NZ526085A - Substituted imidazopyridines - Google Patents
Substituted imidazopyridinesInfo
- Publication number
- NZ526085A NZ526085A NZ526085A NZ52608501A NZ526085A NZ 526085 A NZ526085 A NZ 526085A NZ 526085 A NZ526085 A NZ 526085A NZ 52608501 A NZ52608501 A NZ 52608501A NZ 526085 A NZ526085 A NZ 526085A
- Authority
- NZ
- New Zealand
- Prior art keywords
- alkyl
- alkenyl
- aryl
- compounds
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Abstract
Disclosed are compounds of formula (I), wherein: X is alkylene or alkenylene, Y is -CO-, -CS-, or -SO2-, Z is a bond, -O-, -S-, or -NR5-, R1 is optionally substituted aryl, heteroaryl, heterocyclyl, alkyl or alkenyl, R2 is H, alkyl, alkenyl, -alkyl-O-alkyl, -alkyl-S-alkyl, -alkyl-O-aryl, -alkyl-S-aryl, -alkyl-O-alkenyl, -alkyl-S-alkenyl, or optionally substituted alkyl or alkenyl, R3 and R4 are independently alkyl, alkenyl, halogen, alkoxy, amino, alkylamino, dialklyamino or alkylthio, each R5 is H or alkyl. The compounds are used in the manufacture of medicaments for inducing cytokine biosynthesis in animals, the treatment of viral diseases or neoplastic diseases.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25422800P | 2000-12-08 | 2000-12-08 | |
| PCT/US2001/046915 WO2002046194A2 (en) | 2000-12-08 | 2001-12-06 | Substituted imidazopyridines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ526085A true NZ526085A (en) | 2004-12-24 |
Family
ID=22963437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ526085A NZ526085A (en) | 2000-12-08 | 2001-12-06 | Substituted imidazopyridines |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP1343783A2 (en) |
| JP (1) | JP2004525868A (en) |
| KR (1) | KR20030070048A (en) |
| CN (1) | CN1249062C (en) |
| AR (1) | AR035670A1 (en) |
| AU (2) | AU2002239547B2 (en) |
| BR (1) | BR0116034A (en) |
| CA (1) | CA2431040A1 (en) |
| CZ (1) | CZ20031593A3 (en) |
| EE (1) | EE200300273A (en) |
| HK (1) | HK1063466A1 (en) |
| HR (1) | HRP20030465A2 (en) |
| HU (1) | HUP0600592A2 (en) |
| IL (1) | IL155885A0 (en) |
| MX (1) | MXPA03005013A (en) |
| NO (1) | NO20032453L (en) |
| NZ (1) | NZ526085A (en) |
| PL (1) | PL365739A1 (en) |
| RU (1) | RU2294934C2 (en) |
| SK (1) | SK7142003A3 (en) |
| TW (1) | TWI243819B (en) |
| UA (1) | UA74593C2 (en) |
| WO (1) | WO2002046194A2 (en) |
| ZA (1) | ZA200305238B (en) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5741908A (en) | 1996-06-21 | 1998-04-21 | Minnesota Mining And Manufacturing Company | Process for reparing imidazoquinolinamines |
| UA67760C2 (en) | 1997-12-11 | 2004-07-15 | Міннесота Майнінг Енд Мануфакчурінг Компані | Imidazonaphthyridines and use thereof to induce the biosynthesis of cytokines |
| US6541485B1 (en) | 1999-06-10 | 2003-04-01 | 3M Innovative Properties Company | Urea substituted imidazoquinolines |
| US6756382B2 (en) | 1999-06-10 | 2004-06-29 | 3M Innovative Properties Company | Amide substituted imidazoquinolines |
| US6331539B1 (en) | 1999-06-10 | 2001-12-18 | 3M Innovative Properties Company | Sulfonamide and sulfamide substituted imidazoquinolines |
