WO2005020882A1 - Ｓ１ｐ受容体結合能を有する化合物およびその医薬用途 - Google Patents

Ｓ１ｐ受容体結合能を有する化合物およびその医薬用途

Info

Publication number
WO2005020882A1
WO2005020882A1 PCT/JP2004/012768 JP2004012768W WO2005020882A1 WO 2005020882 A1 WO2005020882 A1 WO 2005020882A1 JP 2004012768 W JP2004012768 W JP 2004012768W WO 2005020882 A1 WO2005020882 A1 WO 2005020882A1
Authority
WO
WIPO (PCT)
Prior art keywords
edg
binding
compound capable
receptor
pharmaceutical use
Prior art date
Application number
PCT/JP2004/012768
Other languages
English (en)
French (fr)
Other versions
WO2005020882A2 (ja
WO2005020882A3 (ja
Inventor
Shinji Nakade
Hirotaka Mizuno
Takeji Ono
Masashi Minami
Hiroshi Saga
Hiroshi Hagiya
Takaki Komiya
Hiromu Habashita
Haruto Kurata
Kazuhiro Ohtsuki
Kensuke Kusumi
Original Assignee
Ono Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA2537093A priority Critical patent/CA2537093C/en
Priority to EP04772717.7A priority patent/EP1661881B1/en
Application filed by Ono Pharmaceutical Co., Ltd. filed Critical Ono Pharmaceutical Co., Ltd.
Priority to KR1020067004275A priority patent/KR101186386B1/ko
Priority to ES04772717.7T priority patent/ES2527117T3/es
Priority to US10/569,831 priority patent/US7825109B2/en
Priority to BRPI0413923-2A priority patent/BRPI0413923A/pt
Priority to EP14190717.0A priority patent/EP2883865B1/en
Priority to JP2005513544A priority patent/JP4947406B2/ja
Priority to AU2004268455A priority patent/AU2004268455B2/en
Priority to NZ545805A priority patent/NZ545805A/en
Priority to MXPA06002310A priority patent/MXPA06002310A/es
Publication of WO2005020882A1 publication Critical patent/WO2005020882A1/ja
Publication of WO2005020882A2 publication Critical patent/WO2005020882A2/ja
Publication of WO2005020882A3 publication Critical patent/WO2005020882A3/ja
Priority to IL173973A priority patent/IL173973A/en
Priority to NO20061372A priority patent/NO20061372L/no
Priority to ZA2006/02558A priority patent/ZA200602558B/en
Priority to IL206888A priority patent/IL206888A0/en
Priority to US12/879,158 priority patent/US8791159B2/en
Priority to US14/295,799 priority patent/US20140288034A1/en

Links

PCT/JP2004/012768 2003-08-29 2004-08-27 Ｓ１ｐ受容体結合能を有する化合物およびその医薬用途 WO2005020882A2 (ja)

Priority Applications (17)

Application Number Priority Date Filing Date Title
MXPA06002310A MXPA06002310A (es) 2003-08-29 2004-08-27 Compuesto capaz de enlazarse al receptor s1p y uso farmaceutico del mismo.
NZ545805A NZ545805A (en) 2003-08-29 2004-08-27 Compound capable of binding S1P receptor and pharmaceutical use thereof
KR1020067004275A KR101186386B1 (ko) 2003-08-29 2004-08-27 Ｓ１ｐ 수용체 결합능을 갖는 화합물 및 그 의약 용도
EP04772717.7A EP1661881B1 (en) 2003-08-29 2004-08-27 Compound capable of binding s1p receptor and pharmaceutical use thereof
US10/569,831 US7825109B2 (en) 2003-08-29 2004-08-27 Compound capable of binding S1P receptor and pharmaceutical use thereof
BRPI0413923-2A BRPI0413923A (pt) 2003-08-29 2004-08-27 composto capaz de ligar o receptor de s1p e uso farmacêutico do mesmo
EP14190717.0A EP2883865B1 (en) 2003-08-29 2004-08-27 Compound capable of binding S1P receptor and pharmaceutical use thereof
JP2005513544A JP4947406B2 (ja) 2003-08-29 2004-08-27 Ｓ１ｐ受容体結合能を有する化合物およびその医薬用途
AU2004268455A AU2004268455B2 (en) 2003-08-29 2004-08-27 Compound capable of binding S1P receptor and pharmaceutical use thereof
CA2537093A CA2537093C (en) 2003-08-29 2004-08-27 Compound capable of binding s1p receptor and pharmaceutical use thereof
ES04772717.7T ES2527117T3 (es) 2003-08-29 2004-08-27 Compuesto capaz de unirse a receptor SIP y uso farmacéutico del mismo
IL173973A IL173973A (en) 2003-08-29 2006-02-27 (naphthalenyl-methyl)-azetidinecarboxylic acid, derivatives thereof and pharmaceutical compositions containing it
NO20061372A NO20061372L (no) 2003-08-29 2006-03-27 Forbindelse som er i stand til a binde SIP reseptor og farmasoytisk anvendelse derav
ZA2006/02558A ZA200602558B (en) 2003-08-29 2006-03-28 Compound capable of binding s1p receptor and pharmaceutical use thereof
IL206888A IL206888A0 (en) 2003-08-29 2010-07-08 Compound capable of binding s1p receptor and pharmaceutical use thereof
US12/879,158 US8791159B2 (en) 2003-08-29 2010-09-10 Compound capable of binding S1P receptor and pharmaceutical use thereof
US14/295,799 US20140288034A1 (en) 2003-08-29 2014-06-04 Compound capable of binding s1p receptor and pharmaceutical use thereof

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP2003-306088 2003-08-29
JP2003306088 2003-08-29
JP2004110573 2004-04-02
JP2004-110573 2004-04-02
JP2004-169958 2004-06-08
JP2004169958 2004-06-08
JP2004198523 2004-07-05
JP2004-198523 2004-07-05

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10/569,831 A-371-Of-International US7825109B2 (en) 2003-08-29 2004-08-27 Compound capable of binding S1P receptor and pharmaceutical use thereof
US12/879,158 Continuation US8791159B2 (en) 2003-08-29 2010-09-10 Compound capable of binding S1P receptor and pharmaceutical use thereof

Publications (3)

Publication Number Publication Date
WO2005020882A1 true WO2005020882A1 (ja) 2005-03-10
WO2005020882A2 WO2005020882A2 (ja) 2005-03-10
WO2005020882A3 WO2005020882A3 (ja) 2005-04-21

Family

ID=34279965

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2004/012768 WO2005020882A2 (ja) 2003-08-29 2004-08-27 Ｓ１ｐ受容体結合能を有する化合物およびその医薬用途

Country Status (14)

Country Link
US (2) US8791159B2 (ja)
EP (2) EP1661881B1 (ja)
JP (4) JP4947406B2 (ja)
KR (2) KR20110140139A (ja)
AU (1) AU2004268455B2 (ja)
BR (1) BRPI0413923A (ja)
CA (2) CA2537093C (ja)
ES (2) ES2527117T3 (ja)
IL (2) IL173973A (ja)
MX (1) MXPA06002310A (ja)
NO (1) NO20061372L (ja)
NZ (1) NZ545805A (ja)
WO (1) WO2005020882A2 (ja)
ZA (1) ZA200602558B (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101589332B1 (ko) 2008-12-05 2016-01-27 아스텔라스세이야쿠 가부시키가이샤 ２ｈ-크로멘 화합물 및 그의 유도체
JP7211410B2 (ja) 2018-02-22 2023-01-24 小野薬品工業株式会社 Ｓ１ｐ５受容体作動活性を有する化合物

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY150088A (en) 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
JP4728962B2 (ja) * 2003-05-19 2011-07-20 アイアールエム・リミテッド・ライアビリティ・カンパニー 免疫抑制化合物および組成物
NZ545805A (en) * 2003-08-29 2009-12-24 Ono Pharmaceutical Co Compound capable of binding S1P receptor and pharmaceutical use thereof
TW200538433A (en) * 2004-02-24 2005-12-01 Irm Llc Immunosuppressant compounds and compositiions
EP1760071A4 (en) 2004-06-23 2008-03-05 Ono Pharmaceutical Co COMPOUND WITH S1P RECEPTOR BINDING ABILITY AND USE THEREOF
WO2006064757A1 (ja) * 2004-12-13 2006-06-22 Ono Pharmaceutical Co., Ltd. アミノカルボン酸誘導体およびその医薬用途
NZ562562A (en) * 2005-03-23 2010-11-26 Actelion Pharmaceuticals Ltd Hydrogenated benzo(C)thiophene derivatives as immunomodulators
US20060223792A1 (en) * 2005-03-31 2006-10-05 Butler Christopher R Phenyl and pyridyl LTA4H modulators
JP2008546758A (ja) * 2005-06-24 2008-12-25 アクテリオン ファーマシューティカルズ リミテッド 新規チオフェン誘導体
US7919519B2 (en) 2005-11-23 2011-04-05 Epix Pharmaceuticals Inc. S1P receptor modulating compounds and use thereof
AR057894A1 (es) * 2005-11-23 2007-12-26 Actelion Pharmaceuticals Ltd Derivados de tiofeno
WO2007061458A2 (en) 2005-11-23 2007-05-31 Epix Delaware, Inc. S1p receptor modulating compounds and use thereof
EP2010524A2 (en) 2006-03-21 2009-01-07 Epix Delaware, Inc. S1p receptor modulating compounds
WO2007109334A2 (en) * 2006-03-21 2007-09-27 Epix Delaware, Inc. Sip receptor modulating compounds and use thereof
US20090324581A1 (en) 2006-05-09 2009-12-31 Daiichi Sankyo Company Limited Heteroarylamide lower carboxylic acid derivative
WO2007129473A1 (ja) * 2006-05-09 2007-11-15 Daiichi Sankyo Company, Limited 二環性アリール誘導体
MX2009001457A (es) 2006-08-08 2009-02-19 Kyorin Seiyaku Kk Derivados de aminoalcohol e inmunosupresores que contienen lo mismo como ingrediente activo.
SG174028A1 (en) 2006-08-08 2011-09-29 Kyorin Seiyaku Kk Aminophosphoric acid ester derivative and s1p receptor modulator containing the same as active ingredient
AU2011235934A1 (en) * 2006-09-26 2011-11-03 Novartis Ag Pharmaceutical compositions comprising an S1P modulator
EP1923058A1 (en) * 2006-09-26 2008-05-21 Novartis AG Coated pharmaceutical composition comprising an S1P agonist or modulator
EP2086514A2 (en) 2006-09-26 2009-08-12 Novartis Ag Pharmaceutical compositions comprising an s1p modulator
EP1923054A1 (en) * 2006-09-26 2008-05-21 Novartis AG Fast disintegrating pharmaceutical composition comprising an S1P agonist or modulator
EP1923055A1 (en) * 2006-09-26 2008-05-21 Novartis AG Freeze-dried pharmaceutical composition comprising an S1P agonist or modulator
MX2009011421A (es) * 2007-04-23 2009-12-15 Novartis Ag Derivados de ftalazina e isoquinolina con actividades moduladoras del receptor de la s1p.
AU2008302746B2 (en) 2007-09-20 2014-07-03 Amgen Inc. 1-(4-(benzylbenzamid0) -benzyl) azetidine-3-carboxylic acid derivatives and related compounds as SlP receptor modulators for the treatment of immune disorders
EP3210966B1 (en) 2007-10-05 2020-01-08 Acucela, Inc. Alkoxyphenylpropylamines for the treatment of age-related macular degeneration
TW200946105A (en) 2008-02-07 2009-11-16 Kyorin Seiyaku Kk Therapeutic agent or preventive agent for inflammatory bowel disease containing amino alcohol derivative as active ingredient
MX354134B (es) 2008-07-23 2018-02-14 Arena Pharm Inc Derivados de acido 1,2,3,4-tetrahidrociclopenta [b] indol-3-il) acetico sustituidos utiles en el tratamiento de enfermedades autoinmune e inflamatorias.
CA2733671C (en) 2008-08-27 2018-01-02 Arena Pharmaceuticals, Inc. Substituted tricyclic acid derivatives as s1p1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders
CN102186845B (zh) 2008-10-17 2016-09-07 阿卡制药有限公司 S1p受体调节剂以及它们的用途
CA2739901A1 (en) 2008-10-17 2010-04-22 Akaal Pharma Pty Ltd S1p receptors modulators
US10471027B2 (en) 2009-07-02 2019-11-12 Acucela, Inc. Pharmacology of visual cycle modulators
