IL206888A0 - Compound capable of binding s1p receptor and pharmaceutical use thereof - Google Patents

Compound capable of binding s1p receptor and pharmaceutical use thereof

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Publication number
IL206888A0
IL206888A0 IL206888A IL20688810A IL206888A0 IL 206888 A0 IL206888 A0 IL 206888A0 IL 206888 A IL206888 A IL 206888A IL 20688810 A IL20688810 A IL 20688810A IL 206888 A0 IL206888 A0 IL 206888A0
Authority
IL
Israel
Prior art keywords
receptor
binding
compound capable
pharmaceutical use
pharmaceutical
Prior art date
Application number
IL206888A
Original Assignee
Ono Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co
Publication of IL206888A0 publication Critical patent/IL206888A0/en

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    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • AHUMAN NECESSITIES
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    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401Proline; Derivatives thereof, e.g. captopril
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
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    • C07C229/04Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/14Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of carbon skeletons containing rings
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    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
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    • C07C229/04Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
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    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
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    • C07C229/34Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
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    • C07C233/46Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07C255/00Carboxylic acid nitriles
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    • C07C255/41Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by carboxyl groups, other than cyano groups
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    • C07C323/11Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/12Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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IL206888A 2003-08-29 2010-07-08 Compound capable of binding s1p receptor and pharmaceutical use thereof IL206888A0 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2003306088 2003-08-29
JP2004110573 2004-04-02
JP2004169958 2004-06-08
JP2004198523 2004-07-05
PCT/JP2004/012768 WO2005020882A2 (en) 2003-08-29 2004-08-27 Compound capable of binding s1p receptor and pharmaceutical use thereof

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IL206888A0 true IL206888A0 (en) 2011-08-01

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Family Applications (2)

