WO2002102313A2 - Pyrimidine inhibitors of phosphodiesterase (pde) 7 - Google Patents
Pyrimidine inhibitors of phosphodiesterase (pde) 7 Download PDFInfo
- Publication number
- WO2002102313A2 WO2002102313A2 PCT/US2002/019097 US0219097W WO02102313A2 WO 2002102313 A2 WO2002102313 A2 WO 2002102313A2 US 0219097 W US0219097 W US 0219097W WO 02102313 A2 WO02102313 A2 WO 02102313A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- optionally substituted
- heteroaryl
- groups
- heterocyclo
- Prior art date
Links
- 0 Cc1c(*)nc(N(C)*)nc1I Chemical compound Cc1c(*)nc(N(C)*)nc1I 0.000 description 13
- WDLIOPSIMOHHFU-RGPKZFNQSA-N C/N=C1/N=CC=C/C1=C/C=C Chemical compound C/N=C1/N=CC=C/C1=C/C=C WDLIOPSIMOHHFU-RGPKZFNQSA-N 0.000 description 1
- ZNIOXSUDJJWDMN-UHFFFAOYSA-N C1NC2SCCN2C1 Chemical compound C1NC2SCCN2C1 ZNIOXSUDJJWDMN-UHFFFAOYSA-N 0.000 description 1
- DZJQZQKZDNNEBT-UHFFFAOYSA-N CC1(C)C=Nc(cccc2)c2N=C1 Chemical compound CC1(C)C=Nc(cccc2)c2N=C1 DZJQZQKZDNNEBT-UHFFFAOYSA-N 0.000 description 1
- WQDQROHBIVAGLJ-UHFFFAOYSA-N CC1=C2C=CC=C[C]2OC=N1 Chemical compound CC1=C2C=CC=C[C]2OC=N1 WQDQROHBIVAGLJ-UHFFFAOYSA-N 0.000 description 1
- QDHFNBUJIIZYNP-UHFFFAOYSA-N CCOC(c1c(C)nc(NC(N2)=NC(C(F)(F)F)=CC2=O)[s]1)=O Chemical compound CCOC(c1c(C)nc(NC(N2)=NC(C(F)(F)F)=CC2=O)[s]1)=O QDHFNBUJIIZYNP-UHFFFAOYSA-N 0.000 description 1
- JNUWTJQNFCGSSD-UHFFFAOYSA-N CCOC(c1c(C)nc(Nc2nc(C(F)(F)F)cc(Cl)n2)[s]1)=O Chemical compound CCOC(c1c(C)nc(Nc2nc(C(F)(F)F)cc(Cl)n2)[s]1)=O JNUWTJQNFCGSSD-UHFFFAOYSA-N 0.000 description 1
- RIZMNVWFOINTMD-UHFFFAOYSA-N CCOC(c1c(C)nc(Nc2nc(C(OCC)=O)cc(NCc(cc3)ccc3S(N)(=O)=O)n2)[s]1)=O Chemical compound CCOC(c1c(C)nc(Nc2nc(C(OCC)=O)cc(NCc(cc3)ccc3S(N)(=O)=O)n2)[s]1)=O RIZMNVWFOINTMD-UHFFFAOYSA-N 0.000 description 1
- BBCBGTBOZRVMCU-UHFFFAOYSA-N CCOC(c1c(C)nc(Nc2nc(N(CC3)CCC3O)cc(-c(cc3OC)cc(OC)c3OC)n2)[s]1)=O Chemical compound CCOC(c1c(C)nc(Nc2nc(N(CC3)CCC3O)cc(-c(cc3OC)cc(OC)c3OC)n2)[s]1)=O BBCBGTBOZRVMCU-UHFFFAOYSA-N 0.000 description 1
- CXOFJSWNKJYDNK-UHFFFAOYSA-N CCOC(c1c(C)nc(Nc2nc(N(CC3)CCC3O)cc(Cl)n2)[s]1)=O Chemical compound CCOC(c1c(C)nc(Nc2nc(N(CC3)CCC3O)cc(Cl)n2)[s]1)=O CXOFJSWNKJYDNK-UHFFFAOYSA-N 0.000 description 1
- XXIUBTYOHPJMCL-UHFFFAOYSA-N Cc1ccccc1NC=C Chemical compound Cc1ccccc1NC=C XXIUBTYOHPJMCL-UHFFFAOYSA-N 0.000 description 1
- TWWWGBSUPNNTMJ-UHFFFAOYSA-N Cc1ccccc1OC=C Chemical compound Cc1ccccc1OC=C TWWWGBSUPNNTMJ-UHFFFAOYSA-N 0.000 description 1
- RBKYIOBKUKIPSH-UHFFFAOYSA-N Cc1ccccc1SC=C Chemical compound Cc1ccccc1SC=C RBKYIOBKUKIPSH-UHFFFAOYSA-N 0.000 description 1
- BSKHPKMHTQYZBB-UHFFFAOYSA-N Cc1ccccn1 Chemical compound Cc1ccccn1 BSKHPKMHTQYZBB-UHFFFAOYSA-N 0.000 description 1
- FTPYETOWPNDAOE-UHFFFAOYSA-N Cc1ccnc2c1[s]cc2 Chemical compound Cc1ccnc2c1[s]cc2 FTPYETOWPNDAOE-UHFFFAOYSA-N 0.000 description 1
