CA2456626C - Microstructures destinees a distribuer une composition par voie cutanee dans la peau au moyen de structures rotatives - Google Patents

Microstructures destinees a distribuer une composition par voie cutanee dans la peau au moyen de structures rotatives Download PDF

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Publication number
CA2456626C
CA2456626C CA002456626A CA2456626A CA2456626C CA 2456626 C CA2456626 C CA 2456626C CA 002456626 A CA002456626 A CA 002456626A CA 2456626 A CA2456626 A CA 2456626A CA 2456626 C CA2456626 C CA 2456626C
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CA
Canada
Prior art keywords
skin
microelements
substrate
microelement
rotatable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002456626A
Other languages
English (en)
Other versions
CA2456626A1 (fr
Inventor
Vladimir Gartstein
Faiz Feisal Sherman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corium Inc
Original Assignee
Corium International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/952,391 external-priority patent/US7108681B2/en
Priority claimed from US10/216,148 external-priority patent/US20040087992A1/en
Application filed by Corium International Inc filed Critical Corium International Inc
Publication of CA2456626A1 publication Critical patent/CA2456626A1/fr
Application granted granted Critical
Publication of CA2456626C publication Critical patent/CA2456626C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B17/322—Skin grafting apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00761—Removing layer of skin tissue, e.g. wrinkles, scars or cancerous tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00765—Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B2017/320004—Surgical cutting instruments abrasive
    • A61B2017/320008—Scrapers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Transplantation (AREA)
  • Medicinal Preparation (AREA)
  • Surgical Instruments (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

L'invention concerne une méthode et un appareil améliorés sous la forme d'un système permettant de distribuer une composition, de préférence une composition médicale ou pharmaceutique ou une substance active, par l'intermédiaire de la couche cornée de la peau, sans saignement ou endommagement du tissu et sans douleur ou autre traumatisme. La taille et la forme des micro-éléments sont ajustées en fonction de la profondeur de pénétration souhaitée dans la peau. Les micro-éléments peuvent être creux, d'où la formation de passages traversants permettant l'écoulement de la composition dans la peau à partir d'une chambre et par l'intermédiaire des micro-éléments. Ces micro-éléments peuvent éventuellement être solides, la composition étant alors appliquée directement sur la peau juste avant ou juste après l'application des micro-éléments sur la surface de la peau, d'où la formation d'ouvertures dans la couche cornée. Dans un autre mode de réalisation, on utilise des microstructures cylindriques appliquées par rotation sur la peau, ces microstructures pénétrant dans la couche cornée et permettant la distribution d'un fluide au moyen de plusieurs structures différentes.
CA002456626A 2001-09-14 2002-09-13 Microstructures destinees a distribuer une composition par voie cutanee dans la peau au moyen de structures rotatives Expired - Lifetime CA2456626C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US09/952,391 US7108681B2 (en) 2000-10-16 2001-09-14 Microstructures for delivering a composition cutaneously to skin
US09/952,391 2001-09-14
US10/216,148 US20040087992A1 (en) 2002-08-09 2002-08-09 Microstructures for delivering a composition cutaneously to skin using rotatable structures
US10/216,148 2002-08-09
PCT/US2002/029228 WO2003024518A2 (fr) 2001-09-14 2002-09-13 Microstructures destinees a distribuer une composition par voie cutanee dans la peau au moyen de structures rotatives

Publications (2)

Publication Number Publication Date
CA2456626A1 CA2456626A1 (fr) 2003-03-27
CA2456626C true CA2456626C (fr) 2009-01-20

Family

ID=26910709

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002456626A Expired - Lifetime CA2456626C (fr) 2001-09-14 2002-09-13 Microstructures destinees a distribuer une composition par voie cutanee dans la peau au moyen de structures rotatives

Country Status (5)

Country Link
EP (1) EP1425064A2 (fr)
JP (1) JP2005503210A (fr)
AU (1) AU2002333636A1 (fr)
CA (1) CA2456626C (fr)
WO (1) WO2003024518A2 (fr)

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Also Published As

Publication number Publication date
JP2005503210A (ja) 2005-02-03
WO2003024518A2 (fr) 2003-03-27
EP1425064A2 (fr) 2004-06-09
WO2003024518A3 (fr) 2003-09-25
CA2456626A1 (fr) 2003-03-27
AU2002333636A1 (en) 2003-04-01

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Effective date: 20220913