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IL173973A IL173973A (en) 2003-08-29 2006-02-27 (naphthalenyl-methyl)-azetidinecarboxylic acid, derivatives thereof and pharmaceutical compositions containing it
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Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY150088A (en) 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
JP4728962B2 (en) * 2003-05-19 2011-07-20 アイアールエム・リミテッド・ライアビリティ・カンパニー Immunosuppressive compounds and compositions
JP4947406B2 (en) * 2003-08-29 2012-06-06 小野薬品工業株式会社 Compound having S1P receptor binding ability and pharmaceutical use thereof
TW200538433A (en) * 2004-02-24 2005-12-01 Irm Llc Immunosuppressant compounds and compositiions
US8039674B2 (en) 2004-06-23 2011-10-18 Ono Pharmaceutical Co., Ltd. Compound having S1P receptor binding potency and use thereof
PL1826197T3 (en) * 2004-12-13 2012-06-29 Ono Pharmaceutical Co Aminocarboxylic acid derivative and medicinal use thereof
PT1863787E (en) * 2005-03-23 2011-07-29 Actelion Pharmaceuticals Ltd Hydogrenated benzo[c]thiophene derivatives as immunomodulators
EP1868605A2 (en) * 2005-03-31 2007-12-26 Janssen Pharmaceutica, N.V. Phenyl and pyridyl lta4h modulators
CA2612661A1 (en) * 2005-06-24 2006-12-28 Actelion Pharmaceuticals Ltd. Novel thiophene derivatives
AR057894A1 (en) * 2005-11-23 2007-12-26 Actelion Pharmaceuticals Ltd THIOPHEN DERIVATIVES
US7919519B2 (en) 2005-11-23 2011-04-05 Epix Pharmaceuticals Inc. S1P receptor modulating compounds and use thereof
WO2007061458A2 (en) * 2005-11-23 2007-05-31 Epix Delaware, Inc. S1p receptor modulating compounds and use thereof
CA2646469A1 (en) 2006-03-21 2007-09-27 Epix Delaware, Inc. S1p receptor modulating compounds
US20090324581A1 (en) 2006-05-09 2009-12-31 Daiichi Sankyo Company Limited Heteroarylamide lower carboxylic acid derivative
WO2007129473A1 (en) * 2006-05-09 2007-11-15 Daiichi Sankyo Company, Limited Bicyclic aryl derivative
RS53080B (en) 2006-08-08 2014-06-30 Kyorin Pharmaceutical Co. Ltd. Aminophosporic acid ester derivative and s1p receptor modulator containing the same as active ingredient
MY146775A (en) 2006-08-08 2012-09-28 Kyorin Seiyaku Kk Amino alcohol derivative and immunosuppressive agent having same as an active ingredient
AU2011235934A1 (en) * 2006-09-26 2011-11-03 Novartis Ag Pharmaceutical compositions comprising an S1P modulator
EP1923055A1 (en) * 2006-09-26 2008-05-21 Novartis AG Freeze-dried pharmaceutical composition comprising an S1P agonist or modulator
EP1923058A1 (en) * 2006-09-26 2008-05-21 Novartis AG Coated pharmaceutical composition comprising an S1P agonist or modulator
EP1923054A1 (en) * 2006-09-26 2008-05-21 Novartis AG Fast disintegrating pharmaceutical composition comprising an S1P agonist or modulator
CN102579387A (en) * 2006-09-26 2012-07-18 诺瓦提斯公司 Pharmaceutical compositions comprising an S1P modulator
EP2121648A2 (en) * 2007-03-21 2009-11-25 EPIX Pharmaceuticals, Inc. S1p receptor modulating compounds and use thereof
JP2010525016A (en) * 2007-04-23 2010-07-22 ノバルティス アーゲー Phthalazine and isoquinoline derivatives having SLP receptor modulating activity
ATE505454T1 (en) * 2007-09-20 2011-04-15 Amgen Inc 1-(4-(4-BENZYLBENZAMIDE)-BENZYL)-AZETIDINE-3-CARBOXYLIC ACID DERIVATIVES AND CORRESPONDING COMPOUNDS AS S1P RECEPTOR MODULATORS FOR THE TREATMENT OF IMMUNE DISEASES
RU2014151622A (en) 2007-10-05 2015-08-20 Акусела Инк. COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASES
WO2009099174A1 (en) 2008-02-07 2009-08-13 Kyorin Pharmaceutical Co., Ltd. Therapeutic agent or preventive agent for inflammatory bowel disease containing amino alcohol derivative as active ingredient
HUE030424T2 (en) 2008-07-23 2017-05-29 Arena Pharm Inc SUBSTITUTED 1,2,3,4- TETRAHYDROCYCLOPENTA[b]INDOL-3-YL) ACETIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS
ES2583630T3 (en) 2008-08-27 2016-09-21 Arena Pharmaceuticals, Inc. Derivatives of substituted tricyclic acid as S1P1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders
WO2010042998A1 (en) 2008-10-17 2010-04-22 Akaal Pharma Pty Ltd S1p receptors modulators
CA2740484C (en) * 2008-10-17 2021-09-21 Akaal Pharma Pty Ltd S1p receptors modulators and their use thereof
BRPI0922135B1 (en) 2008-12-05 2021-07-13 Astellas Pharma Inc 2H-CROMENE COMPOUND OR A SALT THEREOF, PHARMACEUTICAL COMPOSITION COMPRISING SUCH COMPOUND AND USE OF THE SAME TO PREVENT OR TREAT A DISEASE INDUCED BY UNDESIRABLE LYMPHOCYTE INFILTRATION ASSOCIATED WITH S1P1
