WO2004092155A1 - Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof - Google Patents

Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof Download PDF

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Publication number
WO2004092155A1
WO2004092155A1 PCT/US2004/009268 US2004009268W WO2004092155A1 WO 2004092155 A1 WO2004092155 A1 WO 2004092155A1 US 2004009268 W US2004009268 W US 2004009268W WO 2004092155 A1 WO2004092155 A1 WO 2004092155A1
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WO
WIPO (PCT)
Prior art keywords
trifluoro
sulfonamide
thiophene
hydroxymethyl
chloro
Prior art date
Application number
PCT/US2004/009268
Other languages
English (en)
French (fr)
Inventor
Anthony Frank Kreft
Lynn Resnick
Scott Christian Mayer
George Diamantidis
Derek Cecil Cole
Tingzhong Wang
Rocco John Galante
Molly Hoke
Boyd Lynn Harrison
Minsheng Zhang
Original Assignee
Wyeth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth filed Critical Wyeth
Priority to JP2006509331A priority Critical patent/JP2006522126A/ja
Priority to AU2004230844A priority patent/AU2004230844B2/en
Priority to CN2004800087813A priority patent/CN1780829B/zh
Priority to MXPA05010368A priority patent/MXPA05010368A/es
Priority to BRPI0408962-6A priority patent/BRPI0408962A/pt
Priority to EP04758978A priority patent/EP1608638A1/en
Priority to CA002517155A priority patent/CA2517155A1/en
Priority to UAA200510177A priority patent/UA82093C2/uk
Priority to NZ542468A priority patent/NZ542468A/en
Publication of WO2004092155A1 publication Critical patent/WO2004092155A1/en
Priority to NO20054263A priority patent/NO20054263L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PCT/US2004/009268 2003-03-31 2004-03-26 Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof WO2004092155A1 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP2006509331A JP2006522126A (ja) 2003-03-31 2004-03-26 βアミロイド生産のフルオロ含有およびトリフルオロアルキル含有複素環スルホンアミド阻害物質およびその誘導体
AU2004230844A AU2004230844B2 (en) 2003-03-31 2004-03-26 Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof
CN2004800087813A CN1780829B (zh) 2003-03-31 2004-03-26 β淀粉样蛋白生成抑制剂含氟和三氟烷基杂环磺酰胺及其衍生物
MXPA05010368A MXPA05010368A (es) 2003-03-31 2004-03-26 Sulfonamidas heterociclicas que contienen fluor- y trifluoroalquilo como inhibidores de la produccion beta amiloide y derivados de las mismas.
BRPI0408962-6A BRPI0408962A (pt) 2003-03-31 2004-03-26 inibidores sulfonamidas heterocìclicos contendo flúor- e trifluoroalquila da produção de beta amilóide e seus derivados
EP04758978A EP1608638A1 (en) 2003-03-31 2004-03-26 Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof
CA002517155A CA2517155A1 (en) 2003-03-31 2004-03-26 Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof
UAA200510177A UA82093C2 (uk) 2003-03-31 2004-03-26 Фтор- та трифторалкіловмісні гетероциклічні сульфонамідні інгібітори утворення бета-амілоїду та їх похідні
NZ542468A NZ542468A (en) 2003-03-31 2004-03-26 Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof
NO20054263A NO20054263L (no) 2003-03-31 2005-09-15 Fluor- og trifluoralkyl-innholdende heterocykliske sulfonamid inhibitorer av beta amyloid produksjon og derivatar derav

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45922803P 2003-03-31 2003-03-31
US60/459,228 2003-03-31

Publications (1)

Publication Number Publication Date
WO2004092155A1 true WO2004092155A1 (en) 2004-10-28

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ID=33299665

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PCT/US2004/009268 WO2004092155A1 (en) 2003-03-31 2004-03-26 Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof

Country Status (22)

