WO2003026603A1 - Association de principes actifs, en particulier de triterpenes et cyclodextrines, a usage cosmetique et/ou dermatologique - Google Patents
Association de principes actifs, en particulier de triterpenes et cyclodextrines, a usage cosmetique et/ou dermatologique Download PDFInfo
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- WO2003026603A1 WO2003026603A1 PCT/EP2002/010042 EP0210042W WO03026603A1 WO 2003026603 A1 WO2003026603 A1 WO 2003026603A1 EP 0210042 W EP0210042 W EP 0210042W WO 03026603 A1 WO03026603 A1 WO 03026603A1
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- Prior art keywords
- cyclodextrin
- polyethylene glycol
- skin
- weight
- formulation according
- Prior art date
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- 0 CC(C)(CC[C@](CC[C@@]1(C)[C@]2(C)CC3)(C4C1=CCC2[C@@](*)(C[C@]1O)C3[C@@](C)(CO)[C@]1O)C(O[C@]([C@@]([C@]1O)O)O[C@](CO)[C@]1O)=O)C4O Chemical compound CC(C)(CC[C@](CC[C@@]1(C)[C@]2(C)CC3)(C4C1=CCC2[C@@](*)(C[C@]1O)C3[C@@](C)(CO)[C@]1O)C(O[C@]([C@@]([C@]1O)O)O[C@](CO)[C@]1O)=O)C4O 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/066—Multiple emulsions, e.g. water-in-oil-in-water
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/738—Cyclodextrins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/02—Preparations containing skin colorants, e.g. pigments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
Definitions
- the invention relates to preparations with extremely low so-called "stinging potential" and cosmetic or dermatological formulations which the skin - z. B. after sunbathing - take special care and reduce the skin's reactions to the effects of UV radiation.
- Sericoside ie the (D) -glycosyl ester of 2 ⁇ , 3ß, 19 ⁇ , 24-tetrahydroxy-olean-12-en-28-carboxy acid
- Sericoside ie the (D) -glycosyl ester of 2 ⁇ , 3ß, 19 ⁇ , 24-tetrahydroxy-olean-12-en-28-carboxy acid
- Terminalia Sericea is part of the plant extract from Terminalia Sericea.
- the termalia are large trees with hard wood, of which about 150 species occur in the tropics of all parts of the world.
- Cyclodextrins are made up of 6, 7, 8 or even more ⁇ -1, 4-linked glucose units, the cyclohexaamylose ( ⁇ -cyclodextrin) being distinguished by the structure
- Cycloheptaamylose (ß-cyclodextrin) is characterized by its structure
- Cyclooctaamylose ( ⁇ -cyclodextrin) is characterized by its structure
- Cycloenneaamylose ( ⁇ -cyclodextrin) is characterized by its structure
- Cyclodextrins can also be propoxylated or methylated. Hydroxypropyl- ⁇ -cyclodextrin, hydroxypropyl- ⁇ -cyclodextrin and methyl- ⁇ -cyclodextrin are particularly important.
- GB 1493926 describes certain pentacyclic triterpenes, also sericoside and its free carboxylic acid, as active pharmaceutical ingredients which can be incorporated into cosmetics and / or pharmaceutical preparations.
- a use for the treatment of dermatological disorders is particularly useful.
- the desirable use as an active ingredient encapsulated in cyclodextrins is not specifically disclosed.
- the object of the present invention was to convert pentacyclic triterpenes, in particular sericoside, into cosmetic and / or dermatological ones Incorporate preparations so that the corresponding active ingredient is more bioavailable and can also be incorporated stably into the preparation.