| US6545017B1 (en) | 2000-12-08 | 2003-04-08 | 3M Innovative Properties Company | Urea substituted imidazopyridines |
| US6677347B2 (en) | 2000-12-08 | 2004-01-13 | 3M Innovative Properties Company | Sulfonamido ether substituted imidazoquinolines |
| US6664264B2 (en) | 2000-12-08 | 2003-12-16 | 3M Innovative Properties Company | Thioether substituted imidazoquinolines |
| US6664265B2 (en) | 2000-12-08 | 2003-12-16 | 3M Innovative Properties Company | Amido ether substituted imidazoquinolines |
| US6545016B1 (en) | 2000-12-08 | 2003-04-08 | 3M Innovative Properties Company | Amide substituted imidazopyridines |
| US6667312B2 (en) | 2000-12-08 | 2003-12-23 | 3M Innovative Properties Company | Thioether substituted imidazoquinolines |
| US6525064B1 (en) | 2000-12-08 | 2003-02-25 | 3M Innovative Properties Company | Sulfonamido substituted imidazopyridines |
| US6660735B2 (en) | 2000-12-08 | 2003-12-09 | 3M Innovative Properties Company | Urea substituted imidazoquinoline ethers |
| US20020107262A1 (en) * | 2000-12-08 | 2002-08-08 | 3M Innovative Properties Company | Substituted imidazopyridines |
| UA74852C2 (en) | 2000-12-08 | 2006-02-15 | 3M Innovative Properties Co | Urea-substituted imidazoquinoline ethers |
| US6677348B2 (en) | 2000-12-08 | 2004-01-13 | 3M Innovative Properties Company | Aryl ether substituted imidazoquinolines |
| CA2467828C (en) | 2001-11-29 | 2011-10-04 | 3M Innovative Properties Company | Pharmaceutical formulations comprising an immune response modifier |
| CA2365732A1 (en) | 2001-12-20 | 2003-06-20 | Ibm Canada Limited-Ibm Canada Limitee | Testing measurements |
| WO2003101949A2 (en) * | 2002-05-29 | 2003-12-11 | 3M Innovative Properties Company | Process for imidazo[4,5-c]pyridin-4-amines |
| WO2004032829A2 (en) | 2002-08-15 | 2004-04-22 | 3M Innovative Properties Company | Immunostimulatory compositions and methods of stimulating an immune response |
| US6818650B2 (en) | 2002-09-26 | 2004-11-16 | 3M Innovative Properties Company | 1H-imidazo dimers |
| EP1590348A1 (en) | 2002-12-20 | 2005-11-02 | 3M Innovative Properties Company | Aryl / hetaryl substituted imidazoquinolines |
| JP2006512391A (en) | 2002-12-30 | 2006-04-13 | スリーエム イノベイティブ プロパティズ カンパニー | Combination immunostimulant |
| AU2004218349A1 (en) | 2003-03-04 | 2004-09-16 | 3M Innovative Properties Company | Prophylactic treatment of UV-induced epidermal neoplasia |
| US7699057B2 (en) * | 2003-03-13 | 2010-04-20 | 3M Innovative Properties Company | Methods for treating skin lesions |
| US8426457B2 (en) | 2003-03-13 | 2013-04-23 | Medicis Pharmaceutical Corporation | Methods of improving skin quality |
| US20040192585A1 (en) | 2003-03-25 | 2004-09-30 | 3M Innovative Properties Company | Treatment for basal cell carcinoma |
| AU2004244962A1 (en) | 2003-04-10 | 2004-12-16 | 3M Innovative Properties Company | Delivery of immune response modifier compounds using metal-containing particulate support materials |
| US6943255B2 (en) | 2003-06-06 | 2005-09-13 | 3M Innovative Properties Company | Process for imidazo[4,5-c]pyridin-4-amines |
| WO2005018556A2 (en) | 2003-08-12 | 2005-03-03 | 3M Innovative Properties Company | Hydroxylamine substituted imidazo-containing compounds |
| JP2007503268A (en) | 2003-08-25 | 2007-02-22 | スリーエム イノベイティブ プロパティズ カンパニー | Delivery of immune response modifying compounds |
| ES2406730T3 (en) | 2003-08-27 | 2013-06-07 | 3M Innovative Properties Company | Imidazoquinolines substituted with aryloxy and arylalkylenoxy |
| AU2004270201A1 (en) | 2003-09-05 | 2005-03-17 | 3M Innovative Properties Company | Treatment for CD5+ B cell lymphoma |
| US7544697B2 (en) | 2003-10-03 | 2009-06-09 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridines and analogs thereof |
| CA2540541C (en) | 2003-10-03 | 2012-03-27 | 3M Innovative Properties Company | Alkoxy substituted imidazoquinolines |
| WO2005048945A2 (en) | 2003-11-14 | 2005-06-02 | 3M Innovative Properties Company | Hydroxylamine substituted imidazo ring compounds |
| EP1685129A4 (en) | 2003-11-14 | 2008-10-22 | 3M Innovative Properties Co | Oxime substituted imidazo ring compounds |
| JP4891088B2 (en) | 2003-11-25 | 2012-03-07 | スリーエム イノベイティブ プロパティズ カンパニー | Substituted imidazo ring systems and methods |
| US8940755B2 (en) | 2003-12-02 | 2015-01-27 | 3M Innovative Properties Company | Therapeutic combinations and methods including IRM compounds |
| JP2007517035A (en) | 2003-12-29 | 2007-06-28 | スリーエム イノベイティブ プロパティズ カンパニー | Arylalkenyl and arylalkynyl substituted imidazoquinolines |
| WO2005066172A1 (en) * | 2003-12-29 | 2005-07-21 | 3M Innovative Properties Company | Piperazine, [1,4]diazepane, [1,4]diazocane, and [1,5]diazocane fused imidazo ring compounds |
| CA2551399A1 (en) | 2003-12-30 | 2005-07-21 | 3M Innovative Properties Company | Imidazoquinolinyl, imidazopyridinyl, and imidazonaphthyridinyl sulfonamides |
| CA2559863A1 (en) | 2004-03-24 | 2005-10-13 | 3M Innovative Properties Company | Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines |
| US8017779B2 (en) | 2004-06-15 | 2011-09-13 | 3M Innovative Properties Company | Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines |
| US7915281B2 (en) | 2004-06-18 | 2011-03-29 | 3M Innovative Properties Company | Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and method |
| WO2006038923A2 (en) | 2004-06-18 | 2006-04-13 | 3M Innovative Properties Company | Aryl substituted imidazonaphthyridines |
| US8026366B2 (en) | 2004-06-18 | 2011-09-27 | 3M Innovative Properties Company | Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines |
| AU2005326708C1 (en) | 2004-12-30 | 2012-08-30 | 3M Innovative Properties Company | Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds |
| AU2005322898B2 (en) | 2004-12-30 | 2011-11-24 | 3M Innovative Properties Company | Chiral fused (1,2)imidazo(4,5-c) ring compounds |
| CA2597092A1 (en) | 2005-02-04 | 2006-08-10 | Coley Pharmaceutical Group, Inc. | Aqueous gel formulations containing immune reponse modifiers |
| WO2006086634A2 (en) | 2005-02-11 | 2006-08-17 | Coley Pharmaceutical Group, Inc. | Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods |
| EP1869043A2 (en) | 2005-04-01 | 2007-12-26 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridine-1,4-diamines and analogs thereof |
