WO2003024518A3 - Microstructures destinees a distribuer une composition par voie cutanee dans la peau au moyen de structures rotatives - Google Patents

Microstructures destinees a distribuer une composition par voie cutanee dans la peau au moyen de structures rotatives Download PDF

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Publication number
WO2003024518A3
WO2003024518A3 PCT/US2002/029228 US0229228W WO03024518A3 WO 2003024518 A3 WO2003024518 A3 WO 2003024518A3 US 0229228 W US0229228 W US 0229228W WO 03024518 A3 WO03024518 A3 WO 03024518A3
Authority
WO
WIPO (PCT)
Prior art keywords
skin
microelements
composition
stratum corneum
microstructures
Prior art date
Application number
PCT/US2002/029228
Other languages
English (en)
Other versions
WO2003024518A2 (fr
Inventor
Vladimir Gartstein
Faiz Feisal Sherman
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/952,391 external-priority patent/US7108681B2/en
Priority claimed from US10/216,148 external-priority patent/US20040087992A1/en
Application filed by Procter & Gamble filed Critical Procter & Gamble
Priority to EP02798965A priority Critical patent/EP1425064A2/fr
Priority to CA002456626A priority patent/CA2456626C/fr
Priority to AU2002333636A priority patent/AU2002333636A1/en
Priority to JP2003528611A priority patent/JP2005503210A/ja
Publication of WO2003024518A2 publication Critical patent/WO2003024518A2/fr
Publication of WO2003024518A3 publication Critical patent/WO2003024518A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B17/322—Skin grafting apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00761—Removing layer of skin tissue, e.g. wrinkles, scars or cancerous tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00765—Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B2017/320004—Surgical cutting instruments abrasive
    • A61B2017/320008—Scrapers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Transplantation (AREA)
  • Medicinal Preparation (AREA)
  • Surgical Instruments (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

L'invention concerne une méthode et un appareil améliorés sous la forme d'un système permettant de distribuer une composition, de préférence une composition médicale ou pharmaceutique ou une substance active, par l'intermédiaire de la couche cornée de la peau, sans saignement ou endommagement du tissu et sans douleur ou autre traumatisme. La taille et la forme des micro-éléments sont ajustées en fonction de la profondeur de pénétration souhaitée dans la peau. Les micro-éléments peuvent être creux, d'où la formation de passages traversants permettant l'écoulement de la composition dans la peau à partir d'une chambre et par l'intermédiaire des micro-éléments. Ces micro-éléments peuvent éventuellement être solides, la composition étant alors appliquée directement sur la peau juste avant ou juste après l'application des micro-éléments sur la surface de la peau, d'où la formation d'ouvertures dans la couche cornée. Dans un autre mode de réalisation, on utilise des microstructures cylindriques appliquées par rotation sur la peau, ces microstructures pénétrant dans la couche cornée et permettant la distribution d'un fluide au moyen de plusieurs structures différentes.
PCT/US2002/029228 2001-09-14 2002-09-13 Microstructures destinees a distribuer une composition par voie cutanee dans la peau au moyen de structures rotatives WO2003024518A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP02798965A EP1425064A2 (fr) 2001-09-14 2002-09-13 Microstructures destinees a distribuer une composition par voie cutanee dans la peau au moyen de structures rotatives
CA002456626A CA2456626C (fr) 2001-09-14 2002-09-13 Microstructures destinees a distribuer une composition par voie cutanee dans la peau au moyen de structures rotatives
AU2002333636A AU2002333636A1 (en) 2001-09-14 2002-09-13 Microstructures for delivering a composition cutaneously to skin using rotatable structures
JP2003528611A JP2005503210A (ja) 2001-09-14 2002-09-13 回転可能構造を用いて皮膚を介して組成物を皮膚に送達するための微細構造

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/952,391 2001-09-14
US09/952,391 US7108681B2 (en) 2000-10-16 2001-09-14 Microstructures for delivering a composition cutaneously to skin
US10/216,148 US20040087992A1 (en) 2002-08-09 2002-08-09 Microstructures for delivering a composition cutaneously to skin using rotatable structures
US10/216,148 2002-08-09

Publications (2)

Publication Number Publication Date
WO2003024518A2 WO2003024518A2 (fr) 2003-03-27
WO2003024518A3 true WO2003024518A3 (fr) 2003-09-25

Family

ID=26910709

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/029228 WO2003024518A2 (fr) 2001-09-14 2002-09-13 Microstructures destinees a distribuer une composition par voie cutanee dans la peau au moyen de structures rotatives