- the cyclodextrin content is 0.001-20.0% by weight, preferably 0.01-10.0% by weight, particularly preferably 0.1-5.0% by weight, based in each case the total weight of the composition is advantageous if the pentacyclic triterpenes or sericoside and / or sericoside-containing plant extracts are present, the content of pentacyclic triterpenes being selected from the range from 0.001 to 2% by weight, based on the total weight of the Preparation. It is advantageous if the mass ratio of cyclodextrin to sericoside is 1: 3 to 5: 1, preferably 2: 3 to 3: 1, particularly preferably 1: 1 to 2: 1.
- the above-mentioned preparations can advantageously be in the form of solutions, emulsions of the water-in-oil (W / O) or oil-in-water (O / W) type, multiple emulsions, for example of the water-in-oil type. in water (W / O / W) or oil-in-water-in-oil (O / W / O), hydrodispersions or lipodispersions, gels, solid sticks or aerosols, particularly preferably in the form of a cream, a lotion, a cosmetic milk, an emulsion foam which can be removed from an aerosol container and an emulsion which serves as a soaking medium for wipes.
- the invention also encompasses a cosmetic method for preventing and / or combating inflammatory skin conditions and / or skin protection in the case of sensitive, determined dry skin, and for caring for the skin after exposure to sunlight and / or for reducing the after-reaction of the skin to the action of UV radiation or a cosmetic method for immunostimulation of the skin, preferably for immunostimulation in the sense of treating injured skin, particularly preferably for treating wounds, characterized in that the formulation according to the invention is brought into contact with the affected area.
- the active substance combinations according to the invention or cosmetic or dermatological preparations containing such active substance combinations are extremely satisfactory preparations in every respect. It was not foreseeable for the person skilled in the art that the preparations according to the invention
- the active ingredient according to the invention or cosmetic or topical dermatological preparations with an effective content of the active ingredient according to the invention also serves in a surprising manner
- laser and abrasive treatments serve the reduction of skin folds and scars to counteract the resulting skin irritation and to promote the regeneration processes in the injured skin.
- the addition of at least one further cyclodextrin and / or cyclodextrin derivative, selected from the group of the native cyclodextrins ⁇ -, ⁇ - and ⁇ -cyclodextrin, is wholly or partly etherified and / or esterified and / or esterified on the hydroxyl groups differently derivatized ⁇ -, ⁇ - and ⁇ -cyclodextrins, in particular the hydroxypropyl- ⁇ -cyclodextrin, hydroxypropyl- ⁇ -cyclodextrin and the methyl- ⁇ -cyclodextrin.
- a concentration of 0.001 to 20% and in particular of 0.1 to 5% by weight, based on the total weight of the preparation, of at least one cyclodextrin species and / or its derivatives is advantageous.
- cyclodextrins and / or cyclodextrin derivatives to increase the solubility of sericoside is advantageous according to the invention.
- cyclodextrins and / or cyclodextrin derivatives to improve the biological effectiveness of sericoside is also advantageous. It is particularly important that pentacyclic triterpenes contained in Terminalia sericea and cyclodextrins form host-guest compounds. These are the reason for the special properties of the preparations according to the invention.
- thiols e.g. thioredoxin, Glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl, oleyi, ⁇ -linoleyl, cholesteryl and glyceryl esters ) and their salts, dilauryl thiodipropionate, distearyl thio dipropionate, thiodipropionic acid and their derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) as well as sulfoximine compounds (e.g.
- buthionine sulfoximines in very low tolerable doses (e.g. pmol to ⁇ mol / kg), also (metal) chelators (e.g. ⁇ -hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin), ⁇ -hydroxy acids (e.g.
- citric acid citric acid, lactic acid, malic acid
- humic acid bile acid
- Biliary extracts bilirubin, biliverdin, EDTA, EGTA and their derivatives
- unsaturated fatty acids and their derivatives e.g. ⁇ -linolenic acid, linoleic acid, oleic acid
- folic acid and their derivatives ubiquinone and ubiquinol and their derivatives
- vitamin C and derivatives e.g. ascorbyl palmitate, Mg ascorbyl phosphate, ascorbyl acetate
- tocopherols and derivatives e.g.
