WO2003007948A1 - Antipaludique contenant un compose de rhodacyanine - Google Patents

Antipaludique contenant un compose de rhodacyanine Download PDF

Info

Publication number
WO2003007948A1
WO2003007948A1 PCT/JP2002/007255 JP0207255W WO03007948A1 WO 2003007948 A1 WO2003007948 A1 WO 2003007948A1 JP 0207255 W JP0207255 W JP 0207255W WO 03007948 A1 WO03007948 A1 WO 03007948A1
Authority
WO
WIPO (PCT)
Prior art keywords
group
ion
methyl
antimalarial
dye compound
Prior art date
Application number
PCT/JP2002/007255
Other languages
English (en)
Japanese (ja)
Inventor
Masataka Ihara
Kiyosei Takasu
Hiroshi Inoue
Yusuke Wataya
Hye-Sook Kim
Original Assignee
Japan Science And Technology Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Science And Technology Corporation filed Critical Japan Science And Technology Corporation
Publication of WO2003007948A1 publication Critical patent/WO2003007948A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • the F28-7 strain a wild strain of mouse breast cancer-derived FM3A cells, was used.
  • Medium was added to a 2% fetal calf serum inactivated in ES medium, C ⁇ 2 concentration of 5% were cultured at 3 7 ° C.
  • the doubling time of FM3A cells under these conditions was about 12 hours.
  • Preculture was performed, and cells that had entered the logarithmic growth phase were diluted with a medium so as to have a concentration of 5 ⁇ 10 4 ce 11 s ZmL, and a sample prepared at the time of measuring the malaria activity was used.
  • the sample solution prepared in Example 7 was added to a 24-well culture plate in an amount of 5 to 10 ⁇ L each. Two to three tests were performed for each test sample.

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne un antipaludique efficace contre le plasmode paludéen présentant une résistance a divers antipaludiques et ayant des effets secondaires réduits. L'antipaludique contient en tant que principe actif un composé de rhodacyanine de formule (I), dans laquelle: R1 et R2 représentent indépendamment hydrogène, alkyle en C¿1?-C8 substitué ou non substitué, ou aryle en C6-C8 ou R?1 et R2¿ sont liés l'un à l'autre pour former un noyau à six chaînons substitué ou non substitué; B représente un système conjugué; n est 0, 1 ou 2; A représente un groupe nécessaire à la formation d'un hétérocycle à cinq ou six chaînons, pouvant être non substitué ou ayant un ou des substituants, qui peuvent être liés l'un à l'autre; et Q représente un anion pharmaceutiqement acceptable.
PCT/JP2002/007255 2001-07-19 2002-07-17 Antipaludique contenant un compose de rhodacyanine WO2003007948A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001-220579 2001-07-19
JP2001220579A JP2003034641A (ja) 2001-07-19 2001-07-19 ロダシアニン系色素化合物を含有する抗マラリア剤

Publications (1)

Publication Number Publication Date
WO2003007948A1 true WO2003007948A1 (fr) 2003-01-30

Family

ID=19054378

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/007255 WO2003007948A1 (fr) 2001-07-19 2002-07-17 Antipaludique contenant un compose de rhodacyanine

Country Status (2)

Country Link
JP (1) JP2003034641A (fr)
WO (1) WO2003007948A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1800682A1 (fr) * 2004-10-04 2007-06-27 Japan Science and Technology Agency Préparation médicamenteuse pour le traitement prophylactique ou thérapeutique d une infection protozoaire parasitaire

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004331545A (ja) * 2003-05-06 2004-11-25 Japan Science & Technology Agency 抗リーシュマニア剤
JP4553354B2 (ja) 2004-10-04 2010-09-29 正隆 井原 抗トリパノソーマ剤
JPWO2006137258A1 (ja) * 2005-06-24 2009-01-08 独立行政法人科学技術振興機構 アザロダシアニン化合物を有効成分として含有する医薬組成物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5360803A (en) * 1991-08-13 1994-11-01 Dan Farber Cancer Institute Composition and method for treating cancer
JPH0859467A (ja) * 1994-08-18 1996-03-05 Fuji Photo Film Co Ltd 皮膚疾患治療薬
JP2000191531A (ja) * 1998-12-28 2000-07-11 Fuji Photo Film Co Ltd 抗マラリア剤

