WO2002089966A2 - Apparatus for mixing and reacting at least two fluids - Google Patents
Apparatus for mixing and reacting at least two fluids Download PDFInfo
- Publication number
- WO2002089966A2 WO2002089966A2 PCT/US2002/014383 US0214383W WO02089966A2 WO 2002089966 A2 WO2002089966 A2 WO 2002089966A2 US 0214383 W US0214383 W US 0214383W WO 02089966 A2 WO02089966 A2 WO 02089966A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fluid
- mixing chamber
- mixing
- supply
- distribution
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/30—Injector mixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/421—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions by moving the components in a convoluted or labyrinthine path
- B01F25/422—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions by moving the components in a convoluted or labyrinthine path between stacked plates, e.g. grooved or perforated plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/432—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
- B01F33/3012—Interdigital streams, e.g. lamellae
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
- B01F33/3017—Mixing chamber
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/304—Micromixers the mixing being performed in a mixing chamber where the products are brought into contact
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/24—Stationary reactors without moving elements inside
- B01J19/248—Reactors comprising multiple separated flow channels
- B01J19/249—Plate-type reactors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F2025/91—Direction of flow or arrangement of feed and discharge openings
- B01F2025/912—Radial flow
- B01F2025/9122—Radial flow from the circumference to the center
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F2025/91—Direction of flow or arrangement of feed and discharge openings
- B01F2025/914—Tangential flow, i.e. flow spiraling in a tangential direction in a flat plane or belt-like area
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00819—Materials of construction
- B01J2219/00835—Comprising catalytically active material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00873—Heat exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00889—Mixing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00891—Feeding or evacuation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/24—Stationary reactors without moving elements inside
- B01J2219/2401—Reactors comprising multiple separate flow channels
- B01J2219/245—Plate-type reactors
- B01J2219/2451—Geometry of the reactor
- B01J2219/2453—Plates arranged in parallel
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/24—Stationary reactors without moving elements inside
- B01J2219/2401—Reactors comprising multiple separate flow channels
- B01J2219/245—Plate-type reactors
- B01J2219/2451—Geometry of the reactor
- B01J2219/2456—Geometry of the plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/24—Stationary reactors without moving elements inside
- B01J2219/2401—Reactors comprising multiple separate flow channels
- B01J2219/245—Plate-type reactors
- B01J2219/2469—Feeding means
- B01J2219/247—Feeding means for the reactants
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/24—Stationary reactors without moving elements inside
- B01J2219/2401—Reactors comprising multiple separate flow channels
- B01J2219/245—Plate-type reactors
- B01J2219/2474—Mixing means, e.g. fins or baffles attached to the plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/24—Stationary reactors without moving elements inside
- B01J2219/2401—Reactors comprising multiple separate flow channels
- B01J2219/245—Plate-type reactors
- B01J2219/2476—Construction materials
- B01J2219/2483—Construction materials of the plates
- B01J2219/2488—Glass
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/24—Stationary reactors without moving elements inside
- B01J2219/2401—Reactors comprising multiple separate flow channels
- B01J2219/245—Plate-type reactors
- B01J2219/2491—Other constructional details
- B01J2219/2492—Assembling means
- B01J2219/2493—Means for assembling plates together, e.g. sealing means, screws, bolts
Definitions
- the present invention relates to a novel apparatus for mixing and reacting at least two fluids.
- the apparatus comprises a mixing chamber, at least two conduits to supply fluids in both tangential and radial directions into the chamber, and a mixing chamber outlet to discharge a stream of mixed fluids.
- a reaction zone may be incorporated either within the mixing chamber or separate therefrom.
- a further advantage of static mixers is a reduction in component size, allowing greater ease of integration with adjoining equipment, such as heat exchangers and reactors. Process optimization may also be enhanced due to forced interactions between two or more components within a confined space.
- Static mixers apply to forming not only liquid/liquid and gas/gas mixtures, but also liquid/liquid emulsions and liquid/gas dispersions. Static mixers have also found use in multiphase and phase- transfer reactions.
- a static mixer operating using the principle of multilamination or fluid layering has, in one plane, a structure of intermingled channels of a width of 25-
- the channels divide two fluids to be mixed into a multiplicity of separate fluid streams, arranged to flow parallel and alternately in opposite directions. Adjacent fluid streams are removed vertically upward out of a horizontal
- the channel geometries and therefore the fluid layer widths can be reduced to the submicron range to only a limited extent.
- a further reduction in the size of fluid layers using the multilamination principle is achieved by so-called geometric focusing.
- a static mixer using this principle for reacting hazardous substances is described by T. M. Floyd et al. in Microreaction technology: industrial prospects; proceedings of the Third International Conference on Microreaction Technology/IMRET3, W. Ehrfeld, Springer 2000, pp. 171-179.
- Alternately adjacent channels for the two fluids to be mixed open outward in a semicircle, radially from the outside, into a chamber extending into a funnel shape and merging into a narrow, elongate channel.
- the layered fluid stream is combined in the chamber and then transferred to the narrow channel, so that the individual fluid layer width is reduced.
- the apparatus of present invention provides a solution to the well-known problem of mixing at least two fluids rapidly and uniformly, while at the same time maintaining low pressure drop characteristics and an economical design.
- the efficient mixing provided is used in combination with chemical reactions. Prior to reaction, the feed components are mixed in a manner utilizing a vortex or mixing chamber that promotes complete mixing without significant pressure loss. Of particular interest are those reactions where extremely good dispersion of reactants can overcome diffusion limitations.
- the invention may be used in a wide variety of applications, it is particularly suited for small-scale or micromixing operations that are coupled with reaction.
- the present invention is a mixer/reactor apparatus for mixing and reacting at least two fluids and method of mixing that overcome limitations of high pressure drop and insufficient diffusion. Mixing is accomplished by injecting streams of individual fluids in both tangential and radial directions about a mixing chamber to provide an overall helical flow path.
- the invention may be used in a wide variety of applications, the invention is particularly suited for small-scale mixing operations, or micromixing. The invention may also be coupled with reaction.
- the present invention is an apparatus for mixing a first fluid stream and a second fluid stream.
- the apparatus comprises a first supply conduit having a first supply conduit receiving end for receiving the first fluid stream and having a first supply conduit discharge end opposite the first supply conduit receiving end.
- the apparatus further comprises a second supply conduit having a second supply conduit receiving end for receiving the second fluid stream and having a second supply conduit discharge end opposite the second supply conduit receiving end.
- the apparatus further comprises a mixing chamber in fluid communication with the first and second supply conduits at first and second supply conduit discharge ends.
- One of the first or second supply conduit discharge ends leads substantially tangentially into the mixing chamber and the other of the first or second supply conduit discharge ends leads substantially radially into the mixing chamber.
- the apparatus further comprises a mixing chamber outlet in fluid communication with the central region of the mixing chamber for discharging a product stream.
- the present invention is an apparatus for mixing and reacting a first fluid stream and a second fluid stream.
- the apparatus comprises a first supply conduit having a first supply conduit receiving end for receiving the first fluid stream and having a first supply conduit discharge end opposite the first supply conduit receiving end.
- the apparatus further comprises a second supply conduit having a second supply conduit receiving end for receiving the second fluid stream and having a second supply conduit discharge end opposite the second supply conduit receiving end.
- the apparatus further comprises a mixing chamber having a catalyst disposed therein.
- the mixing chamber in fluid communication with the first and second supply conduits at first and second supply conduit discharge ends.
- One of the first or second supply conduit discharge ends leads substantially tangentially into the mixing chamber and the other of the first or second supply conduit discharge ends leads substantially radially into the mixing chamber.
- the apparatus further comprises a mixing chamber outlet in fluid communication with the central region of the mixing chamber for discharging a product stream.
- the present invention is an apparatus for mixing and reacting a first fluid stream and a second fluid stream.
- the apparatus comprises a first supply conduit having a first supply conduit receiving end for receiving the first fluid stream and having a first supply conduit discharge end opposite the first supply conduit receiving end.