- vitamin E acetate
- vitamin A and derivatives vitamin A palmitate
- ⁇ -Lipoic acids ubiquinone, Q10 and ⁇ -glycosylrutin are particularly preferred.
- the amount of the antioxidants (one or more compounds) in the preparations is preferably 0.001 to 30% by weight, particularly preferably 0.05 to 20% by weight, in particular 1 to 10% by weight, based on the total weight of the preparation ,
- vitamin E and / or its derivatives represent the antioxidant (s)
- vitamin A or vitamin A derivatives or carotenes or their derivatives represent the antioxidant or antioxidants, it is advantageous to determine their respective concentrations from the range from 0.001-10% by weight, based on the total weight of the formulation.
- Medical topical compositions in the sense of the present invention generally contain one or more medicaments in an effective concentration.
- medicaments in an effective concentration.
- Preparations according to the invention can also advantageously contain substances which absorb UV radiation in the UVB range, the total amount of filter substances e.g. 0.1% by weight to 30% by weight, preferably 0.5 to 10% by weight, in particular 1.0 to 6.0% by weight, based on the total weight of the preparations, in order to produce cosmetic preparations To provide that protect the hair or skin from the entire range of ultraviolet radiation. They can also serve as a sunscreen for the hair.
- the inorganic pigments are in hydrophobic form, i.e. that they have been treated to be water-repellent on the surface.
- This surface treatment can consist in that the pigments are provided with a thin hydrophobic layer by methods known per se.
- Such a method consists, for example, in that the hydrophobic surface layer according to a direction
- n and m are stoichiometric parameters to be used at will, R and R 'are the desired organic radicals.
- hydrophobized pigments shown in analogy to DE-OS 33 14 742 are advantageous.
- Advantageous TiO 2 pigments are available, for example, under the trade names MT 100 T from TAYCA, M 160 from Kemira and T 805 from Degussa.
- the prophylaxis or the cosmetic or dermatological treatment with the active ingredient used according to the invention or with the cosmetic or topical dermatological preparations with an effective content of active ingredient used according to the invention is carried out in the usual way, namely in such a way that the active ingredient used according to the invention or the cosmetic or topical dermatological preparations with an effective content of active ingredient used according to the invention is applied to the affected skin areas.
- the active ingredient used according to the invention can advantageously be incorporated into customary cosmetic and dermatological preparations, which come in various forms can be present.
- they can be a solution, an emulsion of the type water-in-oil (W / O) or of the type oil-in-water (O / W), or a multiple emulsions, for example of the type water-in-oil-in -Water (W / O / W) or oil-in-water-in-oil (O / W / O), a hydrodispersion or lipodispersion, a gel, a solid stick or an aerosol.
- Oils such as triglycerides of capric or caprylic acid as well as natural oils such as e.g. Castor oil;
- Silicone oils such as dimethylpolysiloxanes, diethylpolysiloxanes, diphenylpolysiloxanes and mixed forms thereof.
- the oils are advantageously selected from the group of the esters from saturated and / or unsaturated, branched and / or unbranched alkane carboxylic acids with a chain length of 3 to 30 carbon atoms and saturated and / or unsaturated, branched and / or unbranched alcohols with a chain length of 3 to 30 carbon atoms, from the group of esters of aromatic carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols with a chain length of 3 to 30 carbon atoms.
- any mixtures of such oil and wax components can also be used advantageously for the purposes of the present invention. It may also be advantageous to use waxes, for example cetyl palmitate, as the sole lipid component of the oil phase.
- hydrocarbons paraffin oil, squalane and squalene can be used advantageously for the purposes of the present invention.
- the oil phase can also contain cyclic or linear silicone oils or consist entirely of such oils, although it is preferred, in addition to the silicone oil or silicone oils, to have an additional content of other oil phase compounds.
