WO2003024942A1 - Derive thiazolidine et son utilisation medicamenteuse - Google Patents
Derive thiazolidine et son utilisation medicamenteuse Download PDFInfo
- Publication number
- WO2003024942A1 WO2003024942A1 PCT/JP2002/009419 JP0209419W WO03024942A1 WO 2003024942 A1 WO2003024942 A1 WO 2003024942A1 JP 0209419 W JP0209419 W JP 0209419W WO 03024942 A1 WO03024942 A1 WO 03024942A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- thiazolidine derivative
- remedy
- preventive
- medicinal use
- derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003528790A JPWO2003024942A1 (ja) | 2001-09-14 | 2002-09-13 | チアゾリジン誘導体およびその医薬用途 |
US10/489,622 US20040259883A1 (en) | 2001-09-14 | 2002-09-13 | Thiazolidine derivative and medicinal use thereof |
CA002460512A CA2460512A1 (en) | 2001-09-14 | 2002-09-13 | Thiazolidine derivatives and medicinal use thereof |
EP02767958A EP1426366A4 (en) | 2001-09-14 | 2002-09-13 | THIAZOLIDE DERIVATIVES AND THEIR MEDICAL USE |
KR10-2004-7003689A KR20040033048A (ko) | 2001-09-14 | 2002-09-13 | 티아졸리딘 유도체 및 이의 약학적 용도 |
US11/774,941 US7790725B2 (en) | 2001-09-14 | 2007-07-09 | Thiazolidine derivatives and medicinal use thereof |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001279084 | 2001-09-14 | ||
JP2001-279084 | 2001-09-14 | ||
JP2001304650 | 2001-09-28 | ||
JP2001-304650 | 2001-09-28 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10489622 A-371-Of-International | 2002-09-13 | ||
US11/774,941 Division US7790725B2 (en) | 2001-09-14 | 2007-07-09 | Thiazolidine derivatives and medicinal use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003024942A1 true WO2003024942A1 (fr) | 2003-03-27 |
Family
ID=26622197
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2002/009419 WO2003024942A1 (fr) | 2001-09-14 | 2002-09-13 | Derive thiazolidine et son utilisation medicamenteuse |
Country Status (8)
Country | Link |
---|---|
US (2) | US20040259883A1 (ja) |
EP (1) | EP1426366A4 (ja) |
JP (1) | JPWO2003024942A1 (ja) |
KR (1) | KR20040033048A (ja) |
CN (1) | CN100341862C (ja) |
CA (1) | CA2460512A1 (ja) |
TW (1) | TWI246510B (ja) |
WO (1) | WO2003024942A1 (ja) |
Cited By (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004016587A1 (ja) * | 2002-08-19 | 2004-02-26 | Ono Pharmaceutical Co., Ltd. | 含窒素化合物 |
WO2004098591A2 (en) | 2003-05-05 | 2004-11-18 | Probiodrug Ag | Inhibitors of glutaminyl cyclase and their use in the treatment of neurological diseases |
WO2004098625A2 (en) | 2003-05-05 | 2004-11-18 | Probiodrug Ag | Medical use of inhibitors of glutaminyl and glutamate cyclases |
WO2005075436A2 (en) | 2004-02-05 | 2005-08-18 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
WO2006001750A1 (en) * | 2004-06-24 | 2006-01-05 | Astrazeneca Ab | Imidazole variants as modulators of gaba receptor for the treatment of gi disorders |
US7026316B2 (en) | 2001-03-27 | 2006-04-11 | Merck & Co., Inc. | Dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
WO2006073167A1 (ja) * | 2005-01-07 | 2006-07-13 | Ono Pharmaceutical Co., Ltd. | ピロリジン誘導体 |
US7132443B2 (en) | 2001-06-27 | 2006-11-07 | Smithklinebeecham Corporation | Fluoropyrrolidines as dipeptidyl peptidase inhibitors |
WO2006129785A1 (ja) * | 2005-06-03 | 2006-12-07 | Mitsubishi Tanabe Pharma Corporation | 医薬の併用およびその用途 |
WO2007120702A2 (en) | 2006-04-11 | 2007-10-25 | Arena Pharmaceuticals, Inc. | Use of gpr119 receptor agonists for increasing bone mass and for treating osteoporosis, and combination therapy relating thereto |
US7348346B2 (en) | 2004-03-08 | 2008-03-25 | Abbott Laboratories | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) |
WO2008055945A1 (en) | 2006-11-09 | 2008-05-15 | Probiodrug Ag | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
WO2008065141A1 (en) | 2006-11-30 | 2008-06-05 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
WO2008120813A1 (ja) | 2007-04-03 | 2008-10-09 | Mitsubishi Tanabe Pharma Corporation | ジペプチジルペプチダーゼ4阻害化合物と甘味料との併用 |
EP2088154A1 (en) | 2004-03-09 | 2009-08-12 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
EP2116235A1 (en) | 2005-01-10 | 2009-11-11 | Arena Pharmaceuticals, Inc. | Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP-1 level |
