WO2004020562A1 - Composition destinee a desinfecter ou a laver des instruments medicaux et procede de preparation de cette composition - Google Patents

Composition destinee a desinfecter ou a laver des instruments medicaux et procede de preparation de cette composition Download PDF

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Publication number
WO2004020562A1
WO2004020562A1 PCT/KR2003/001742 KR0301742W WO2004020562A1 WO 2004020562 A1 WO2004020562 A1 WO 2004020562A1 KR 0301742 W KR0301742 W KR 0301742W WO 2004020562 A1 WO2004020562 A1 WO 2004020562A1
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WIPO (PCT)
Prior art keywords
weight
composition
disinfecting
acid
medical instrument
Prior art date
Application number
PCT/KR2003/001742
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English (en)
Inventor
Jin-Sik Lee
Jin-Tae Lee
Do-Hoon Kim
Chan-Ho Jeong
Original Assignee
Jin-Sik Lee
Jin-Tae Lee
Do-Hoon Kim
Chan-Ho Jeong
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Publication date
Application filed by Jin-Sik Lee, Jin-Tae Lee, Do-Hoon Kim, Chan-Ho Jeong filed Critical Jin-Sik Lee
Priority to AU2003253481A priority Critical patent/AU2003253481A1/en
Priority to JP2004532432A priority patent/JP2005537356A/ja
Publication of WO2004020562A1 publication Critical patent/WO2004020562A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/39—Organic or inorganic per-compounds
    • C11D3/3947—Liquid compositions
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66—Non-ionic compounds
    • C11D1/722—Ethers of polyoxyalkylene glycols having mixed oxyalkylene groups; Polyalkoxylated fatty alcohols or polyalkoxylated alkylaryl alcohols with mixed oxyalkylele groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005—Other compounding ingredients characterised by their effect
    • C11D3/0073—Anticorrosion compositions
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/02—Inorganic compounds ; Elemental compounds
    • C11D3/04—Water-soluble compounds
    • C11D3/042—Acids
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2075—Carboxylic acids-salts thereof
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/36—Organic compounds containing phosphorus
    • C11D3/361—Phosphonates, phosphinates or phosphonites
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/37—Polymers
    • C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C11D3/3707—Polyethers, e.g. polyalkyleneoxides
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/39—Organic or inorganic per-compounds
    • C11D3/3942—Inorganic per-compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/39—Organic or inorganic per-compounds
    • C11D3/3945—Organic per-compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions

Definitions

  • the present invention relates to a peracetic acid (PAA) composition for disinfecting or cleaning a medical instrument, the composition comprising a surfactant with alcoholic groups at both terminals, and a preparation process thereof.
  • PAA peracetic acid
  • Endoscopy has experienced widespread use for a variety of medical areas including digestive trouble diagnosis, and the number of cases of endoscopic examination is gradually increasing.
  • it is important to prevent hospital infection that frequently arises during endoscopic surgery and to keep endoscopes functioning properly. Since around 1980, there has been an increasing awareness of the seriousness of hospital infection in America, England, Japan and other countries, and research into endoscope disinfection or cleaning is being extensively progressed.
  • Hospital infection during endoscopy can affect any person in hospital, that is, not only patients but also doctors and even the hospital personnel may be affected by infection. Thus, it is necessary to take comprehensive measures for preventing hospital infection caused by microorganisms, e.g., Helicobacter Pylori or Tuberculous Bacillus.
  • microorganisms e.g., Helicobacter Pylori or Tuberculous Bacillus.
  • compositions for disinfecting or cleaning the medical instrument that is, peracetic acid (PAA) compositions comprising peracetic acid, acetic acid and hydrogen peroxide, have been developed, as disclosed in PCT publication Nos. WO 88/08667, WO 93/07909 and WO 94/14321 , European patent application EP 596,493, U.S. Patent No. 6,168,808, etc.
  • PAA peracetic acid
  • the conventional PAA composition for disinfecting or cleaning a medical instrument generally includes peracetic acid, acetic acid, hydrogen peroxide and, purified water, and further includes a stabilizer such as phosphoric acid or phosphonic acid, a nonionic surfactant such as sorbitan monopalmitate or polyoxyethylene cetyl etheFramtne ⁇ oxides, and the like. Since the disinfecting or cleaning composition exhibits sterilizing effects fast, it is suitably used for automatic washers and manual cleaning.
  • the disinfecting or cleaning composition with a low content of peracetic acid presents limitations to its use because it exhibits poor cleaning ability to organic matter, e.g., mucus or other contaminants. Also, when the PAA composition is used in endoscopes, forceps or surgical operating instruments made of copper and zinc compounds and the like, corrosion may occur to those instruments.
  • the present invention provides a peracetic acid (PAA) composition for disinfecting or cleaning a medical instrument, and its preparation process, the PAA composition comprising a surfactant with alcoholic groups at both terminals, which can minimize generation of foams and occurrence of corrosion.
  • PAA peracetic acid
  • a composition for disinfecting or cleaning a medical instrument comprising 0.08 to 0.35% by weight of peracetic acid, 0.1 to 20% by weight of acetic acid, 1 to 6% by weight of hydrogen peroxide, 0.1 to 20% by weight of phosphoric acid, 0.1 to 5% by weight of 1 ,1-diphosphonic acid, 0.001 to 10% by weight of at least one surfactant represented by the formula (I), 0.001 to 5% by weight of a corrosion inhibitor, and the remainder of the total composition being dist ⁇ ted ⁇ water, reverse osmosis water or deionized water:
  • I, m and n are integers between 1 and 50, and the sum of I and n is between 2 and 50.
  • a process for preparing a composition for disinfecting or cleaning a medical instrument comprising (a) mixing 79 to 80% by weight of distilled water, reverse osmosis water or deionized water, 0.1 to 10% by weight of phosphoric acid and 0.1 to 1.0% by weight of 1 ,1-diphosphonic acid, (b) mixing 0.2 to 2.0% by weight of acetic acid with the solution obtained in step (a), (c) mixing 5 to 7% by weight of hydrogen peroxide with the solution obtained in step (b) to form peracetic acid, (d) warming the solution obtained in step (c) at 35 to 45 ° C for 4 to 7 hours and then maturing the same at room temperature, (e) mixing 0.001 to 5% by weight of at least one corrosion inhibitor selected from the group consisting of sodium silicate, sodium nitrate, sodium benzoate, benzotriazole, polyacrylate copolymers with the solution obtained in step (d), and (f) mixing 0.00
  • the composition for disinfecting or cleaning a medical instrument includes 0.08 to 0.35% by weight of peracetic acid, 0.1 to 20% by weight of acetic acid, 1 to 6% by weight of hydrogen peroxide, 0.1 to 20% by weight of phosphoric acid, 0.1 to 5% by weight of 1 ,1-diphosphonic acid, 0.001 to 10% by weight of at least one surfactant represented by the formula (I), 0.001 to 5% by weight of a corrosion inhibitor, aner th remainder of the total composition being distilled water, reverse osmosis water or deionized water:
  • I, m and n are integers between 1 and 50, and the sum of I and n is between 2 and 50.
  • the peracetic acid and hydrogen peroxide are directly related to germicidal function and exist in an equilibrium state in the disinfecting or cleaning composition.
  • Phosphoric acid and 1 ,1-diphosphonic acid form a mixed stabilizer, each represented by the following formulas: Phosphoric acid 1 ,1-diphosphonic acid
  • the mixed stabilizer stabilizes peracetic acid and hydrogen peroxide.
  • Phosphoric acid contained in the mixed stabilizer allows acidity for removing scales, thereby improving capability of removing scales, e.g., calcium carbonate (CaCOa) or calcium sulfate (CaS0 4 ).
  • the mixed stabilizer functions to stabilize the disinfecting or cleaning composition according to the present invention and to adjust the acidity thereof to be in a desirable range.
  • the disinfecting or cleaning composition according to the present invention includes a surfactant represented by the following formula:
  • I, m and n are integers between 1 and 50 and the sum of I and n, i.e., l+n, is in a range from 2 to 50.
  • the sum of I and n, corresponding to the amount of an ethylene oxide moiety, is preferably from about 4 to about 50 mole, and m corresponding to the amount of a propylene oxide moiety is preferably from about 5 to about 40 mole.