- Such silicones or silicone oils can be present as monomers, which are generally characterized by structural elements, as follows:
- Cyclomethicone e.g. decamethylcyclopentasiloxane
- silicone oils can also be used advantageously for the purposes of the present invention, for example undecamethylcyclotrisiloxane, polydimethylsiloxane, poly (methylphenylsiloxane), cetyldimethicone, behenoxydimethicone.
- the aqueous phase of the preparations according to the invention optionally advantageously contains alcohols, diols or polyols of low C number, and also their ethers, preferably ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether , Diethy- glycol monomethyiV or - ⁇ monoethyl ether and analog products, further-alcohols of low carbon number, for example ethanol, isopropanol, 1, 2-propanediol, glycerol and in particular one or more thickening agents, which one or which can be advantageously selected from the group silicon dioxide , Aluminum silicates.
- alcohols, diols or polyols of low C number and also their ethers, preferably ethanol, isopropanol, propylene glycol, g
- Hydrocolloids These hydrocolloids can advantageously be selected from the aforementioned group.
- Gums include plant or tree sap that harden in the air and form resins or extracts from aquatic plants. Gum arabic, locust bean gum, tragacanth, karaya, guar gum, pectin, gellan gum, carrageenan, agar, algine, chondrus, xanthan gum can advantageously be selected from this group for the purposes of the present invention.
- derivatized gums such as e.g. Hydroxypropyl guar (Jaguar® HP 8).
- polysaccharides and dehvates are e.g. Hyaluronic acid, chitin and chitosan, chondroitin sulfates, starch and starch derivatives.
- cellulose derivatives are e.g. Methyl cellulose, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose.
- Layered silicates contain naturally occurring and synthetic clays such as Montmorillonite, bentonite, hectorite, laponite, magnesium aluminum silicates such as Veegum®. These can be used as such or in a modified form such as e.g. Stearylalkonium hektorite.
- silica gels can also advantageously be used.
- the polyacrylates include e.g. Carbopol types from Goodrich (Carbopol 980, 981, 1382, 5984, 2984, ETD 2001, ETD 2020, ETD 2050, Ultrez 10 or Pemulen TR1 & TR2).
- Carbopol types from Goodrich (Carbopol 980, 981, 1382, 5984, 2984, ETD 2001, ETD 2020, ETD 2050, Ultrez 10 or Pemulen TR1 & TR2).
- polymers e.g. Polyacrylamides (Seppigel 305), polyvinyl alcohols, PVP, PVP / VA copolymers, polyglycols.
- Preparations according to the invention in the form of emulsions contain one or more emulsifiers.
- emulsifiers can advantageously be selected from the group of nonionic, anionic, cationic or amphoteric emulsifiers.
- nonionic emulsifiers are those that are nonionic emulsifiers.
- Partial fatty acid esters and fatty acid esters of polyhydric alcohols and their ethoxylated derivatives e.g. glyceryl monostearates, sorbitan stearates, glyceryl stearyl citrates, sucrose stearates
- ethoxylated fatty alcohols and fatty acids e.g. glyceryl monostearates, sorbitan stearates, glyceryl stearyl citrates, sucrose stearates
- alkylphenol polyglycol ether e.g. Triton X
- Sugar derivatives esters and / or ethers of glucose, sucrose and other sugars; e.g. alkyl polyglucose such as polyglyceryl-3-methyl glucose distearate, methyl glucose sesquistearate)
- soaps e.g. sodium stearate
- amphoteric emulsifiers are amphoteric emulsifiers.
- emulsifiers which include beeswax, wool wax, lecithin and sterols.