EP2165703A2 (en) | 2004-01-20 | 2010-03-24 | Novartis Pharma AG. | Direct compression formulation and process |
US7696250B2 (en) | 2005-03-21 | 2010-04-13 | Virobay, Inc. | Alpha ketoamide compounds as cysteine protease inhibitors |
WO2010047982A1 (en) | 2008-10-22 | 2010-04-29 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
WO2010051206A1 (en) | 2008-10-31 | 2010-05-06 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
US7728146B2 (en) | 2006-04-12 | 2010-06-01 | Probiodrug Ag | Enzyme inhibitors |
EP2191824A1 (en) | 2005-06-10 | 2010-06-02 | Novartis AG | Modified release 1-[(3-hydroxy-adamant-1-ylamino)-acetyl]-pyrrolidine-2(s)-carbonitrile formulation |
EP2206496A1 (en) | 2003-05-05 | 2010-07-14 | Probiodrug AG | Medical use of inhibitors of glutaminyl and glutamate cyclases |
US7842707B2 (en) | 2004-07-23 | 2010-11-30 | Nuada, Llc | Peptidase inhibitors |
WO2011005929A1 (en) | 2009-07-09 | 2011-01-13 | Arena Pharmaceuticals, Inc. | Piperidine derivative and its use for the treatment of diabets and obesity |
EP2289498A1 (en) | 2003-10-15 | 2011-03-02 | Probiodrug AG | Use of inhibitors of glutaminyl clyclase |
WO2011029920A1 (en) | 2009-09-11 | 2011-03-17 | Probiodrug Ag | Heterocylcic derivatives as inhibitors of glutaminyl cyclase |
EP2305352A1 (en) | 2004-04-02 | 2011-04-06 | Merck Sharp & Dohme Corp. | 5-alpha-reductase inhibitors for use in the treatment of men with metabolic and anthropometric disorders |
WO2011069038A2 (en) | 2009-12-03 | 2011-06-09 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
US7960384B2 (en) | 2006-03-28 | 2011-06-14 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
EP2338490A2 (en) | 2003-11-03 | 2011-06-29 | Probiodrug AG | Combinations Useful for the Treatment of Neuronal Disorders |
WO2011106273A1 (en) | 2010-02-25 | 2011-09-01 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
WO2011107530A2 (en) | 2010-03-03 | 2011-09-09 | Probiodrug Ag | Novel inhibitors |
WO2011110613A1 (en) | 2010-03-10 | 2011-09-15 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
WO2011127051A1 (en) | 2010-04-06 | 2011-10-13 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
US8084605B2 (en) | 2006-11-29 | 2011-12-27 | Kelly Ron C | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
WO2012040279A1 (en) | 2010-09-22 | 2012-03-29 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
US8222411B2 (en) | 2005-09-16 | 2012-07-17 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
WO2012116145A1 (en) | 2011-02-25 | 2012-08-30 | Merck Sharp & Dohme Corp. | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
WO2012123563A1 (en) | 2011-03-16 | 2012-09-20 | Probiodrug Ag | Benz imidazole derivatives as inhibitors of glutaminyl cyclase |
WO2012135570A1 (en) | 2011-04-01 | 2012-10-04 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
WO2012145604A1 (en) | 2011-04-22 | 2012-10-26 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
WO2012145361A1 (en) | 2011-04-19 | 2012-10-26 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
WO2012145603A1 (en) | 2011-04-22 | 2012-10-26 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
WO2012165547A1 (ja) * | 2011-06-01 | 2012-12-06 | 田辺三菱製薬株式会社 | ピラゾール誘導体の製造方法 |
WO2012170702A1 (en) | 2011-06-08 | 2012-12-13 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
WO2013055910A1 (en) | 2011-10-12 | 2013-04-18 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
WO2013138352A1 (en) | 2012-03-15 | 2013-09-19 | Synergy Pharmaceuticals Inc. | Formulations of guanylate cyclase c agonists and methods of use |
WO2013154109A1 (ja) * | 2012-04-10 | 2013-10-17 | 大日本住友製薬株式会社 | 新規1位置換インダゾール誘導体 |
WO2014022528A1 (en) | 2012-08-02 | 2014-02-06 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
WO2014061031A1 (en) | 2012-10-17 | 2014-04-24 | Cadila Healthcare Limited | 2-phenyl-5-heterocyclyl-tetrahydro-2h-pyran-3-amine compounds for use in the treatment of diabetes and its associated disorders |
WO2014074668A1 (en) | 2012-11-08 | 2014-05-15 | Arena Pharmaceuticals, Inc. | Modulators of gpr119 and the treatment of disorders related thereto |