UA107360C2 (en) 2009-08-05 2014-12-25 Biogen Idec Inc Bicyclic aryl sphingosine 1-phosphate analogs
UY32858A (es) * 2009-08-31 2011-03-31 Abbott Healthcare Products Bv Derivados de (tio)morfolina como moduladores de sip
BR112012012261A2 (pt) * 2009-11-24 2016-04-26 Allergan Inc compostos como moduladores de receptor com utilidade terapêutica
EP4148045A1 (en) 2010-01-27 2023-03-15 Arena Pharmaceuticals, Inc. Intermediate compounds for the preparation of (r)-2-(7-(4-cyclopentyl-3- (trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b] indol-3-yl)acetic acid and salts thereof
US8791100B2 (en) * 2010-02-02 2014-07-29 Novartis Ag Aryl benzylamine compounds
SG10201501575VA (en) 2010-03-03 2015-04-29 Arena Pharm Inc Processes for the preparation of s1p1 receptor modulators and crystalline forms thereof
CN103347517B (zh) 2010-08-11 2018-10-02 德雷克塞尔大学 治疗帕金森病中运动障碍的d3多巴胺受体激动剂
WO2012109108A1 (en) 2011-02-07 2012-08-16 Biogen Idec Ma Inc. S1p modulating agents
SG194184A1 (en) * 2011-04-14 2013-11-29 Allergan Inc Phenyl bicyclic methyl amine derivatives as sphingosine-1 phosphate receptors modulators
RU2013150332A (ru) * 2011-04-18 2015-05-27 Аллерган, Инк. Замещенные бициклические метиламинные производные как модуляторы рецепторов сфингозин-1-фосфата
PT2762466T (pt) 2011-09-29 2017-07-31 Ono Pharmaceutical Co Derivado de fenilo
WO2013109991A1 (en) 2012-01-20 2013-07-25 Acucela Inc. Substituted heterocyclic compounds for disease treatment
WO2014018891A1 (en) * 2012-07-27 2014-01-30 Biogen Idec Ma Inc. Compounds that are s1p modulating agents and/or atx modulating agents
EP2925721B1 (en) 2012-11-20 2017-06-07 Biogen MA Inc. S1p and/or atx modulating agents
US9765016B2 (en) * 2013-01-29 2017-09-19 Biogen Ma Inc. S1P modulating agents
EP2980072B1 (en) 2013-03-26 2018-04-25 ONO Pharmaceutical Co., Ltd. Phenyl derivative
WO2014175287A1 (ja) 2013-04-26 2014-10-30 国立大学法人 京都大学 脳動脈瘤の形成および／または増大の抑制若しくは縮小用医薬組成物
EP3228615B1 (en) * 2014-12-04 2021-01-20 ONO Pharmaceutical Co., Ltd. Dihydronaphthalene derivatives useful in the treatment of s1p5-mediated diseases
AU2016205361C1 (en) 2015-01-06 2021-04-08 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the S1P1 receptor
IL285890B (en) 2015-06-22 2022-07-01 Arena Pharm Inc Slate-free crystal of the arginine salt of (Ar)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-4,3,2,1-tetrahydro-cyclopent[b]indole-3-yl ) acetic acid
WO2017036978A1 (en) * 2015-08-28 2017-03-09 Abbvie Inc. Fused heterocyclic compounds as s1p modulators
PL3416962T3 (pl) * 2016-02-15 2021-11-22 Sanofi Pochodne 6,7-dihydro-5H-benzo[7]annulenu jako modulatory receptorów estrogenowych
US11534424B2 (en) 2017-02-16 2022-12-27 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of primary biliary cholangitis
US11478448B2 (en) 2017-02-16 2022-10-25 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations
US11555015B2 (en) 2018-09-06 2023-01-17 Arena Pharmaceuticals, Inc. Compounds useful in the treatment of autoimmune and inflammatory disorders
WO2021033729A1 (ja) 2019-08-20 2021-02-25 小野薬品工業株式会社 Ｓ１ｐ５受容体作動活性を有する化合物の塩および結晶形
US20230055568A1 (en) 2020-02-06 2023-02-23 Mitsubishi Tanabe Pharma Corporation Therapeutic agent for myalgic encephalomyelitis/chronic fatigue syndrome
KR102649355B1 (ko) * 2020-03-31 2024-03-19 주식회사 엘지화학 췌도 이식 보호용 조성물
US20230398099A1 (en) * 2020-11-09 2023-12-14 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the s1p1 receptor
WO2022220613A1 (ko) * 2021-04-14 2022-10-20 주식회사 엘지화학 스핑고신-1-인산 수용체 효능제의 신규한 제조방법
CN117177964A (zh) * 2021-04-14 2023-12-05 株式会社Lg化学 制备鞘氨醇-1-磷酸酯受体激动剂的新方法
WO2022220610A1 (ko) * 2021-04-14 2022-10-20 주식회사 엘지화학 스핑고신-1-인산 수용체 효능제 합성을 위한 중간체의 제조방법
WO2024025862A1 (en) * 2022-07-28 2024-02-01 The Board Of Regents Of The University Of Oklahoma Agonists of peroxisome proliferator-activated receptor alpha (ppara) and methods of use