- O / W emulsifiers can, for example, advantageously be selected from the group of the polyethoxylated or polypropoxylated or polyethoxylated and polypropoxylated products, e.g .:
- RO - (- CH 2 -CH 2 -O-) n -CH 2 -COOH and n represent a number from 5 to 30,
- alkyl ether sulfates of the general formula RO - (- CH 2 -CH 2 -O-) n -SO 3 -H
- alkyl ether sulfates or the acids on which these sulfates are based of the general formula RO - (- CH 2 -CH (CH 3 ) -O-) n -SO 3 -H
- the polyethoxylated or polypropoxylated or polyethoxylated and polypropoxylated O / W emulsifiers selected are particularly advantageously selected from the group of substances with HLB values of 11-18, very particularly advantageously with HLB values of 14.5-15. 5, provided the O ⁇ / V emulsifiers have saturated radicals R and R '. If the O W emulsifiers have unsaturated radicals R and / or R ', or if isoalkyl derivatives are present, the preferred HLB value of such emulsifiers can also be lower or higher.
- fatty alcohol ethoxylates from the group of the ethoxylated stearyl alcohols, cetyl alcohols, cetylstearyl alcohols (cetearyl alcohols).
- cetyl alcohols cetylstearyl alcohols
- cetearyl alcohols cetearyl alcohols
- Polyethylene glycol (12) lauryl ether (Laureth-12), polyethylene glycol (12) isolauryl ether (Isolaueth-12).
- Sodium laureth-11 carboxylate can advantageously be used as the ethoxylated alkyl ether carboxylic acid or its salt.
- Sodium laureth 1-4 sulfate can advantageously be used as alkyl ether sulfate.
- Polyethylene glycol (30) cholesteryl ether can advantageously be used as the ethoxylated cholesterol derivative.
- Polyethylene glycol (25) soyasterol has also proven itself.
- polyethylene glycol (20) glyceryl laurate polyethylene glycol (21) glyceryl laurate
- polyethylene glycol (22) glyceryl laurate polyethylene glycol (23) glyceryl laur
- sorbitan esters from the group consisting of polyethylene glycol (20) sorbitan monolaurate, polyethylene glycol (20) sorbitan monostearate, polyethylene glycol (20) sorbitan monoisostearate, polyethylene glycol (20) sorbitan monopalmitate, polyethylene glycol (20) sorbitan monooleate.
- W / O emulsifiers that can be used are: fatty alcohols with 8 to 30 carbon atoms, monoglycerol esters of saturated and / or unsaturated, branched and / or unbranched aikanecarboxylic acids with a chain length of 8 to 24, in particular 12 to 18 carbon atoms, diglycerol esters saturated and / or unsaturated, branched and / or unbranched aikanecarboxylic acids with a chain length of 8 to 24, in particular 12 - 18 C atoms, monoglycerol ethers saturated and / or unsaturated, branched and / or unbranched alcohols with a chain length of 8 to 24, in particular 12 - 18 C- Atoms, diglycerin ethers of saturated and / or unsaturated, branched and / or unbranched alcohols with a chain length of 8 to 24, in particular 12-18 C atoms, propylene glycol esters of saturated and / or unsaturated,
- W / O emulsifiers are glyceryl stearate Glycerylmonoiso-, glyceryl monomyristate, glyceryl, diglyceryl monostearate, Diglycerylmono- isostearate, propylene glycol caprylate, propylene glycol monoisostearate, propylene glycol, propylene glycol, sorbitan, sorbitan, sorbitan monocaprylate, Sorbitanmonoisooleat, sucrose, cetyl alcohol, stearyl alcohol, Arachidyl alcohol, behenyl alcohol, isobehenyl alcohol, selachyl alcohol, chimyl alcohol, polyethylene glycol (2) stearyl ether (Steareth-2), glyceryl monolaurate, glyceryl monocaprinate, glyceryl monocaprylate.
- Glycerol, panthenol, chitosan, fucogel, propylene glycol, dipropylene glycol, butylene glycol, mannitol, lactic acid can advantageously be used as skin moisturizers.
- Glycerol, lactic acid, butylene glycol, urea, hyaluronic acid are particularly suitable.