- CAWHJQAVHZEVTJ-UHFFFAOYSA-N Cc1cnccn1 Chemical compound Cc1cnccn1 CAWHJQAVHZEVTJ-UHFFFAOYSA-N 0.000 description 1
- FWOPJXVQGMZKEP-UHFFFAOYSA-N Cc1n[nH]c2c1cccc2 Chemical compound Cc1n[nH]c2c1cccc2 FWOPJXVQGMZKEP-UHFFFAOYSA-N 0.000 description 1
- GAUKCDPSYQUYQL-UHFFFAOYSA-N Cc1n[o]c2c1cccc2 Chemical compound Cc1n[o]c2c1cccc2 GAUKCDPSYQUYQL-UHFFFAOYSA-N 0.000 description 1
- DQSHFKPKFISSNM-UHFFFAOYSA-N Cc1nc(cccc2)c2[o]1 Chemical compound Cc1nc(cccc2)c2[o]1 DQSHFKPKFISSNM-UHFFFAOYSA-N 0.000 description 1
- DXYYSGDWQCSKKO-UHFFFAOYSA-N Cc1nc(cccc2)c2[s]1 Chemical compound Cc1nc(cccc2)c2[s]1 DXYYSGDWQCSKKO-UHFFFAOYSA-N 0.000 description 1
- NVXPSQIYZCKHMN-UHFFFAOYSA-N Cc1nc(cccn2)c2[s]1 Chemical compound Cc1nc(cccn2)c2[s]1 NVXPSQIYZCKHMN-UHFFFAOYSA-N 0.000 description 1
- CGSWTRTYXLGAFI-UHFFFAOYSA-N Cc1nc(nccc2)c2[s]1 Chemical compound Cc1nc(nccc2)c2[s]1 CGSWTRTYXLGAFI-UHFFFAOYSA-N 0.000 description 1
- LDZYRENCLPUXAX-UHFFFAOYSA-N Cc1nc2ccccc2[nH]1 Chemical compound Cc1nc2ccccc2[nH]1 LDZYRENCLPUXAX-UHFFFAOYSA-N 0.000 description 1
- JQZGNIIKYRMWLF-UHFFFAOYSA-N Cc1nc2nccnc2[s]1 Chemical compound Cc1nc2nccnc2[s]1 JQZGNIIKYRMWLF-UHFFFAOYSA-N 0.000 description 1
- OKGXJRGLYVRVNE-UHFFFAOYSA-N NC(NC(N)=S)=N Chemical compound NC(NC(N)=S)=N OKGXJRGLYVRVNE-UHFFFAOYSA-N 0.000 description 1
- RQAXXQFWIDJSTM-UHFFFAOYSA-N c(cc1)cc2c1N=[I]N=C2 Chemical compound c(cc1)cc2c1N=[I]N=C2 RQAXXQFWIDJSTM-UHFFFAOYSA-N 0.000 description 1
- PXXPVOPQOOGZPS-UHFFFAOYSA-N c1c[s]c2c1C=[I]C=N2 Chemical compound c1c[s]c2c1C=[I]C=N2 PXXPVOPQOOGZPS-UHFFFAOYSA-N 0.000 description 1
- YJSKZIATOGOJEB-UHFFFAOYSA-N c1c[s]c2c1nccn2 Chemical compound c1c[s]c2c1nccn2 YJSKZIATOGOJEB-UHFFFAOYSA-N 0.000 description 1
- UFBBWLWUIISIPW-UHFFFAOYSA-N c1cnc2[s]cc[n]12 Chemical compound c1cnc2[s]cc[n]12 UFBBWLWUIISIPW-UHFFFAOYSA-N 0.000 description 1
Classifications
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HU0402352A HUP0402352A2 (hu) | 2001-06-19 | 2002-06-17 | Foszfodiészteráz (PDE) 7 inhibitorként alkalmazható pirimidinszármazékok és ezeket tartalmazó gyógyszerkészítmények |
CA002450934A CA2450934A1 (en) | 2001-06-19 | 2002-06-17 | Pyrimidine inhibitors of phosphodiesterase (pde) 7 |
JP2003504902A JP2005500294A (ja) | 2001-06-19 | 2002-06-17 | ホスホジエステラーゼ7に対するピリミジン阻害剤 |
EP02744381A EP1397142A4 (en) | 2001-06-19 | 2002-06-17 | PYRIMIDINE PHOSPHODIESTERASE (PDE) INHIBITORS 7 |
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US36875202P | 2002-03-29 | 2002-03-29 | |
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WO2002102313A3 (en) | 2003-04-03 |
JP2005500294A (ja) | 2005-01-06 |
US7087614B2 (en) | 2006-08-08 |
EP1397142A2 (en) | 2004-03-17 |
EP1397142A4 (en) | 2004-11-03 |
US20030162802A1 (en) | 2003-08-28 |
HUP0402352A2 (hu) | 2005-02-28 |
CA2450934A1 (en) | 2002-12-27 |
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