WO2005066183A1 - Spirocyclische cyclohexan-derivate mit affinität zum orl1-rezeptor - Google Patents
Spirocyclische cyclohexan-derivate mit affinität zum orl1-rezeptor Download PDFInfo
- Publication number
- WO2005066183A1 WO2005066183A1 PCT/EP2004/014539 EP2004014539W WO2005066183A1 WO 2005066183 A1 WO2005066183 A1 WO 2005066183A1 EP 2004014539 W EP2004014539 W EP 2004014539W WO 2005066183 A1 WO2005066183 A1 WO 2005066183A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- unsubstituted
- polysubstituted
- alkyl
- monosubstituted
- heteroaryl
- Prior art date
Links
- 0 CNC(CC1)(CCC1(*C(*)C1*)C(C(*)C2)=C1c1c2c(*)c(*)c(*)c1*)c1c[s]cc1 Chemical compound CNC(CC1)(CCC1(*C(*)C1*)C(C(*)C2)=C1c1c2c(*)c(*)c(*)c1*)c1c[s]cc1 0.000 description 1
- JIFKFXAXDGTNBD-UHFFFAOYSA-N CNC(CC1)(CCC1=O)C1C=CSC1 Chemical compound CNC(CC1)(CCC1=O)C1C=CSC1 JIFKFXAXDGTNBD-UHFFFAOYSA-N 0.000 description 1
- ZBXGFNMJCNRLAQ-UHFFFAOYSA-N OC(CC1)(CCC1(c1c[s]cc1)N=C=O)O Chemical compound OC(CC1)(CCC1(c1c[s]cc1)N=C=O)O ZBXGFNMJCNRLAQ-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P7/10—Antioedematous agents; Diuretics
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
Abstract
Description
Claims
Priority Applications (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MXPA06007171A MXPA06007171A (es) | 2003-12-23 | 2004-12-21 | Derivados de ciclohexano espirociclicos con afinidad para el receptor orl1. |
KR1020067014815A KR101152693B1 (ko) | 2003-12-23 | 2004-12-21 | Orl1 수용체에 대해 친화력을 가진 스피로사이클사이클로헥산 유도체 |
CA2550868A CA2550868C (en) | 2003-12-23 | 2004-12-21 | Spirocyclic cyclohexane derivatives with affinity for the orl1-receptor |
DK04804136T DK1725567T3 (da) | 2003-12-23 | 2004-12-21 | Spirocykliske cyclohexanderivater med affinitet for ORL1-receptoren |
DE502004006697T DE502004006697D1 (de) | 2003-12-23 | 2004-12-21 | Spirocyclische cyclohexan-derivate mit affinität zum orl1-rezeptor |
EP04804136A EP1725567B1 (de) | 2003-12-23 | 2004-12-21 | Spirocyclische cyclohexan-derivate mit affinität zum orl1-rezeptor |
NZ548317A NZ548317A (en) | 2003-12-23 | 2004-12-21 | Spirocyclic cyclohexane derivatives with affinity for the ORL1-receptor |
CN2004800420360A CN1922189B (zh) | 2003-12-23 | 2004-12-21 | 对orl1受体具有亲合力的螺环环己烷衍生物 |
PL04804136T PL1725567T3 (pl) | 2003-12-23 | 2004-12-21 | Spirocykliczne pochodne cykloheksanu o powinowactwie do receptora-ORL1 |
JP2006546040A JP4885733B2 (ja) | 2003-12-23 | 2004-12-21 | Orl1レセプターに対する親和性を有するスピロ環状シクロヘキサン誘導体 |
AU2004312147A AU2004312147B2 (en) | 2003-12-23 | 2004-12-21 | Spirocyclic cyclohexane derivatives with affinity for the ORL1-receptor |
SI200430663T SI1725567T1 (sl) | 2003-12-23 | 2004-12-21 | Spirociklični cikloheksanski derivati z afiniteto za ORL1 receptor |
BRPI0418052A BRPI0418052A2 (pt) | 2003-12-23 | 2004-12-21 | derivados de ciclohexano espiro-cíclicos com afinidade para o receptor orl1 |
IL176457A IL176457A (en) | 2003-12-23 | 2006-06-21 | Cyclohexane Spiro History Compressed with Ortho-Compressed Tricyclic System, Process for Preparation and Pharmaceuticals Containing Them |
NO20063422A NO337127B1 (no) | 2003-12-23 | 2006-07-24 | Spirosykliske sykloheksanderivater, fremgangsmåter for deres fremstilling, legemidler inneholdende derivatene samt anvendelse av derivatene for fremstilling av legemidler |
HK07103179A HK1095831A1 (en) | 2003-12-23 | 2007-02-23 | Spirocyclic cyclohexane derivatives with affinity to the orl-1 receptor |