- the content of skin moisturizers is advantageously 1% by weight to 30% by weight, preferably 2 to 25% by weight, in particular 5 to 20% by weight, based on the total weight of the preparations.
- Preparations according to the invention can also contain anionic, nonionic and / or amphoteric surfactants, especially if crystalline or microcrystalline solids, for example inorganic micropigments, are to be incorporated into the preparations according to the invention.
- Surfactants are amphiphilic substances that can dissolve organic, non-polar substances in water.
- hydrophilic parts of a surfactant molecule are mostly polar functional groups, for example -COO " , -OSO 3 2" , -SO 3 ⁇ , while the hydrophobic parts generally represent non-polar hydrocarbon radicals.
- Surfactants are generally classified according to the type and charge of the hydrophilic part of the molecule. There are four groups:
- the surface-active substance can be present in the preparations according to the invention in a concentration between 1 and 30% by weight, based on the total weight of the preparations.
- Example 12 Gel cream or hydrodispersion
Abstract
L'invention concerne une formulation cosmétique et/ou dermatologique présentant une certaine teneur en cyclodextrines et triterpènes pentacycliques, notamment en séricoside.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10146500A DE10146500A1 (de) | 2001-09-21 | 2001-09-21 | Kosmetische und/oder dermatologische Wirkstoffkombination |
DE10146500.9 | 2001-09-21 |
Publications (1)
Publication Number | Publication Date |
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WO2003026603A1 true WO2003026603A1 (fr) | 2003-04-03 |
Family
ID=7699753
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/EP2002/010042 WO2003026603A1 (fr) | 2001-09-21 | 2002-09-07 | Association de principes actifs, en particulier de triterpenes et cyclodextrines, a usage cosmetique et/ou dermatologique |
Country Status (2)
Country | Link |
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DE (1) | DE10146500A1 (fr) |
WO (1) | WO2003026603A1 (fr) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2414479A (en) * | 2004-05-27 | 2005-11-30 | Croda Int Plc | Reactive cyclodextrins derivatised with proteins |
WO2008037226A3 (fr) * | 2006-09-27 | 2008-07-31 | Univerzita Karlova V Praze Pri | Procédé d'élaboration d'une préparation soluble de terpénoïdes tétra- et pentacycliques insolubles dans l'eau, préparation soluble d'un terpénoïde tétra- ou pentacyclique et composition pharmaceutique contenant cette préparation soluble |
EP2363108A1 (fr) * | 2010-03-02 | 2011-09-07 | Neubourg Skin Care GmbH & Co. KG | Formulation d'une mousse contenant au moins un triterpénoïde |
WO2012058722A1 (fr) * | 2010-11-03 | 2012-05-10 | Cimtech Pty Limited | Procédés et compositions pour maintenir et améliorer la santé de la peau |
US9468590B2 (en) | 2009-12-10 | 2016-10-18 | Neubourg Skin Care Gmbh & Co. Kg | Emulsifier-free, polymer-stabilized foam formulations |
FR3095754A1 (fr) * | 2019-05-10 | 2020-11-13 | Pierre Fabre Dermo-Cosmetique | Triterpènes pentacycliques dans le traitement du vitiligo |
IT202200010646A1 (it) * | 2022-05-23 | 2023-11-23 | Giuliani Spa | Forme di dosaggio per la somministrazione topica di triterpeni pentaciclici |