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE555319A (ja) 1956-03-21 1900-01-01
US3095355A (en) 1961-10-12 1963-06-25 Revlon Aerosol composition
JPS58162949A (ja) * 1982-03-20 1983-09-27 Konishiroku Photo Ind Co Ltd ハロゲン化銀カラ−写真感光材料
DE3508398A1 (de) * 1985-03-08 1986-11-06 Hoechst Ag, 6230 Frankfurt Fungizide mittel auf der basis von 3-(hetero)-arylpropylaminen sowie neue (hetero)-aryl-propylamine und verfahren zu ihrer herstellung
EP0411751A1 (en) * 1989-06-06 1991-02-06 Beecham Group p.l.c. Renin inhibitory peptides
EP0466254A1 (en) * 1990-07-11 1992-01-15 Merck & Co. Inc. 2-naphthyl-carbapenems
ES2126658T3 (es) 1992-10-21 1999-04-01 Yoshitomi Pharmaceutical Compuesto de 2-amino-1,3-propanodiol e inmunosupresor.
IL110172A (en) 1993-07-22 2001-10-31 Lilly Co Eli Bicycle compounds and pharmaceuticals containing them
WO1996013497A1 (fr) * 1994-11-01 1996-05-09 Terumo Kabushiki Kaisha Derive de tetrahydroisoquinoleine et preparation medicinale contenant ce derive
DE19527568A1 (de) * 1995-07-28 1997-01-30 Merck Patent Gmbh Endothelin-Rezeptor-Antagonisten
PT971878E (pt) 1997-02-27 2008-07-08 Takeda Pharmaceutical Compostos de amina, sua produção e utilização como inibidores da produção de amilóide beta
CA2333554A1 (en) 1998-06-17 1999-12-23 Chu-Baio Xue Cyclic hydroxamic acids as metalloproteinase inhibitors
EP1218336A2 (en) 1999-09-20 2002-07-03 Takeda Chemical Industries, Ltd. Melanin concentrating hormone antagonist
US6458822B2 (en) * 2000-03-13 2002-10-01 Pfizer Inc. 2-oxo-imidazolidine-4-carboxylic acid hydroxamide compounds that inhibit matrix metalloproteinases
ATE315558T1 (de) 2000-08-29 2006-02-15 Allergan Inc Verbindungen mit cytochrom p450ra1 hemmenden aktivität
JP2004521079A (ja) * 2000-08-29 2004-07-15 ファルマシア・コーポレーション アルファーｖベータ３アンタゴニストとして有用な二環式環系を含有する化合物
US6410733B1 (en) * 2000-09-11 2002-06-25 Genentech, Inc. Amidine inhibitors of serine proteases
ATE319706T1 (de) * 2000-09-19 2006-03-15 Centre Nat Rech Scient Pyridinon und pyridinethion-derivate mit hiv- hemmenden eigenschaften
CA2424540A1 (en) 2000-10-05 2003-04-02 Bayer Aktiengesellschaft Propionic acid derivatives with ppar-alpha activating properties
CA2446593A1 (en) 2001-05-10 2002-11-21 Ono Pharmaceutical Co., Ltd. Carboxylic acid derivatives and pharmaceutical compositions comprising the same as an active ingredient