- the apparatus further comprises a second supply conduit having a second supply conduit receiving end for receiving the second fluid stream and having a second supply conduit discharge end opposite the second supply conduit receiving end.
- the apparatus further comprises a mixing chamber in fluid communication with the first and second supply conduits at first and second supply conduit discharge ends.
- One of the first or second supply conduit discharge ends leads substantially tangentially into the mixing chamber and the other of the first or second supply conduit discharge ends leads substantially radially into the mixing chamber.
- the apparatus further comprises a mixing chamber outlet in fluid communication with the central region of the mixing chamber for discharging a mixed stream of the first and second fluids.
- the apparatus further comprises a reactor having an inlet and an outlet and defining a catalyst retention space, wherein the reactor inlet is in fluid communication with the mixing chamber outlet.
- the present invention is an apparatus for mixing and reacting a first fluid stream and a second fluid stream.
- the apparatus comprises a first supply conduit having a first supply conduit receiving end for receiving the first fluid stream and having a first supply conduit discharge end opposite the first supply conduit receiving end.
- the apparatus further comprises a second supply conduit having a second supply conduit receiving end for receiving the second fluid stream and having a second supply conduit discharge end opposite the second supply conduit receiving end.
- the apparatus further comprises a mixing chamber in fluid communication with the first and second supply conduits at first and second supply conduit discharge ends, where one of the first or second supply conduit discharge ends leads substantially tangentially into the mixing chamber and the other of the first or second supply conduit discharge ends leads substantially radially into the mixing chamber.
- the apparatus further comprises a mixing chamber outlet for discharging a mixed stream of the first and second fluid streams from the mixing chamber, the mixing chamber outlet in fluid communication with the central region of the mixing chamber.
- the apparatus further comprises a reactor having an inlet and an outlet and defining a catalyst retention space, where the reactor inlet is in fluid communication with the mixing chamber outlet.
- the present invention is a layered assembly for mixing at least two fluids.
- the assembly comprises a substantially planar cover layer having external and internal faces and defining first and second feed channels for receiving first and second fluids into the assembly.
- the first and second feed channels extend from the external surface to the internal surface to form first and second inlet ports.
- the assembly further comprises a substantially planar mixing layer having an upper and a lower face, where the mixing layer upper face is seahngly disposed on the cover layer internal face to define a first supply channel having a first supply channel receiving end in fluid communication with the first feed channel and a first supply channel discharge end opposite the first supply channel receiving end.
- the cover and mixing layers further define a second supply channel having a second supply channel receiving end in fluid communication with the second feed channel and a second supply channel discharge end opposite the second supply channel receiving end.
- the cover and mixing layers further define a mixing chamber in fluid communication with the first and second supply channel discharge ends, where one of the first or second supply channel discharge ends leads substantially tangentially into the mixing chamber and the other of the first or second supply channel discharge ends leads substantially radially into the mixing chamber.
- the cover and mixing layers further define a mixing chamber outlet channel in fluid communication with the mixing chamber for discharging a mixed stream of the first and second fluids from the mixing chamber.
- the present invention is a layered assembly for at least two fluids.
- the assembly comprises a substantially planar cover layer having external and internal faces and defining first and second feed channels for receiving first and second fluids into the assembly, the first and second feed channels extending from the external surface to the internal surface to form first and second inlet ports.
- the layered assembly further comprises a substantially planar mixing layer having an upper and a lower face, the mixing layer upper face seahngly disposed on the cover layer internal face to define a first supply channel having a first supply channel receiving end in fluid communication with the first feed channel and a first supply channel discharge end opposite the first supply channel receiving end.
- the mixing layer and cover layer are sealingly connected to further define a second supply channel having a second supply channel receiving end in fluid communication with the second feed channel and a second supply channel discharge end opposite the second supply channel receiving end.
- the mixing layer and cover layer are sealingly connected to further define a mixing chamber having a catalyst disposed therein.
- the mixing chamber is in fluid communication with the first and second supply channel discharge ends, where one of the first or second supply channel discharge ends leads substantially tangentially into the mixing chamber and the other of the first or second supply channel discharge ends leads substantially radially into the mixing chamber.
- a mixing chamber outlet channel is in fluid communication with the mixing chamber for discharging a product stream from the mixing chamber.
- the present invention is a process for mixing, and optionally reacting, at least two fluid streams.
- the process comprises flowing a first fluid stream through a first feed channel and injecting the first fluid stream radially into a mixing chamber.
- the process further comprises flowing a second fluid stream thorough a second feed channel, injecting the second fluid stream tangentially into the mixing chamber to create a vortex, and withdrawing a stream of mixed first and second fluids from the central portion of the vortex.
- the process optionally, further comprises reacting the mixed fluids in a reaction chamber.
- FIG. 1 is a plan view of a mixing chamber with multiple supply conduits leading thereto in alternating tangential and radial directions.
- FIG. 2 is a plan view showing the pre-mixing of two fluids in a supply conduit prior to injection into the mixing chamber.
- FIG. 3 is a plan view showing multiple supply conduits where two fluids are mixed and where the supply conduits alternate between tangential and radial directions about the mixing chamber.
- FIG. 4 depicts a static mixer/reactor comprising a stacked plate arrangement with individual plates separated for clarity, where a mixer plate defines the open structure of a mixing chamber with multiple supply channels leading thereto in alternating tangential and radial directions and a reaction plate below the mixer plate defines the open structure of a reactor.
- FIG. 4 depicts a static mixer/reactor comprising a stacked plate arrangement with individual plates separated for clarity, where a mixer plate defines the open structure of a mixing chamber with multiple supply channels leading thereto in alternating tangential and radial directions and a reaction plate below the mixer plate defines the open structure of a reactor.
- FIG. 5 depicts a static mixer/reactor comprising a stacked plate arrangement with individual plates separated for clarity, where the mixer plate is configured to allow pre-mixing of two fluids in a supply channel prior to injection into the mixing chamber and a reaction plate above the reactor defines the open structure of a reactor.
- the invention relates to an improved apparatus for mixing and reacting two or more fluids.
- the fluids can be broadly any gaseous or liquid substances or mixtures of substances.
- the fluids may also have solid components dissolved or dispersed therein, so that solutions of dissolved solids and slurries, for example slurries of liquid reactants containing solid catalyst particles, are also applicable to the present invention.
- Other fluids comprising multiple phases such as gas/liquid mixtures, particle- entrained gases, and three-phase slurries are also pertinent.
- the mixing achieved prior to reaction, according to the present invention also encompasses the known operations of dissolving, emulsifying, and dispersing.
- the resulting mixture includes solutions, liquid/liquid emulsions, and gas/liquid and solid/liquid dispersions.
- the mixer/reactor apparatus and method according to the invention are advantageously applied in forming a gas/liquid dispersion, in which case at least one fluid introduced into a mixing chamber contains a gas or a gas mixture and at least one further fluid introduced contains a liquid, a liquid mixture, a solution, a dispersion, or an emulsion.
- the mixer/reactor according to the present invention is used for carrying out chemical reactions, especially those characterized as diffusion limited.
- the reactant streams may be introduced separately into a mixing chamber or they may be pre-mixed in supply conduits leading to this chamber.
- the optimal choice depends on the specific nature of the reaction. For example, reactions requiring long residence times may be best effected using pre-mixing, while reactions where non- selective by-products may be formed in the absence of a catalyst are best carried out by avoiding contact between reactants upstream of the mixing chamber.
- Devices for controlling the chemical reaction such as for example temperature or pressure sensors, flow meters, heater elements, or heat exchangers, can be integrated with the mixer/reactor apparatus.
- these devices may be arranged at a layer above or below the mixing chamber and may be functionally connected thereto.
- the mixer/reactor apparatus may additionally contain catalytic material.
- supplemental fluids include, for example, chemical stabilizers, emulsifiers, corrosion inhibitors, reaction promoters, polymerization chain terminating agents, and the like.
- a solid or liquid catalyst may be introduced into the mixing chamber to carry out the desired reaction.
