WO2002056849A1 - Stimulants de croissance capillaire - Google Patents

Stimulants de croissance capillaire Download PDF

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Publication number
WO2002056849A1
WO2002056849A1 PCT/JP2001/000284 JP0100284W WO02056849A1 WO 2002056849 A1 WO2002056849 A1 WO 2002056849A1 JP 0100284 W JP0100284 W JP 0100284W WO 02056849 A1 WO02056849 A1 WO 02056849A1
Authority
WO
WIPO (PCT)
Prior art keywords
hair
hair restorer
scalp
hair growth
restorer
Prior art date
Application number
PCT/JP2001/000284
Other languages
English (en)
Japanese (ja)
Inventor
Atsushi Shimizu
Original Assignee
Biotech Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotech Inc. filed Critical Biotech Inc.
Priority to JP2002557359A priority Critical patent/JP3663404B2/ja
Priority to PCT/JP2001/000284 priority patent/WO2002056849A1/fr
Publication of WO2002056849A1 publication Critical patent/WO2002056849A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm

Definitions

  • the scalp is an extension of the skin of the face, and the fact that the hair itself is composed of keratin proteins similar to skin improves the scalp that is the soil of the hair.
  • Growing and becoming dandruff and falling off is an important element of hair growth. In other words, it is important for hair growth to improve the rhythm of the scalp cycle (which we call the scalp rhythm) and restore it to the normal cycle just like the hair cycle.
  • an object of the present invention is to provide a hair restorer that can easily penetrate into the scalp and efficiently grow hair without damaging the scalp or hair. Disclosure of the invention
  • the emulsion is diluted with an aqueous solution in which a water-soluble hair restorer is dissolved, as described in claim 2.
  • the emulsion is not particularly limited.
  • the emulsion can be produced by using a known micro-mouth emulsifier such as a high-pressure homogenizer.
  • the water-soluble hair-growing component is not particularly limited, and includes dipotassium glycyrrhizinate, pantoturethyl ether, sodium salt of d1-pyrrolidonecarboxylic acid, trimethylglycine, sorbit solution, glycine and the like, which have been conventionally used as a hair-growth agent.
  • dipotassium glycyrrhizinate pantoturethyl ether
  • sodium salt of d1-pyrrolidonecarboxylic acid trimethylglycine
  • sorbit solution glycine and the like
  • the hair restorer according to the present invention has an average particle size of not more than 300 nm (more preferably, not more than 300 nm, which is composed of ethurest radioisole and hinokitiol as oily hair restorer effective for hair restorer, and squalane and d1- ⁇ -tocopherol acetate as fat component).
  • this hair restorer has an average particle size of 300 nm or less (more preferably, 100 nm or less) in suspended particles composed of an oily hair growth component and a fat component effective for hair growth.
  • the active ingredient penetrates into the inside of the skin by sewing the gaps in the lamella structure of the scalp, which did not penetrate with the conventional hair restorer.
  • the obtained emulsion and an aqueous solution of a water-soluble active ingredient having the following composition were mixed with a stirrer (Satake Co., Ltd.) so that the ratio of 2.0 parts by weight of the noodles and 98.0 parts by weight of the aqueous solution was obtained.
  • the mixture was stirred with a Portable Mixer Model A 520V) to obtain a tonic hair restorer.
  • Example 2 The same blending components as in Example 1 were mixed using a high-pressure homogenizer (-210 CE / H, manufactured by Microfluidics) at 30 ° C. and a pressure of 20500 PSI (1435 kg / cra2).
  • a tonic hair restorer was obtained in the same manner as in Example 1 except that a / W emulsion was obtained.
  • the particle size of the suspended particles of the obtained emulsion was measured in the same manner as in Example 1 and found to be 80 nm on average.
  • the hair restorer according to the present invention is constituted as described above, it not only acts on the root of the hair, but also penetrates into the scalp without damaging the scalp, and exhibits a large hair restorer effect.
  • the scalp does not require elaborate cleaning of the scalp with shampoo or scalp putting with a brush before application to the scalp.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Birds (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne des stimulants de croissance capillaire comprenant une émulsion de type huile dans l'eau, des particules comprenant des composantes huileuses de stimulation de croissance capillaire s'avérant efficaces pour la croissance capillaire (éthynyl estardiol, hinokitiol, etc.) et des composantes grasses telles que squalane et dl-α-tocophérol acétate étant mises en suspension dans un état où elles ont un diamètre de particule moyen de 100 nm ou moins. Ces stimulants de croissance capillaire peuvent facilement pénétrer dans le cuir chevelu et stimuler efficacement la croissance capillaire sans endommager le cuir chevelu ou les cheveux.
PCT/JP2001/000284 2001-01-17 2001-01-17 Stimulants de croissance capillaire WO2002056849A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2002557359A JP3663404B2 (ja) 2001-01-17 2001-01-17 育毛剤
PCT/JP2001/000284 WO2002056849A1 (fr) 2001-01-17 2001-01-17 Stimulants de croissance capillaire

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2001/000284 WO2002056849A1 (fr) 2001-01-17 2001-01-17 Stimulants de croissance capillaire

Publications (1)

Publication Number Publication Date
WO2002056849A1 true WO2002056849A1 (fr) 2002-07-25

