WO2003007911A1 - Verfahren zur herstellung von artikeln aus polymerstoffen mit medikamentöser depotwirkung - Google Patents
Verfahren zur herstellung von artikeln aus polymerstoffen mit medikamentöser depotwirkung Download PDFInfo
- Publication number
- WO2003007911A1 WO2003007911A1 PCT/EP2002/007938 EP0207938W WO03007911A1 WO 2003007911 A1 WO2003007911 A1 WO 2003007911A1 EP 0207938 W EP0207938 W EP 0207938W WO 03007911 A1 WO03007911 A1 WO 03007911A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- crosslinking
- polymer material
- sterilization
- carried out
- hoses
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
- A61L2/087—Particle radiation, e.g. electron-beam, alpha or beta radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
- A61L2/081—Gamma radiation
Definitions
- the present invention relates to a process for the production of articles from polymer materials with a medicinal depot effect by missing the starting materials, forms of the mixture and crosslinking the polymer material.
- this method is unsuitable for the production of articles such as, for example, drainage tubes made of polymeric materials with a medicinal depot effect, because, for example, the material for cutting out drainage holes and further assembly work in the uncrosslinked state is too soft and easily deformable.
- the task of producing articles such as drainage tubes from polymeric substances with a medicinal depot effect is achieved according to the invention by mixing the starting materials, forms of the mixture, crosslinking the polymeric material at least to a sufficient dimensional stability, performing all the necessary assembly work, placing the article in protective packaging, sterilizing the packaged article if necessary with further crosslinking of the polymer material.
- the method according to the invention is particularly suitable for the production of drainage hoses, the mixture being shaped into a hose, cut to length, networked to the necessary stability and then assembled. This can include: making drainage holes, rounding off the edges, closing one end, inserting T-pieces and / or other additional parts.
- the article is then introduced into protective packaging, sterilization of the packaged article and, if appropriate, further crosslinking of the polymer material.
- the method according to the invention is also suitable for the production of extrudates, molded parts, coatings on textile fabrics, wire mesh and plastic parts. They can be single and multi-layered, but always require assembly work that must be carried out before being placed in protective packaging.
- the crosslinking and sterilization is preferably carried out by electron radiation, although this process can also be carried out with the aid of gamma rays or a combination of both types of radiation.
- Radiation doses of 10 to 120 KGy are generally used for crosslinking and sterilization, with radiation doses of 20 to 66 KGy generally being sufficient.
- Silicone rubber is particularly suitable as a polymer material for the manufacture of articles with a medicinal depot effect, such as drainage tubes.
- the active ingredient is preferably bound to an inorganic or organic carrier substance before mixing with the polymer material.
- Molecular sieves and / or layered silicates have proven particularly useful as carrier substances.
- a large number of substances with a medicinal effect are used as active ingredients for the manufacture of articles with a medicinal depot effect.
- active ingredients include, for example, antithrombotics, antibiotics, other bactericidal and virucidal substances, local anesthetics.
- anticoagulant active ingredients include sodium pentosan polysulfate (SP 54) has proven particularly useful.
- the articles according to the invention made of polymeric substances with a medicinal depot effect, insofar as they are used within humans, preferably have a marking strip which can also be seen in the X-ray image.
- Barium sulfate to which a color pigment recognizable with the naked eye is added if desired, has proven particularly useful as an X-ray contrast medium. They are thus marked as X-ray active.
- calcium carbonate and other biologically inactive substances are suitable as a further filler for the polymer material.
- the polymer material together with the active ingredient which may be bound to a carrier substance and, if appropriate, fillers, is mixed and shaped to give an article, for example a tube, which is crosslinked, unpackaged, by electron radiation until it has adequate dimensional stability.
- the article can then be cut to length, for example drainage holes can be cut out, and the other packaging can be done.
- this primarily includes rounding off the cut edges and / or closing a hose end and / or attaching additional parts and / or T-pieces.
- the article prepared in this way is then sealed in protective packaging and then sterilized with electron beams and / or gamma rays. This can result in further networking and thus mechanical stabilization of the article.