- the fluids to be mixed and reacted may already contain an admixed auxiliary substance.
- the mixture formed in the mixing chamber, whether or not a reaction also takes place in the mixing chamber by disposing catalyst therein, is removed via a mixing chamber outlet in fluid communication with the mixing chamber, preferably at its central region.
- the mixer/reactor according to the present invention for mixing at least two fluids prior to reaction includes a mixing chamber and at least two supply conduits for injecting the fluids into the chamber and arranged about its perimeter.
- the supply conduits open into the mixing chamber in such a manner that particular fluids introduced at defined flow rates will form a fluid spiral flowing concentrically inward. This vortex formation extends the fluid residence time within the mixing chamber considerably, thereby improving mixing characteristics.
- Establishment of the desired helical and inward liquid flow path is primarily a function of both the angle of fluid introduction into the mixing chamber and the fluid kinetic energy.
- Fluids introduced radially, or, in the case of a cylindrical mixing chamber, directly toward its center, will not assume a helical flow path unless acted upon by another fluid with sufficient kinetic energy in the tangential direction.
- the present invention achieves exceptional mixing by introducing the first and second fluids to be mixed both tangentially and radially. It is preferred that the tangential fluid kinetic energy components are adequate to bend the radial flow components so that they assume the overall helical flow pattern with a sufficient number of windings to allow effective mixing. Since one fluid is introduced tangentially and another radially, it is preferred that the ratio of fluid kinetic energy of the tangentially flowing fluid to that of the radially flowing is greater than 0.5 to provide the desired helical and inward flow pattern.
- a further advantage associated with the present invention is the contact between one winding of the fluid spiral or vortex and the previous and subsequent windings, contributing to the diffusive mixing of the reactants.
- laminar flow conditions prevail from the circular fluid motion in the interior of the mixing chamber.
- localized turbulent flow conditions to result from the overall inward flow of the fluid spiral or vortex.
- At least one of the supply conduits is arranged to open at an acute angle or tangentially into the mixing chamber.
- the fluids may be introduced either as their bulk composition entering the mixer/reactor or as fluid boundary layers that have been pre-mixed to some extent before entering one or more supply channels.
- the tangentially directed fluid maintains laminar flow conditions upon entry into the mixing chamber, in order to form the desired fluid vortex with a multiplicity of windings extending perpendicularly with respect to the plane of the vortex.
- the supply conduits may be arranged to open out in one plane around the common mixing chamber.
- the supply conduits are preferably distributed symmetrically around the circumference of the mixing chamber.
- These supply conduits can be used to supply the same reactant fluids, for example the reactant A may be supplied separately in each of supply conduits 1 and 3, while reactant B is supplied in conduits 2 and 4.
- each conduit can supply a different fluid, for example conduits 1, 2, 3, and 4 can supply the fluids A, B, C, and D, respectively.
- the supply channels can be arranged in a plurality of planes around the mixing chamber. The same or different fluids can be introduced into the mixing chamber at supply channels arranged in any given plane.
- fluids may be introduced into a common type of mixing chamber, for example one having a circular cross section in a horizontal plane, through supply channels at various axial heights about the mixing chamber.
- a common type of mixing chamber for example one having a circular cross section in a horizontal plane
- the mixing chamber is preferably substantially cylindrical in shape and therefore preferably has a substantially circular cross section. It is also possible that the cross section is circular but that the circle diameter decreases or increases with axial height, so that the mixing chamber is actually conical rather than cylindrical in shape.
- the mixing chamber cross section is advantageously fixed in a substantially horizontal plane from which the mixing chamber outlet leads substantially perpendicularly or in a general vertical direction.
- the mixing chamber may have another cross sectional shape, particularly a rounded form such an oval or ellipse. Even forms such as a triangle or other polygons may be acceptable if the corners normally formed at their vertices are rounded. The rounded or curved form prevents "dead" zones (i.e. regions without a constant flow) that could be problematic if corners or edges are present.
- the height of the supply conduits at least in the region where they open into the mixing chamber, is preferably less than or equal to the height of the mixing chamber.
- multiple supply channels alternately open tangentially and radially into the mixing chamber.
- This particular embodiment of the apparatus is especially useful for providing gas/liquid dispersions that are to be reacted.
- supply channels for the liquid streams optimally open into the mixing chamber at a more acute angle than those for the gas streams.
- the gas streams are broken into individual gas bubbles by the swirling liquids.
- supply channels for the liquids open tangentially into the mixing chamber, and the supply channels for the gases open radially into the mixing chamber. This arrangement promotes the formation of gas/liquid dispersions with a small, closely distributed bubble size and thus provides an essentially homogeneous mixture prior to reaction.
- the mixer/reactor apparatus comprises a mixing chamber outlet that supplies the stream of mixed fluids for downstream applications.
- the mixing chamber outlet is in fluid communication with, and withdraws mixed fluid from, the central region of the mixing chamber, preferably at its center point.
- the mixing chamber is cylindrical and therefore has a circular cross section, the mixing chamber outlet will extract mixed fluid from its center, h a preferred embodiment, the mixing chamber has a substantially circular cross section oriented horizontally and the mixing chamber outlet leads substantially perpendicularly, either upward or downward, therefrom.
- the cross- sectional area of the outlet compared to that of both the mixing chamber and the cross- sectional areas of the supply channels opening into it will be set, in view of the specific fluids and their properties, to allow the formation of the desired inwardly flowing fluid vortex with a multiplicity of windings.
- the mixing chamber outlet conduit has a circular cross section, as would be the case for a pipe or tube, and the ratio of the diameters of the mixing chamber and mixing chamber outlet is greater than 5.
- the recycle stream may be introduced into the mixing chamber either through a tangentially or radially directed supply conduit. Otherwise, it is also possible to pre-mix the recycle stream with one of the reactant streams, in a manner described below, prior to introducing the recycle stream to the mixing chamber.
- Another possibility is to recycle the separated fluid, or a portion thereof, to the mixing chamber outlet directly upstream of the catalyst bed.
- the separator may use any number of known separation techniques known in the art, including flash separation, distillation, membrane separation, extraction, crystallization, and the like.
- one or more additional fluids enter into the mixing chamber either through a separate supply conduit or through a supply conduit where the additional fluid is pre-mixed with one of the fluids to be mixed.
- Such additional fluids may contain an auxiliary substance that stabilizes the mixture, for example an emulsifier.
- further supply channels are used to supply such a substance, they advantageously open tangentially into the mixing chamber, so that there is in each case one stream of the additional fluid between adjacent windings of the fluid spiral.
- further supply channels are used to supply a gaseous component into a fluid vortex which contains at least one liquid in the mixing chamber, these supply channels for the gas advantageously open into the mixing chamber radially or at an intermediate angle between tangentially and radially.
- the gas that is supplied is broken up into small gas bubbles by the fluid spiral and is finely dispersed.
- At least one of the supply conduits provides a substantially tangential injection of fluid into the mixing chamber and at least one also provides a substantially radial injection. It is the tangential fluid motion that imparts a spiral or vortex formation within the chamber, which breaks apart or finely divides the radially flowing fluid.
- radial flow is meant a fluid flow directed toward the center of the mixing chamber, whether the chamber be circular, elliptical, or oval in shape.
- Tangential flow refers to a flow directed at a right angle to this radial flow and generally at or near the surface of the mixing chamber.
- Substantially tangential or radial flow means that the superior mixing characteristics of the present invention may also be obtained when the flows are not exactly tangentially or radially directed, but are within 30° of these directions.
- the mixer/reactor apparatus comprises not merely two, but a plurality of supply conduits leading alternately substantially tangentially and substantially radially into the mixing chamber.
- the term "alternately” refers to the tangentially directed supply conduits, designated T, and the radially directed supply conduits, designated R, lying in the order TRTR in at least one plane about the circumference of the mixing chamber.
- the supply channels may also lie alternately in more than one plane, for example they may be offset in the manner of a chess board in two dimensions about the circumference and length of the mixing chamber.