  • an average molecular weight of the surfactant is preferably from about 1500 to about 3000, more preferably about 2,500.
  • the surfactant useful in the present invention include any surfactants which are commercially available in an amount within the range defined above, including polyoxyethylene and oxypropylene block copolymers and the like, e.g., Koremul-PE62 (Hannong Chemicals Inc., Korea).
  • the surfactant Since the surfactant has high stability and cleaning efficiency, and low foamability and toxicity with respect to peroxides, cleaning performance of the disinfecting or cleaning composition according to the present invention can be enhanced using only a small amount of peracetic acid. Also, since the surfactant exhibits a low surface tension and low foaming, it can minimize environmental problems due to the presence of an antifoamer used in conventional medical instrument cleaning.
  • the corrosion inhibitor useful in the present invention include at least one selected from the group consisting of sodium silicate, sodium nitrate, sodium benzoate, benzotriazole and polyacrylate copolymers, which are preferably used because they have corrosion inhibiting properties against aluminum, copper and/or zinc compounds.
  • the polyacrylate copolymer has a molecular weight from about 50,000 to about 100,000 and a pH from about 2 to about 3, and examples thereof include copolymers commercially available in the trade- names of Acrysol from Rohm and Hass Co., Sokalan from BASF Corp., TPA50 from Taechang Corp., and so on.
  • composition for disinfecting or cleaning a medical instrument employs water as the solvent, distilled water, that is, substantially pure water that is not contaminated, is preferred, and reverse osmosis (RO) water or deionized (Dl) water is more preferred.
  • water as the solvent, distilled water, that is, substantially pure water that is not contaminated, is preferred, and reverse osmosis (RO) water or deionized (Dl) water is more preferred.
  • the amounts of all ingredients contained in the disinfecting or cleaning composition are amounts of the respective ingredients contained in the finally obtained composition at an equilibrium state.
  • the disinfecting or cleaning composition being at an equilibrium state comprises 0.08 to 0.35% by weight of peracetic acid, 0.1 to 20% by weight of acetic acid, and 1 to 6% by weight of hydrogen peroxide.
  • the amounts may slightly deviate from the range defined above in view of sufficient disinfecting or cleaning efficiency, which should, however, be construed to be within the range defined above for the disinfecting or cleaning composition according to the present invention.
  • phosphoric acid and 1 ,1-diphosphonic acid as a stabilizer and a scale remover are preferably used in amounts of 0.1 to 20% and 0.1 to 5%, by weight, respectively.
  • the amounts of phosphoric acid and 1 ,1-diphosphonic acid may also slightly deviate from the range defined above in view of sufficient stabilizing and descaling efficiency, which should, however, be construed to be within the range defined above for the disinfecting or cleaning composition according to the present invention.
  • the surfactant represented by the formula (I) is preferably used in an amount of 0.001 to 10% by weight, more preferably 0.5 to 5% by weight.
  • the corrosion inhibitor is preferably used in an amount of 0.001 to 5% by weight.
  • the amount of the corrosion inhibitor may also slightly deviate from the range defined above in view of sufficient anticorrosion efficiency, which should, however, be construed to be within the range defined above for the disinfecting or cleaning composition according to the present invention.
  • Distilled water, RO water or Dl water supplied as the solvent or diluent in the disinfecting or cleaning composition according to the present invention is used in an appropriate amount to be the remainder to 100%, forming the final composition with other ingredients.
  • Medical instruments that can be applied to the disinfecting or cleaning composition according to the present invention include, but not limited to, an endoscope, a surgical operating instrument, general medical instrument, an anesthetic device, a pulmotor or peripheral devices thereof, an obstetric and gynecological instrument, a dental device, a Chinese medical instrument and the like.
  • a process for preparing the composition for disinfecting or cleaning a medical instrument comprising (a) mixing 79 to 80% by weight of distilled water, reverse osmosis water or deionized water, 0.1 to 10% by weight of phosphoric acid with 0.1 to 1.0% by weight of 1 ,1-diphosphonic acid, (b) mixing 0.2 to 2.0% by weight of acetic acid with the solution obtained in step (a), (c) mixing 5 to 7% by weight of hydrogen peroxide with the solution obtained in step (b) to form peracetic acid, (d) warming the solution obtained in step (c) at 35 to 45 ° C for 4 to 7 hours and then maturing the same at room temperature, (e) mixing 0.001 to 5% by weight of at least one corrosion inhibitor selected from the group consisting of sodium silicate, sodium nitrate, sodium benzoate, benzotriazole, polyacrylate copolymers with the solution obtained in step (d), and (f) mixing
  • the warming is performed for the purpose of facilitating a reaction between hydrogen peroxide and acetic acid.
  • the amount of hydrogen peroxide is adjusted to an appropriate level, for example, to less than 6% by weight.
  • the maturing is preferably performed for about 3 days.
  • a contact time of about 5 to about 10 minutes can be used to effectively disinfect or clean a medical instrument, such as an endoscope, a surgical operating instrument, a general medical instrument, an anesthetic device, a pulmotor or peripheral devices thereof, an obstetric and gynecological instrument, a dental device or a Chinese medical instrument.
  • the contact time is adjustably increased or decreased as needed.
  • peracetic acid is contained at a low concentration level, it is not necessary to separately dilute the composition.
