time, they are suitable as health supplements or as raw materials for other foods and drinks.
- Example I-7 Broccoli powder
- ⁇ ,; 8-trehalose inhibits the decomposition of lipids that make up the lipid membrane contained in broccoli powder, so that nutrients such as procoli flavor and ⁇ -carotene can be stably maintained for a long period of time. Because it is retained, it is suitable as a dietary supplement or a raw material thereof.
- Example II-8 Kelp powder
- hydrous crystals ⁇ , ⁇ - A, ⁇ -Trehalose sugar in powder form prepared by the method of Example A-2 of 27% and Hayashibara Shoji Co., Ltd., trademark “Treha”)
- Aqueous solution containing 3% of carbohydrate derivative-containing saccharide containing 4.1% of ⁇ -maltosyl ⁇ -darcoside and 52.5% of ⁇ -maltotrisyl ⁇ -glycoside in terms of anhydride
- 60 0 parts by mass was added, and the whole amount was absorbed by kelp.
- the kelp was spread on a stainless steel mesh, and dried with a ventilation dryer at 60 ° C for 16 hours to prepare dried kelp.
- This product has a good flavor even after long-term storage because ⁇ , ⁇ -trehalose and saccharide derivatives of ⁇ , ⁇ -trehalose inhibit the decomposition of lipids that constitute the lipid membrane of kelp. Well held.
- ⁇ , ⁇ ;-trehalose since it is impregnated with ⁇ , ⁇ ;-trehalose, it has an appropriate hardness, and has the characteristic that it can be easily powdered, which is difficult with ordinary dried kelp.
- the dried kelp was pulverized using a crusher to prepare a fine powder of the dried kelp having an average particle size of 11 m.
- This product does not absorb moisture, and ⁇ , ⁇ -trehalose inhibits the decomposition of the lipids that make up the lipid membrane of kelp. You. Moreover, it does not swell when added to water, and is suitable as a raw material for powder seasonings and health supplements.
- Example II-9 Shiitake mushroom powder
- 100 parts by mass of commercially available dried shiitake mushrooms (water content) are crushed into chips having a diameter of 3 to 4 mm, and hydrated crystals ⁇ , ⁇ -trehalose (available from Hayashibara Shoji Co., Ltd. Reha ”) 400 parts by mass, an aqueous solution prepared by dissolving 50 parts by mass of an ⁇ , monotrehalose-containing saccharide prepared by the method of Example III-3 and 3 parts by mass of pullulan in 800 parts by mass of water was added. Then, the whole amount of this solution was absorbed into the crushed shiitake mushrooms. Spread it on a tray and use a draft dryer at 60 ° C. After drying for 18 hours, dried shiitake mushrooms were prepared.
- This product has a good flavor even after long-term storage because ⁇ , ⁇ -trehalose and 0!, / 3-trehalose inhibit the decomposition of the lipids constituting the lipid membrane of Shiitake mushrooms. It is well impregnated. Also, since it is impregnated with a, ⁇ -trehalose and ⁇ , j8-trehalose, it has an appropriate hardness and can be easily powdered with ordinary dried shiitake mushrooms. It has the feature of.
- the dried shiitake mushroom was pulverized with a pulverizer to prepare a fine powder of the dried shiitake mushroom having a water content of about 6%.
- This product does not absorb moisture, and a, ⁇ -Trehachirose inhibits the decomposition of the lipids that make up the lipid membrane of shiitake mushrooms. You. Moreover, it does not swell even when returned to water, and is suitable as a raw material for powder seasonings and health supplements.
- Example III-10 bonito powder
- a fresh bonito was used, and as an aqueous solution to be used when the fish meat was boiled, a scallop-like lipid membrane containing ⁇ , ⁇ -trehalose prepared by the method of Example A-1 was constructed.
- 200 parts by mass of a lipid decomposition inhibitor and powdery saccharide derivative of a, ⁇ -trehalose prepared by the method of Example A-2 of JP-A-7-143876 5 parts by mass (contained in terms of anhydride (containing 4.1% of ⁇ -glycoside ⁇ -glycoside and 52.5% of ⁇ -glycoside ⁇ -glycoside) 50 parts by mass of 75 parts by mass
- the dried bonito was prepared in the usual manner except that an aqueous solution dissolved in a part of water was used, and the product was ⁇ , ⁇ -trehalose, ⁇ ,
- the dried bonito was pulverized with a crusher to prepare a fine powder of bonito having a water content of about 5%.
- This product does not absorb moisture and is easily suspended when put in water.
