WO2004087145A3 - Agents antibacteriens - Google Patents

Agents antibacteriens Download PDF

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Publication number
WO2004087145A3
WO2004087145A3 PCT/US2004/009371 US2004009371W WO2004087145A3 WO 2004087145 A3 WO2004087145 A3 WO 2004087145A3 US 2004009371 W US2004009371 W US 2004009371W WO 2004087145 A3 WO2004087145 A3 WO 2004087145A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibacterial agents
quinoline
mammals
treatment
bacterial infections
Prior art date
Application number
PCT/US2004/009371
Other languages
English (en)
Other versions
WO2004087145A2 (fr
Inventor
Alan J Hennessy
William Henry Miller
Mark Andrew Seefeld
Original Assignee
Glaxo Group Ltd
Alan J Hennessy
William Henry Miller
Mark Andrew Seefeld
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd, Alan J Hennessy, William Henry Miller, Mark Andrew Seefeld filed Critical Glaxo Group Ltd
Priority to US10/550,676 priority Critical patent/US20060189601A1/en
Priority to JP2006509364A priority patent/JP2006521401A/ja
Priority to DE602004019399T priority patent/DE602004019399D1/de
Priority to EP04758428A priority patent/EP1605938B1/fr
Publication of WO2004087145A2 publication Critical patent/WO2004087145A2/fr
Publication of WO2004087145A3 publication Critical patent/WO2004087145A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'invention concerne des dérivés de quinoline et de naphtyridine que l'on utilise dans le traitement d'infections bactériennes chez les mammifères, particulièrement les êtres humains.
PCT/US2004/009371 2003-03-27 2004-03-26 Agents antibacteriens WO2004087145A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US10/550,676 US20060189601A1 (en) 2003-03-27 2004-03-26 Antibacterial agents
JP2006509364A JP2006521401A (ja) 2003-03-27 2004-03-26 抗菌物質
DE602004019399T DE602004019399D1 (de) 2003-03-27 2004-03-26 Antibakterielle Naphthydrin- und Quinolinderivate
EP04758428A EP1605938B1 (fr) 2003-03-27 2004-03-26 Dérivés antibacteriens de la naphthydrine et quinoline

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45814703P 2003-03-27 2003-03-27
US60/458.147 2003-03-27

Publications (2)

Publication Number Publication Date
WO2004087145A2 WO2004087145A2 (fr) 2004-10-14
WO2004087145A3 true WO2004087145A3 (fr) 2004-11-04

Family

ID=33131758

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/009371 WO2004087145A2 (fr) 2003-03-27 2004-03-26 Agents antibacteriens

Country Status (9)