  • the disinfecting or cleaning composition according to the present invention can be appropriately diluted, by necessity, within the range acceptable in the art.
  • An aqueous solvent preferably distilled water, RO water or and Dl water, can be used as a diluent.
  • Example 1 88.3 g of RO water, 1.0 g of phosphoric acid and 0.1 g of
  • 1 ,1-diphosphonic acid were mixed together and then mixed with 1 g of acetic acid, followed by mixing with 6 g of hydrogen peroxide, thereby preparing peracetic acid and warming the same at 35 to 45 °C for about 7 hours.
  • the resultant material was agitated at room temperature to be matured, and 0.5 g of TPA50 commercially available from Taechang Corp.
  • composition for disinfecting or cleaning a medical instrument was prepared in the same manner as in Example 1 , except for 0.3 g of acetic acid being used. Concentrations of peracetic acid and hydrogen peroxide contained in the acquired composition were 0.20% and 2.10%, respectively.
  • composition for disinfecting or cleaning a medical instrument was prepared in the same manner as in Example 1 , except for 0.1 g of acetic acid being used. Concentrations of peracetic acid and hydrogen peroxide contained in the acquired composition were 0.09% and 2.20%, respectively.
  • Example 4 The composition for disinfecting or cleaning a medical instrument was prepared in the same manner as in Example 1 , except for 0.3 g of acetic acid and 3.0 g of hydrogen peroxide being used. Concentrations of peracetic acid and hydrogen peroxide contained in the acquired composition were 0.18% and 1.01%, respectively.
  • composition for disinfecting or cleaning a medical instrument was prepared in the same manner as in Example 1 , except for 0.1 g of acetic acid and 3.0 g of hydrogen peroxide being used. Concentrations of peracetic acid and hydrogen peroxide contained in the acquired composition were 0.08% and 1.05%, respectively.
  • Corrosion products and impurities were removed from a test sample surface made of aluminum using 70% nitric acid and was brought into contact with the composition prepared in Example 1 for about 5 hours, followed by weighing the test sample. Then, a corrosion rate was calculated using the following equation:
  • Corrosion rate 534 x (Loss in weight)/(D x A x T) wherein D represents the density indicated in unit of g/cm 3 , A represents the area of the test sample indicated in unit of in 2 and T represents the time indicated in unit of hours.
  • the corrosion rate of the composition obtained by the above equation was 1.67 mm/yr.
  • the disinfecting or cleaning composition according to the present invention showed a significant reduction in the corrosion rate.
  • Example 7 Corrosion test (2) Corrosion products and impurities were removed from a test sample surface made of brass using 20% hydrochloric acid and was brought into contact with the composition prepared in Example 1 for about 30 minutes, followed by weighing the test sample. Then, the corrosion rate obtained in the same manner as in Example 6 was 5.25 mm/yr. When compared with the corrosion rates of the conventional PPA compositions, that is, about 109.37 mm/yr, the disinfecting or cleaning composition according to the present invention showed a significant reduction in the corrosion rate.
  • Example 1 An endoscope which is commercially available from
  • Disinfecting and cleaning tests were performed based on the diagnostic guidelines provided by the Korean Society of Gastrointestinal Endoscopy.
  • specimens were harvested from two parts of each endoscope for culturing.
  • a saline solution was slowly injected into a suction channel through a biopsy cavity using a 50 ml needle and the water falling down to a distal end of an insertion site of the endoscope was collected in a sterile tube, yielding a specimen S-1. Also, a portion between the distal end of the insertion site of the endoscope and a body part of the endoscope was smeared with a cotton swab wet by a saline solution, yielding a specimen S-2. To examine contamination of an automatic endoscope washer, the automatic endoscope washer was rinsed with a rinse solution and 100 ml of the rinse solution was sampled twice.
  • the specimen S-1 and a specimen from the rinse solution of the automatic endoscope washer were allowed to pass through each 0.22 ⁇ m nitrocellulose membrane filter under negative pressure. Immediately thereafter, the membrane filters were evenly spread plated onto blood agar plates. Jhe specimen S-2 sampled with a cotton swab was evenly inoculated directly on a blood agar broth.
  • the disinfection test result is as follows.
  • the composition according to the present invention can effectively disinfect and clean endoscopes effectively without generating foams, and no corrosion occurs to the endoscopes.
  • 0.1 ml of a bacteria solution which was cultured in a nutrient broth and a tryptic soy broth for 24 hours, and 10 ml of the composition prepared in Example 1 , were shakingly mixed and reacted for one minute. Then, 1 ml of the reactant solution was put in a test tube having 9 ml of a neutralizer containing 4.26 % sodium phosphate dibasic, 3% tween, 0.5 % sodium thiosulfate pentahydrate, 0.3 % L- ⁇ -lecithin and 0.1 % L- histidine. 1 ml of the mixed solution was diluted 10 times with peptone-containing water.
  • 0.1 ml of a fungi solution which was cultured in a yeast malt broth for 48 hours, and 10 ml of the composition prepared in Example 1 , were shakingly mixed and reacted for 10 minutes. After 10 minutes, 1 ml of the reactant solution was put in a test tube having 9 ml of a neutralizer containing 4.26 % sodium phosphate dibasic, 3% tween, 0.5 % sodium thiosulfate pentahydrate, 0.3 % L- ⁇ -lecithin and 0.1 % L- histidine. 1 ml of the mixed solution was diluted 10 times with peptone-containing water.
  • the disinfection test results of the bacteria and fungi are as follows.
  • the disinfecting or cleaning composition of the present invention can effectively kill bacteria and fungi.
  • the disinfecting or cleaning composition according to the present invention can effectively enhance cleaning efficiency without causing a reduction in sterilizing efficiency. Also, problems due to foams and corrosion can be minimized.