- ⁇ -trehalose and saccharide derivatives of a a-trehalose inhibit the decomposition of the lipid constituting the lipid membrane of bonito, the flavor is good even after long-term storage. It is retained and is suitable as a raw material for powder seasonings and health supplements.
- Example B-11 Powder seasoning
- Example B— 10 parts by mass of the kelp powder prepared in Example B-8, 10 parts by mass of the shiitake mushroom powder prepared in Example B-9, and 10 parts by mass of the bonito node powder prepared in Example B_10 The powder was mixed homogeneously to prepare a powdered pear. This product does not absorb moisture, is easy to handle, and can be easily removed by suspending it in water when preparing boiled foods and soups. Also, since ⁇ , a-trehalose inhibits the decomposition of the lipid constituting the lipid membrane of kelp, shiitake and bonito, its flavor is well maintained even after long-term storage. '' Example B— 1 2
- a, a-trehalose and, 0-trehalose suppress the degradation of lipids that constitute the lipid membrane of the ovaries of the ovaries, so that they are less denatured by refrigeration or chilled storage.
- this product must be Even after cooking, the oxidation and decomposition of lipids constituting the lipid membrane and the denaturation of proteins were suppressed, and the taste was unpleasant. ⁇ The odor was low, and the taste, aroma, color and texture were good.
- Example B-13 Suzuki Fillet
- This product is trehalose and trehalose
- the sugar derivative of sesame inhibits the oxidation of the fats that make up the lipid membrane of the cells of the Japanese anchovy, so it is a flavorful dried sardine that has no off-flavor or fishy odor and good color.
- this product has excellent storage stability because it suppresses lipid oxidation and decomposition, drying and moisture absorption even when stored at room temperature, refrigerated, chilled, or frozen.
- the frozen pickpocket of Skewered cod has a good freshness even after refrigerated storage because ⁇ , ⁇ -trehalose and a ;, ⁇ -trehalose impart excellent freezing resistance to evening proteins.
- Example B 16: Smelt boiled smelt
- Example A-2 22 parts by mass of sodium chloride, 2.5 parts by mass of powdered saccharide containing a, / 3-trehalose prepared by the method of Example A-3, 1 part by mass of sugar, JP-A-7-14438 76 parts by mass of a saccharide containing a carbohydrate derivative of a, a-trehalose prepared by the method of Example A-2 of No.
- This product is stored at 30 ° C for 1 month, thawed at 30 ° C and 85% humidity for 90 minutes, and fermented at 27 ° C for 100 minutes according to the standard method. After that, it was divided, formed, fermented at 39 ° C for 60 minutes in a hoist, and baked to produce a pan.
- This bread had no mottling on the surface of the outer skin, the dough swelled sufficiently, and had a good texture, aroma and taste.
- the HVJ virus as a seed was ingested into chicken eggs having developing embryos, cultured at 37 ° C for 48 hours, and the showa fluid containing the propagated virus was collected.
- 8 parts by mass of Dulbecco's MEM medium manufactured by Nissui Co., Ltd.
- 0.5 ml was dispensed into a glass spear bottle and lyophilized by a conventional method.
- ⁇ -trehalose inhibits the decomposition of the lipids that make up the ribosome lipid membrane and stabilizes the ribosome lipid membrane. Therefore, the oxidation and degradation of L-ascorbic acid 2-glycoside and glycosyltransferred rutin encapsulated in ribosomes are also suppressed, and are maintained stably for a long period of time, so that health foods containing ascorbic acid 2-darcoside and rutin can be used. It can be used advantageously as a raw material.
- Example B_21 Drink preparation
- amino acid mixture 4 parts by mass of isoleucine, 6 parts by mass of leucine, 8 parts by mass of lysine, 8 parts by mass of fenylalanine, 1 part by mass of tyrosine, 12 parts by mass of triptophan, 8 parts by mass of parin, 1 part by mass of aspartic acid
- This product reduces the prevention and aging of inflammatory symptoms, such as skin irritation and itching, because a, ⁇ -toray-8-rose inhibits the decomposition of lipids that constitute the lipid membrane of cells on the skin surface. It can be used advantageously for treatment, prevention and the like. In addition, this product has a well-painted surface, does not have a moist feeling after application, and is a milky lotion d for whitening that is easy to use.
- Example B_23 Cosmetic cream for ribosome-containing external use for skin
- Distilled water (5 ml) was added to the dried lipid mixture, and the mixture was heated to 60 ° C and homogenized. Then, the L-ascorbic acid 2-darcoside heated to 60 ° C was added thereto.