WO2014130608A1 (en) | 2013-02-22 | 2014-08-28 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
WO2014139388A1 (en) | 2013-03-14 | 2014-09-18 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
WO2014151200A2 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
WO2014151206A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
US8853385B2 (en) | 2008-01-17 | 2014-10-07 | Mitsubishi Tanabe Pharma Corporation | Combination therapy comprising SGLT inhibitors and DPP4 inhibitors |
US8883714B2 (en) | 2008-04-07 | 2014-11-11 | Arena Pharmaceuticals, Inc. | Pharmaceutical compositions comprising GPR119 agonists which act as peptide YY (PYY) secretagogues |
US8906901B2 (en) | 2005-09-14 | 2014-12-09 | Takeda Pharmaceutical Company Limited | Administration of dipeptidyl peptidase inhibitors |
EP2810951A2 (en) | 2008-06-04 | 2014-12-10 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
WO2014197720A2 (en) | 2013-06-05 | 2014-12-11 | Synergy Pharmaceuticals, Inc. | Ultra-pure agonists of guanylate cyclase c, method of making and using same |
EP2839832A2 (en) | 2003-11-17 | 2015-02-25 | Novartis AG | Use of dipeptidyl peptidase IV inhibitors |
WO2015051725A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
EP2865670A1 (en) | 2007-04-18 | 2015-04-29 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
JP2015096495A (ja) * | 2013-10-08 | 2015-05-21 | 大日本住友製薬株式会社 | 新規1位置換インダゾール誘導体からなる医薬 |
EP2998314A1 (en) | 2007-06-04 | 2016-03-23 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
EP3241839A1 (en) | 2008-07-16 | 2017-11-08 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
WO2018106518A1 (en) | 2016-12-06 | 2018-06-14 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
WO2018118670A1 (en) | 2016-12-20 | 2018-06-28 | Merck Sharp & Dohme Corp. | Antidiabetic spirochroman compounds |
EP3461819A1 (en) | 2017-09-29 | 2019-04-03 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
US10555929B2 (en) | 2015-03-09 | 2020-02-11 | Coherus Biosciences, Inc. | Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy |
US11253508B2 (en) | 2017-04-03 | 2022-02-22 | Coherus Biosciences, Inc. | PPARy agonist for treatment of progressive supranuclear palsy |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1894234A (zh) | 2003-03-25 | 2007-01-10 | 武田药品工业株式会社 | 二肽基肽酶抑制剂 |
US7678909B1 (en) | 2003-08-13 | 2010-03-16 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US7723344B2 (en) | 2003-08-13 | 2010-05-25 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
US7169926B1 (en) | 2003-08-13 | 2007-01-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
EP1699777B1 (en) | 2003-09-08 | 2012-12-12 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US7732446B1 (en) | 2004-03-11 | 2010-06-08 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
CN102134230B (zh) | 2004-03-15 | 2019-06-28 | 武田药品工业株式会社 | 二肽基肽酶抑制剂 |
EP1753748B1 (en) | 2004-05-12 | 2009-07-29 | Pfizer Products Inc. | Proline derivatives and their use as dipeptidyl peptidase iv inhibitors |
US7687638B2 (en) | 2004-06-04 | 2010-03-30 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
WO2006008644A1 (en) * | 2004-07-13 | 2006-01-26 | Pfizer Products Inc. | Antidiabetic compounds |
WO2006019965A2 (en) | 2004-07-16 | 2006-02-23 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
EP1828192B1 (en) | 2004-12-21 | 2014-12-03 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
NZ561489A (en) | 2005-02-18 | 2010-10-29 | Mitsubishi Tanabe Pharma Corp | Salt of proline derivative, solvate thereof, and production method thereof |
WO2006116157A2 (en) | 2005-04-22 | 2006-11-02 | Alantos Pharmaceuticals Holding, Inc. | Dipeptidyl peptidase-iv inhibitors |
US20090149504A1 (en) * | 2005-06-17 | 2009-06-11 | Aurigene Discovery Technologies Limited | Novel 5-Substituted Indole Derivatives As Dipeptidyl Peptidase IV (DPP-IV) Inhibitors |
JP2009521426A (ja) * | 2005-12-23 | 2009-06-04 | アストラゼネカ・アクチエボラーグ | ヘテロ環gaba−bモジュレーター |
EP1968947A1 (en) * | 2005-12-23 | 2008-09-17 | AstraZeneca AB | Gaba-b receptor modulators |
KR20080090449A (ko) * | 2005-12-23 | 2008-10-08 | 아스트라제네카 아베 | Gerd 및 ibs의 치료를 위한 피라졸 |