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Medicinal Preparation (AREA)
- Treatments Of Macromolecular Shaped Articles (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Polymerisation Methods In General (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/483,831 US8187513B2 (en) | 2001-07-19 | 2002-07-17 | Method for producing articles consisting of polymer materials having a medicamentous depot effect |
DK02754897T DK1406590T3 (da) | 2001-07-19 | 2002-07-17 | Fremgangsmåde til fremstilling af genstande af polymermaterialer med medikamentel depotvirkning |
DE50202927T DE50202927D1 (de) | 2001-07-19 | 2002-07-17 | Verfahren zur herstellung von artikeln aus polymerstoffen mit medikamentöser depotwirkung |
AT02754897T ATE293956T1 (de) | 2001-07-19 | 2002-07-17 | Verfahren zur herstellung von artikeln aus polymerstoffen mit medikamentöser depotwirkung |
EP02754897A EP1406590B1 (de) | 2001-07-19 | 2002-07-17 | Verfahren zur herstellung von artikeln aus polymerstoffen mit medikamentöser depotwirkung |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10135144 | 2001-07-19 | ||
DE10135144.5 | 2001-07-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003007911A1 true WO2003007911A1 (de) | 2003-01-30 |
Family
ID=7692342
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2002/007938 WO2003007911A1 (de) | 2001-07-19 | 2002-07-17 | Verfahren zur herstellung von artikeln aus polymerstoffen mit medikamentöser depotwirkung |
Country Status (8)
Country | Link |
---|---|
US (1) | US8187513B2 (de) |
EP (1) | EP1406590B1 (de) |
AT (1) | ATE293956T1 (de) |
DE (1) | DE50202927D1 (de) |
DK (1) | DK1406590T3 (de) |
ES (1) | ES2240780T3 (de) |
PT (1) | PT1406590E (de) |
WO (1) | WO2003007911A1 (de) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2114842A2 (de) * | 2007-01-22 | 2009-11-11 | Mertens, Phillip | Zubereitungsform mit verzögerter freisetzungsrate für wasserlösliche und/oder wasserunlösliche stoffe |
CN101920044A (zh) * | 2010-05-09 | 2010-12-22 | 海南医学院 | 一种纳米金属硅橡胶的制备方法 |
CN110694118A (zh) * | 2019-09-23 | 2020-01-17 | 江苏理工学院 | 一种抗菌抗凝血脑室腹腔分流管硅胶管体及其制备方法和应用 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102007050582B4 (de) | 2007-10-23 | 2018-09-06 | Khs Corpoplast Gmbh | Verfahren und Vorrichtung zum Sterilisieren sowie Vorrichtung zur Blasformung von Behältern |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3744289A1 (de) * | 1986-12-30 | 1988-07-14 | Politechnika Lodzka | Verfahren zur darstellung von hydrogelverbaenden |
DD275697A1 (de) * | 1988-09-22 | 1990-01-31 | Thueringen Gummiwerke Veb | Verfahren zur vulkanisation von schlaeuchen aus hochmolekularen, biologisch wirksamen polymerwerkstoffen |
WO1996035459A1 (de) * | 1995-05-10 | 1996-11-14 | Veritas Gummiwerke Ag | Verfahren zur herstellung von erzeugnissen aus polymerwerkstoffen mit medikamentöser depotwirkung |
WO1998035631A1 (en) * | 1997-02-14 | 1998-08-20 | Pathak Chandrashekar | Biocompatible polymers and methods for their use |
WO2001030407A1 (en) * | 1999-10-27 | 2001-05-03 | Department Of Atomic Energy | A process for manufacture of hydrogels for burn and injury treatment |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4212304A (en) * | 1978-04-07 | 1980-07-15 | Medical Engineering Corp. | Uretheral catheter stent |
JPH02174703A (ja) | 1989-11-10 | 1990-07-06 | Earth Chem Corp Ltd | 徐放性害虫用殺虫・忌避材 |
US5837313A (en) * | 1995-04-19 | 1998-11-17 | Schneider (Usa) Inc | Drug release stent coating process |
-
2002
- 2002-07-17 WO PCT/EP2002/007938 patent/WO2003007911A1/de not_active Application Discontinuation
- 2002-07-17 PT PT02754897T patent/PT1406590E/pt unknown
- 2002-07-17 EP EP02754897A patent/EP1406590B1/de not_active Expired - Lifetime
- 2002-07-17 ES ES02754897T patent/ES2240780T3/es not_active Expired - Lifetime
- 2002-07-17 US US10/483,831 patent/US8187513B2/en not_active Expired - Fee Related
- 2002-07-17 AT AT02754897T patent/ATE293956T1/de active
- 2002-07-17 DE DE50202927T patent/DE50202927D1/de not_active Expired - Lifetime
- 2002-07-17 DK DK02754897T patent/DK1406590T3/da active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3744289A1 (de) * | 1986-12-30 | 1988-07-14 | Politechnika Lodzka | Verfahren zur darstellung von hydrogelverbaenden |
DD275697A1 (de) * | 1988-09-22 | 1990-01-31 | Thueringen Gummiwerke Veb | Verfahren zur vulkanisation von schlaeuchen aus hochmolekularen, biologisch wirksamen polymerwerkstoffen |
WO1996035459A1 (de) * | 1995-05-10 | 1996-11-14 | Veritas Gummiwerke Ag | Verfahren zur herstellung von erzeugnissen aus polymerwerkstoffen mit medikamentöser depotwirkung |
WO1998035631A1 (en) * | 1997-02-14 | 1998-08-20 | Pathak Chandrashekar | Biocompatible polymers and methods for their use |
WO2001030407A1 (en) * | 1999-10-27 | 2001-05-03 | Department Of Atomic Energy | A process for manufacture of hydrogels for burn and injury treatment |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2114842A2 (de) * | 2007-01-22 | 2009-11-11 | Mertens, Phillip | Zubereitungsform mit verzögerter freisetzungsrate für wasserlösliche und/oder wasserunlösliche stoffe |
CN101920044A (zh) * | 2010-05-09 | 2010-12-22 | 海南医学院 | 一种纳米金属硅橡胶的制备方法 |
CN110694118A (zh) * | 2019-09-23 | 2020-01-17 | 江苏理工学院 | 一种抗菌抗凝血脑室腹腔分流管硅胶管体及其制备方法和应用 |
Also Published As
Publication number | Publication date |
---|---|
ES2240780T3 (es) | 2005-10-16 |
EP1406590B1 (de) | 2005-04-27 |
DE50202927D1 (de) | 2005-06-02 |
US8187513B2 (en) | 2012-05-29 |
PT1406590E (pt) | 2005-07-29 |
EP1406590A1 (de) | 2004-04-14 |
US20040251580A1 (en) | 2004-12-16 |
ATE293956T1 (de) | 2005-05-15 |
DK1406590T3 (da) | 2005-08-22 |
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