WO2002046194A3 - Imidazopyridines substituees - Google Patents

Imidazopyridines substituees Download PDF

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Publication number
WO2002046194A3
WO2002046194A3 PCT/US2001/046915 US0146915W WO0246194A3 WO 2002046194 A3 WO2002046194 A3 WO 2002046194A3 US 0146915 W US0146915 W US 0146915W WO 0246194 A3 WO0246194 A3 WO 0246194A3
Authority
WO
WIPO (PCT)
Prior art keywords
useful
compounds
substituted imidazopyridines
biosynthesis
induce
Prior art date
Application number
PCT/US2001/046915
Other languages
English (en)
Other versions
WO2002046194A2 (fr
Inventor
Kyle J Lindstrom
Original Assignee
3M Innovative Properties Co
Kyle J Lindstrom
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to UA2003042937A priority Critical patent/UA74593C2/uk
Priority to SK714-2003A priority patent/SK7142003A3/sk
Priority to NZ526085A priority patent/NZ526085A/xx
Priority to KR10-2003-7007533A priority patent/KR20030070048A/ko
Priority to JP2002547931A priority patent/JP2004525868A/ja
Priority to AU2002239547A priority patent/AU2002239547B2/en
Priority to BR0116034-6A priority patent/BR0116034A/pt
Priority to CA002431040A priority patent/CA2431040A1/fr
Priority to AU3954702A priority patent/AU3954702A/xx
Priority to IL15588501A priority patent/IL155885A0/xx
Application filed by 3M Innovative Properties Co, Kyle J Lindstrom filed Critical 3M Innovative Properties Co
Priority to HU0600592A priority patent/HUP0600592A2/hu
Priority to PL01365739A priority patent/PL365739A1/xx
Priority to EP01987315A priority patent/EP1343783A2/fr
Priority to EEP200300273A priority patent/EE200300273A/xx
Priority to MXPA03005013A priority patent/MXPA03005013A/es
Publication of WO2002046194A2 publication Critical patent/WO2002046194A2/fr
Publication of WO2002046194A3 publication Critical patent/WO2002046194A3/fr
Priority to NO20032453A priority patent/NO20032453L/no
Priority to HR20030465A priority patent/HRP20030465A2/hr
Priority to HK04106187A priority patent/HK1063466A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)

Abstract

L'invention concerne des composés d'imidazopyridine renfermant une fonctionnalité amine substituée en position 1. Ces composés sont utiles comme modificateurs de la réponse immune. Les composés et compositions selon l'invention peuvent induire la biosynthèse de différentes cytokines et sont utiles dans le traitement d'une palette de pathologies, notamment des maladies virales et néoplastiques.
PCT/US2001/046915 2000-12-08 2001-12-06 Imidazopyridines substituees WO2002046194A2 (fr)

Priority Applications (18)

Application Number Priority Date Filing Date Title
UA2003042937A UA74593C2 (en) 2000-12-08 2001-06-12 Substituted imidazopyridines
EEP200300273A EE200300273A (et) 2000-12-08 2001-12-06 Asendatud imidasopüridiinid
KR10-2003-7007533A KR20030070048A (ko) 2000-12-08 2001-12-06 치환 이미다조피리딘
JP2002547931A JP2004525868A (ja) 2000-12-08 2001-12-06 置換イミダゾピリジン類
AU2002239547A AU2002239547B2 (en) 2000-12-08 2001-12-06 Substituted imidazopyridines
BR0116034-6A BR0116034A (pt) 2000-12-08 2001-12-06 Imidazopiridinas substituìdas
CA002431040A CA2431040A1 (fr) 2000-12-08 2001-12-06 Imidazopyridines substituees
HU0600592A HUP0600592A2 (en) 2000-12-08 2001-12-06 Substituted imidazopyridines, pharmaceutical compositions containing them and intermediates
IL15588501A IL155885A0 (en) 2000-12-08 2001-12-06 Substituted imidazopyridines
SK714-2003A SK7142003A3 (en) 2000-12-08 2001-12-06 Substituted imidazopyridines
AU3954702A AU3954702A (en) 2000-12-08 2001-12-06 Substituted imidazopyridines
PL01365739A PL365739A1 (en) 2000-12-08 2001-12-06 Substituted imidazopyridines
EP01987315A EP1343783A2 (fr) 2000-12-08 2001-12-06 Imidazopyridines substituees
NZ526085A NZ526085A (en) 2000-12-08 2001-12-06 Substituted imidazopyridines
MXPA03005013A MXPA03005013A (es) 2000-12-08 2001-12-06 Imidazopiridinas sustituidas.
NO20032453A NO20032453L (no) 2000-12-08 2003-05-28 Substituerte imidazopyridiner
HR20030465A HRP20030465A2 (en) 2000-12-08 2003-06-06 Substituted imidazopyridines
HK04106187A HK1063466A1 (en) 2000-12-08 2004-08-18 Substituted imidazopyridines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25422800P 2000-12-08 2000-12-08
US60/254,228 2000-12-08