Country Status (5)

Country Link
EP (1) EP1425064A2 (fr)
JP (1) JP2005503210A (fr)
AU (1) AU2002333636A1 (fr)
CA (1) CA2456626C (fr)
WO (1) WO2003024518A2 (fr)

Cited By (2)

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Publication number Priority date Publication date Assignee Title
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
US9114238B2 (en) 2007-04-16 2015-08-25 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient

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US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US6821281B2 (en) 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
US6663820B2 (en) 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
IL152912A0 (en) * 2002-11-18 2003-06-24 Nanopass Ltd Micro needle systems
US7888546B2 (en) 2003-07-03 2011-02-15 Corium International, Inc. Wound dressing, ingredient delivery device and IV hold-down, and method relating to same
CN100478040C (zh) 2003-11-10 2009-04-15 新加坡科技研究局 微型针以及微型针的制造
JP2005246595A (ja) * 2004-03-05 2005-09-15 Ritsumeikan マイクロニードルアレイ及びその製造方法
CA2562643A1 (fr) 2004-04-12 2005-11-24 Allergan, Inc. Systeme d'injection multi-sites
WO2005109996A2 (fr) * 2004-04-30 2005-11-24 Gyung Su Cho Dispositif de dermabrasion electrique
US20070078414A1 (en) 2005-08-05 2007-04-05 Mcallister Devin V Methods and devices for delivering agents across biological barriers
JP5066566B2 (ja) 2006-07-03 2012-11-07 ホナム ペトロケミカル コープ マイクロニードルローラアセンブリ
JP4821993B2 (ja) * 2006-07-21 2011-11-24 芳一 飛永 マイクロインプリメント及びその製造方法
KR200451185Y1 (ko) 2007-02-15 2010-12-01 (주)클리니칼레졸루션아시아 모듈식 마이크로니들 롤러
GB2448493B (en) * 2007-04-16 2009-10-14 Dewan Fazlul Hoque Chowdhury Microneedle transdermal delivery device
JP2011505900A (ja) * 2007-12-07 2011-03-03 ディティエス ローラーズ カンパニー リミテッド ディスクニードルローラ
WO2009130926A1 (fr) * 2008-04-22 2009-10-29 南部化成株式会社 Procédé endermique, organisateur d'aiguille et dispositif d'injecteur endermique
WO2009144624A1 (fr) * 2008-05-28 2009-12-03 Koninklijke Philips Electronics N.V. Dispositif d'apport de médicament commandé
US8721574B2 (en) * 2008-09-03 2014-05-13 Dts Lab Co., Ltd Skin stimulator
US20110144591A1 (en) * 2009-12-11 2011-06-16 Ross Russell F Transdermal Delivery Device
EP2566501B1 (fr) 2010-05-04 2019-03-13 Corium International, Inc. Méthode et dispositif permettant l'administration transdermique d'hormone parathyroïdienne au moyen d'un réseau de microprojections
GB201107642D0 (en) 2011-05-09 2011-06-22 Univ Cork Method
JP6182137B2 (ja) * 2012-06-12 2017-08-16 久光製薬株式会社 マイクロニードル・シート
MX2015007227A (es) * 2012-12-06 2016-02-18 Srgi Holdings Llc Dispositivos médicos de arreglo de pixeles y métodos.
CA2896188C (fr) 2012-12-21 2021-02-23 Corium International, Inc. Micro-reseau pour la distribution d'un agent therapeutique et ses procedes d'utilisation
ES2921481T3 (es) 2013-03-12 2022-08-26 Corium Inc Aplicadores para microproyecciones
AU2014233695A1 (en) 2013-03-15 2015-10-01 Corium International, Inc. Microarray for delivery of therapeutic agent and methods of use
AU2014237279B2 (en) 2013-03-15 2018-11-22 Corium Pharma Solutions, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
EP2968751B1 (fr) 2013-03-15 2022-11-30 Corium, Inc. Applicateurs de microprojection d'impacts multiples
WO2014144973A1 (fr) 2013-03-15 2014-09-18 Corium International, Inc. Micro-réseau pour administrer un agent thérapeutique, procédés d'utilisation et procédés de fabrication
JP6038311B2 (ja) 2013-06-18 2016-12-07 久光製薬株式会社 アプリケータ
KR101782752B1 (ko) 2013-06-19 2017-09-27 히사미쓰 세이야꾸 가부시키가이샤 어플리케이터
US9694142B2 (en) 2013-09-03 2017-07-04 Visage Sculpture, PLLC Device for percutaneous delivery of therapeutic agents, and a method for its use
JP6272333B2 (ja) 2013-09-06 2018-01-31 久光製薬株式会社 マイクロニードル・シート
CN106061544B (zh) 2014-02-27 2019-11-26 久光制药株式会社 微型针薄片
WO2016036866A1 (fr) 2014-09-04 2016-03-10 Corium International, Inc. Matrice de microstructures, procédé de production et procédés d'utilisation
TWI679997B (zh) 2014-12-05 2019-12-21 日商久光製藥股份有限公司 微針裝置系統
US10004887B2 (en) * 2015-02-18 2018-06-26 Alma Therapeutics Ltd. Transdermal delivery assembly
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
WO2017104491A1 (fr) 2015-12-15 2017-06-22 久光製薬株式会社 Feuille à micro-aiguilles
JP6941105B2 (ja) 2016-09-01 2021-09-29 久光製薬株式会社 マイクロニードル・シート
KR101906336B1 (ko) * 2018-03-22 2018-10-10 한국바이오기술공사(주) 펌프 내장형 니들 디스크 롤러 장치
CN109925590B (zh) * 2019-03-28 2021-10-08 吴晓苏 一种耦合剂快速刷涂及擦拭装置

