WO2003069328A1 - Method of analyzing aminofunctional compound and analytical reagent - Google Patents

Method of analyzing aminofunctional compound and analytical reagent Download PDF

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Publication number
WO2003069328A1
WO2003069328A1 PCT/JP2003/001463 JP0301463W WO03069328A1 WO 2003069328 A1 WO2003069328 A1 WO 2003069328A1 JP 0301463 W JP0301463 W JP 0301463W WO 03069328 A1 WO03069328 A1 WO 03069328A1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
aminofunctional
analyzing
aminofunctional compound
analytical reagent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2003/001463
Other languages
English (en)
French (fr)
Japanese (ja)
Inventor
Hiroshi Miyano
Akihisa Yahashi
Kazutaka Shimbo
Masakazu Nakazawa
Kazuo Hirayama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
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Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Priority to CA2475011A priority Critical patent/CA2475011C/en
Priority to AU2003211941A priority patent/AU2003211941A1/en
Priority to EP03705088.7A priority patent/EP1475632B1/en
Priority to JP2003568398A priority patent/JP4453363B2/ja
Publication of WO2003069328A1 publication Critical patent/WO2003069328A1/ja
Anticipated expiration legal-status Critical
Priority to US10/918,380 priority patent/US7148069B2/en
Priority to US11/514,130 priority patent/US9274123B2/en
Priority to US15/003,235 priority patent/US9658234B2/en
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/13—Tracers or tags
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
PCT/JP2003/001463 2002-02-14 2003-02-13 Method of analyzing aminofunctional compound and analytical reagent Ceased WO2003069328A1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA2475011A CA2475011C (en) 2002-02-14 2003-02-13 Method for analysis of compounds with amino group and analytical reagent therefor
AU2003211941A AU2003211941A1 (en) 2002-02-14 2003-02-13 Method of analyzing aminofunctional compound and analytical reagent
EP03705088.7A EP1475632B1 (en) 2002-02-14 2003-02-13 Method of analyzing aminofunctional compound and analytical reagent
JP2003568398A JP4453363B2 (ja) 2002-02-14 2003-02-13 アミノ官能性化合物の分析方法及び分析試薬
US10/918,380 US7148069B2 (en) 2002-02-14 2004-08-16 Method for analysis of compounds with amino group and analytical reagent therefor
US11/514,130 US9274123B2 (en) 2002-02-14 2006-09-01 Method for analysis of compounds with amino group and analytical reagent therefor
US15/003,235 US9658234B2 (en) 2002-02-14 2016-01-21 Method for analysis of compounds with amino group and analytical reagent therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002-36446 2002-02-14
JP2002036446 2002-02-14

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/918,380 Continuation US7148069B2 (en) 2002-02-14 2004-08-16 Method for analysis of compounds with amino group and analytical reagent therefor

Publications (1)

Publication Number Publication Date
WO2003069328A1 true WO2003069328A1 (en) 2003-08-21

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ID=27678084

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2003/001463 Ceased WO2003069328A1 (en) 2002-02-14 2003-02-13 Method of analyzing aminofunctional compound and analytical reagent

Country Status (6)

Country Link
US (3) US7148069B2 (enExample)
EP (3) EP1475632B1 (enExample)
JP (6) JP4453363B2 (enExample)
AU (1) AU2003211941A1 (enExample)
CA (1) CA2475011C (enExample)
WO (1) WO2003069328A1 (enExample)

Cited By (24)