US20080312305A1 (en) * | 2005-12-23 | 2008-12-18 | Udo Bauer | Imidazoles as Gaba- B Receptor Modulators |
CA2632016A1 (en) * | 2005-12-23 | 2007-06-28 | Astrazeneca Ab | Imidazole derivatives for the treatment of gastrointestinal disorders |
DK1971862T3 (da) | 2006-04-11 | 2011-02-14 | Arena Pharm Inc | Fremgangsmåder til anvendelse af GPR119-receptor til identificering af forbindelser anvendelige til øgning af knoglemasse hos en person |
JP5323684B2 (ja) | 2006-05-04 | 2013-10-23 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 多形体 |
PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
JP2010526033A (ja) * | 2007-04-18 | 2010-07-29 | アストラゼネカ・アクチエボラーグ | 正のアロステリックgabab受容体モジュレータ効果を有するキサンチン化合物 |
WO2008130313A1 (en) * | 2007-04-18 | 2008-10-30 | Astrazeneca Ab | Imidazole derivatives as modulators of the gaba receptor for the treatment of gastrointestinal disorders |
PE20091730A1 (es) | 2008-04-03 | 2009-12-10 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
EP2488030B1 (de) | 2009-10-12 | 2015-01-07 | Bayer CropScience AG | 1-(pyrid-3-yl)-pyrazole und 1-(pyrimid-5-yl)-pyrazole als schädlingsbekämpfungsmittel |
AR083878A1 (es) | 2010-11-15 | 2013-03-27 | Boehringer Ingelheim Int | Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento |
AR104882A1 (es) | 2015-06-05 | 2017-08-23 | Orion Corp | DERIVADOS DE 2-(1-HETEROARILPIPERAZIN-4-IL)METIL-1,4-BENZODIOXANO COMO ANTAGONISTAS DE a2C |
CN105085510B (zh) * | 2015-09-11 | 2018-03-02 | 沧州那瑞化学科技有限公司 | 一种(s)‑4‑氧代‑2‑(噻唑烷‑3‑羰基)吡咯烷‑1‑羧酸叔丁酯的制备方法 |
EP3496715B1 (en) | 2016-08-15 | 2021-11-03 | Merck Sharp & Dohme Corp. | Compounds useful for altering the levels of bile acids for the treatment of diabetes and cardiometabolic disease |
US10414774B2 (en) | 2016-08-15 | 2019-09-17 | Merck Sharp & Dohme Corp. | Compound useful for altering the levels of bile acids for the treatment of diabetes and cardiometabolc disease |
KR102068299B1 (ko) * | 2018-12-21 | 2020-01-20 | 한국기초과학지원연구원 | Cyp4a 저해 화합물을 유효성분으로 포함하는 대사질환의 예방 또는 치료용 조성물 |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0450352A1 (en) * | 1990-03-30 | 1991-10-09 | POLI INDUSTRIA CHIMICA S.p.A. | Liposome formulations of immunomodulating drugs for the topical and aerosol administrations |
WO1995015309A1 (en) * | 1993-12-03 | 1995-06-08 | Ferring B.V. | Dp-iv-serine protease inhibitors |
US5462928A (en) * | 1990-04-14 | 1995-10-31 | New England Medical Center Hospitals, Inc. | Inhibitors of dipeptidyl-aminopeptidase type IV |
DE19826972A1 (de) * | 1998-06-18 | 1999-12-23 | Univ Magdeburg Tech | Verwendung von Enzyminhibitoren und pharmazeutische Zubereitung zur Therapie von dermatologischen Erkrankungen mit follikulären und epidermalen Hyperkeratosen und einer verstärkten Keratinozytenproliferation |
WO2001081337A1 (en) * | 2000-04-26 | 2001-11-01 | Ferring B.V. | Inhibitors of dipeptidyl peptidase iv |
WO2002014271A1 (fr) * | 2000-08-10 | 2002-02-21 | Mitsubishi Pharma Corporation | Dérivés de proline et leur utilisation comme médicaments |
WO2002068420A1 (de) * | 2001-02-24 | 2002-09-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Xanthinderivate, deren herstellung und deren verwendung als arzneimittel |
JP2002265439A (ja) * | 2001-03-08 | 2002-09-18 | Mitsubishi Pharma Corp | シアノピロリジン誘導体およびその医薬用途 |
EP1245568A1 (fr) * | 2001-03-28 | 2002-10-02 | Les Laboratoires Servier | Dérives sulfonyles d'-aminoacides et leur utilisation en tant qu'inhibiteurs de dipeptidyl-peptidase IV ( DPP IV) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW492957B (en) | 1996-11-07 | 2002-07-01 | Novartis Ag | N-substituted 2-cyanopyrrolidnes |
DE19823831A1 (de) | 1998-05-28 | 1999-12-02 | Probiodrug Ges Fuer Arzneim | Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen |
-
2002
- 2002-09-13 US US10/489,622 patent/US20040259883A1/en not_active Abandoned
- 2002-09-13 KR KR10-2004-7003689A patent/KR20040033048A/ko active IP Right Grant
- 2002-09-13 TW TW091120937A patent/TWI246510B/zh not_active IP Right Cessation
- 2002-09-13 EP EP02767958A patent/EP1426366A4/en not_active Withdrawn
- 2002-09-13 CN CNB028180844A patent/CN100341862C/zh not_active Expired - Fee Related