Country Link
US (1) US20060189601A1 (fr)
EP (1) EP1605938B1 (fr)
JP (1) JP2006521401A (fr)
AR (1) AR043938A1 (fr)
AT (1) ATE422495T1 (fr)
DE (1) DE602004019399D1 (fr)
ES (1) ES2321618T3 (fr)
TW (1) TW200507841A (fr)
WO (1) WO2004087145A2 (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200409637A (en) * 2002-06-26 2004-06-16 Glaxo Group Ltd Compounds
AR040335A1 (es) 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de ciclohexano o ciclohexeno, uso del mismo para preparar un medicamento, composicion farmaceutica que lo comprende, procedimiento y compuestos intermediarios de utilidad para preparar dicho compuesto
DE60334016D1 (de) 2002-11-05 2010-10-14 Glaxo Group Ltd Antibakterielle mittel
EP1560821B8 (fr) 2002-11-05 2010-05-19 Glaxo Group Limited Agents antibacteriens
AU2003294565A1 (en) 2002-12-04 2004-06-23 Glaxo Group Limited Quinolines and nitrogenated derivatives thereof and their use as antibacterial agents
US7160888B2 (en) 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
EP1796466A4 (fr) 2004-06-15 2009-09-02 Glaxo Group Ltd Agents antibacteriens
WO2006014580A1 (fr) * 2004-07-08 2006-02-09 Glaxo Group Limited Agents antibacteriens
EP1781669B1 (fr) 2004-08-02 2010-10-13 Glaxo Group Limited Agents antibacteriens
JP2008528598A (ja) * 2005-01-25 2008-07-31 グラクソ グループ リミテッド 抗菌剤
JP2008528588A (ja) * 2005-01-25 2008-07-31 グラクソ グループ リミテッド 抗菌剤
US7511035B2 (en) * 2005-01-25 2009-03-31 Glaxo Group Limited Antibacterial agents
JP2008528587A (ja) * 2005-01-25 2008-07-31 グラクソ グループ リミテッド 抗菌剤
JP5023054B2 (ja) 2005-03-31 2012-09-12 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 抗バクテリア剤としての二環式ピラゾール化合物
MY150958A (en) 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
US7935706B2 (en) 2006-02-23 2011-05-03 Shionogi & Co., Ltd. Nitrogen-containing heterocycle derivatives substituted with cyclic group
EP2007377A4 (fr) 2006-04-06 2011-08-17 Glaxo Group Ltd Agents antibactériens
EP2001887B1 (fr) 2006-04-06 2010-09-15 Glaxo Group Limited Derives de pyrrolo-quinoxalinone en tant qu'agents antibacteriens
EP1992628A1 (fr) 2007-05-18 2008-11-19 Glaxo Group Limited Dérivés et analogues de N-éthylquinolones et N-éthylazaquinolones
SI2137196T1 (sl) * 2007-04-20 2011-01-31 Glaxo Group Ltd Glaxo Welcome House Tricikliäśne spojine, ki vsebujejo duĺ ik, uporabne kot antibakterijska sredstva
WO2009034546A2 (fr) * 2007-09-13 2009-03-19 Actelion Pharmaceuticals Ltd Dérivés de trans-décahydroisoquinoline
EP2080761A1 (fr) 2008-01-18 2009-07-22 Glaxo Group Limited Composés
EP2352734A1 (fr) 2008-10-17 2011-08-10 Glaxo Group Limited Composés azotés tricycliques utilisés comme agents antibactériens
JP5653935B2 (ja) 2009-01-15 2015-01-14 グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ 抗菌薬として有用なナフチリジン―２（１ｈ）−オン化合物
EP2387564A1 (fr) 2009-01-15 2011-11-23 Rutgers, The State University of New Jersey Benzoýc¨phénanthridines comme agents antimicrobiens
WO2010127307A1 (fr) 2009-04-30 2010-11-04 Rutgers, The State University Of New Jersey Agents antimicrobiens
WO2011156626A1 (fr) 2010-06-09 2011-12-15 Rutgers, The State University Of New Jersey Agents antimicrobiens
CA2803890A1 (fr) 2010-06-25 2011-12-29 Rutgers, The State University Of New Jersey Agents antimicrobiens
US9822108B2 (en) 2012-01-13 2017-11-21 Rutgers, The State University Of New Jersey Antimicrobial agents
EP2828245A1 (fr) 2012-03-21 2015-01-28 Rutgers, The State University of New Jersey Agents anti-microbiens
AR096135A1 (es) 2013-05-02 2015-12-09 Actelion Pharmaceuticals Ltd Derivados de la quinolona
US9458150B2 (en) 2013-11-08 2016-10-04 Rutgers, The State University Of New Jersey Antimicrobial agents
AR101674A1 (es) 2014-08-22 2017-01-04 Glaxosmithkline Ip Dev Ltd Uso de un compuesto tricíclico que contiene nitrógeno
MA41168A (fr) * 2014-12-17 2017-10-24 Acraf Nouveaux composés antibactériens
MA41169A (fr) * 2014-12-17 2017-10-24 Acraf Composés antibactériens à large spectre d'activité
TW201722965A (zh) 2015-08-16 2017-07-01 葛蘭素史密斯克藍智慧財產發展有限公司 用於抗菌應用之化合物
US10513528B2 (en) 2016-02-25 2019-12-24 Taxis Pharmaceuticals, Inc. Synthetic processes and intermediates
US10774093B2 (en) 2017-03-30 2020-09-15 Taxis Pharmaceuticals, Inc. Synthetic processes and synthetic intermediates
US11884647B2 (en) 2019-10-18 2024-01-30 The Regents Of The University Of California Compounds and methods for targeting pathogenic blood vessels