- the supply conduits are in fluid communication with the fluids to be mixed, or feeds, and the discharge ends are in fluid communication with the mixing chamber and are responsible for directing the fluid flow with respect thereto.
- the supply channels may be of substantially uniform cross section over their entire length from their receiving end to their discharge end. A substantial change in direction from the receiving end to the discharge end of a supply conduit is certainly possible and may even be desired if space about the mixing chamber for multiple conduits is limited.
- acceleration of the fluid into the mixing chamber is conveniently accomplished through the narrowing of a supply conduit in the direction from its receiving end to its discharge end.
- supply conduits that narrow in this manner include those having the shapes of funnels, drops, or triangles.
- the first and second fluids may be mixed prior to their injection into the mixing chamber (i.e. pre-mixed).
- the apparatus may further comprise the necessary elements to accomplish such mixing within the supply channels.
- the supply channels should be sufficiently long to provide good pre-mixing without being so long as to promote excessive pressure drop.
- One particular method involves the use of distributing manifolds, so that the streams to be pre-mixed in the supply channels are first divided among a plurality of smaller streams flowing through distribution conduits. These smaller streams of the feed or starting fluids may then be directed at various points, preferably in an arrangement of a repeating or interdigitated sequence, into the supply conduit inlets.
- a “repeating sequence” is meant, in the case of two fluids A, B, that fluid streams lie next to one another in a recurring pattern at least one plane.
- An alternating order of ABAB for example, is a repeating sequence.
- other repeating sequences are possible, for example AABAAB.
- the same principals may be used for pre-mixing more than two fluid streams.
- the term "repeating sequence” would also encompass many possible orders of individual fluid boundary layers, such as ABCABC or ABACABAC.
- the fluid layers or distribution conduits from which they are formed may also lie in a repeating sequence in more than one plane. For example, they may be offset in the manner of a chess board in two dimensions.
- the fluid streams and conduits associated with the different fluids are preferably arranged parallel to one another and in the same direction.
- the fluids to be pre-mixed are divided among a plurality of smaller distribution streams that are then alternately layered or arranged in a repeating sequence before being fed into a supply conduit. Since the supply conduit generally has a significantly smaller cross sectional area than the sum of the cross sectional areas of the individual distribution streams feeding thereto, the premixed stream can be referred to as "focused" prior to introduction into the mixing chamber. This focusing increases the flow velocity of the divided streams and reduces their layer thickness, promoting the formation in the mixing chamber of an inwardly flowing spiral with as many windings as possible.
- the ratio of the sum of the cross sectional areas of the distribution conduits to the cross sectional area of the supply conduit into which they are merged at its receiving end is from 1.5 to 500.
- the manifold used for receiving the arranged fluid streams and discharging them into a single conduit i.e. a supply conduit
- the length to width ratio is from 1 to 30.
- a fluid spiral is formed that flows concentrically inward, and the resulting mixture is then removed from the center of the fluid vortex.
- three fluids are mixed, prior to reaction, using the mixer/reactor apparatus of the present invention, with the second and third fluids being premixed upstream of the second supply conduit.
- the apparatus comprises a plurality of second distribution conduits and a plurality of third distribution conduits dividing, respectively, the second and third fluids.
- a manifold can be used to receive the second and third fluid distribution conduits arranged in a repeating sequence to force individual boundary layers of the second and third fluid streams in close proximity in the second supply conduit prior to injection into the mixing chamber.
- the first fluid can be fed into the mixing chamber without mixing through a first supply conduit.
- This particular embodiment is especially advantageous when the second and third fluids are liquids, injected tangentially, and the first fluid is a gas, injected radially, into the mixing chamber.
- a specific type of mixer/reactor that accomplishes the excellent mixing characteristics in accordance with the broadly defined apparatus described above comprises at least two substantially planar layers joined together sealingly, or in a fluid- tight manner.
- the conduits, mixing chamber, and other fluid- guiding structures are defined by the sealing connections established between adjacent layers.
- the layers may be formed as plates having recesses or apertures impressed into, or cut completely away from, the plates.
- the mixing chamber When joined together in a fluid- tight arrangement, adjacent plates will surround these recesses and apertures to form structures, such a channels, capable of containing fluid streams under pressure.
- Some structures, for example the mixing chamber may be defined completely by a sealing connection between two or more plates, depending on the plate thickness and the chamber height. If the mixing chamber is merely impressed into, but not completely cut away from, one side or face of a single plate, then the mixing chamber outlet structure may also be included in the same plate, extending from the mixing chamber to the opposite face of the plate into which the mixing chamber is impressed. If the mixing chamber is completely cut out of a plate, the mixing chamber outlet structure will require the use of at least one other plate joined in a sealing connection. Some structures such as feed conduits may pass completely through two or more plates.
- the mixer/reactor apparatus in one embodiment of the present invention comprises at least two discreet layers, characterized by their function. Specific functions that occur at various substantially planar layers include distributing, channeling, and mixing the feed components.
- individual layers may comprise more than one plate, or, with certain specialized molding techniques, possibly more than one function or layer may be present in the form of a single plate.
- the first layer is a substantially planar cover layer used to supply the external fluid streams to be mixed to the internal structures of the mixer/reactor apparatus.
- the cover layer has both external and internal faces and defines first and second feed channels for receiving first and second fluids into the assembly. These first and second feed channels extend from the external surface to the internal surface to form first and second inlet ports.
- the second layer is a substantially planar mixing layer having an upper and a lower face, where the mixing layer upper face is sealingly disposed on the cover layer internal face.
- the fluid-tight connection between the layers defines a first supply channel having a first supply channel receiving end in fluid communication with the first feed channel and a first supply channel discharge end opposite the first supply channel receiving end.
- a second supply channel having a second supply channel receiving end in fluid communication with the second feed channel and a second supply channel discharge end opposite the second supply channel receiving end.
- a mixing chamber in fluid communication with the first and second supply channel discharge ends, where one of the first or second supply channel discharge ends leads substantially tangentially into the mixing chamber and the other of the first or second supply channel discharge ends leads substantially radially into the mixing chamber.
- the connection between the two layers also defines a mixing chamber outlet channel in fluid communication with the mixing chamber for discharging a mixed stream of the first and second fluids from the mixing chamber.
- the mixing chamber may have a catalyst disposed therein to effect a desired chemical reaction. If catalyst is not included in the mixing chamber, the mixed feed components are reacted in a separate structure.
- structures are formed from connecting two or more plates.
- Recesses such as grooves or blind holes, are typical structures that are surrounded by material in one plane and perpendicularly to this plane.
- Structures defining channels such as fluid supply channels may be formed as slots extending in depth either partially or completely through a plate. Apertures, such as slots or holes, pass through the material, i.e. are only laterally surrounded by the material in one plane.
- the open structures formed by the recesses and apertures as a result of stacking with other layers in a sealing manner, form fluid-guiding structures, such as supply channels, mixing chambers or feeds.
- a cover layer and/or base layer closing off the layered assembly in a fluid-tight manner with respect to the outside defines feed channels, which may be apertures or grooves, for the fluids to be mixed and/or at least one outlet for the mixture which is formed.
- the layered assembly comprises stacked plates
- they should be made from a material that is sufficiently inert with respect to the process fluids to be mixed as well as the reaction products made. This will help avoid corrosion, erosion, deformation, cracking, or expansion/contraction of the plates, or other detrimental effects potentially resulting from exposure to the fluids under processing conditions.
- inert materials from which the apparatus is constructed are selected from the group consisting of polymers (e.g. plastics such as polyvinylchloride or polyethylene), metals, alloys, glass, quartz, ceramic, and semiconductor materials. The same or different materials may be used for the various plates, depending on the properties desired at different stages of mixing and/or reaction.
- the cover plate, channel plate, distributor plate, and mixer plate are formed from a transparent material, especially glass, quartz glass, or light sensitive glass to allow convenient observation of the mixing operation.