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US3918449A (en) * 1973-06-06 1975-11-11 Guerin A Ets Device for cutaneous therapeutic treatment
FR2535602A1 (fr) * 1982-11-05 1984-05-11 Stallergenes Lab Dispositif scarificateur
EP0312662A1 (fr) * 1984-08-24 1989-04-26 David George Vlock Distributeur de fluides
EP0407063A1 (fr) * 1989-07-06 1991-01-09 Connaught Laboratories Limited Structure de dents pour applicateur clinique
DE19518974A1 (de) * 1994-05-23 1995-11-30 Samsung Electro Mech Perforationsvorrichtung für Verabreichungen über die Haut
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WO2002007813A1 (fr) * 2000-07-21 2002-01-31 Smithkline Beecham Biologicals S.A. Vaccins
WO2002032331A2 (fr) * 2000-10-16 2002-04-25 The Procter & Gamble Company Microstructures permettant de traiter et de conditionner la peau

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Publication number Priority date Publication date Assignee Title
DE2319591A1 (de) * 1973-04-18 1974-11-14 Kirchner & Wilhelm Nadelapparat fuer medizinische zwecke und vorrichtung zur sterilisation seines nadelkoerpers
US3918449A (en) * 1973-06-06 1975-11-11 Guerin A Ets Device for cutaneous therapeutic treatment
FR2535602A1 (fr) * 1982-11-05 1984-05-11 Stallergenes Lab Dispositif scarificateur
EP0312662A1 (fr) * 1984-08-24 1989-04-26 David George Vlock Distributeur de fluides
EP0407063A1 (fr) * 1989-07-06 1991-01-09 Connaught Laboratories Limited Structure de dents pour applicateur clinique
DE19518974A1 (de) * 1994-05-23 1995-11-30 Samsung Electro Mech Perforationsvorrichtung für Verabreichungen über die Haut
WO1996017648A1 (fr) * 1994-12-09 1996-06-13 Novartis Ag Systeme transdermique
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WO1998000193A1 (fr) * 1996-07-03 1998-01-08 Altea Technologies, Inc. Microporation mecanique multiple de la peau ou de la muqueuse
WO2000035530A1 (fr) * 1998-12-18 2000-06-22 Minimed Inc. Ensembles d'injection pourvus d'elements de micro-perforation, utilises avec des dispositifs medicaux, et leurs procedes d'utilisation
WO2002007813A1 (fr) * 2000-07-21 2002-01-31 Smithkline Beecham Biologicals S.A. Vaccins
WO2002032331A2 (fr) * 2000-10-16 2002-04-25 The Procter & Gamble Company Microstructures permettant de traiter et de conditionner la peau

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
US9114238B2 (en) 2007-04-16 2015-08-25 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient
US9452280B2 (en) 2007-04-16 2016-09-27 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient
US9498524B2 (en) 2007-04-16 2016-11-22 Corium International, Inc. Method of vaccine delivery via microneedle arrays

Also Published As

Publication number Publication date
WO2003024518A2 (fr) 2003-03-27
CA2456626A1 (fr) 2003-03-27
JP2005503210A (ja) 2005-02-03
CA2456626C (fr) 2009-01-20
EP1425064A2 (fr) 2004-06-09
AU2002333636A1 (en) 2003-04-01

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