Publications (2)

Publication Number Publication Date
WO2002046194A2 WO2002046194A2 (fr) 2002-06-13
WO2002046194A3 true WO2002046194A3 (fr) 2003-02-06

Family

ID=22963437

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/046915 WO2002046194A2 (fr) 2000-12-08 2001-12-06 Imidazopyridines substituees

Country Status (24)

Country Link
EP (1) EP1343783A2 (fr)
JP (1) JP2004525868A (fr)
KR (1) KR20030070048A (fr)
CN (1) CN1249062C (fr)
AR (1) AR035670A1 (fr)
AU (2) AU2002239547B2 (fr)
BR (1) BR0116034A (fr)
CA (1) CA2431040A1 (fr)
CZ (1) CZ20031593A3 (fr)
EE (1) EE200300273A (fr)
HK (1) HK1063466A1 (fr)
HR (1) HRP20030465A2 (fr)
HU (1) HUP0600592A2 (fr)
IL (1) IL155885A0 (fr)
MX (1) MXPA03005013A (fr)
NO (1) NO20032453L (fr)
NZ (1) NZ526085A (fr)
PL (1) PL365739A1 (fr)
RU (1) RU2294934C2 (fr)
SK (1) SK7142003A3 (fr)
TW (1) TWI243819B (fr)
UA (1) UA74593C2 (fr)
WO (1) WO2002046194A2 (fr)
ZA (1) ZA200305238B (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8871782B2 (en) 2003-10-03 2014-10-28 3M Innovative Properties Company Alkoxy substituted imidazoquinolines
US8961477B2 (en) 2003-08-25 2015-02-24 3M Innovative Properties Company Delivery of immune response modifier compounds