- the plates preferably have a thickness in the range from 10 microns to 5 millimeters. Of course, thicker plates may be more appropriate for forming the mixing chamber. Otherwise two or more plates may be used to form the chamber or an elongated channel. Suitable methods for connecting the plates to one another in a fluid-tight manner include, for example, pressing, welding, sealing, adhesive bonding, or anodic bonding.
- Suitable methods for structuring the plates include known precision mechanics and micromechanics production methods, such as for example laser ablation, spark erosion, injection molding, stamping, or electrodeposition.
- Other standard industrial methods which comprise at least the steps of structuring using high-energy radiation and electrodeposition, as well as, if appropriate, molding, are also suitable.
- the conduit structures are generally formed as channels in the plates.
- the open structures of the supply channels and the mixing chamber are defined by at least one plate serving as a mixer plate. These open structures are closed off by a cover plate connected in a fluid-tight manner to the mixer plate, where the cover plate defines feed channels for receiving the fluids to be mixed from sources upstream of the mixer/reactor.
- open structures defined by various other plates described later are closed off when engaged in a sealing connection with at least one other adjacent plate. It is also possible, but not necessary, for the cover plate to define a channel, namely the mixing chamber outlet channel, for discharging the mixed fluids.
- these plates may define the feed channels and/or mixing chamber outlet channel. Since the plates themselves are most conveniently fabricated to a constant thickness or depth, it is advantageous if the supply channels and/or the mixing chamber defined by these plates are also of the same depth.
- the supply channels may be of uniform cross section or they may narrow in the direction leading to the mixing chamber
- the supply channels narrow or maintain substantially constant cross sectional areas, it is preferred that the ratio of the width of the supply channels, as measured at their respective points opening into the mixing chamber, to the width of the mixing chamber in the plane of the fluid spiral that forms during operation is advantageously less than or equal to 1 : 10.
- the ratio of the diameter of the mixing chamber to the width of each supply channel discharge end is greater than 10. In the case of a conically shaped mixing chamber, this ratio applies to the average diameter of the mixing chamber.
- the mixer plate may also define the open structures of a plurality of supply channels, each in alternate tangential/radial fluid communication with the mixing chamber.
- further plates such as a channeling plate and a distributor plate
- the channeling plate is connected to the mixer plate at one face and defines open structures of a plurality of first and second distribution ports, each in fluid communication at one end, respectively, with first and second fluid distributing structures defined by the distributor plate.
- the distributor plate is connected to the face of the channeling plate that is not connected to the mixer plate, and the first and second distributing structures are in fluid communication, respectively, with the first and second feed channels.
- the ends of the first and second distribution ports not in fluid communication with the fluid distributing structures are then each separately in fluid communication with the supply channels of the mixer plate to provide spatially alternating injection of the first and second fluids about the mixing chamber.
- channeling and distributor plates for other types of functions.
- two fluid streams may be pre-mixed upstream of a supply channel before introduction into the mixing chamber with a third feed.
- the channeling plate will define open structures of a plurality of second and third distribution ports in fluid communication with their respective fluid distributing structures.
- the distribution ports may advantageously form a row of apertures for each of the second and third fluids to be supplied, with each aperture being precisely assigned to one supply channel.
- the apertures are each alternately used to supply the second and third fluids, through a common supply channel, to the mixing chamber.
- the mixer plate will now further define the open structure of a focusing chamber to accept alternating divided streams of the first and second fluids and combine them into a single supply channel.
- the focusing chamber serves a function similar to that of the manifold described in the general apparatus of the present invention.
- the first fluid may be introduced into the mixing chamber through a separate supply channel used for the first fluid only, or it may also be mixed with either of the other two fluids.
- the embodiments described above represent preferred mixer/reactor apparatuses for carrying out reactions
- the plates may be arranged in various orders to promote different types of operations.
- a distributor plate as described above, when the mixing function incorporates multiple supply channels or a pre-mixing of feed streams.
- This distributor plate may be located between the cover plate and mixer plate or below the mixer plate.
- the channeling plate may lie either above or below these plates as desired.
- FIG 1 depicts a plan view of a preferred mixing chamber 14, having tangential 10 and radial 12 supply conduits connected thereto.
- the tangentially directed conduits 10 impart a swirling or helical motion to the fluid that is necessary to establish the proper residence time and mixing.
- the kinetic energy of the tangentially introduced fluid should be great enough relative to that of the radially introduced fluid to convert the path of the latter fluid from directly toward the mixing chamber outlet (not shown) at the center of the mixing chamber 14 to a helical path.
- the kinetic energy of the tangentially flowing fluid is at least 0.5 times that of the radially flowing fluid.
- the initially radially directed fluid may or may not be bent into a path as tightly wound as the tangentially directed fluid, depending on the relative kinetic energies of the two fluids. That is, the initially radially directed fluid may have as many windings along its path toward the mixing chamber outlet as the tangentially directed fluid or it may have fewer windings.
- the tangentially directed conduits will be reserved for a first fluid and the radially directed conduits for a second fluid. Therefore, the first fluid would be distributed, using a plurality of first fluid distribution conduits (not shown), to each of the tangentially directed supply conduits 10.
- the second fluid would be distributed, using a plurality of second fluid distribution conduits (not shown), to each of the radially directed supply conduits 12.
- the designation of a conduit as tangentially or radially directed is based on the orientation of the conduit discharge ends 18 leading into the supply chamber.
- both the tangentially directed supply conduits 10 and the radially directed supply conduits 12 are depicted as having closed ends in the plan view.
- the fluids feeding these supply conduits at their respective receiving ends 16 enter either above or below the cross section depicted. It is, of course, possible that the supply conduits are fed through conduits within the same plane (as well as the same plate).
- FIG 2 depicts an embodiment of the invention where a tangentially directed supply conduit 10' is fed through two feed conduits 26, 28 in the same plane as the mixing chamber 14'.
- the mixer/reactor apparatus comprises a radially directed supply conduit 12' that is also in fluid communication with the mixing chamber 14'.
- the radially directed supply conduit 12' may be used to supply a first fluid A to the mixing chamber, while the tangentially directed supply conduit 10' may be used to supply a mixed stream of second B and third C fluids.
- the second B and third C fluid streams are each distributed into a number of smaller streams using a plurality of second 20 and third 22 fluid distribution conduits.
- distribution conduits are interdigitated at the inlet of a manifold 24 to provide pre-mixing of the second B and third C fluids upstream of their respective, tangentially directed supply conduit 10' . While the inlet of the manifold 24 is in fluid communication with the second 20 and third 22 distribution conduits, the outlet is in fluid communication with only the supply conduit 10' at its receiving end 16', which is the end not in fluid communication with the mixing chamber 14'.
- a mixing chamber outlet 19 extends either above or below the plane of the cross section of the mixing chamber 14' to withdraw a stream of the mixed fluids.
- the supply conduit 10' for supplying the mixed fluid stream to the mixing chamber 14' is narrower than either of the conduits 26, 28 used for supplying the second B and third C fluids to be mixed. Also depicted in FIG 2 is a tangentially directed supply conduit 10' that is smaller in width than the sum of the widths of the distribution conduits 20, 22 leading to the inlet of the manifold 24.
- the fluid velocity entering the mixing chamber is inversely proportional to the area of the supply conduit at the point of injection thereto.
- narrow supply channels, or narrowing the supply conduit in the direction leading to the mixing chamber 14', as shown for the radially directed supply conduit 12' accelerates the fluid velocity into the mixing chamber 14' and generally improves mixing characteristics.
- FIG 3 shows a further embodiment, where fluid entering the mixing chamber 14' through the radially directed conduit 12' has been premixed in a similar manner to fluid entering through the tangentially directed conduit 10'.
- a plurality of distribution conduits 30 in fluid communication with fourth fluid D and also a plurality of distribution conduits 32 in fluid communication with a fifth fluid E are each used to divide these fluids among smaller streams. These streams are then distributed in an interdigitated arrangement to the inlet of a second manifold 34 leading to the radially directed supply conduit 12' .
- the velocities of the fluids are increased prior to their introduction into the mixing chamber 14'.
- a mixing chamber outlet 19' extends either above or below the cross section of the mixing chamber 14' to withdraw a stream of mixed fluids.
- FIG 4 illustrates a stacked plate apparatus for mixing and reacting fluids in a manner consistent with the apparatus of FIG 1.
- a plurality of both tangentially 10' and radially 12' directed conduits are in alternating fluid communication with both the mixing chamber 14' and with two separate fluid streams, so that one fluid is introduced exclusively tangentially and the other exclusively radially into the mixing chamber 14'.
- FIG 4 illustrates a specific type of mixer/reactor comprising a fluid tight plate stack, where the plates are shown separately for ease of understanding.
- a cover plate 40 or layer defines the open structures of feed channels 42, 44 for receiving each fluid individually.
- the channels in this case are in the form of holes extending through the cover plate 40 and providing fluid communication of the individual fluids with the plate below, namely the distributor plate 46.
- the distributor plate 46 or layer defines the open structures of first 48 and second 50 fluid distributing structures in exclusive fluid communication with their respective feed channels 42, 44. These fluid distributing structures 48, 50 extend through the distributor plate 46 and provide alternate fluid communication of the first and second fluids at discrete points with a plurality of both first 52 and second 54 distribution ports.
- the open structures of these fluid distribution ports 52, 54 are defined by a channeling plate 56 or layer that is connected at one face directly below the distributor plate 46.
- the fluid distribution ports 52, 54 are holes extending through the channeling plate 56.
- the fluid distribution ports 52, 54 are each in alternating fluid communication with the first 48 and second 50 fluid distributing structures at one end and, at their opposite ends, are also each in alternate fluid communication with tangentially 10' and radially 12' directed supply channels.
- the fluid distribution ports 52, 54 are in fluid communication with the supply channels 10', 12' at their respective receiving ends 16' .
- the discharge ends 18' of the tangentially and radially directed supply channels 10', 12' are in fluid communication with a mixing chamber 14' to introduce streams of the first and second fluids thereto.
- the structures of the mixing chamber 14' and the plurality of supply channels 10', 12' each having a receiving end 16' and a discharge end 18', are defined by a mixer plate 58, connected at its upper face to the lower face of the channeling plate 56.
- the discharge ends 18' of the supply channels 10', 12' lead alternately tangentially and radially into the mixing chamber 14'.
- a mixing chamber outlet 19' is in fluid communication with the central region of the mixing chamber 14' and extends perpendicularly from the mixer plate 58 to allow discharge of the mixed fluid stream.
- the mixing chamber outlet 19' in this embodiment is a hole extending through a further plate, namely a transfer plate 60, that is connected at its top face with the bottom face of the mixer plate 58.
- the feed channels 42, 44 as well as the mixing chamber outlet 19' may be threaded to allow connection between further conduits and equipment within an overall processing scheme. They may also be otherwise adapted for use with various fittings or attached thereto by bonding, brazing, or other known means.
- FIG 4 illustrates the use of both a mixer plate 58 and a transfer plate 60, for the case where the mixing chamber 14' and supply channels 10', 12' extend completely through the mixer plate 58. It is also possible to construct the assembly of FIG 4 by impressing or etching the structures of the mixing chamber 58 and supply channels 10', 12' into the mixer plate so that only the mixing chamber outlet 19' extends through to the opposite side of the mixer plate 58. Therefore, if the stacked plate arrangement is considered in broader terms as a layered assembly with each layer characterized by a separate function, the mixing layer as shown in FIG 4 comprises both the mixer plate 58 and the transfer plate 60.
- the mixing layer may comprise only a single plate.
- the apparatus of the present invention can be used to effect a chemical reaction in the mixing chamber 14' by disposing a catalyst therein. Otherwise, reaction between the fluids may be maintained completely separate from the mixing chamber using a distinct reaction plate 62 defining the open structure of a reactor 64 having an inlet at one end or face of the reaction plate 62 and having an outlet at the other end. Thus, the reactor 64 as depicted extends completely through the reaction plate 62. The reactor inlet is in fluid communication with the mixing chamber outlet 19' .
- a support plate 66 is positioned below the reaction plate 62 to provide a reactor effluent channel 68 for directing reaction product out of the layered assembly or to additional structures (e.g. a separator) within the assembly.
- the reactor effluent channel 68 is in fluid communication with the reactor outlet.
- the reactor 64 which is formed by the sealing connection between the reaction plate 62 and the transfer plate 60, may have a means, for example a screen or other porous medium, for retaining catalyst therein.
- catalyst is retained within the reactor 64 by placing such medium at the bottom of the reactor 64.
- the medium is supported by the ringed surface of the upper face of the support plate 66 that is formed within the reactor when the smaller reactant effluent channel 68 is aligned with the outlet opening of the reactor 64.
- the function of the reaction layer is carried out using a single plate sealingly disposed below the transfer plate 60.
- the reactor does not extend completely through a single plate, but rather it is impressed into a plate to a desired depth that is less than the plate thickness.
- the reactor outlet channel than extends from the bottom of the reactor through to the opposite side of the plate.
- the transfer plate 60, the reaction plate 62, and the support plate 66 are of sufficient thickness to separate the mixing and reaction functions, provide a catalyst retention space, and further separate the reaction function from other possible downstream functions (e.g. flash separation).
- FIG 5 illustrates another stacked plate static mixer/reactor apparatus, consistent with the manner in which fluids are mixed according to the apparatus of FIG 2.
- Tangentially 10' and radially 12' directed supply channels lead into the mixing chamber 14', communicating therewith through the discharge ends 18' of the supply channels 10', 12'.
- a first fluid feed channel 42' is in fluid communication with the receiving end 16' of the radially directed supply channel 12', which narrows in the direction leading to the mixing chamber 14'.
- a cover plate 40' defines not only the open structure of this first feed channel 42', but also that of second 26' and third 28' feed channels for receiving second and third fluids to be mixed.
- the cover plate also defines the reactor effluent channel 68' extending perpendicularly and upward from the plane defining the cross section of the mixing chamber 64.
- the reactor effluent channel 68' directs reaction product out of the layered assembly or to additional structures (e.g. a separator) within the assembly.
- the reactor effluent channel 68 is in fluid communication with the reactor outlet.
- the reactor is separated from the mixing chamber using a distinct reaction plate 62' defining the open structure of a reactor 64' having an inlet at one end or face of the reaction plate 62' and having an outlet at the other end.
- the reactor 64 as depicted extends completely through the reaction plate 62.
- the reaction plate 62' in this case is disposed below the cover plate 40', and the reactor inlet at the bottom face of the reaction plate 62' is in fluid communication with the mixing chamber outlet 19' , extending upward from the mixing chamber 14' .
- a transfer plate 60' is positioned below the reaction plate 62 to provide the mixing chamber outlet 19' that is in fluid communication with the inlet of the reactor 64.
- the mixing chamber outlet 19' is in fluid communication with the central region of the mixing chamber to discharge a mixed stream of fluids.
- the mixer plate 58' further defines the open structure of a focusing chamber 24' having an inlet and an outlet, where the focusing chamber inlet is in fluid communication with both a plurality of second fluid distribution channels 20' and a plurality of third fluid distribution channels 22' arranged in an interdigitated sequence.
- the focusing chamber outlet is in fluid communication with the receiving end of the tangentially directed supply channel 10' .
- a channeling plate 56 Connected directly below the mixer plate 58' at its lower face is a channeling plate 56 defining a plurality of second distribution ports 54' and also plurality of third distribution ports 55.
- One end of each of the second distribution ports 54' is in fluid communication with a second fluid distributing structure 50' .
- the opposite end of each of the second distribution ports is in fluid communication with the second distribution channels 20' leading to the focusing chamber 24'.
- one end of each of the third distribution ports 55 is in fluid communication with a third fluid distributing structure 51.
- the opposite end of each of the third distribution ports 55 is in fluid communication with the third distribution channels 22' leading to the focusing chamber 24'.
- the mixer/reactor comprises a base plate 61' defining the open structures of the second and third fluid distributing structures 50', 51 in fluid communication with the second and third fluid feed channels 26' , 28' , respectively.
- feed channels 26', 28' in contrast to those of FIG 4, extend through more than a single plate, and in fact they penetrate the mixer plate 58' and channeling plate 56' in addition to the cover plate 40' .
- the upper face of the base plate 61' is sealingly connected to the lower face of the channeling plate 56' .
- FIG 5 includes a plurality of second 20' and third 22' distribution channels, it is also possible that the second 54' and third 55 distribution ports are directly in communication with the inlet of the focusing chamber 24' , without the need for distribution channels.
- a static mixer comprising an arrangement of stacked plates and using the principle of cyclone mixing as described previously was constructed of glass to observe cyclone formation under various conditions. Water and air were injected into the mixing chamber in tangential and radial directions, respectively, with respect thereto. A high speed camera with digital image processing was used to observe whether a helical flow of the flowing liquid was established. This was readily determined from observing the path of gas bubbles within the water stream. The results of these experiments are summarized in Table 1.
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Accessories For Mixers (AREA)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020037014513A KR100845200B1 (ko) | 2001-05-07 | 2002-05-06 | 2개 이상의 유체를 혼합 및 반응시키는 장치 |
JP2002587091A JP2005512760A (ja) | 2001-05-07 | 2002-05-06 | 少なくとも2つの流体を混合及び反応させるための装置 |
EP02746348A EP1412067A2 (en) | 2001-05-07 | 2002-05-06 | Apparatus for mixing and reacting at least two fluids |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/850,439 | 2001-05-07 | ||
US09/850,470 | 2001-05-07 | ||
US09/850,439 US6863867B2 (en) | 2001-05-07 | 2001-05-07 | Apparatus for mixing and reacting at least two fluids |
US09/850,470 US6655829B1 (en) | 2001-05-07 | 2001-05-07 | Static mixer and process for mixing at least two fluids |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002089966A2 true WO2002089966A2 (en) | 2002-11-14 |
WO2002089966A3 WO2002089966A3 (en) | 2004-02-12 |
Family
ID=27126932
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/014383 WO2002089966A2 (en) | 2001-05-07 | 2002-05-06 | Apparatus for mixing and reacting at least two fluids |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1412067A2 (zh) |
JP (1) | JP2005512760A (zh) |
KR (1) | KR100845200B1 (zh) |
CN (1) | CN1280005C (zh) |
WO (1) | WO2002089966A2 (zh) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004108261A1 (en) * | 2003-06-11 | 2004-12-16 | Agency For Science, Technology And Research | Micromixer apparatus and methods of using same |
EP1674150A2 (de) * | 2004-12-23 | 2006-06-28 | Forschungszentrum Karlsruhe GmbH | Statischer Mikrovermischer |
EP1674152A2 (de) * | 2004-12-23 | 2006-06-28 | Forschungszentrum Karlsruhe GmbH | Statischer Mikrovermischer |
DE102005015433A1 (de) * | 2005-04-05 | 2006-10-12 | Forschungszentrum Karlsruhe Gmbh | Mischersystem, Reaktor und Reaktorsystem |
JP2006528541A (ja) * | 2003-07-25 | 2006-12-21 | ウエラ アクチェンゲゼルシャフト | 静止型マイクロミキサーのための構成部品、当該構成部品から構成されたマイクロミキサー、および混合、分散または化学反応の実施のためのそれらの使用 |
US7192562B1 (en) * | 2003-04-17 | 2007-03-20 | Uop Llc | Hydrogen-oxygen mixer-sparger |
DE102005060280A1 (de) * | 2005-12-16 | 2007-06-28 | Ehrfeld Mikrotechnik Bts Gmbh | Integrierbarer Mikromischer sowie dessen Verwendung |
WO2008085522A1 (en) * | 2007-01-11 | 2008-07-17 | Uop Llc | Hydrogen-oxygen mixer-sparger |
CN104117326A (zh) * | 2014-07-29 | 2014-10-29 | 无锡华中科技有限公司 | 一种沥青放油装置 |
FR3068621A1 (fr) * | 2017-07-10 | 2019-01-11 | IFP Energies Nouvelles | Procede d’oligomerisation mettant en oeuvre un vortex |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4631508B2 (ja) * | 2005-03-31 | 2011-02-16 | Dic株式会社 | マイクロミキサー |
CN1326605C (zh) * | 2005-07-08 | 2007-07-18 | 清华大学 | 一种多通道微结构反应器 |
CN100413618C (zh) * | 2006-05-16 | 2008-08-27 | 中山大学 | 一种超细金属粉的气相合成装置 |
KR100790904B1 (ko) * | 2006-08-31 | 2008-01-04 | 삼성전자주식회사 | 원심력을 이용하는 미세유체 처리 기판 내에서 적어도 두종류의 유체를 혼합하는 방법 |
JP5030520B2 (ja) * | 2006-09-29 | 2012-09-19 | 富士フイルム株式会社 | 流体混合方法及びマイクロデバイス |
US20100093098A1 (en) * | 2008-10-14 | 2010-04-15 | Siemens Medical Solutions | Nonflow-through appratus and mehod using enhanced flow mechanisms |
KR100952612B1 (ko) | 2009-09-28 | 2010-04-15 | 조계만 | 마이크로 버블에 의한 기능성 세정수의 무동력 소용량 생산장치 |
KR100952611B1 (ko) | 2009-09-28 | 2010-04-15 | 조계만 | 마이크로 버블에 의한 기능성 세정수의 소용량 생산장치 |
KR20110077494A (ko) * | 2009-12-30 | 2011-07-07 | 삼성전기주식회사 | 공급관 및 이를 구비하는 혼합조 |
CN103007792B (zh) * | 2012-12-20 | 2015-11-11 | 北京大学 | 一种基于超临界流体的微通道混合方法 |
CN103203803A (zh) * | 2013-04-23 | 2013-07-17 | 上海三瑞高分子材料有限公司 | 多种液体连续混合装置 |
NL2011856C2 (en) * | 2013-11-28 | 2014-09-25 | Avantium Technologies B V | Reactor system for high throughput applications. |
CN105265576A (zh) * | 2014-07-02 | 2016-01-27 | 广东德豪润达电气股份有限公司 | 奶粉胶囊 |
US10290762B2 (en) | 2015-06-18 | 2019-05-14 | Toshiba Mitsubishi-Electric Industrial Systems Corporation | Metal oxide film formation method |
CN105195053B (zh) * | 2015-09-22 | 2018-06-19 | 北京工业大学 | 一种基于微气泡驱动的震荡射流式微混合器 |
EP3225304A1 (de) * | 2016-03-31 | 2017-10-04 | Hirschberg Engineering | Kontakter |
EP3595803B1 (en) * | 2017-04-21 | 2021-09-29 | Commonwealth Scientific and Industrial Research Organisation | Flow distribution system |
CN107261879A (zh) * | 2017-07-28 | 2017-10-20 | 朱明� | 一种用于润滑油生产的预混合装置 |
US20190070571A1 (en) * | 2017-09-06 | 2019-03-07 | Waters Technologies Corporation | Fluid mixer |
CN108404698B (zh) * | 2018-05-09 | 2024-02-23 | 苏州倍丰智能科技有限公司 | 流体混合器及导流装置 |
CN109682862A (zh) * | 2019-02-22 | 2019-04-26 | 珠海格力电器股份有限公司 | 可测试制冷剂导电率的流体测试装置 |
EP4013539A1 (en) | 2019-08-12 | 2022-06-22 | Waters Technologies Corporation | Mixer for chromatography system |
US11772058B2 (en) | 2019-10-18 | 2023-10-03 | Taiwan Semiconductor Manufacturing Company Limited | Gas mixing system for semiconductor fabrication |
CN111250027B (zh) * | 2020-03-05 | 2022-03-11 | 内蒙古兰格生物科技有限公司 | 药物中间体反应管及生产线 |
CN112206695B (zh) * | 2020-09-16 | 2021-11-19 | 复旦大学 | 一种多层次结构微通道混合器及其流体混合方法 |
CN114011265B (zh) * | 2021-11-08 | 2022-09-27 | 宁波九胜创新医药科技有限公司 | 一种低压降、高混合效率的短路径微混合器 |