HR20080272T HRP20080272T3 (en) | 2003-12-23 | 2008-06-18 | Spirocyclic cyclohexane derivatives with affinity to the orl-1 receptor |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10360792A DE10360792A1 (de) | 2003-12-23 | 2003-12-23 | Spirocyclische Cyclohexan-Derivate |
DE10360792.7 | 2003-12-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2005066183A1 true WO2005066183A1 (de) | 2005-07-21 |
Family
ID=34706497
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2004/014539 WO2005066183A1 (de) | 2003-12-23 | 2004-12-21 | Spirocyclische cyclohexan-derivate mit affinität zum orl1-rezeptor |
Country Status (28)
Country | Link |
---|---|
US (1) | US7332519B2 (de) |
EP (1) | EP1725567B1 (de) |
JP (1) | JP4885733B2 (de) |
KR (1) | KR101152693B1 (de) |
CN (1) | CN1922189B (de) |
AR (1) | AR047163A1 (de) |
AT (1) | ATE390430T1 (de) |
AU (1) | AU2004312147B2 (de) |
BR (1) | BRPI0418052A2 (de) |
CA (1) | CA2550868C (de) |
CY (1) | CY1107975T1 (de) |
DE (2) | DE10360792A1 (de) |
DK (1) | DK1725567T3 (de) |
EC (1) | ECSP066667A (de) |
ES (1) | ES2303964T3 (de) |
HK (1) | HK1095831A1 (de) |
HR (1) | HRP20080272T3 (de) |
IL (1) | IL176457A (de) |
MX (1) | MXPA06007171A (de) |
NO (1) | NO337127B1 (de) |
NZ (1) | NZ548317A (de) |
PE (1) | PE20050758A1 (de) |
PL (1) | PL1725567T3 (de) |
PT (1) | PT1725567E (de) |
RU (1) | RU2383544C2 (de) |
SI (1) | SI1725567T1 (de) |
WO (1) | WO2005066183A1 (de) |
ZA (1) | ZA200606067B (de) |
Cited By (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006108565A1 (de) * | 2005-04-11 | 2006-10-19 | Grünenthal GmbH | Spirocyclishe cyclohexanderivate zur behandlung von substanzabhängigkeit |
WO2007124903A1 (de) | 2006-04-27 | 2007-11-08 | Grünenthal GmbH | Spirocycliche cyclohexanderivate mit analgesischer wirkung |
WO2008009416A1 (de) * | 2006-07-18 | 2008-01-24 | Grünenthal GmbH | Spirocyclische azaindol-derivate |
DE102006046745A1 (de) * | 2006-09-29 | 2008-04-03 | Grünenthal GmbH | Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz |
WO2008101660A1 (de) | 2007-02-22 | 2008-08-28 | Grünenthal GmbH | Spirocyclische cyclohexan-derivate |
WO2009118169A1 (de) * | 2008-03-27 | 2009-10-01 | Grünenthal GmbH | Spiro(5.5)undecan derivate |
WO2009118173A1 (de) * | 2008-03-27 | 2009-10-01 | Grünenthal GmbH | Substituierte spirocyclische cyclohexan-derivate |
WO2009118168A1 (de) | 2008-03-27 | 2009-10-01 | Grünenthal GmbH | Substituierte 4-aminocyclohexan-derivate |
WO2011009602A1 (en) | 2009-07-22 | 2011-01-27 | Grünenthal GmbH | Hot-melt extruded controlled release dosage form |
WO2011060035A1 (en) * | 2009-11-16 | 2011-05-19 | Eli Lilly And Company | Spiropiperidine compounds as orl-1 receptor antagonists |
WO2011060217A1 (en) * | 2009-11-16 | 2011-05-19 | Eli Lilly And Company | Spiropiperidine compounds as orl-1 receptor antagonists |
US7977370B2 (en) | 2008-03-27 | 2011-07-12 | Gruenenthal Gmbh | (Hetero)aryl cyclohexane derivatives |
US8075872B2 (en) | 2003-08-06 | 2011-12-13 | Gruenenthal Gmbh | Abuse-proofed dosage form |
WO2012013343A1 (de) | 2010-07-28 | 2012-02-02 | Grünenthal GmbH | Cis-tetrahydro-spiro(cyclohexan-1,1'-pyrido[3,4-b]indol)-4-amin-derivate |
US8114383B2 (en) | 2003-08-06 | 2012-02-14 | Gruenenthal Gmbh | Abuse-proofed dosage form |
US8114384B2 (en) | 2004-07-01 | 2012-02-14 | Gruenenthal Gmbh | Process for the production of an abuse-proofed solid dosage form |
WO2012028318A1 (en) | 2010-09-02 | 2012-03-08 | Grünenthal GmbH | Tamper resistant dosage form comprising an anionic polymer |
WO2012028319A1 (en) | 2010-09-02 | 2012-03-08 | Grünenthal GmbH | Tamper resistant dosage form comprising inorganic salt |
WO2012028317A1 (en) | 2010-09-02 | 2012-03-08 | Grünenthal GmbH | Tamper resistant dosage form comprising an anionic polymer |
US8192722B2 (en) | 2003-08-06 | 2012-06-05 | Grunenthal Gmbh | Abuse-proof dosage form |
EP2478896A1 (de) | 2005-02-04 | 2012-07-25 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
US8288406B2 (en) | 2008-03-27 | 2012-10-16 | Gruenenthal Gmbh | Hydroxymethylcyclohexylamines |
US8357705B2 (en) | 2008-03-27 | 2013-01-22 | Gruenenthal Gmbh | Substituted cyclohexyldiamines |
WO2013017242A1 (en) | 2011-07-29 | 2013-02-07 | Grünenthal GmbH | Tamper-resistant tablet providing immediate drug release |
WO2013017234A1 (en) | 2011-07-29 | 2013-02-07 | Grünenthal GmbH | Tamper-resistant tablet providing immediate drug release |
US8383152B2 (en) | 2008-01-25 | 2013-02-26 | Gruenenthal Gmbh | Pharmaceutical dosage form |
WO2013113857A1 (en) * | 2012-02-03 | 2013-08-08 | Grünenthal GmbH | (1r,4r)-6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro-[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine for treating fibromyalgia and chronic fatigue syndrome |
WO2013127830A1 (en) | 2012-02-28 | 2013-09-06 | Grünenthal GmbH | Tamper-resistant pharmaceutical dosage form comprising nonionic surfactant |
WO2013127831A1 (en) | 2012-02-28 | 2013-09-06 | Grünenthal GmbH | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
WO2013156453A1 (en) | 2012-04-18 | 2013-10-24 | Grünenthal GmbH | Tamper resistant and dose-dumping resistant pharmaceutical dosage form |
WO2013167735A1 (en) | 2012-05-11 | 2013-11-14 | Grünenthal GmbH | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
WO2013170969A1 (en) * | 2012-05-18 | 2013-11-21 | Grünenthal GmbH | Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano'[3,4,b]indol]-4-amine and paracetamol or propacetamol |
WO2013170971A1 (en) * | 2012-05-18 | 2013-11-21 | Grünenthal GmbH | Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano [3,4,b]indol]-4-amine and a nsar |
WO2013170968A1 (en) * | 2012-05-18 | 2013-11-21 | Grünenthal GmbH | Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro [cyclohexane-1,1'-pyrano-[3,4,b]indol]-4-amine and a salicylic acid component |
WO2013170967A1 (en) * | 2012-05-18 | 2013-11-21 | Grünenthal GmbH | Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative |
WO2013170965A1 (en) * | 2012-05-18 | 2013-11-21 | Grünenthal GmbH | Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano [3,4,b]indol]-4-amine and antidepressants |
WO2013170970A1 (en) * | 2012-05-18 | 2013-11-21 | Grünenthal GmbH | Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano [3,4,b]indol]-4-amine and an oxicam |
WO2013170966A1 (en) * | 2012-05-18 | 2013-11-21 | Grünenthal GmbH | Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano [3,4,b]indol]-4-amine and a gabapentinoid |
WO2013170972A1 (en) * | 2012-05-18 | 2013-11-21 | Grünenthal GmbH | Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano [3,4,b]indol]-4-amine and an anticonvulsant |
US8722086B2 (en) | 2007-03-07 | 2014-05-13 | Gruenenthal Gmbh | Dosage form with impeded abuse |
WO2015091352A1 (en) | 2013-12-16 | 2015-06-25 | Grünenthal GmbH | Tamper resistant dosage form with bimodal release profile manufactured by co-extrusion |
US9161917B2 (en) | 2008-05-09 | 2015-10-20 | Grünenthal GmbH | Process for the preparation of a solid dosage form, in particular a tablet, for pharmaceutical use and process for the preparation of a precursor for a solid dosage form, in particular a tablet |
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