- Add 3 ml of a solution containing glycosyltransferred hesperidin and indigo blue ethanol extract homogenize again, and reconstitute the ribosome solution containing L-ascorbic acid 2-darcoside, glycosyltransferred hesperidin and indigo ethanol extract. A liquid was prepared.
- squalane 15 parts by mass of reduced lanolin, 10 parts by mass of beeswax, 8 parts by mass of oleyl alcohol, 5 parts by mass of fatty acid glycerin, and polyethylenoxyethylene sorbitan monoleate (20 E.O. ) 3 parts by mass, 3 parts by mass of lipophilic glyceryl monostearate, 3 parts by mass of L-ascorbic acid 2-darcoside, 1 part by mass of glycyrrhizic acid dikalymate.
- the appropriate amount of perfume and antioxidant was adjusted to 70 ° C. Under the conditions, the mixture was mixed to a uniform state to prepare an oil phase.
- the oil phase was added to the aqueous phase and preliminarily emulsified according to a conventional method, and then uniformly emulsified with a homomixer and cooled to obtain an oil-in-water type external cream for skin.
- This product exhibits excellent moisturizing properties on the skin, and decomposes the lipids that make up the liposome lipid membrane and the indigo extract that is encapsulated inside the lipid membranes to form ⁇ , ⁇ -trehalose and a, Since it is suppressed by ⁇ -trihalose, it can be advantageously used as a high-quality skin external preparation with excellent storage stability.
- the cream contains a useful component of indigo, L-ascorbic acid 2 -darcoside and glycosyltransferred hesperidin, which are encapsulated in ribosomes, and rapidly translocates to the skin. Therefore, the useful component of indigo and / or glycyrrhizic acid have hyaluronidase activity.
- Various effects including the inhibitory effect exerted effects such as suppression of skin inflammation, and as a result, aging of the skin represented by occurrence of spots, wrinkles and wrinkles was suppressed. It has the effect of maintaining a firm and fresh skin.
- this product contains ci, 1-trehalose, and a carbohydrate derivative of 1-trehalose, it inhibits the oxidation of the lipids that make up the lipid membrane of skin cells and reduces the generation of radicals and lipid peroxides. Suppresses skin cells and activates skin cells, so that external stress such as dryness or ultraviolet light promptly restores normal skin to inflamed or inflamed skin and suppresses aging. Can be done. In addition, this product has excellent moisturizing properties and low irritation to the skin, so it can be used without worrying about hypersensitivity. Excellent, lotion.
- Example B-25 Toothpaste
- Example A-2 6 parts by mass of a lipid decomposition inhibitor composing a syrup-like lipid membrane containing ⁇ -trehalose, 1.5 parts by mass of sodium lauryl sulfate, and 0.1 part of sodium monofluorophosphate prepared by the above method.
- Toothpaste was prepared by mixing 7 parts by mass, 0.5 parts by mass of polyoxyethylene sorbitan laurate, 0.05 parts by mass of preservative, and 0.02 parts by mass of saccharin sodium with 22 parts by mass of water.
- This product is useful for gingiva, tongue, etc., because it inhibits the decomposition of lipids that constitute the lipid membrane of cells in the oral cavity. It can be used advantageously for reducing or treating inflammatory symptoms in the oral cavity that are observed.
- this product has a reduced bitterness, such as the bitterness of sodium lauryl sulfate and the aftertaste of saccharin, so that it has a good mouthfeel, good usability, gloss and detergency, and has a bad breath after use. It is good for toothpaste because of its reduction.
- Example B-27 Eye drops
- 6-Trehalose (reagent grade, sold by Hayashibara Biochemical Laboratory Co., Ltd.) is dissolved in purified water, treated with activated charcoal, and then subjected to microfiltration.
- 5 parts by mass (in terms of anhydride) of a constituent of a lipid decomposition inhibitor, 0.4 parts by mass of sodium chloride, 0.15 parts by mass of potassium chloride, 0.2 parts by mass of sodium dihydrogen phosphate, 0.1 parts of borax 5 parts by mass and 0.1 parts by mass of dipotassium glycyrrhizinate are mixed, and an appropriate amount of sterilized purified water is added so that the total amount becomes 100 parts by mass.
- a sterile ophthalmic solution was prepared without containing.
- ⁇ , -trehalose inhibits the decomposition of lipids that make up the lipid membrane of the conjunctiva and cells on the surface containing the product, this product develops in these sites due to allergies, atopy, and infectious diseases. It can be used advantageously for reducing or treating inflammatory symptoms that occur.