CN114452914B (zh) * | 2022-03-02 | 2023-08-08 | 重庆东庚工程技术有限公司 | 一种雾化微混合器 |
CN114534657B (zh) * | 2022-03-02 | 2023-08-08 | 重庆东庚工程技术有限公司 | 一种微通道快速反应器 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB909865A (en) * | 1959-05-08 | 1962-11-07 | Courtaulds Ltd | Improvements in and relating to the mixing of fluids |
US4087862A (en) * | 1975-12-11 | 1978-05-02 | Exxon Research & Engineering Co. | Bladeless mixer and system |
SU1494952A1 (ru) * | 1986-12-22 | 1989-07-23 | А.Ф. Немчин, Л.И. Пищенко и А.С. Мачинский | Кавитационный смеситель |
DE19748481A1 (de) * | 1997-11-03 | 1999-05-12 | Inst Mikrotechnik Mainz Gmbh | Statischer Mikrovermischer, und Mikroreaktor sowie dessen Verwendung |
-
2002
- 2002-05-06 WO PCT/US2002/014383 patent/WO2002089966A2/en active Application Filing
- 2002-05-06 KR KR1020037014513A patent/KR100845200B1/ko not_active IP Right Cessation
- 2002-05-06 CN CNB028113551A patent/CN1280005C/zh not_active Expired - Fee Related
- 2002-05-06 JP JP2002587091A patent/JP2005512760A/ja active Pending
- 2002-05-06 EP EP02746348A patent/EP1412067A2/en not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB909865A (en) * | 1959-05-08 | 1962-11-07 | Courtaulds Ltd | Improvements in and relating to the mixing of fluids |
US4087862A (en) * | 1975-12-11 | 1978-05-02 | Exxon Research & Engineering Co. | Bladeless mixer and system |
SU1494952A1 (ru) * | 1986-12-22 | 1989-07-23 | А.Ф. Немчин, Л.И. Пищенко и А.С. Мачинский | Кавитационный смеситель |
DE19748481A1 (de) * | 1997-11-03 | 1999-05-12 | Inst Mikrotechnik Mainz Gmbh | Statischer Mikrovermischer, und Mikroreaktor sowie dessen Verwendung |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7192562B1 (en) * | 2003-04-17 | 2007-03-20 | Uop Llc | Hydrogen-oxygen mixer-sparger |
WO2004108261A1 (en) * | 2003-06-11 | 2004-12-16 | Agency For Science, Technology And Research | Micromixer apparatus and methods of using same |
JP2006528541A (ja) * | 2003-07-25 | 2006-12-21 | ウエラ アクチェンゲゼルシャフト | 静止型マイクロミキサーのための構成部品、当該構成部品から構成されたマイクロミキサー、および混合、分散または化学反応の実施のためのそれらの使用 |
EP1674152A3 (de) * | 2004-12-23 | 2006-07-05 | Forschungszentrum Karlsruhe GmbH | Statischer Mikrovermischer |
DE102004062076A1 (de) * | 2004-12-23 | 2006-07-06 | Forschungszentrum Karlsruhe Gmbh | Statischer Mikrovermischer |
EP1674152A2 (de) * | 2004-12-23 | 2006-06-28 | Forschungszentrum Karlsruhe GmbH | Statischer Mikrovermischer |
EP1674150A2 (de) * | 2004-12-23 | 2006-06-28 | Forschungszentrum Karlsruhe GmbH | Statischer Mikrovermischer |
EP1674150A3 (de) * | 2004-12-23 | 2006-07-05 | Forschungszentrum Karlsruhe GmbH | Statischer Mikrovermischer |
US7829039B2 (en) | 2005-04-05 | 2010-11-09 | Forschungszentrum Karlsruhe Gmbh | Mixer system, reactor and reactor system |
DE102005015433A1 (de) * | 2005-04-05 | 2006-10-12 | Forschungszentrum Karlsruhe Gmbh | Mischersystem, Reaktor und Reaktorsystem |
DE102005060280A1 (de) * | 2005-12-16 | 2007-06-28 | Ehrfeld Mikrotechnik Bts Gmbh | Integrierbarer Mikromischer sowie dessen Verwendung |
DE102005060280B4 (de) | 2005-12-16 | 2018-12-27 | Ehrfeld Mikrotechnik Bts Gmbh | Integrierbarer Mikromischer sowie dessen Verwendung |
WO2008085522A1 (en) * | 2007-01-11 | 2008-07-17 | Uop Llc | Hydrogen-oxygen mixer-sparger |
JP2010515653A (ja) * | 2007-01-11 | 2010-05-13 | ユーオーピー エルエルシー | 水素−酸素のミキサー−スパージャー |
CN104117326A (zh) * | 2014-07-29 | 2014-10-29 | 无锡华中科技有限公司 | 一种沥青放油装置 |
FR3068621A1 (fr) * | 2017-07-10 | 2019-01-11 | IFP Energies Nouvelles | Procede d’oligomerisation mettant en oeuvre un vortex |
WO2019011609A1 (fr) * | 2017-07-10 | 2019-01-17 | IFP Energies Nouvelles | Procede d'oligomerisation mettant en œuvre un vortex |
Also Published As
Publication number | Publication date |
---|---|
CN1280005C (zh) | 2006-10-18 |
JP2005512760A (ja) | 2005-05-12 |
KR100845200B1 (ko) | 2008-07-10 |
EP1412067A2 (en) | 2004-04-28 |
CN1537029A (zh) | 2004-10-13 |
KR20040020900A (ko) | 2004-03-09 |
WO2002089966A3 (en) | 2004-02-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6863867B2 (en) | Apparatus for mixing and reacting at least two fluids | |
US6655829B1 (en) | Static mixer and process for mixing at least two fluids | |
EP1412067A2 (en) | Apparatus for mixing and reacting at least two fluids | |
US7097347B2 (en) | Static mixer and process for mixing at least two fluids | |
JP4339163B2 (ja) | マイクロデバイスおよび流体の合流方法 | |
US7195747B2 (en) | Process for mixing and reacting two or more fluids | |
JP4803671B2 (ja) | 静止型マイクロミキサー | |
US20040125689A1 (en) | Method and statistical micromixer for mixing at least two liquids | |
US8476382B2 (en) | Multiple continuous microfluidic reactors for the scaled up synthesis of gel or polymer particles | |
RU2288028C2 (ru) | Устройство для смешивания по меньшей мере двух текучих сред | |
EP1997553B1 (en) | Fluid mixer and method for forming mixed fluid | |
US20040027915A1 (en) | Method and statistical micromixer for mixing at least two liquids | |
JP3794687B2 (ja) | マイクロ乳化器 | |
JP2013542051A (ja) | マイクロ流体装置 | |
US6982064B1 (en) | Micromixer | |
CN102802779A (zh) | 微型反应器 | |
WO2007037007A1 (ja) | マイクロデバイスおよび流体の合流方法 | |
US6334985B1 (en) | Static mixing reactor for uniform reactant temperatures and concentrations | |
JP3939556B2 (ja) | マイクロミキサー | |
US20080181833A1 (en) | Scalable microreactors and methods for using same | |
US20070280040A1 (en) | Method and Apparatus for Mixing at Least Two Fluids in a Micromixing Reactor | |
JP2024023013A (ja) | フロー合成装置用マイクロミキサー及びフロー合成装置 | |
JP2002346354A (ja) | マイクロ混合器 | |
CN118304839A (zh) | 一种用于制备微乳液和杂环化合物的微通道反应器 | |
JP2010234302A (ja) | 反応器の合流流路 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2002587091 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1020037014513 Country of ref document: KR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1897/DELNP/2003 Country of ref document: IN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2002746348 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 028113551 Country of ref document: CN |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWP | Wipo information: published in national office |
Ref document number: 2002746348 Country of ref document: EP |