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5741908A (en) 1996-06-21 1998-04-21 Minnesota Mining And Manufacturing Company Process for reparing imidazoquinolinamines
UA67760C2 (uk) 1997-12-11 2004-07-15 Міннесота Майнінг Енд Мануфакчурінг Компані Імідазонафтиридин та тетрагідроімідазонафтиридин, фармацевтична композиція, спосіб індукування біосинтезу цитокінів та спосіб лікування вірусної інфекції, проміжні сполуки
US6756382B2 (en) 1999-06-10 2004-06-29 3M Innovative Properties Company Amide substituted imidazoquinolines
US6331539B1 (en) 1999-06-10 2001-12-18 3M Innovative Properties Company Sulfonamide and sulfamide substituted imidazoquinolines
US6541485B1 (en) 1999-06-10 2003-04-01 3M Innovative Properties Company Urea substituted imidazoquinolines
US6545016B1 (en) 2000-12-08 2003-04-08 3M Innovative Properties Company Amide substituted imidazopyridines
US6525064B1 (en) 2000-12-08 2003-02-25 3M Innovative Properties Company Sulfonamido substituted imidazopyridines
US6677347B2 (en) 2000-12-08 2004-01-13 3M Innovative Properties Company Sulfonamido ether substituted imidazoquinolines
US6667312B2 (en) 2000-12-08 2003-12-23 3M Innovative Properties Company Thioether substituted imidazoquinolines
US6664264B2 (en) 2000-12-08 2003-12-16 3M Innovative Properties Company Thioether substituted imidazoquinolines
UA75622C2 (en) 2000-12-08 2006-05-15 3M Innovative Properties Co Aryl ether substituted imidazoquinolines, pharmaceutical composition based thereon
US20020107262A1 (en) * 2000-12-08 2002-08-08 3M Innovative Properties Company Substituted imidazopyridines
US6664265B2 (en) 2000-12-08 2003-12-16 3M Innovative Properties Company Amido ether substituted imidazoquinolines
US6660735B2 (en) 2000-12-08 2003-12-09 3M Innovative Properties Company Urea substituted imidazoquinoline ethers
US6677348B2 (en) 2000-12-08 2004-01-13 3M Innovative Properties Company Aryl ether substituted imidazoquinolines
US6545017B1 (en) 2000-12-08 2003-04-08 3M Innovative Properties Company Urea substituted imidazopyridines
ES2312659T3 (es) 2001-11-29 2009-03-01 3M Innovative Properties Company Formulaciones farmaceuticas que comprenden un modificador de la respuesta inmune.
CA2365732A1 (fr) 2001-12-20 2003-06-20 Ibm Canada Limited-Ibm Canada Limitee Etalonnages
EP1511746A2 (fr) * 2002-05-29 2005-03-09 3M Innovative Properties Company Procede permettant d'obtenir des imidazo[4,5-c]pyridin-4-amines
US7427629B2 (en) 2002-08-15 2008-09-23 3M Innovative Properties Company Immunostimulatory compositions and methods of stimulating an immune response
WO2004028539A2 (fr) 2002-09-26 2004-04-08 3M Innovative Properties Company Dimeres 1h-imidazo
US7091214B2 (en) 2002-12-20 2006-08-15 3M Innovative Properties Co. Aryl substituted Imidazoquinolines
EP2572714A1 (fr) 2002-12-30 2013-03-27 3M Innovative Properties Company Combinaisons immunostimulantes
CA2517528A1 (fr) 2003-03-04 2004-09-16 3M Innovative Properties Company Traitement prophylactique de la neoplasie epidermique induite par les uv
KR20050109562A (ko) 2003-03-13 2005-11-21 쓰리엠 이노베이티브 프로퍼티즈 컴파니 피부의 질을 개선시키는 방법
WO2004080293A2 (fr) * 2003-03-13 2004-09-23 3M Innovative Properties Company Methodes de diagnostic de lesions de la peau
US20040192585A1 (en) 2003-03-25 2004-09-30 3M Innovative Properties Company Treatment for basal cell carcinoma
JP2007500210A (ja) 2003-04-10 2007-01-11 スリーエム イノベイティブ プロパティズ カンパニー 金属含有微粒子担体材料を使用した免疫反応調節物質化合物の送達
US6943255B2 (en) 2003-06-06 2005-09-13 3M Innovative Properties Company Process for imidazo[4,5-c]pyridin-4-amines
JP2007502293A (ja) 2003-08-12 2007-02-08 スリーエム イノベイティブ プロパティズ カンパニー ヒドロキシルアミン置換イミダゾ含有化合物
RU2006105101A (ru) 2003-08-27 2007-10-10 3М Инновейтив Пропертиз Компани (US) Арилокси и арилалкиленокси замещенные имидазохинолины
CA2537763A1 (fr) 2003-09-05 2005-03-17 3M Innovative Properties Company Traitement pour le lymphome a cellules b cd5<sp>+</sp>
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
US8598192B2 (en) 2003-11-14 2013-12-03 3M Innovative Properties Company Hydroxylamine substituted imidazoquinolines
JP2007511527A (ja) 2003-11-14 2007-05-10 スリーエム イノベイティブ プロパティズ カンパニー オキシム置換イミダゾ環化合物
WO2005051317A2 (fr) 2003-11-25 2005-06-09 3M Innovative Properties Company Systèmes cycliques d'imidazo substitués et procédés
US8940755B2 (en) 2003-12-02 2015-01-27 3M Innovative Properties Company Therapeutic combinations and methods including IRM compounds
AU2004312510A1 (en) * 2003-12-29 2005-07-21 3M Innovative Properties Company Piperazine, [1,4]diazepane, [1,4]diazocane, and [1,5]diazocane fused imidazo ring compounds
WO2005066170A1 (fr) 2003-12-29 2005-07-21 3M Innovative Properties Company Imidazoquinolines a substitution arylalcenyle et arylalkynyle
CA2551399A1 (fr) 2003-12-30 2005-07-21 3M Innovative Properties Company Sulfonamides d'imidazoquinolinyle, d'imidazopyridinyle et d'imidazonaphtyridinyle
US8697873B2 (en) 2004-03-24 2014-04-15 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
US8017779B2 (en) 2004-06-15 2011-09-13 3M Innovative Properties Company Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
US7897609B2 (en) 2004-06-18 2011-03-01 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
US7915281B2 (en) 2004-06-18 2011-03-29 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and method
US8026366B2 (en) 2004-06-18 2011-09-27 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
JP5313502B2 (ja) 2004-12-30 2013-10-09 スリーエム イノベイティブ プロパティズ カンパニー 置換キラル縮合［１，２］イミダゾ［４，５−ｃ］環状化合物
JP5543068B2 (ja) 2004-12-30 2014-07-09 スリーエム イノベイティブ プロパティズ カンパニー キラル縮合［１，２］イミダゾ［４，５−ｃ］環状化合物
JP2008530022A (ja) 2005-02-04 2008-08-07 コーリー ファーマシューティカル グループ，インコーポレイテッド 免疫反応調節物質を含む水性ゲル処方物
AU2006213746A1 (en) 2005-02-11 2006-08-17 Coley Pharmaceutical Group, Inc. Oxime and hydroxylamine substituted imidazo(4,5-c) ring compounds and methods
AU2006232375A1 (en) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. 1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
WO2006107853A2 (fr) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. Pyrazolopyridine-1,4-diamines et analogues associes
EP1937683A4 (fr) * 2005-09-23 2010-08-25 Coley Pharm Group Inc Procede de preparation de 1h-imidazoý4,5-c¨pyridines et d'analogues de ceux-ci
CN100344325C (zh) * 2005-10-17 2007-10-24 华南师范大学 一种治疗宫颈癌的药物及其制备方法与应用
WO2008008432A2 (fr) 2006-07-12 2008-01-17 Coley Pharmaceutical Group, Inc. Composés à cycle [1,2] imidazo [4,5-c] fusionné chiral substitué et procédés correspondants
WO2009034411A1 (fr) * 2007-09-12 2009-03-19 Centre National De La Recherche Scientifique Perharidines en tant qu'inhibiteurs de cdk
CN112587671A (zh) 2012-07-18 2021-04-02 博笛生物科技有限公司 癌症的靶向免疫治疗
JP6469692B2 (ja) 2013-12-09 2019-02-13 ユーシービー バイオファルマ エスピーアールエル Ｔｎｆ活性のモジュレーターとしてのイミダゾピリジン誘導体
ES2916873T3 (es) 2014-01-10 2022-07-06 Birdie Biopharmaceuticals Inc Compuestos y composiciones para inmunoterapia
CN105440135A (zh) 2014-09-01 2016-03-30 博笛生物科技有限公司 用于治疗肿瘤的抗-pd-l1结合物
CN105233291A (zh) 2014-07-09 2016-01-13 博笛生物科技有限公司 用于治疗癌症的联合治疗组合物和联合治疗方法
JP6760919B2 (ja) 2014-07-09 2020-09-23 バーディー バイオファーマシューティカルズ インコーポレイテッド 腫瘍を治療するための抗ｐｄ−ｌ１組み合わせ
CN106943598A (zh) 2016-01-07 2017-07-14 博笛生物科技（北京）有限公司 用于治疗肿瘤的抗-her2组合
CN115554406A (zh) 2016-01-07 2023-01-03 博笛生物科技有限公司 用于治疗肿瘤的抗-cd20组合
CN115252792A (zh) 2016-01-07 2022-11-01 博笛生物科技有限公司 用于治疗肿瘤的抗-egfr组合
CN108794467A (zh) 2017-04-27 2018-11-13 博笛生物科技有限公司 2-氨基-喹啉衍生物
WO2018232725A1 (fr) 2017-06-23 2018-12-27 Birdie Biopharmaceuticals, Inc. Compositions pharmaceutiques