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Detergent Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)

Abstract

L'invention concerne une composition destinée à désinfecter ou à nettoyer un instrument médical ainsi qu'un procédé de préparation de cette composition. La composition comprend de 0,08 à0,35 % en poids d'acide peracétique, 0,1 à 20 % en poids d'acide acétique, 1 à 6 % en poids de peroxyde d'hydrogène, 0,1 à 20 % en poids d'acide phosphorique, 0,1 à 5 % en poids d'acide 1,1-diphosphonique, 0,001 à 10 % en poids d'au moins un tensioactif comportant un groupe alcoolique à chaque extrémité, 0,001 à 5 % en poids d'un inhibiteur de corrosion, le reste de la composition étant constitué d'eau distillée, obtenue par osmose inverse ou déionisée.
PCT/KR2003/001742 2002-08-28 2003-08-28 Composition destinee a desinfecter ou a laver des instruments medicaux et procede de preparation de cette composition WO2004020562A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2003253481A AU2003253481A1 (en) 2002-08-28 2003-08-28 A composition for disinfecting or washing medical instruments and a process for the preparation thereof
JP2004532432A JP2005537356A (ja) 2002-08-28 2003-08-28 医療機器消毒または洗浄用組成物及びその製造方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2002-0051154 2002-08-28
KR10-2002-0051154A KR100515928B1 (ko) 2002-08-28 2002-08-28 양쪽 말단에 알콜성 기를 갖는 계면활성제를 함유한 의료기기 소독 세척제 및 그의 제조방법 1

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WO2004020562A1 true WO2004020562A1 (fr) 2004-03-11