ES2897527T3 (en) 2009-07-02 2022-03-01 Acucela Inc Pharmacology of visual cycle modulators
UA107360C2 (en) 2009-08-05 2014-12-25 Biogen Idec Inc Bicyclic aryl sphingosine 1-phosphate analogs
AR077969A1 (en) * 2009-08-31 2011-10-05 Abbott Healthcare Products Bv DERIVATIVES OF (TIO) MORFOLINA COMOMODULADORES DE S1P
NZ599966A (en) * 2009-11-24 2014-09-26 Allergan Inc Novel compounds as receptor modulators with therapeutic utility
CN103221391B (en) 2010-01-27 2018-07-06 艾尼纳制药公司 (R) preparation method of -2- (7- (4- cyclopenta -3- (trifluoromethyl) benzyls oxygroup) -1,2,3,4- tetrahydro cyclopentyl diene simultaneouslies [b] indol-3-yl) acetic acid and its salt
US8791100B2 (en) * 2010-02-02 2014-07-29 Novartis Ag Aryl benzylamine compounds
JP2013521301A (en) 2010-03-03 2013-06-10 アリーナ ファーマシューティカルズ, インコーポレイテッド Process for the preparation of S1P1 receptor modulators and their crystalline forms
CN109745313A (en) 2010-08-11 2019-05-14 德雷克塞尔大学 The D3 dopamine-receptor stimulant for treating dyskinesia in Parkinson's disease
PT2672823T (en) 2011-02-07 2016-11-21 Biogen Ma Inc S1p modulating agents
CA2833313A1 (en) * 2011-04-14 2012-10-18 Allergan, Inc. Phenyl bicyclic methyl amine derivatives as sphingosine-1 phosphate receptors modulators
MX2013012211A (en) * 2011-04-18 2013-12-09 Allergan Inc Substituted bicyclic methyl amine derivatives as sphingosine-1-phosphate receptors modulators.
PT2762466T (en) 2011-09-29 2017-07-31 Ono Pharmaceutical Co Phenyl derivative
CN104703598A (en) 2012-01-20 2015-06-10 奥克塞拉有限公司 Substituted heterocyclic compounds for disease treatment
ES2671194T3 (en) 2012-07-27 2018-06-05 Biogen Ma Inc. Compounds that are S1P modulating agents and / or ATX modulating agents
US9850206B2 (en) 2012-11-20 2017-12-26 Biogen Ma Inc. S1P and/or ATX modulating agents
CN105026360B (en) * 2013-01-29 2017-08-25 比奥根Ma公司 S1P conditioning agents
RU2639875C2 (en) 2013-03-26 2017-12-25 Оно Фармасьютикал Ко., Лтд. Phenyl derivative
EP2990055B1 (en) 2013-04-26 2019-06-05 Kyoto University Composition comprising a sphingosine-1-phosphate receptor 1 agonist for inhibiting formation and/or enlargement of cerebral aneurysm or for shrinking it
US11471436B2 (en) 2014-12-04 2022-10-18 Ono Pharmaceutical Co., Ltd. Dihydronaphthalene derivative
CN107405332A (en) 2015-01-06 2017-11-28 艾尼纳制药公司 Treatment and S1P1The method of receptor related illness
US10301262B2 (en) 2015-06-22 2019-05-28 Arena Pharmaceuticals, Inc. Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta [b]indol-3-yl)acetic acid(Compund1) for use in SIPI receptor-associated disorders
CN108368107B (en) * 2015-08-28 2021-11-26 艾伯维公司 Fused heterocyclic compounds as S1P modulators
PL3416962T3 (en) * 2016-02-15 2021-11-22 Sanofi 6,7-dihydro-5h-benzo[7]annulene derivatives as estrogen receptor modulators
EP3582772A1 (en) 2017-02-16 2019-12-25 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of primary biliary cholangitis
MA47503A (en) 2017-02-16 2021-04-21 Arena Pharm Inc COMPOUNDS AND METHODS FOR THE TREATMENT OF CHRONIC INFLAMMATORY DISEASES OF THE INTESTINE WITH EXTRAINTESTINAL MANIFESTATIONS
TWI789495B (en) 2018-02-22 2023-01-11 日商小野藥品工業股份有限公司 Compound having sip5 receptor agonist activity
EP3847158A1 (en) 2018-09-06 2021-07-14 Arena Pharmaceuticals, Inc. Compounds useful in the treatment of autoimmune and inflammatory disorders
WO2021033729A1 (en) 2019-08-20 2021-02-25 小野薬品工業株式会社 Salt and crystal form of compound having agonistic activity to s1p5 receptor
WO2021157682A1 (en) 2020-02-06 2021-08-12 田辺三菱製薬株式会社 Therapeutic agent for myalgic encephalomyelitis/chronic fatigue syndrome
US20230148589A1 (en) * 2020-03-31 2023-05-18 Lg Chem, Ltd. Composition for protecting islet transplantation
CA3201000A1 (en) * 2020-11-09 2022-05-12 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the s1p1 receptor
TWI823341B (en) * 2021-04-14 2023-11-21 南韓商Lg化學股份有限公司 Novel method for preparing sphingosine-1-phosphate receptor agonist
CN117242057A (en) * 2021-04-14 2023-12-15 株式会社Lg化学 Process for preparing intermediates useful in the synthesis of sphingosine-1-phosphate receptor agonists
KR20220142388A (en) * 2021-04-14 2022-10-21 주식회사 엘지화학 Novel method of preparing sphinosine-1-phosphate receptor agonist
WO2024025862A1 (en) * 2022-07-28 2024-02-01 The Board Of Regents Of The University Of Oklahoma Agonists of peroxisome proliferator-activated receptor alpha (ppara) and methods of use