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4689338A (en) * 1983-11-18 1987-08-25 Riker Laboratories, Inc. 1H-Imidazo[4,5-c]quinolin-4-amines and antiviral use
US4929624A (en) * 1989-03-23 1990-05-29 Minnesota Mining And Manufacturing Company Olefinic 1H-imidazo(4,5-c)quinolin-4-amines
US5268376A (en) * 1991-09-04 1993-12-07 Minnesota Mining And Manufacturing Company 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines
US5389640A (en) * 1991-03-01 1995-02-14 Minnesota Mining And Manufacturing Company 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines
US5494916A (en) * 1993-07-15 1996-02-27 Minnesota Mining And Manufacturing Company Imidazo[4,5-C]pyridin-4-amines
EP0894797A1 (fr) * 1997-01-09 1999-02-03 Terumo Kabushiki Kaisha Nouveaux derives d'amide et intermediaires utilises pour leur synthese
WO1999029693A1 (fr) * 1997-12-11 1999-06-17 Minnesota Mining And Manufacturing Company Imidazonaphthyridines et leur utilisation dans l'activation de la biosynthese de cytokines
WO2000076518A1 (fr) * 1999-06-10 2000-12-21 3M Innovative Properties Company Imidazoquinolines substituees par uree
WO2000076519A1 (fr) * 1999-06-10 2000-12-21 3M Innovative Properties Company Imidazoquinolines substituees sulfonamide et sulfamide
WO2000076505A1 (fr) * 1999-06-10 2000-12-21 3M Innovative Properties Company Imidazoquinolines substituees amides