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PCT/KR2003/001742 WO2004020562A1 (fr) 2002-08-28 2003-08-28 Composition destinee a desinfecter ou a laver des instruments medicaux et procede de preparation de cette composition

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JP (1) JP2005537356A (fr)
KR (1) KR100515928B1 (fr)
CN (1) CN1297644C (fr)
AU (1) AU2003253481A1 (fr)
WO (1) WO2004020562A1 (fr)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006138088A2 (fr) * 2005-06-15 2006-12-28 3M Innovative Properties Company Compositions et procedes d'utilisation desdites compositions
WO2007118835A1 (fr) * 2006-04-13 2007-10-25 Akzo Nobel N.V. Composition aqueuse contenant du peroxyde d'hydrogène et utilisation pour le nettoyage de surfaces
EP1897934A1 (fr) * 2006-09-04 2008-03-12 Miura Co., Ltd. Fluide de nettoyage
WO2009147327A1 (fr) * 2008-06-05 2009-12-10 Laboratoires Anios Composition pour la desinfection et la decontamination de corps contamines par des prions ainsi que par des agents transmissibles conventionnels
WO2009147328A2 (fr) * 2008-06-05 2009-12-10 Laboratoires Anios Composition pour la désinfection et la décontamination simultanées de corps contaminés par des agents transmissibles conventionnels (atc) et non conventionnels (atnc)
CN102258803A (zh) * 2011-07-20 2011-11-30 王旋旋 一种长效医用皮肤消毒棉球
US8263540B2 (en) 2010-08-27 2012-09-11 Ecolab Usa Inc. Detergent compositions with combinations of acrylic and maleic acid homopolymers and/or salts thereof for aluminum protection
US8691018B2 (en) 2010-08-27 2014-04-08 Ecolab Usa Inc. High molecular weight polyacrylates for aluminum protection in warewash applications
WO2015167644A1 (fr) * 2014-04-28 2015-11-05 American Sterilizer Company Procédé de décontamination ou de stérilisation d'un article avec une composition contenant un peroxyde et un agent antimicrobien
EP2925846A4 (fr) * 2012-11-29 2016-05-25 Ecolab Usa Inc Additif de nettoyage et procédé de nettoyage l'utilisant
WO2017082961A1 (fr) * 2015-11-10 2017-05-18 American Sterilizer Company Composition nettoyante et désinfectante
US10455838B2 (en) 2014-04-28 2019-10-29 American Sterilizer Company Wipe for killing spores
WO2020252402A1 (fr) * 2019-06-14 2020-12-17 Armis Biopharma, Inc. Compositions pour le nettoyage de prothèses dentaires amovibles
US11006629B2 (en) 2008-11-20 2021-05-18 Armis Biopharma, Inc. Antimicrobial, disinfecting, and wound healing compositions and methods for producing and using the same
US11969399B2 (en) 2017-07-07 2024-04-30 Armis Biopharma, Inc. Compositions and methods for remediating chemical warfare agent exposed skin