- 2002-09-13 WO PCT/JP2002/009419 patent/WO2003024942A1/ja active Application Filing
- 2002-09-13 CA CA002460512A patent/CA2460512A1/en not_active Abandoned
- 2002-09-13 JP JP2003528790A patent/JPWO2003024942A1/ja active Pending
-
2007
- 2007-07-09 US US11/774,941 patent/US7790725B2/en not_active Expired - Fee Related
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0450352A1 (en) * | 1990-03-30 | 1991-10-09 | POLI INDUSTRIA CHIMICA S.p.A. | Liposome formulations of immunomodulating drugs for the topical and aerosol administrations |
US5462928A (en) * | 1990-04-14 | 1995-10-31 | New England Medical Center Hospitals, Inc. | Inhibitors of dipeptidyl-aminopeptidase type IV |
WO1995015309A1 (en) * | 1993-12-03 | 1995-06-08 | Ferring B.V. | Dp-iv-serine protease inhibitors |
DE19826972A1 (de) * | 1998-06-18 | 1999-12-23 | Univ Magdeburg Tech | Verwendung von Enzyminhibitoren und pharmazeutische Zubereitung zur Therapie von dermatologischen Erkrankungen mit follikulären und epidermalen Hyperkeratosen und einer verstärkten Keratinozytenproliferation |
WO2001081337A1 (en) * | 2000-04-26 | 2001-11-01 | Ferring B.V. | Inhibitors of dipeptidyl peptidase iv |
WO2002014271A1 (fr) * | 2000-08-10 | 2002-02-21 | Mitsubishi Pharma Corporation | Dérivés de proline et leur utilisation comme médicaments |
WO2002068420A1 (de) * | 2001-02-24 | 2002-09-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Xanthinderivate, deren herstellung und deren verwendung als arzneimittel |
JP2002265439A (ja) * | 2001-03-08 | 2002-09-18 | Mitsubishi Pharma Corp | シアノピロリジン誘導体およびその医薬用途 |
EP1245568A1 (fr) * | 2001-03-28 | 2002-10-02 | Les Laboratoires Servier | Dérives sulfonyles d'-aminoacides et leur utilisation en tant qu'inhibiteurs de dipeptidyl-peptidase IV ( DPP IV) |
Non-Patent Citations (1)
Title |
---|
See also references of EP1426366A4 * |
Cited By (96)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7026316B2 (en) | 2001-03-27 | 2006-04-11 | Merck & Co., Inc. | Dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
US7132443B2 (en) | 2001-06-27 | 2006-11-07 | Smithklinebeecham Corporation | Fluoropyrrolidines as dipeptidyl peptidase inhibitors |
WO2004016587A1 (ja) * | 2002-08-19 | 2004-02-26 | Ono Pharmaceutical Co., Ltd. | 含窒素化合物 |
WO2004098591A2 (en) | 2003-05-05 | 2004-11-18 | Probiodrug Ag | Inhibitors of glutaminyl cyclase and their use in the treatment of neurological diseases |
WO2004098625A2 (en) | 2003-05-05 | 2004-11-18 | Probiodrug Ag | Medical use of inhibitors of glutaminyl and glutamate cyclases |
EP2206496A1 (en) | 2003-05-05 | 2010-07-14 | Probiodrug AG | Medical use of inhibitors of glutaminyl and glutamate cyclases |
DE202004021723U1 (de) | 2003-05-05 | 2010-07-15 | Probiodrug Ag | Medizinische Verwendung von Hemmern von Glutaminyl- und Glutamatcyclasen |
EP2289498A1 (en) | 2003-10-15 | 2011-03-02 | Probiodrug AG | Use of inhibitors of glutaminyl clyclase |
EP2338490A2 (en) | 2003-11-03 | 2011-06-29 | Probiodrug AG | Combinations Useful for the Treatment of Neuronal Disorders |
EP2839832A2 (en) | 2003-11-17 | 2015-02-25 | Novartis AG | Use of dipeptidyl peptidase IV inhibitors |
EP3738585A1 (en) | 2004-01-20 | 2020-11-18 | Novartis Ag | Direct compression formulation and process |
EP3366283A1 (en) | 2004-01-20 | 2018-08-29 | Novartis AG | Direct compression formulation and process |
EP3023095A1 (en) | 2004-01-20 | 2016-05-25 | Novartis AG | Direct compression formulation and process |
EP2165703A2 (en) | 2004-01-20 | 2010-03-24 | Novartis Pharma AG. | Direct compression formulation and process |
US7897633B2 (en) | 2004-02-05 | 2011-03-01 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
WO2005075436A2 (en) | 2004-02-05 | 2005-08-18 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
US7671076B2 (en) | 2004-03-08 | 2010-03-02 | Abbott Laboratories | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) |
US7348346B2 (en) | 2004-03-08 | 2008-03-25 | Abbott Laboratories | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) |
EP2088154A1 (en) | 2004-03-09 | 2009-08-12 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