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE555319A (en) 1956-03-21 1900-01-01
US3095355A (en) 1961-10-12 1963-06-25 Revlon Aerosol composition
JPS58162949A (en) * 1982-03-20 1983-09-27 Konishiroku Photo Ind Co Ltd Color photographic sensitive silver halide material
DE3508398A1 (en) * 1985-03-08 1986-11-06 Hoechst Ag, 6230 Frankfurt FUNGICIDES BASED ON 3- (HETERO) -ARYLPROPYLAMINES AND NEW (HETERO) -ARYL-PROPYLAMINS AND METHOD FOR THE PRODUCTION THEREOF
EP0411751A1 (en) * 1989-06-06 1991-02-06 Beecham Group p.l.c. Renin inhibitory peptides
EP0466254A1 (en) * 1990-07-11 1992-01-15 Merck & Co. Inc. 2-naphthyl-carbapenems
DK0627406T3 (en) 1992-10-21 1999-07-12 Taito Co 2-Amino-1,3-propanediol compounds and immunosuppressants
IL110172A (en) * 1993-07-22 2001-10-31 Lilly Co Eli Bicyclic compounds and pharmaceutical compositions containing them
US5789595A (en) * 1994-11-01 1998-08-04 Terumo Kabushiki Kaisha Tetrahydroisoquinoline derivative and medical preparation containing the same
DE19527568A1 (en) * 1995-07-28 1997-01-30 Merck Patent Gmbh Endothelin receptor antagonists
DE69839305T2 (en) 1997-02-27 2009-04-09 Takeda Pharmaceutical Co. Ltd. AMIN DERIVATIVES, THEIR PREPARATION AND USE AS INHIBITORS OF THE PRODUCTION OF AMYLOID BETA
JP2002518368A (en) 1998-06-17 2002-06-25 デュポン ファーマシューティカルズ カンパニー Cyclic hydroxamic acids as metalloproteinase inhibitors
EP1218336A2 (en) 1999-09-20 2002-07-03 Takeda Chemical Industries, Ltd. Melanin concentrating hormone antagonist
US6458822B2 (en) * 2000-03-13 2002-10-01 Pfizer Inc. 2-oxo-imidazolidine-4-carboxylic acid hydroxamide compounds that inhibit matrix metalloproteinases
ATE315558T1 (en) 2000-08-29 2006-02-15 Allergan Inc COMPOUNDS WITH CYTOCHROME P450RA1 INHIBITIVE ACTIVITY
WO2002018377A1 (en) * 2000-08-29 2002-03-07 Pharmacia Corporation Compounds containing a bicyclic ring system useful as alpha v beta 3 antagonists
AU2001288819A1 (en) * 2000-09-11 2002-03-26 Genentech, Inc. Amidine inhibitors of serine proteases
US7115608B2 (en) * 2000-09-19 2006-10-03 Centre National De La Recherche Schentifique Pyridinone and pyridinethione derivatives having HIV inhibiting properties
WO2002028821A2 (en) 2000-10-05 2002-04-11 Bayer Aktiengesellschaft Propionic acid derivatives with ppar-alpha activating properties
WO2002092068A1 (en) * 2001-05-10 2002-11-21 Ono Pharmaceutical Co., Ltd. Carboxylic acid derivatives and drugs containing the same as the active ingredient
US20050143372A1 (en) * 2001-10-30 2005-06-30 Shomir Ghosh Compounds, pharmaceutical compositions and methods of use therefor
US20040058894A1 (en) * 2002-01-18 2004-03-25 Doherty George A. Selective S1P1/Edg1 receptor agonists
DE60329073D1 (en) * 2002-01-18 2009-10-15 Merck & Co Inc EDG RECEPTOR AGONISTS
DE60330047D1 (en) * 2002-01-18 2009-12-24 Merck & Co Inc "n-(benzyl)aminoalkyl carboxylate, phosphinate, phosphonate und tetrazole als edg rezeptoragonisten"
EP1469863A2 (en) * 2002-01-18 2004-10-27 Merck & Co., Inc. Selective s1p1/edg1 receptor agonists
PT1501804E (en) * 2002-04-26 2009-10-29 Hoffmann La Roche Isoquinoline derivatives mao-b inhibitors
CA2488117A1 (en) * 2002-06-17 2003-12-24 Merck & Co., Inc. 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)pyrrolidine-3-carboxylates as edg receptor agonists
DE60321207D1 (en) * 2002-09-19 2008-07-03 Lilly Co Eli Diaryläther als opioid-rezeptor antagonisten
JP4594611B2 (en) * 2002-11-08 2010-12-08 武田薬品工業株式会社 Receptor function regulator
DE60335827D1 (en) 2002-12-20 2011-03-03 Merck Sharp & Dohme 1- (AMINO) INDANE AS EDG RECEPTOR AGONISTS
US20060135403A1 (en) * 2002-12-24 2006-06-22 Francine Gervais Therapeutic formulations for the treatment of beta-amyloid related diseases
MY150088A (en) * 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
US7060697B2 (en) * 2003-05-19 2006-06-13 Irm Llc Immunosuppressant compounds and compositions
PE20050158A1 (en) * 2003-05-19 2005-05-12 Irm Llc IMMUNOSUPPRESSOR COMPOUNDS AND COMPOSITIONS
JP4728962B2 (en) * 2003-05-19 2011-07-20 アイアールエム・リミテッド・ライアビリティ・カンパニー Immunosuppressive compounds and compositions
DE10335092B3 (en) 2003-08-01 2005-02-03 Aventis Pharma Deutschland Gmbh Substituted benzoylureido-o-benzoylamides, process for their preparation and their use
CN101407471A (en) * 2003-08-29 2009-04-15 小野药品工业株式会社 Compound capable of binding S1P receptor and pharmaceutical use thereof
JP4947406B2 (en) * 2003-08-29 2012-06-06 小野薬品工業株式会社 Compound having S1P receptor binding ability and pharmaceutical use thereof

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