RU2816950C2 (ru) * | 2019-05-10 | 2024-04-08 | Пьер Фабр Дермо-Косметик | Пентациклические тритерпены в лечении витилиго |
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GB1493926A (en) * | 1974-01-29 | 1977-11-30 | Inverni Della Beffa Spa | Pentacyclic triterpenes obtainable from terminalia sericea and their derivatives |
JPS61227517A (ja) * | 1985-04-01 | 1986-10-09 | Lion Corp | 皮膚化粧料 |
EP0283713A2 (fr) * | 1987-02-26 | 1988-09-28 | INDENA S.p.A. | Complexes de saponines avec des phospholipides et compositions pharmaceutiques et cosmétiques les contenant |
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GB2414479A (en) * | 2004-05-27 | 2005-11-30 | Croda Int Plc | Reactive cyclodextrins derivatised with proteins |
WO2008037226A3 (fr) * | 2006-09-27 | 2008-07-31 | Univerzita Karlova V Praze Pri | Procédé d'élaboration d'une préparation soluble de terpénoïdes tétra- et pentacycliques insolubles dans l'eau, préparation soluble d'un terpénoïde tétra- ou pentacyclique et composition pharmaceutique contenant cette préparation soluble |
CZ300722B6 (cs) * | 2006-09-27 | 2009-07-22 | Univerzita Karlova v Praze, Prírodovedecká fakulta | Zpusob prípravy inkluzního komplexu pentacyklických a tetracyklických terpenoidu a farmaceutického prostredku obsahujícího tento inkluzní komplex, inkluzní komplex pentacyklického nebo tetracyklického terpenoidu a farmaceutický prostredek obsahující |
JP2010504921A (ja) * | 2006-09-27 | 2010-02-18 | ウニヴェルジタ カルロヴァ ウ プラゼ,プリーロドヴェデカー ファクルタ | 水不溶性の五環性テルペノイドおよび四環性テルペノイドの可溶性処方物の調製方法、五環性テルペノイドまたは四環性テルペノイドの可溶性処方物、およびこの可溶性処方物を含んだ薬学的組成物 |
US9468590B2 (en) | 2009-12-10 | 2016-10-18 | Neubourg Skin Care Gmbh & Co. Kg | Emulsifier-free, polymer-stabilized foam formulations |
EP2363108A1 (fr) * | 2010-03-02 | 2011-09-07 | Neubourg Skin Care GmbH & Co. KG | Formulation d'une mousse contenant au moins un triterpénoïde |
CN102883701A (zh) * | 2010-03-02 | 2013-01-16 | 诺伊堡皮肤护理两合公司 | 包含至少一种三萜类化合物的泡沫制剂 |
WO2011107522A3 (fr) * | 2010-03-02 | 2011-12-22 | Neubourg Skin Care Gmbh & Co. Kg | Formulations de mousse contenant au moins un triterpénoïde |
CN102883701B (zh) * | 2010-03-02 | 2016-10-26 | 诺伊堡皮肤护理两合公司 | 包含至少一种三萜类化合物的泡沫制剂 |
EA027038B1 (ru) * | 2010-03-02 | 2017-06-30 | Нойбург Скин Кэйр Гмбх & Ко. Кг | Составы в виде пены, содержащие по меньшей мере один тритерпеноид |
WO2012058722A1 (fr) * | 2010-11-03 | 2012-05-10 | Cimtech Pty Limited | Procédés et compositions pour maintenir et améliorer la santé de la peau |
FR3095754A1 (fr) * | 2019-05-10 | 2020-11-13 | Pierre Fabre Dermo-Cosmetique | Triterpènes pentacycliques dans le traitement du vitiligo |
WO2020229403A1 (fr) * | 2019-05-10 | 2020-11-19 | Pierre Fabre Dermo-Cosmetique | Triterpènes pentacycliques dans le traitement du vitiligo |
RU2816950C2 (ru) * | 2019-05-10 | 2024-04-08 | Пьер Фабр Дермо-Косметик | Пентациклические тритерпены в лечении витилиго |
IT202200010646A1 (it) * | 2022-05-23 | 2023-11-23 | Giuliani Spa | Forme di dosaggio per la somministrazione topica di triterpeni pentaciclici |
WO2023228079A1 (fr) * | 2022-05-23 | 2023-11-30 | Giuliani S.P.A. | Formes posologiques pour l'administration topique de triterpènes pentacycliques |
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