WO2003037271A2 (en) * 2001-10-30 2003-05-08 Millennium Pharmaceuticals,Inc. Compounds, pharmaceutical compositions and methods of use therefor
US20040058894A1 (en) 2002-01-18 2004-03-25 Doherty George A. Selective S1P1/Edg1 receptor agonists
WO2003061567A2 (en) 2002-01-18 2003-07-31 Merck & Co., Inc. Selective s1p1/edg1 receptor agonists
CA2472715A1 (en) 2002-01-18 2003-07-31 Merck & Co., Inc. Edg receptor agonists
DE60330047D1 (en) 2002-01-18 2009-12-24 Merck & Co Inc "n-(benzyl)aminoalkyl carboxylate, phosphinate, phosphonate und tetrazole als edg rezeptoragonisten"
EP1501804B1 (en) 2002-04-26 2009-08-26 F. Hoffmann-La Roche Ag Isoquinoline derivatives mao-b inhibitors
CA2488117A1 (en) * 2002-06-17 2003-12-24 Merck & Co., Inc. 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)pyrrolidine-3-carboxylates as edg receptor agonists
ES2392200T3 (es) * 2002-09-19 2012-12-05 Eli Lilly & Company Ésteres de diarilo como antagonistas del receptor opiáceo
JP4594611B2 (ja) * 2002-11-08 2010-12-08 武田薬品工業株式会社 受容体機能調節剤
ATE496024T1 (de) 2002-12-20 2011-02-15 Merck Sharp & Dohme 1-(amino)indane als edg-rezeptoragonisten
EP1585520A1 (en) * 2002-12-24 2005-10-19 Neurochem (International) Limited Therapeutic formulations for the treatment of beta-amyloid related diseases
AR044402A1 (es) * 2003-05-19 2005-09-14 Irm Llc Compuestos heterociclicos y su uso como inmunodepresores. composiciones farmaceuticas que los contienen.
JP4728962B2 (ja) * 2003-05-19 2011-07-20 アイアールエム・リミテッド・ライアビリティ・カンパニー 免疫抑制化合物および組成物
MY150088A (en) * 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
BRPI0410454A (pt) 2003-05-19 2006-06-13 Irm Llc composições e compostos imunossupressores
DE10335092B3 (de) 2003-08-01 2005-02-03 Aventis Pharma Deutschland Gmbh Substituierte Benzoylureido-o-benzoylamide, Verfahren zu deren Herstellung und deren Verwendung
NZ545805A (en) 2003-08-29 2009-12-24 Ono Pharmaceutical Co Compound capable of binding S1P receptor and pharmaceutical use thereof
CN1874991A (zh) 2003-08-29 2006-12-06 小野药品工业株式会社 能够结合s1p受体的化合物及其药物用途

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101589332B1 (ko) 2008-12-05 2016-01-27 아스텔라스세이야쿠 가부시키가이샤 ２ｈ-크로멘 화합물 및 그의 유도체
JP7211410B2 (ja) 2018-02-22 2023-01-24 小野薬品工業株式会社 Ｓ１ｐ５受容体作動活性を有する化合物
JP7485103B2 (ja) 2018-02-22 2024-05-16 小野薬品工業株式会社 Ｓ１ｐ５受容体作動活性を有する化合物

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