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WO2006138088A2 (fr) * 2005-06-15 2006-12-28 3M Innovative Properties Company Compositions et procedes d'utilisation desdites compositions
WO2006138088A3 (fr) * 2005-06-15 2008-03-06 3M Innovative Properties Co Compositions et procedes d'utilisation desdites compositions
WO2007118835A1 (fr) * 2006-04-13 2007-10-25 Akzo Nobel N.V. Composition aqueuse contenant du peroxyde d'hydrogène et utilisation pour le nettoyage de surfaces
US7824503B2 (en) 2006-04-13 2010-11-02 Akzo Nobel N.V. Aqueous hydrogen peroxide-containing composition and its use for cleaning surfaces
EP1860176A1 (fr) * 2006-05-22 2007-11-28 Akzo Nobel N.V. Composition aqueuse contenant du péroxyde d'hydrogène et son utilisation pour le nettoyage des surfaces
EP1897934A1 (fr) * 2006-09-04 2008-03-12 Miura Co., Ltd. Fluide de nettoyage
WO2009147328A2 (fr) * 2008-06-05 2009-12-10 Laboratoires Anios Composition pour la désinfection et la décontamination simultanées de corps contaminés par des agents transmissibles conventionnels (atc) et non conventionnels (atnc)
FR2932093A1 (fr) * 2008-06-05 2009-12-11 Anios Lab Sarl Composition pour la desinfection et la decontamination simultanees de corps contamines par des agents transmissibles conventionnels (atc) et non conventionnels (atnc).
FR2932094A1 (fr) * 2008-06-05 2009-12-11 Anios Lab Sarl Composition pour la desinfection et la decontamination simultanees de corps contamines par des agents transmissibles conventionnels (atc) et non conventionnels (atnc).
WO2009147328A3 (fr) * 2008-06-05 2010-01-28 Laboratoires Anios Composition pour la désinfection et la décontamination simultanées de corps contaminés par des agents transmissibles conventionnels (atc) et non conventionnels (atnc)
WO2009147327A1 (fr) * 2008-06-05 2009-12-10 Laboratoires Anios Composition pour la desinfection et la decontamination de corps contamines par des prions ainsi que par des agents transmissibles conventionnels
CN102112159A (zh) * 2008-06-05 2011-06-29 安尼奥斯实验室 被朊病毒以及被常规传染性因子污染的物体的消毒和净化用的组合物
US11839213B2 (en) 2008-11-20 2023-12-12 Armis Biopharma, Inc. Antimicrobial, disinfecting, and wound healing compositions and methods for producing and using the same
US11006629B2 (en) 2008-11-20 2021-05-18 Armis Biopharma, Inc. Antimicrobial, disinfecting, and wound healing compositions and methods for producing and using the same
US8480808B2 (en) 2010-08-27 2013-07-09 Ecolab Usa Inc. Detergent compositions with combinations of acrylic and maleic acid homopolymers and/or salts thereof for aluminum protection
US8691018B2 (en) 2010-08-27 2014-04-08 Ecolab Usa Inc. High molecular weight polyacrylates for aluminum protection in warewash applications
US9029314B2 (en) 2010-08-27 2015-05-12 Ecolab Usa Inc. High molecular weight polyacrylates for aluminum protection in warewash applications
US9567552B2 (en) 2010-08-27 2017-02-14 Ecolab Usa Inc. High molecular weight polyacrylates for aluminum protection in warewash applications
US8263540B2 (en) 2010-08-27 2012-09-11 Ecolab Usa Inc. Detergent compositions with combinations of acrylic and maleic acid homopolymers and/or salts thereof for aluminum protection
US10472438B2 (en) 2010-08-27 2019-11-12 Ecolab Usa Inc. High molecular weight polyacrylates for aluminum protection in warewash applications
CN102258803A (zh) * 2011-07-20 2011-11-30 王旋旋 一种长效医用皮肤消毒棉球
EP2925846A4 (fr) * 2012-11-29 2016-05-25 Ecolab Usa Inc Additif de nettoyage et procédé de nettoyage l'utilisant
US10455838B2 (en) 2014-04-28 2019-10-29 American Sterilizer Company Wipe for killing spores
US10463754B2 (en) 2014-04-28 2019-11-05 American Sterilizer Company Process for decontaminating or sterilizing an article
US10869479B2 (en) 2014-04-28 2020-12-22 American Sterilizer Company Wipe for killing spores
WO2015167644A1 (fr) * 2014-04-28 2015-11-05 American Sterilizer Company Procédé de décontamination ou de stérilisation d'un article avec une composition contenant un peroxyde et un agent antimicrobien
US10307498B2 (en) 2015-11-10 2019-06-04 American Sterilizer Company Cleaning and disinfecting composition
US10183087B2 (en) 2015-11-10 2019-01-22 American Sterilizer Company Cleaning and disinfecting composition
WO2017082961A1 (fr) * 2015-11-10 2017-05-18 American Sterilizer Company Composition nettoyante et désinfectante
US11969399B2 (en) 2017-07-07 2024-04-30 Armis Biopharma, Inc. Compositions and methods for remediating chemical warfare agent exposed skin
WO2020252402A1 (fr) * 2019-06-14 2020-12-17 Armis Biopharma, Inc. Compositions pour le nettoyage de prothèses dentaires amovibles

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KR100515928B1 (ko) 2005-09-20
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JP2005537356A (ja) 2005-12-08
CN1694948A (zh) 2005-11-09
AU2003253481A1 (en) 2004-03-19

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