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WO2005116629A1 (ja) * 2004-05-26 2005-12-08 Ajinomoto Co., Inc. アミノ官能性化合物の分析方法及び装置
WO2006017208A1 (en) * 2004-07-12 2006-02-16 Applera Corporation Mass tags for quantitative analyses
JPWO2005050188A1 (ja) * 2003-11-21 2007-06-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 同位体標識化内部標準物質を用いる定量方法、該定量方法を実行する解析システムおよび該解析のためのプログラム
WO2007091628A1 (ja) * 2006-02-08 2007-08-16 Nec Corporation ペプチドの修飾方法及びペプチドの同定方法
WO2009054350A1 (ja) 2007-10-25 2009-04-30 Ajinomoto Co., Inc. 耐糖能異常の評価方法
JP2010532481A (ja) * 2007-06-29 2010-10-07 クエスト ダイアグノスティックス インヴェストメンツ インコーポレイテッド 液体クロマトグラフィー質量分析による体液中のアミノ酸分析
JP4771296B2 (ja) * 2006-02-08 2011-09-14 日本電気株式会社 ペプチドのｃ末端のペプチド結合を切断する方法、及びペプチドのｃ末端アミノ酸配列の決定方法
US8501498B2 (en) 2004-07-12 2013-08-06 Dh Technologies Development Pte. Ltd. Mass tags for quantitative analyses
US8569071B2 (en) 2005-02-09 2013-10-29 Dh Technologies Development Pte. Ltd. Amine-containing compound analysis methods
US8633031B2 (en) 2004-05-19 2014-01-21 Dh Technologies Development Pte. Ltd. Expression quantification using mass spectrometry
KR20140056217A (ko) 2011-07-21 2014-05-09 와코 쥰야꾸 고교 가부시키가이샤 혈장중 아미노산 분석용 표준액
US8969089B2 (en) 2004-10-12 2015-03-03 Quest Diagnostics Investments, Inc. Analysis of amino acids in body fluid by liquid chromatography-mass spectrometry
US9274123B2 (en) 2002-02-14 2016-03-01 Ajinomoto Co., Inc. Method for analysis of compounds with amino group and analytical reagent therefor
US9772333B2 (en) 2011-09-28 2017-09-26 Water Technologies Corporation Rapid fluorescence tagging of glycans and other biomolecules with enhanced MS signals
WO2019130920A1 (ja) 2017-12-28 2019-07-04 味の素株式会社 給餌管理システムおよび給餌管理方法
US10436790B2 (en) 2011-09-28 2019-10-08 Waters Technologies Corporation Rapid fluorescence tagging of glycans and other biomolecules with enhanced MS signals
US10502720B2 (en) 2014-11-13 2019-12-10 Waters Technologies Corporation Methods for liquid chromatography calibration for rapid labeled N-glycans
WO2020067386A1 (ja) 2018-09-26 2020-04-02 味の素株式会社 軽度認知障害の評価方法、算出方法、評価装置、算出装置、評価プログラム、算出プログラム、記録媒体、評価システムおよび端末装置
US10962550B2 (en) 2004-10-12 2021-03-30 Quest Diagnostics Investments Incorporated Analysis of amino acids in body fluid by liquid chromotography-mass spectrometry
JP2021119345A (ja) * 2014-10-30 2021-08-12 ウオーターズ・テクノロジーズ・コーポレイシヨン 標識化グリコシルアミンの迅速調製およびそれを生成するグリコシル化生体分子の分析方法
US11352325B2 (en) 2011-09-28 2022-06-07 Waters Technologies Corporation Rapid fluorescence tagging of glycans and other biomolecules with enhanced MS signals
EP4428538A2 (en) 2016-06-30 2024-09-11 Ajinomoto Co., Inc. Method for evaluating postpartum ketosis
US12159718B2 (en) 2012-11-27 2024-12-03 Ajinomoto Co., Inc. Method for evaluating pancreatic cancer, pancreatic cancer evaluating apparatus, pancreatic cancer evaluating method, pancreatic cancer evaluating program product, pancreatic cancer evaluating system and information communication terminal apparatus
US12367163B2 (en) 2007-06-29 2025-07-22 Quest Diagnostics Investments Llc Analysis of amino acids in body fluid by liquid chromatography—mass spectrometry

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US20050014279A1 (en) * 2003-07-14 2005-01-20 Nguyen Hoa Duc Method of analysis of amine by mass spectrometry
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JP2007163423A (ja) * 2005-12-16 2007-06-28 Ajinomoto Co Inc 質量分析計によるアミノ酸分析方法
JP2011504596A (ja) * 2007-11-26 2011-02-10 ウオーターズ・テクノロジーズ・コーポレイシヨン サンプル中の分析物を定量測定する際に使用するための内部標準および方法
DK2252584T3 (en) 2008-02-04 2017-01-16 Prozyme Inc COMPOUNDS AND PROCEDURES FOR QUICK LABELING OF N-GLYCANS
DE102009060102A1 (de) * 2009-12-21 2011-06-22 Martin-Luther-Universität Halle-Wittenberg, 06108 Derivatisierungsreagenzien zur tandem-massenspektrometrischen Quantifizierung von Proteinen
KR101627841B1 (ko) * 2015-05-27 2016-06-07 다이아텍코리아 주식회사 싸이오크로멘 타입 화합물 및 그 용도
EP3304051B1 (en) 2015-05-29 2020-08-26 Agilent Technologies, Inc. Compounds for labeling amine-containing compounds, and their use
CN105548432A (zh) * 2015-12-18 2016-05-04 乐普药业股份有限公司 一种比伐卢定中氨基酸的检测分析方法
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CN109642906A (zh) 2016-06-21 2019-04-16 沃特世科技公司 对用两亲强碱性部分改性的聚糖进行电喷雾电离的方法
EP3472132A4 (en) 2016-06-21 2020-01-15 Waters Technologies Corporation FLUORESCENCE LABELING OF GLYCANS AND OTHER BIOMOLECULES BY REDUCING AMINATION FOR IMPROVED MASS SPECTROMETRY SIGNALS
WO2018005139A1 (en) 2016-07-01 2018-01-04 Waters Technologies Corporation Methods for the rapid preparation of labeled glycosylamines from complex matrices using molecular weight cut off filtration and on-filter deglycosylation
WO2018067398A1 (en) 2016-10-03 2018-04-12 Waters Technologies Corporation Labeled glycan amino acid complexes useful in lc-ms analysis and methods of making the same
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Cited By (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9658234B2 (en) 2002-02-14 2017-05-23 Ajinomoto Co., Inc. Method for analysis of compounds with amino group and analytical reagent therefor
US9274123B2 (en) 2002-02-14 2016-03-01 Ajinomoto Co., Inc. Method for analysis of compounds with amino group and analytical reagent therefor
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