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US (3) US7300951B2 (US07858658-20101228-C00033.png)
EP (1) EP1608638A1 (US07858658-20101228-C00033.png)
JP (1) JP2006522126A (US07858658-20101228-C00033.png)
KR (1) KR20060002908A (US07858658-20101228-C00033.png)
CN (2) CN1780829B (US07858658-20101228-C00033.png)
AR (1) AR043940A1 (US07858658-20101228-C00033.png)
AU (1) AU2004230844B2 (US07858658-20101228-C00033.png)
BR (1) BRPI0408962A (US07858658-20101228-C00033.png)
CA (1) CA2517155A1 (US07858658-20101228-C00033.png)
CL (1) CL2004000647A1 (US07858658-20101228-C00033.png)
CO (1) CO5640049A2 (US07858658-20101228-C00033.png)
CR (1) CR7951A (US07858658-20101228-C00033.png)
EC (1) ECSP056128A (US07858658-20101228-C00033.png)
MX (1) MXPA05010368A (US07858658-20101228-C00033.png)
NO (1) NO20054263L (US07858658-20101228-C00033.png)
NZ (1) NZ542468A (US07858658-20101228-C00033.png)
RU (1) RU2342374C2 (US07858658-20101228-C00033.png)
SG (1) SG167669A1 (US07858658-20101228-C00033.png)
TW (1) TWI336698B (US07858658-20101228-C00033.png)
UA (1) UA82093C2 (US07858658-20101228-C00033.png)
WO (1) WO2004092155A1 (US07858658-20101228-C00033.png)
ZA (1) ZA200507896B (US07858658-20101228-C00033.png)

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WO2007098030A1 (en) * 2006-02-17 2007-08-30 Wyeth Selective n-sulfonylation of 2-amino trifluoroalkyl substituted alcohols
WO2007127108A1 (en) * 2006-04-21 2007-11-08 Wyeth Production of chirally pure amino alcohol intermediates, derivatives thereof, and uses thereof
US7476762B2 (en) 2006-04-21 2009-01-13 Wyeth Methods for preparing sulfonamide compounds
WO2009012205A1 (en) * 2007-07-16 2009-01-22 Wyeth Inhibitors of beta amyloid production
US7550629B2 (en) 2006-04-21 2009-06-23 Wyeth Trifluoromethyl-containing phenylsulfonamide beta amyloid inhibitors
WO2009089237A1 (en) * 2008-01-11 2009-07-16 Wyeth Compositions containing o-sulfate and o-phosphate containing aryl sulfonamide derivatives useful as beta-amyloid inhibitors
WO2010126002A1 (ja) * 2009-04-28 2010-11-04 塩野義製薬株式会社 ヘテロ環スルホンアミド化合物を含有する医薬

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US7977362B2 (en) * 2009-03-20 2011-07-12 Bristol-Myers Squibb Company Alpha-(N-benzenesulfonamido)cycloalkyl derivatives
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Cited By (12)

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Publication number Priority date Publication date Assignee Title
WO2007098029A1 (en) * 2006-02-17 2007-08-30 Wyeth Methods for preparing sulfonamide substituted alcohols and intermediates thereof
WO2007098030A1 (en) * 2006-02-17 2007-08-30 Wyeth Selective n-sulfonylation of 2-amino trifluoroalkyl substituted alcohols
US7687666B2 (en) 2006-02-17 2010-03-30 Wyeth Methods for preparing sulfonamide substituted alcohols and intermediates thereof
US7838550B2 (en) 2006-02-17 2010-11-23 Wyeth Llc Selective N-sulfonylation of 2-amino fluoro- and trifluoroalkyl substituted alcohols
WO2007127108A1 (en) * 2006-04-21 2007-11-08 Wyeth Production of chirally pure amino alcohol intermediates, derivatives thereof, and uses thereof
US7476762B2 (en) 2006-04-21 2009-01-13 Wyeth Methods for preparing sulfonamide compounds
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ECSP056128A (es) 2006-03-01
US20090227667A1 (en) 2009-09-10
SG167669A1 (en) 2011-01-28
JP2006522126A (ja) 2006-09-28
CA2517155A1 (en) 2004-10-28
UA82093C2 (uk) 2008-03-11
MXPA05010368A (es) 2005-11-17
US7300951B2 (en) 2007-11-27
RU2342374C2 (ru) 2008-12-27
TWI336698B (en) 2011-02-01
US7547725B2 (en) 2009-06-16
CN1780829A (zh) 2006-05-31
ZA200507896B (en) 2007-03-28
AU2004230844A1 (en) 2004-10-28
EP1608638A1 (en) 2005-12-28
NO20054263D0 (no) 2005-09-15
TW200504047A (en) 2005-02-01
CN1780829B (zh) 2010-12-29
CL2004000647A1 (es) 2005-02-04
NZ542468A (en) 2009-01-31
BRPI0408962A (pt) 2006-04-04
CO5640049A2 (es) 2006-05-31
AR043940A1 (es) 2005-08-17
KR20060002908A (ko) 2006-01-09
AU2004230844B2 (en) 2010-12-09
US20070254929A1 (en) 2007-11-01
RU2005133434A (ru) 2006-07-10
CR7951A (es) 2008-10-29
US7858658B2 (en) 2010-12-28
NO20054263L (no) 2005-12-14
US20040198778A1 (en) 2004-10-07

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