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5360803A (en) * 1991-08-13 1994-11-01 Dan Farber Cancer Institute Composition and method for treating cancer
JPH0859467A (ja) * 1994-08-18 1996-03-05 Fuji Photo Film Co Ltd 皮膚疾患治療薬
JP2000191531A (ja) * 1998-12-28 2000-07-11 Fuji Photo Film Co Ltd 抗マラリア剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KIYOSEI TAKASU ET AL.: "Rhodacyanine dyes as antimalarials. 1. Preliminary evaluation of their activity and toxicity", J. MED. CHEM., vol. 45, no. 5, 2002, pages 995 - 998, XP002957612 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1800682A1 (fr) * 2004-10-04 2007-06-27 Japan Science and Technology Agency Préparation médicamenteuse pour le traitement prophylactique ou thérapeutique d une infection protozoaire parasitaire
EP1800682A4 (fr) * 2004-10-04 2010-06-30 Masataka Ihara Préparation médicamenteuse pour le traitement prophylactique ou thérapeutique d une infection protozoaire parasitaire
US8193224B2 (en) 2004-10-04 2012-06-05 Fujifilm Corporation Medicinal composition for prevention or treatment of parasitic protozoan infection

Also Published As

Publication number Publication date
JP2003034641A (ja) 2003-02-07

Similar Documents

Publication Publication Date Title
US10710987B2 (en) Hydrochloride salt form for EZH2 inhibition
US7119104B2 (en) Activator of peroxisome proliferator-activated receptor delta
ES2442907T3 (es) Tiazolil dihidropirimidinas sustituidas con bromo-fenilo
EA008865B1 (ru) Производные 2-имино-4-оксотиазолидина
US10077258B2 (en) Substituted pyrimidine compounds as phosphatidylinositol 3-kinase delta inhibitor and use thereof
CN109535176B (zh) 喹诺酮咪唑类化合物及其制备方法和应用
EP2919779A1 (fr) Composés pour la médiation d'un récepteur des cannabinoïdes
CN111601788A (zh) 衣壳蛋白装配抑制剂、其药物组合物和用途
US9403814B2 (en) Crystalline forms of dihydropyrimidine derivatives
JP6610975B2 (ja) 複素環イミダゾール類化合物、その医薬組成物及びその調製方法と用途
WO2003007948A1 (fr) Antipaludique contenant un compose de rhodacyanine
JP2004144526A (ja) マラリア感染診断剤及びマラリア原虫染色剤
JP2004331545A (ja) 抗リーシュマニア剤
CN102086212B (zh) 抗真菌剂-2，3，4，5-四氢-4H-苯并[b]噻喃并[4，3-c]吡唑-2-甲酰胺衍生物
JP2003034640A (ja) 四環性複素化合物を含有する抗マラリア剤
WO2001052849A1 (fr) Remedes contre le diabete
JP2018087173A (ja) 悪性脳腫瘍治療薬
JP2003034642A (ja) ロダシアニン色素化合物を含有する抗マラリア剤
TWI811901B (zh) 一種嘧啶甲醯胺類化合物及其應用
CN114957216B (zh) 靶点抑制剂及其制备方法、应用和药物组合物
US9737510B2 (en) Indazole compounds and a process for the preparation thereof
US20220378748A1 (en) Use of Heterocyclic Derivatives with Cardiomyocyte Proliferation Activity for Treatment of Heart Diseases
US7105511B2 (en) Fluorescent fused-ring triazoles that inhibit cell proliferation and uses thereof
US20190092756A1 (en) Crystalline form a of 2-[(2r)-2-methyl-2-pyrrolidyl]-1h-benzimidazole-7-carboxamide dihydrochloride and preparation method thereof
CN102101857B (zh) 一种抗真菌剂1-(4-氯-2H-苯并[b]噻喃-3-甲醛)缩氨基(硫)脲衍生物

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AU US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase