Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/37—Esters of carboxylic acids
  • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/63—Steroids; Derivatives thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
  • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
  • A61K8/9783—Angiosperms [Magnoliophyta]
  • A61K8/9789—Magnoliopsida [dicotyledons]
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin

Definitions

• Lanolin is a product obtained by the purification of degras.
• Degras is a crude grease obtained by the solvent treatment of wool.
• Lanolin is a yellowish to gray semisolid containing 25 to 30% water in its hydrous form, and a brownish-yellow semisolid in its anhydrous form.
• Lanolin contains cholesterol esters of higher fatty acids.
• Lanolin is used as a component of pharmaceuticals, leather finishing compositions, soaps and detergents, face creams, facial tissues, hair-set compositions, suntan preparations, and the like.
• This invention relates to lanolin substitute compositions derived from vegetable materials, which are lanolin-free.
• the lanolin substitute compositions of the invention comprise the following components:
• C) from 1 to 10% by weight, preferably from 3 to 5% by weight, of a polyglyceryl di-fatty acid ester, preferably diisostearate; and D) from 0.25 to 2% by weight, preferably from 0.8 to 1.2% by weight of a glyceryl fatty acid ester, preferably oleate.
• compositions can optionally contain other compatible components including one or more of the following components:
• polyethyleneglycol plant sterol preferably PEG-5 soya sterol
• the optional components can be present in the following quantities, based on the combined weight of components A) through D) represented as 100% by weight:
• microcrystalline wax - from 0 to 40% by weight, preferably from 1 to 40% by weight, and more preferably from 30 to 35% by weight.
• polyethyleneglycol plant sterol - from 0 to 60% by weight, preferably from 1 to 60% by weight, and more preferably from 45 to 50% by weight.
• G pefrolatxim/mineral oil - from 0 to 300% by weight, preferably from 1 to 300% by weight, and more preferably from 250 to 300% by weight.
• Component A) can be any plant sterol fatty acid ester in which the fatty acid moiety is derived from a saturated or olefinically unsaturated, straight or branched chain fatty acid containing from 6 to 22 carbon atoms, preferably from 16 to 18 carbon atoms.
• the preferred sterol is soya sterol, which is a mixture of stigmasterol and sitosterols (dihydrostigmasterols).
• Component B) can be any polyglyceryl di-polyhydroxy fatty acid ester in which the fatty acid moieties are independently derived from a polyhydroxy saturated or olefinically unsaturated, straight or branched chain fatty acid contaimng from 6 to 22 carbon atoms, preferably from 16 to 18 carbon atoms, and most preferably 18 carbon atoms.
• the polyglyceryl moiety can contain from 2 to 12 glyceryl groups, preferably 2 groups.
• Each polyhydroxy fatty acid moiety can contain from 2 to 8 hydroxy groups.
• Preferred compounds are those in which each fatty acid moiety is identical.
• Component C) can be any polyglyceryl di-fatty acid ester in which each fatty acid moiety is independently derived from a saturated or unsaturated, straight or branched chain fatty acid contaimng from 6 to 22 carbon atoms, preferably from 16 to 18 carbon atoms, and most preferably 18 carbon atoms. Preferred compounds are those in which each fatty acid moiety is identical.
• the polyglyceryl moiety can contain from 2 to 12 glyceryl groups, preferably 3 groups.
• Component D) can be any glyceryl fatty acid mono-, di-, or tri- ester in which the fatty acid moiety is independently derived from a saturated or olefinically unsaturated, straight or branched chain fatty acid containing from 6 to 22 carbon atoms, preferably from 16 to 18 carbon atoms, and is most preferably derived from oleic acid.
• Component E) is microcrystalline wax which is a wax that is usually composed of branched-chain paraffins, characterized by a crystalline structure much smaller than that of normal wax.
• Component F) is a polyethyleneglycol plant sterol containing from 2 to 10, and preferably 5 ethyleneglycol groups. The plant sterol is preferably soya sterol.
• Component G is a mixture of from 10 to 70% by weight of petrolatum, a petroleum jelly, and from 30 to 90% by weight of white mineral oil, which is a mixture of liquid hydrocarbons.
• compositions of the invention can be prepared by mixing the components together at a temperature of from 50 to 100°C, preferably from 70 to 75°C.
• compositions comprising polyol esters and petrolatum can be employed as lanolin substitutes.
• Such compositions contain from 5 to 20% by weight of polyol ester, preferably from 8 to 10% based on the weight of petrolatum.
• the above lanolin substitutes can consist of just the above components, or can contain one or more additional components that are compatible therewith, such as one or more of components A) through F) set forth above, in quantities that do not change the lanolin-like characteristics of the components.
• the polyol esters can include one or more of sorbitan fatty acid esters and alkyl glycoside esters.
• the sorbitan fatty acid esters are esters of C 4 -C 22 , preferably C 6 -C 18 , alkyl or alkenyl fatty acids, which can be straight or branched chain. Examples include, but are not limited to, sorbitan monolaurate, sorbitan monooleate, sorbitan monostearate, sorbitan monopalmitate, and sorbitan tristearate.
• the alkyl glycoside esters are C 2 -C 20 alkyl or alkenyl carboxylic acid esters of a reducing saccharide or polysaccharide in which the saccharide contain 5 or 6 carbon atoms, preferably esters of glucoside or a polyglucoside, which also contain an alkyl or alkenyl radical containing from 1 to 20 carbon atoms.
• the alkyl glycoside esters have the formula I:
• Z is a saccharide residue containing 5 or 6 carbon atoms, preferably 6 carbon atoms, and b is a number of from 1 to 6.
• the preferred compound of formula I is methyl glucoside dioleate.
• compositions of the invention can be used as a much less expensive substitute for lanolin in all products that include lanolin as a component, including but not limited to, pharmaceuticals, leather finishing compositions, soaps, detergents, cosmetic compositions, e.g. face creams, facial tissues, hair-set compositions and suntan preparations.
• Example 2 A composition was formulated by mixing together the following components at a temperature of 70-75°C until homogeneous:
• Example 1 Component % by weight composition of Example 1 22.00 microcrystalline wax (1) 7.00 PEG-5 soya sterol (2) 10.70 petrolatum/mineral oil (3) 60.30
• PEG represents polyethyleneglycol

Landscapes

• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• General Health & Medical Sciences (AREA)
• Veterinary Medicine (AREA)
• Public Health (AREA)
• Animal Behavior & Ethology (AREA)
• Epidemiology (AREA)
• Birds (AREA)
• Emergency Medicine (AREA)
• Engineering & Computer Science (AREA)
• Biotechnology (AREA)
• Botany (AREA)
• Microbiology (AREA)
• Mycology (AREA)
• Dermatology (AREA)
• Cosmetics (AREA)
• Fats And Perfumes (AREA)
• Medicinal Preparation (AREA)
• Detergent Compositions (AREA)

Priority Applications (3)

Applications Claiming Priority (4)

Publications (2)

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Cited By (2)

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• 2003
  • 2003-03-20 US US10/393,149 patent/US7217432B2/en not_active Expired - Fee Related
  • 2003-04-11 AU AU2003262378A patent/AU2003262378A1/en not_active Abandoned
  • 2003-04-11 JP JP2003585655A patent/JP4392249B2/ja not_active Expired - Fee Related
  • 2003-04-11 EP EP03746967A patent/EP1496855A4/en not_active Ceased
  • 2003-04-11 WO PCT/US2003/011285 patent/WO2003088902A2/en not_active Ceased
• 2009
  • 2009-04-22 JP JP2009103651A patent/JP2009197236A/ja active Pending

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