EP2305352A1 (en) | 2004-04-02 | 2011-04-06 | Merck Sharp & Dohme Corp. | 5-alpha-reductase inhibitors for use in the treatment of men with metabolic and anthropometric disorders |
WO2006001750A1 (en) * | 2004-06-24 | 2006-01-05 | Astrazeneca Ab | Imidazole variants as modulators of gaba receptor for the treatment of gi disorders |
US7842707B2 (en) | 2004-07-23 | 2010-11-30 | Nuada, Llc | Peptidase inhibitors |
WO2006073167A1 (ja) * | 2005-01-07 | 2006-07-13 | Ono Pharmaceutical Co., Ltd. | ピロリジン誘導体 |
EP2116235A1 (en) | 2005-01-10 | 2009-11-11 | Arena Pharmaceuticals, Inc. | Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP-1 level |
US7696250B2 (en) | 2005-03-21 | 2010-04-13 | Virobay, Inc. | Alpha ketoamide compounds as cysteine protease inhibitors |
US8013183B2 (en) | 2005-03-21 | 2011-09-06 | Virobay, Inc. | Alpha ketoamide compounds as cysteine protease inhibitors |
US8450373B2 (en) | 2005-03-21 | 2013-05-28 | Virobay, Inc. | Alpha ketoamide compounds as cysteine protease inhibitors |
WO2006129785A1 (ja) * | 2005-06-03 | 2006-12-07 | Mitsubishi Tanabe Pharma Corporation | 医薬の併用およびその用途 |
US8754032B2 (en) | 2005-06-03 | 2014-06-17 | Mitsubishi Tanabe Pharma Corporation | Concomitant pharmaceutical agents and use thereof |
EP2191824A1 (en) | 2005-06-10 | 2010-06-02 | Novartis AG | Modified release 1-[(3-hydroxy-adamant-1-ylamino)-acetyl]-pyrrolidine-2(s)-carbonitrile formulation |
US8906901B2 (en) | 2005-09-14 | 2014-12-09 | Takeda Pharmaceutical Company Limited | Administration of dipeptidyl peptidase inhibitors |
US8222411B2 (en) | 2005-09-16 | 2012-07-17 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US7960384B2 (en) | 2006-03-28 | 2011-06-14 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
EP2253311A2 (en) | 2006-04-11 | 2010-11-24 | Arena Pharmaceuticals, Inc. | Use of GPR119 receptor agonists for increasing bone mass and for treating osteoporosis, as well as combination therapy relating thereto |
WO2007120702A2 (en) | 2006-04-11 | 2007-10-25 | Arena Pharmaceuticals, Inc. | Use of gpr119 receptor agonists for increasing bone mass and for treating osteoporosis, and combination therapy relating thereto |
US7728146B2 (en) | 2006-04-12 | 2010-06-01 | Probiodrug Ag | Enzyme inhibitors |
WO2008055945A1 (en) | 2006-11-09 | 2008-05-15 | Probiodrug Ag | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
US8084605B2 (en) | 2006-11-29 | 2011-12-27 | Kelly Ron C | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
WO2008065141A1 (en) | 2006-11-30 | 2008-06-05 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
WO2008120813A1 (ja) | 2007-04-03 | 2008-10-09 | Mitsubishi Tanabe Pharma Corporation | ジペプチジルペプチダーゼ4阻害化合物と甘味料との併用 |
EP2865670A1 (en) | 2007-04-18 | 2015-04-29 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
EP2998314A1 (en) | 2007-06-04 | 2016-03-23 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
US8853385B2 (en) | 2008-01-17 | 2014-10-07 | Mitsubishi Tanabe Pharma Corporation | Combination therapy comprising SGLT inhibitors and DPP4 inhibitors |
US8883714B2 (en) | 2008-04-07 | 2014-11-11 | Arena Pharmaceuticals, Inc. | Pharmaceutical compositions comprising GPR119 agonists which act as peptide YY (PYY) secretagogues |
EP2810951A2 (en) | 2008-06-04 | 2014-12-10 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
EP3241839A1 (en) | 2008-07-16 | 2017-11-08 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
WO2010047982A1 (en) | 2008-10-22 | 2010-04-29 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
WO2010051206A1 (en) | 2008-10-31 | 2010-05-06 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
WO2011005929A1 (en) | 2009-07-09 | 2011-01-13 | Arena Pharmaceuticals, Inc. | Piperidine derivative and its use for the treatment of diabets and obesity |
WO2011029920A1 (en) | 2009-09-11 | 2011-03-17 | Probiodrug Ag | Heterocylcic derivatives as inhibitors of glutaminyl cyclase |
WO2011069038A2 (en) | 2009-12-03 | 2011-06-09 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
EP2923706A1 (en) | 2009-12-03 | 2015-09-30 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia |
WO2011106273A1 (en) | 2010-02-25 | 2011-09-01 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
WO2011107530A2 (en) | 2010-03-03 | 2011-09-09 | Probiodrug Ag | Novel inhibitors |
WO2011110613A1 (en) | 2010-03-10 | 2011-09-15 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
WO2011127051A1 (en) | 2010-04-06 | 2011-10-13 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
EP3323818A1 (en) | 2010-09-22 | 2018-05-23 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
WO2012040279A1 (en) | 2010-09-22 | 2012-03-29 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
EP3243385A1 (en) | 2011-02-25 | 2017-11-15 | Merck Sharp & Dohme Corp. | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
WO2012116145A1 (en) | 2011-02-25 | 2012-08-30 | Merck Sharp & Dohme Corp. | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
WO2012123563A1 (en) | 2011-03-16 | 2012-09-20 | Probiodrug Ag | Benz imidazole derivatives as inhibitors of glutaminyl cyclase |
WO2012135570A1 (en) | 2011-04-01 | 2012-10-04 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
WO2012145361A1 (en) | 2011-04-19 | 2012-10-26 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
WO2012145604A1 (en) | 2011-04-22 | 2012-10-26 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
WO2012145603A1 (en) | 2011-04-22 | 2012-10-26 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
JPWO2012165547A1 (ja) * | 2011-06-01 | 2015-02-23 | 田辺三菱製薬株式会社 | ピラゾール誘導体の製造方法 |
WO2012165547A1 (ja) * | 2011-06-01 | 2012-12-06 | 田辺三菱製薬株式会社 | ピラゾール誘導体の製造方法 |
WO2012170702A1 (en) | 2011-06-08 | 2012-12-13 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
WO2013055910A1 (en) | 2011-10-12 | 2013-04-18 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
EP3708179A1 (en) | 2012-03-15 | 2020-09-16 | Bausch Health Ireland Limited | Formulations of guanylate cyclase c agonists and methods of use |
EP4309673A2 (en) | 2012-03-15 | 2024-01-24 | Bausch Health Ireland Limited | Formulations of guanylate cyclase c agonists and methods of use |
WO2013138352A1 (en) | 2012-03-15 | 2013-09-19 | Synergy Pharmaceuticals Inc. | Formulations of guanylate cyclase c agonists and methods of use |
US8765786B2 (en) | 2012-04-10 | 2014-07-01 | Dainippon Sumitomo Pharma Co., Ltd. | 1-substituted indazole derivative |
CN104395292A (zh) * | 2012-04-10 | 2015-03-04 | 大日本住友制药株式会社 | 新的1-取代的吲唑衍生物 |
US9309221B2 (en) | 2012-04-10 | 2016-04-12 | Sumitomo Dainippon Pharma Co., Ltd. | 1-substituted indazole derivative |
US9051295B2 (en) | 2012-04-10 | 2015-06-09 | Sumitomo Dainippon Pharma Co., Ltd. | 1-substituted indazole derivative |
WO2013154109A1 (ja) * | 2012-04-10 | 2013-10-17 | 大日本住友製薬株式会社 | 新規1位置換インダゾール誘導体 |
JPWO2013154109A1 (ja) * | 2012-04-10 | 2015-12-17 | 大日本住友製薬株式会社 | 新規1位置換インダゾール誘導体 |
WO2014022528A1 (en) | 2012-08-02 | 2014-02-06 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
WO2014061031A1 (en) | 2012-10-17 | 2014-04-24 | Cadila Healthcare Limited | 2-phenyl-5-heterocyclyl-tetrahydro-2h-pyran-3-amine compounds for use in the treatment of diabetes and its associated disorders |
WO2014074668A1 (en) | 2012-11-08 | 2014-05-15 | Arena Pharmaceuticals, Inc. | Modulators of gpr119 and the treatment of disorders related thereto |
WO2014130608A1 (en) | 2013-02-22 | 2014-08-28 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
WO2014139388A1 (en) | 2013-03-14 | 2014-09-18 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
WO2014151200A2 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
WO2014151206A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
WO2014197720A2 (en) | 2013-06-05 | 2014-12-11 | Synergy Pharmaceuticals, Inc. | Ultra-pure agonists of guanylate cyclase c, method of making and using same |
WO2015051725A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
JP2015096495A (ja) * | 2013-10-08 | 2015-05-21 | 大日本住友製薬株式会社 | 新規1位置換インダゾール誘導体からなる医薬 |
US10555929B2 (en) | 2015-03-09 | 2020-02-11 | Coherus Biosciences, Inc. | Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy |
US10772865B2 (en) | 2015-03-09 | 2020-09-15 | Coherus Biosciences, Inc. | Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy |
US11400072B2 (en) | 2015-03-09 | 2022-08-02 | Coherus Biosciences, Inc. | Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy |
WO2018106518A1 (en) | 2016-12-06 | 2018-06-14 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
WO2018118670A1 (en) | 2016-12-20 | 2018-06-28 | Merck Sharp & Dohme Corp. | Antidiabetic spirochroman compounds |
US11253508B2 (en) | 2017-04-03 | 2022-02-22 | Coherus Biosciences, Inc. | PPARy agonist for treatment of progressive supranuclear palsy |
EP3461819A1 (en) | 2017-09-29 | 2019-04-03 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
Also Published As
Publication number | Publication date |
---|---|
CN100341862C (zh) | 2007-10-10 |
TWI246510B (en) | 2006-01-01 |
CN1606549A (zh) | 2005-04-13 |
US7790725B2 (en) | 2010-09-07 |
US20070259880A1 (en) | 2007-11-08 |
EP1426366A4 (en) | 2004-12-08 |
JPWO2003024942A1 (ja) | 2004-12-24 |
CA2460512A1 (en) | 2003-03-27 |
KR20040033048A (ko) | 2004-04-17 |
US20040259883A1 (en) | 2004-12-23 |
EP1426366A1 (en) | 2004-06-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2003024942A1 (fr) | Derive thiazolidine et son utilisation medicamenteuse | |
AU6520998A (en) | 1,4-substituted cyclic amine derivatives | |
HK1077567A1 (en) | Dibenzylamine compound and medicinal use thereof | |
CA2267103A1 (en) | Pyrazolopyridylpyridazinone derivatives and process for the preparation thereof | |
EP1386920A4 (en) | DERIVATIVES OF BENZIMIDAZOLONE | |
EP1669352A4 (en) | THIAZOLINE DERIVATIVE AND ITS USE | |
EP1724258A4 (en) | HETEROARYLPHENYLUREE DERIVATIVE | |
EP1734040A4 (en) | SUBSTITUTED CHINAZOLINE OR PYRIDOPYRIMIDINE DERIVATIVE | |
EP1702919A4 (en) | NEW 2-HETEROARYL SUBSTITUTED BENZIMIDAZOLE DERIVATIVE | |
MXPA04002035A (es) | Derivados de 1, 8-naftiridina y su uso para el tratamiento de la diabetes y trastornos relacionados. | |
HK1048989A1 (en) | Heterocyclic derivatives and pharmaceutical use thereof. | |
EP1008592A3 (en) | Cyclic amide derivatives which inhibit cathepsin K | |
EP1176141A4 (en) | HETEROCYCLIC COMPOUNDS HAVING RECEPTOR ACTIVATION EFFECT $ g (a) 4 $ g (b) 2 OF NICOTINIC ACETYLCHOLINE | |
WO2000068198A3 (en) | Heterosubstituted pyridine derivatives as pde 4 inhibitors | |
WO2008114812A1 (ja) | Jak阻害剤 | |
EP1535922A4 (en) | PYRROLOPYRIDINE DERIVATIVE AND ITS USE | |
EP1364950A4 (en) | PYRIDOPYRIMIDINE OR NAPHTHYRIDINE DERIVATIVE | |
WO2000064874A3 (en) | Heterosubstituted pyridine derivatives as pde 4 inhibitors | |
NO930783L (no) | Kondenserte heterocykliske ketonderivater deres fremstilling og anveendelse | |
WO2003059907A1 (fr) | Composes heterocycliques azotes : procede de preparation et d'utilisation | |
EP1550651A4 (en) | GLYCEROL DERIVATIVE | |
CA2262997A1 (en) | Pharmaceutical products for curing and preventing illnesses connected with the malfunction of vascular endothelial cells | |
AU5566300A (en) | Acylhydrazine derivatives, process for preparing the same and use thereof | |
EP1537879A4 (en) | PREVENTIVE AND / OR THERAPEUTIC DRUGS AGAINST ASTHMA | |
AU6731100A (en) | Integrase inhibitors containing aromatic heterocycle derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BY BZ CA CH CN CO CR CU CZ DE DM DZ EC EE ES FI GB GD GE GH HR HU ID IL IN IS JP KE KG KR KZ LK LR LS LT LU LV MA MD MG MK MW MX MZ NO NZ OM PH PL PT RO SD SE SG SI SK SL TJ TM TN TR TT UA UG US UZ VC VN YU ZA ZM |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW MZ SD SL SZ UG ZM ZW AM AZ BY KG KZ RU TJ TM AT BE BG CH CY CZ DK EE ES FI FR GB GR IE IT LU MC PT SE SK TR BF BJ CF CG CI GA GN GQ GW ML MR NE SN TD TG |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2003528790 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2460512 Country of ref document: CA Ref document number: 1020047003689 Country of ref document: KR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 20028180844 Country of ref document: CN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2002767958 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 10489622 Country of ref document: US |
|
WWP | Wipo information: published in national office |
Ref document number: 2002767958 Country of ref document: EP |