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4689338A (en) * 1983-11-18 1987-08-25 Riker Laboratories, Inc. 1H-Imidazo[4,5-c]quinolin-4-amines and antiviral use
US4929624A (en) * 1989-03-23 1990-05-29 Minnesota Mining And Manufacturing Company Olefinic 1H-imidazo(4,5-c)quinolin-4-amines
US5389640A (en) * 1991-03-01 1995-02-14 Minnesota Mining And Manufacturing Company 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines
US5268376A (en) * 1991-09-04 1993-12-07 Minnesota Mining And Manufacturing Company 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines
US5494916A (en) * 1993-07-15 1996-02-27 Minnesota Mining And Manufacturing Company Imidazo[4,5-C]pyridin-4-amines
EP0894797A1 (fr) * 1997-01-09 1999-02-03 Terumo Kabushiki Kaisha Nouveaux derives d'amide et intermediaires utilises pour leur synthese
WO1999029693A1 (fr) * 1997-12-11 1999-06-17 Minnesota Mining And Manufacturing Company Imidazonaphthyridines et leur utilisation dans l'activation de la biosynthese de cytokines
WO2000076518A1 (fr) * 1999-06-10 2000-12-21 3M Innovative Properties Company Imidazoquinolines substituees par uree
WO2000076519A1 (fr) * 1999-06-10 2000-12-21 3M Innovative Properties Company Imidazoquinolines substituees sulfonamide et sulfamide
WO2000076505A1 (fr) * 1999-06-10 2000-12-21 3M Innovative Properties Company Imidazoquinolines substituees amides

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8961477B2 (en) 2003-08-25 2015-02-24 3M Innovative Properties Company Delivery of immune response modifier compounds
US8871782B2 (en) 2003-10-03 2014-10-28 3M Innovative Properties Company Alkoxy substituted imidazoquinolines

Also Published As

Publication number Publication date
MXPA03005013A (es) 2003-09-05
SK7142003A3 (en) 2003-10-07
AU3954702A (en) 2002-06-18
EE200300273A (et) 2004-02-16
CA2431040A1 (fr) 2002-06-13
ZA200305238B (en) 2004-08-27
KR20030070048A (ko) 2003-08-27
NZ526085A (en) 2004-12-24
EP1343783A2 (fr) 2003-09-17
RU2003116648A (ru) 2005-02-10
HK1063466A1 (en) 2004-12-31
HUP0600592A2 (en) 2006-11-28
CZ20031593A3 (cs) 2004-01-14
RU2294934C2 (ru) 2007-03-10
NO20032453D0 (no) 2003-05-28
UA74593C2 (en) 2006-01-16
PL365739A1 (en) 2005-01-10
JP2004525868A (ja) 2004-08-26
HRP20030465A2 (en) 2004-06-30
CN1249062C (zh) 2006-04-05
AU2002239547B2 (en) 2006-11-30
AR035670A1 (es) 2004-06-23
CN1478090A (zh) 2004-02-25
WO2002046194A2 (fr) 2002-06-13
IL155885A0 (en) 2003-12-23
TWI243819B (en) 2005-11-21
NO20032453L (no) 2003-07-16
BR0116034A (pt) 2004-08-03

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