- x, ⁇ — trehalose is also excellent in water retention and cell protection, so that it can protect the cells of the ocular mucosa and the surface of the eyeball from drying disorders. However, it can also be advantageously used as a preventive or therapeutic agent for dryness of the eyes of patients with general dry eye-Schädadalen syndrome.
- DPPC was dissolved in black-mouthed form to a concentration of 75 mg / mI, 1 mI was placed in a 10 OmI-capacity eggplant-shaped flask, and the rotary evaporator was removed. It was concentrated to dryness and further dried under vacuum overnight in a desiccant containing phosphorus pentoxide. To the dried flask, add 10 ml of physiological saline and 60 mg of Genyumycin for injection (sold by Showa Yakuhin Kako Co., Ltd.), shake at 37, and gently add gentamicin-encapsulated liposome. A solution was prepared.
- the inhibitor for decomposition of lipid constituting the powdery lipid membrane containing ⁇ , ⁇ -trehalose and ⁇ ,; 8-trehalose prepared by the method of Example A-5 4 Dissolve 5 parts by mass, 0.4 parts by mass of sodium chloride, 0.15 parts by mass of potassium chloride, 0.2 parts by mass of sodium dihydrogen phosphate, and 0.15 parts by mass of borax in sterilized purified water. It was 50 mI. An eye drop was prepared by mixing equal amounts of the two solutions. pH was adjusted to 7.3. This product shows that ⁇ , ⁇ -trehalose and ⁇ , ⁇ -trehalose inhibit the inflammation of the eye and protect the mucous membrane of the eye from drying out.
- Example B-29 Ointment for wound treatment
- iodine 3 parts by mass was dissolved in 500 parts by mass of a powdery ⁇ , / 3-trehalose-containing saccharide prepared by the method of Example A-3, and 50 parts by mass of methanol was added.
- a 0% aqueous pullulan solution 200 parts by mass was added and mixed to obtain a wound treatment ointment having appropriate elongation and adhesiveness.
- This product can be used to treat wounds such as cuts, abrasions, burns and athlete's foot, by directly applying it to the wound surface or by applying it to gauze, etc. and using it on the affected area.
- Example III—30 Artificial seawater
- the present invention provides a lipid membrane comprising a, a-trehalose and / or ⁇ ; ⁇ -trehalose in a lipid membrane or a raw material or an intermediate product containing the lipid membrane.
- the present invention also relates to a method for suppressing the decomposition of lipids, and suppressing the decomposition and denaturation of coexisting proteins and carbohydrates by peroxides generated by the decomposition of the lipids.
- a, a-trehalose and / or a,; 8-trehalose are contained in a closed endoplasmic reticulum consisting of a lipid membrane, while suppressing degradation of lipids constituting the lipid membrane.
- the present invention also relates to a lipid decomposition inhibitor comprising ⁇ , ⁇ -trehalose and / or a lipid membrane containing ⁇ , ⁇ -trehalose. Furthermore, since, a-trehalose and / or a, 3-trehalose are safe and very stable as foods, the method of the present invention for inhibiting the decomposition of lipids constituting lipids is used. Fields include foods, agriculture, forestry and fisheries, cosmetics, quasi-drugs, pharmaceuticals, daily necessities, chemicals, fragrances, chemicals, synthetic fibers, dyes, photosensitive dyes, etc. Cross over. The present invention is an invention having such a remarkable effect, and its industrial contribution is very large and a significant invention.
Abstract
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JP2006117534A (ja) * | 2004-10-19 | 2006-05-11 | Kose Corp | 乳化化粧料 |
JP2006207046A (ja) * | 2005-01-25 | 2006-08-10 | Kujira House Kk | 抗菌性の紙、不織布または繊維製品 |
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JP7396585B2 (ja) | 2019-10-31 | 2023-12-12 | 晴義 山田 | Tslp遺伝子発現抑制用、il-33遺伝子発現抑制用、又はフィラグリン産生促進用組成物 |
WO2021210648A1 (fr) * | 2020-04-17 | 2021-10-21 | Next21 Kabushiki Kaisha | Médicament contenant du tréhalose ou un dérivé de tréhalose et vaporisateur nasal |
CN115397433A (zh) * | 2020-04-17 | 2022-11-25 | 21世纪国际新技术株式会社 | 含有海藻糖或海藻糖衍生物的药物和鼻喷雾剂 |
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