| CA2602590A1 (en) | 2005-04-01 | 2006-10-12 | Coley Pharmaceutical Group, Inc. | 1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases |
| KR20080048551A (en) * | 2005-09-23 | 2008-06-02 | 콜레이 파마시티컬 그룹, 인코포레이티드 | Method for 1h-imidazo[4,5-c]pyridines and analogs thereof |
| CN100344325C (en) * | 2005-10-17 | 2007-10-24 | 华南师范大学 | Medicine for treating cervical cancer and preparation method and application thereof |
| WO2008008432A2 (en) | 2006-07-12 | 2008-01-17 | Coley Pharmaceutical Group, Inc. | Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods |
| WO2009034411A1 (en) * | 2007-09-12 | 2009-03-19 | Centre National De La Recherche Scientifique | Perharidines as cdk inhibitors |
| CN112587658A (en) | 2012-07-18 | 2021-04-02 | 博笛生物科技有限公司 | Targeted immunotherapy for cancer |
| CA2930499C (en) | 2013-12-09 | 2021-11-23 | Ucb Biopharma Sprl | Imidazopyridine derivatives as modulators of tnf activity |
| CN105899539B (en) | 2014-01-10 | 2021-11-09 | 博笛生物科技有限公司 | Compounds and compositions for immunotherapy |
| EP4001311A1 (en) | 2014-07-09 | 2022-05-25 | Birdie Biopharmaceuticals Inc. | Anti-pd-l1 combinations for treating tumors |
| CN105440135A (en) | 2014-09-01 | 2016-03-30 | 博笛生物科技有限公司 | Anti-PD-L1 conjugate for treating tumors |
| CN112546230A (en) | 2014-07-09 | 2021-03-26 | 博笛生物科技有限公司 | Combination therapeutic compositions and combination therapeutic methods for treating cancer |
| CN106943597A (en) | 2016-01-07 | 2017-07-14 | 博笛生物科技（北京）有限公司 | Anti-EGFR for treating tumour is combined |
| CN106943596A (en) | 2016-01-07 | 2017-07-14 | 博笛生物科技（北京）有限公司 | Anti-CD 20 for treating tumour is combined |
| CN115350279A (en) | 2016-01-07 | 2022-11-18 | 博笛生物科技有限公司 | anti-HER 2 combinations for the treatment of tumors |
| CN118515666A (en) | 2017-04-27 | 2024-08-20 | 博笛生物科技有限公司 | 2-Amino-quinoline derivatives |
| JP7080501B2 (en) | 2017-06-23 | 2022-06-06 | バーディー バイオファーマシューティカルズ インコーポレイテッド | Pharmaceutical composition |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL73534A (en) * | 1983-11-18 | 1990-12-23 | Riker Laboratories Inc | 1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds |
| US4929624A (en) * | 1989-03-23 | 1990-05-29 | Minnesota Mining And Manufacturing Company | Olefinic 1H-imidazo(4,5-c)quinolin-4-amines |
| US5389640A (en) * | 1991-03-01 | 1995-02-14 | Minnesota Mining And Manufacturing Company | 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
| US5268376A (en) * | 1991-09-04 | 1993-12-07 | Minnesota Mining And Manufacturing Company | 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
| JPH09500128A (en) * | 1993-07-15 | 1997-01-07 | ミネソタ マイニング アンド マニュファクチャリング カンパニー | Imidazo [4,5-c] pyridin-4-amine |
| US6069149A (en) * | 1997-01-09 | 2000-05-30 | Terumo Kabushiki Kaisha | Amide derivatives and intermediates for the synthesis thereof |
| UA67760C2 (en) * | 1997-12-11 | 2004-07-15 | Міннесота Майнінг Енд Мануфакчурінг Компані | Imidazonaphthyridines and use thereof to induce the biosynthesis of cytokines |
| US6331539B1 (en) * | 1999-06-10 | 2001-12-18 | 3M Innovative Properties Company | Sulfonamide and sulfamide substituted imidazoquinolines |