Family

ID=11736919

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2001/000284 WO2002056849A1 (fr) 2001-01-17 2001-01-17 Stimulants de croissance capillaire

Country Status (2)

Country Link
JP (1) JP3663404B2 (fr)
WO (1) WO2002056849A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004064749A2 (fr) * 2003-01-21 2004-08-05 The Gillette Company Reduction de la pousse des cheveux
WO2006073181A1 (fr) * 2005-01-07 2006-07-13 Noevir Co., Ltd. Activateur cellulaire, inhibiteur de mort cellulaire et promoteur de mort cellulaire
WO2006095778A1 (fr) * 2005-03-10 2006-09-14 Hosokawa Powder Technology Research Institute Nanoparticules contenant un ingredient stimulant la croissance des cheveux et leur procede de production, et stimulant de croissance de chevaux utilisant lesdites nanoparticules
JP2007039397A (ja) * 2005-08-04 2007-02-15 Sapporo Breweries Ltd ビール酵母で発酵させたアルコール飲料からコラーゲン産生促進作用を有する組成物を製造する方法及びその組成物
WO2007142349A1 (fr) * 2006-06-08 2007-12-13 Ajinomoto Co., Inc. Préparation destinée à la croissance capillaire
JP2016506406A (ja) * 2012-12-20 2016-03-03 ヒルズ・ペット・ニュートリシャン・インコーポレーテッド ヒト以外の動物における毛の状態を改善するための方法
JP2017114862A (ja) * 2017-01-11 2017-06-29 ヒルズ・ペット・ニュートリシャン・インコーポレーテッド ヒト以外の動物における毛の状態を改善するための方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09241152A (ja) * 1996-03-01 1997-09-16 Sunstar Inc 水中油型エマルション
US5711942A (en) * 1995-12-20 1998-01-27 Wella Aktiengesellschaft Storage stable hair care emulsion containing only natural substances, their mixtures and/or their reaction products
JPH1059829A (ja) * 1996-08-13 1998-03-03 Noevir Co Ltd 養毛剤
JPH1067623A (ja) * 1996-06-22 1998-03-10 Wella Ag デポ効果を有する毛髪処理剤

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0667469B2 (ja) * 1986-11-17 1994-08-31 株式会社資生堂 マイクロエマルシヨン
JP2000238157A (ja) * 1999-02-22 2000-09-05 Hayashi Gijutsu Kenkyusho:Kk 吸音体構造

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5711942A (en) * 1995-12-20 1998-01-27 Wella Aktiengesellschaft Storage stable hair care emulsion containing only natural substances, their mixtures and/or their reaction products
JPH09241152A (ja) * 1996-03-01 1997-09-16 Sunstar Inc 水中油型エマルション
JPH1067623A (ja) * 1996-06-22 1998-03-10 Wella Ag デポ効果を有する毛髪処理剤
JPH1059829A (ja) * 1996-08-13 1998-03-03 Noevir Co Ltd 養毛剤

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004064749A3 (fr) * 2003-01-21 2004-09-10 Gillette Co Reduction de la pousse des cheveux
WO2004064749A2 (fr) * 2003-01-21 2004-08-05 The Gillette Company Reduction de la pousse des cheveux
JPWO2006073181A1 (ja) * 2005-01-07 2008-08-07 株式会社ノエビア 細胞賦活剤、細胞死抑制剤、および細胞死促進剤
WO2006073181A1 (fr) * 2005-01-07 2006-07-13 Noevir Co., Ltd. Activateur cellulaire, inhibiteur de mort cellulaire et promoteur de mort cellulaire
WO2006095778A1 (fr) * 2005-03-10 2006-09-14 Hosokawa Powder Technology Research Institute Nanoparticules contenant un ingredient stimulant la croissance des cheveux et leur procede de production, et stimulant de croissance de chevaux utilisant lesdites nanoparticules
JP2007039397A (ja) * 2005-08-04 2007-02-15 Sapporo Breweries Ltd ビール酵母で発酵させたアルコール飲料からコラーゲン産生促進作用を有する組成物を製造する方法及びその組成物
WO2007142349A1 (fr) * 2006-06-08 2007-12-13 Ajinomoto Co., Inc. Préparation destinée à la croissance capillaire
US8101162B2 (en) 2006-06-08 2012-01-24 Ajinomoto Co., Inc. Hair growth composition
JP5315992B2 (ja) * 2006-06-08 2013-10-16 味の素株式会社 育毛用組成物
TWI476009B (zh) * 2006-06-08 2015-03-11 Ajinomoto Kk Composition for hair growth
JP2016506406A (ja) * 2012-12-20 2016-03-03 ヒルズ・ペット・ニュートリシャン・インコーポレーテッド ヒト以外の動物における毛の状態を改善するための方法
US10314323B2 (en) 2012-12-20 2019-06-11 Colgate-Palmolive Company Methods for improving the condition of hair in non-human animals
JP2017114862A (ja) * 2017-01-11 2017-06-29 ヒルズ・ペット・ニュートリシャン・インコーポレーテッド ヒト以外の動物における毛の状態を改善するための方法

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Publication number Publication date
JPWO2002056849A1 (ja) 2004-05-20
JP3663404B2 (ja) 2005-06-22

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