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6071920A (en) * 1997-08-01 2000-06-06 Recordati S.A. Chemical And Pharmaceutical Company 1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring
WO2000056712A1 (fr) * 1999-03-23 2000-09-28 Smithkline Beecham Plc Dérivés de sulfonamide en tant qu'antagonistes du récepteur 5-ht¿7?
WO2002056882A1 (fr) * 2001-01-22 2002-07-25 Smithkline Beecham P.L.C. Quinolines et leurs derives azotes substitues en position 4 par un groupe contenant une piperidine et leur utilisation en tant qu'agents antibacteriens

Family Cites Families (11)

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DE4425146A1 (de) * 1994-07-15 1996-01-18 Basf Ag Verwendung heterocyclischer Verbindungen
US5534537A (en) * 1995-03-29 1996-07-09 Merck & Co., Inc. Prodrugs of inhibitors of farnesyl-protein transferase
US5578629A (en) * 1995-03-29 1996-11-26 Merck & Co., Inc. Benzamide-containing inhibitors of farnesyl-protein transferase
DE19600934A1 (de) * 1996-01-12 1997-07-17 Basf Ag Substituierte Aza- und Diazacycloheptan- und Cyclooctanverbindungen und deren Verwendung
AR019190A1 (es) * 1998-07-08 2001-12-26 Sod Conseils Rech Applic Derivados de 2-aminopiridinas, productos intermedios para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y su uso para preparar medicamentos
KR20010085555A (ko) * 1999-06-24 2001-09-07 히라이 가쯔히꼬 아드레날린 알파1비 수용체 길항약
CZ290178B6 (cs) * 1999-07-22 2002-06-12 Sankyo Company Limited Deriváty cyklobutenu
CZ20021548A3 (cs) * 1999-11-05 2002-10-16 Societe De Conseils De Recherches Et D'application Nové heterocyklické sloučeniny a jejich pouľití jako léků
GB0031088D0 (en) * 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
FR2822154B1 (fr) * 2001-03-13 2005-10-21 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent
US7494901B2 (en) * 2002-04-05 2009-02-24 Microng Technology, Inc. Methods of forming semiconductor-on-insulator constructions

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6071920A (en) * 1997-08-01 2000-06-06 Recordati S.A. Chemical And Pharmaceutical Company 1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring
WO2000056712A1 (fr) * 1999-03-23 2000-09-28 Smithkline Beecham Plc Dérivés de sulfonamide en tant qu'antagonistes du récepteur 5-ht¿7?
WO2002056882A1 (fr) * 2001-01-22 2002-07-25 Smithkline Beecham P.L.C. Quinolines et leurs derives azotes substitues en position 4 par un groupe contenant une piperidine et leur utilisation en tant qu'agents antibacteriens

Also Published As

Publication number Publication date
TW200507841A (en) 2005-03-01
ES2321618T3 (es) 2009-06-09
JP2006521401A (ja) 2006-09-21
EP1605938A2 (fr) 2005-12-21
EP1605938A4 (fr) 2006-11-22
WO2004087145A2 (fr) 2004-10-14
US20060189601A1 (en) 2006-08-24
ATE422495T1 (de) 2009-02-15
EP1605938B1 (fr) 2009-02-11
DE602004019399D1 (de) 2009-03-26
AR043938A1 (es) 2005-08-17

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