| US6541485B1 (en) * | 1999-06-10 | 2003-04-01 | 3M Innovative Properties Company | Urea substituted imidazoquinolines |
| US6451810B1 (en) * | 1999-06-10 | 2002-09-17 | 3M Innovative Properties Company | Amide substituted imidazoquinolines |
-
2001
- 2001-06-12 UA UA2003042937A patent/UA74593C2/en unknown
- 2001-12-06 WO PCT/US2001/046915 patent/WO2002046194A2/en active IP Right Grant
- 2001-12-06 PL PL01365739A patent/PL365739A1/en not_active Application Discontinuation
- 2001-12-06 EE EEP200300273A patent/EE200300273A/en unknown
- 2001-12-06 KR KR10-2003-7007533A patent/KR20030070048A/en not_active Application Discontinuation
- 2001-12-06 CA CA002431040A patent/CA2431040A1/en not_active Abandoned
- 2001-12-06 IL IL15588501A patent/IL155885A0/en unknown
- 2001-12-06 SK SK714-2003A patent/SK7142003A3/en unknown
- 2001-12-06 RU RU2003116648/04A patent/RU2294934C2/en active
- 2001-12-06 EP EP01987315A patent/EP1343783A2/en not_active Withdrawn
- 2001-12-06 BR BR0116034-6A patent/BR0116034A/en not_active IP Right Cessation
- 2001-12-06 HU HU0600592A patent/HUP0600592A2/en unknown
- 2001-12-06 MX MXPA03005013A patent/MXPA03005013A/en active IP Right Grant
- 2001-12-06 CN CNB018198570A patent/CN1249062C/en not_active Expired - Fee Related
- 2001-12-06 CZ CZ20031593A patent/CZ20031593A3/en unknown
- 2001-12-06 AU AU2002239547A patent/AU2002239547B2/en not_active Ceased
- 2001-12-06 NZ NZ526085A patent/NZ526085A/en unknown
- 2001-12-06 AU AU3954702A patent/AU3954702A/en active Pending
- 2001-12-06 JP JP2002547931A patent/JP2004525868A/en active Pending
- 2001-12-07 TW TW090130400A patent/TWI243819B/en active
- 2001-12-10 AR ARP010105732A patent/AR035670A1/en unknown
-
2003
- 2003-05-28 NO NO20032453A patent/NO20032453L/en not_active Application Discontinuation
- 2003-06-06 HR HR20030465A patent/HRP20030465A2/en not_active Application Discontinuation
- 2003-07-07 ZA ZA200305238A patent/ZA200305238B/en unknown
-
2004
- 2004-08-18 HK HK04106187A patent/HK1063466A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| UA74593C2 (en) | 2006-01-16 |
| NO20032453L (en) | 2003-07-16 |
| AU2002239547B2 (en) | 2006-11-30 |
| RU2294934C2 (en) | 2007-03-10 |
| HK1063466A1 (en) | 2004-12-31 |
| ZA200305238B (en) | 2004-08-27 |
| MXPA03005013A (en) | 2003-09-05 |
| PL365739A1 (en) | 2005-01-10 |
| SK7142003A3 (en) | 2003-10-07 |
| KR20030070048A (en) | 2003-08-27 |
| AR035670A1 (en) | 2004-06-23 |
| HUP0600592A2 (en) | 2006-11-28 |
| HRP20030465A2 (en) | 2004-06-30 |
| IL155885A0 (en) | 2003-12-23 |
| CN1249062C (en) | 2006-04-05 |
| CZ20031593A3 (en) | 2004-01-14 |
| BR0116034A (en) | 2004-08-03 |
| JP2004525868A (en) | 2004-08-26 |
| TWI243819B (en) | 2005-11-21 |
| EP1343783A2 (en) | 2003-09-17 |
| CA2431040A1 (en) | 2002-06-13 |
| WO2002046194A3 (en) | 2003-02-06 |
| EE200300273A (en) | 2004-02-16 |
| NO20032453D0 (en) | 2003-05-28 |
| CN1478090A (en) | 2004-02-25 |
| AU3954702A (en) | 2002-06-18 |
| WO2002046194A2 (en) | 2002-06-13 |
| RU2003116648A (en) | 2005-02-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) |