Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
  • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
  • A61K8/9783—Angiosperms [Magnoliophyta]
  • A61K8/9789—Magnoliopsida [dicotyledons]
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/67—Vitamins
  • A61K8/676—Ascorbic acid, i.e. vitamin C
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
  • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
  • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
  • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
  • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
  • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P17/00—Drugs for dermatological disorders
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
  • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin

Definitions

• Melanin is a black pigment that is found in the skin and hair and is produced enzymatically in the melanosomes from the amino acid tyrosine.
• Melanosomes are components of melanocytes, a type of cell found in the junction between the dermis and epidermis.
• the enzyme tyrosinase is responsible for the formation of melanin from tyrosine. While in many cases the formation of melanin in the sense of skin tanning is at least to a certain extent desired by the consumer, there is also a need for the opposite effect.
• a skin bass is a special beauty feature that is associated with the absence of physical work outdoors and therefore with a certain social status. In individual cases, however, it can simply be a matter of removing age spots or freckles.
• the invention relates to cosmetic preparations containing
• Component (a) according to the invention is produced by customary methods of extracting the plants or parts of plants.
• suitable conventional extraction methods such as maceration, remaceration, digestion, movement maceration, vortex extraction, ultrasound extraction, countercurrent extraction, percolation, repercolation, evacolation (extraction under reduced pressure), diacolation and solid-liquid extraction under continuous reflux , which is carried out in a Soxhlet extractor, which is familiar to a person skilled in the art and in principle all can be used, for the sake of simplicity, for example, on Hager's Handbook of Pharmaceutical Practice, (5th edition, vol. 2, pp. 1026-1030, Springer Verlag , Berlin-Heidelberg-New-York 1991).
• Fresh plants or parts of plants can be used as the starting material, but usually from dried plants and / or parts of plants, which can be mechanically comminuted before extraction, are suitable here all comminution methods known to the person skilled in the art, for example grinding milling.
• Organic solvents water (preferably distilled hot water at a temperature) can be used as the solvent for carrying out the extractions above 80 ° C and in particular between 85 and 90 ° C) or mixtures of organic solvents and water, in particular low molecular weight alcohols with more or less high water contents, are particularly preferred extraction with methanol, ethanol, pentane, hexane, heptane, Acetone, propylene glycols, polyethylene glycols as well as ethyl acetate and mixtures thereof and their water-based mixtures.
• the extracts thus produced can be subjected, for example, to a selective separation of individual undesirable ingredients.
• the extraction can be carried out up to any Degree of extraction take place, but is usually carried out until exhaustion.
• the ocher leaves are in the range from 0.5 to 10% by weight, in particular from 1 to 5% by weight.
• the present invention encompasses the knowledge that the extraction conditions and the yields of the final extracts can be chosen by the person skilled in the art according to the desired field of use Extracts are then subjected, for example, to spray or freeze drying
• ferulic acid (synonym: 4-hydroxy-3-methoxycinnamic acid, caffeic acid 3-methyl ether) as a tyrosinase inhibitor is reported, for example, in the international patent application WO 99/37280 (Unilever); an overview can also be found in PhiuZ 14, 115 (1985).
• Another object of the present invention relates to the use of mixtures containing
• the degree of oligomerization is a statistical mean value which is based on a homolog distribution customary for such technical products
• suitable Partialgiyce ⁇ de are Hydroxysteannsauremonoglycend, steannsaurediglyce ⁇ d hydroxy, Isosteannsauremonoglycerid, Isosteannsaurediglyce ⁇ d, Olsauremonoglycend, Olsaurediglyce ⁇ d, Ricinolsauremoglycend, Ricinolsaurediglycend, Linolsauremonoglycend, Linolsaure- diglyce ⁇ d, ünolensauremonoglyce ⁇ d, Linolensaurediglycend, Erucasauremonoglyce ⁇ d, Erucasaure- diglyce ⁇ d, ⁇ d Weinsauremonoglyce ⁇ d, Weinsaurediglyce ⁇ d, Citron
• Suitable thickeners are, for example, aerosil types (hydrophilic silicas), polysaccharides, in particular xanthan gum, guar guar, agar agar, alginates and tyiosis, carboxymethyl cellulose and hydroxyethyl cellulose, and also higher molecular weight polyethylene glycol mono- and diesters of fatty acids, polyacrylates , (eg Carbopole® and Pemulen types from Goodrich; Synthalene® from Sigma; Keltrol types from Kelco; Sepigel types from Seppic; Saicare types from Allied Colloids), polyacrylamides, polymers, polyvinyl alcohol and polyvinyl pyrrolidone, surfactants such as, for example, ethoxylated fatty acid glycerides, esters of fatty acids with polyols such as, for example, pentaerythnate or trimethylolpropane, fatty alcohol ethoxylates with a narrow homolog distribution or
• the pigments can also be surface-treated, ie hydrophilized or hydrophobicized.
• Typical examples are coated titanium dioxides, such as titanium dioxide T 805 (Degussa) or Eusolex® T2000 (Merck).
• the most hydrophobic coating agents are silicones and, in particular, T ⁇ al - koxyoctylsilane or simethicone in question So-called micro- or nano-pigments are preferably used in sunscreens. Micronized zinc oxide is preferably used.
• Further suitable UV light protection filters can be found in the overview by P Fmkel in S ⁇ FW-Journal 122, 543 (1996) and Perfumery and Cosmetics 3 ( 1999), page 11ff
• Suitable as odor absorbers are substances that absorb and largely retain odor-forming compounds.You can reduce the partial pressure of the individual components and thus also reduce their rate of expansion.It is important that perfumes must remain unaffected. Odor absorbers have no activity against bacteria.For example, they contain a complex zinc salt as the main component Ricmoleic acid or special, largely odorless fragrances known to the person skilled in the art as "fixators", such as extracts from labdanum or styrax or certain abietic acid derivatives. Odorants or perfume oils act as odor suppressors and, in addition to their function as odor eliminators, act as deodorants for the respective deodorants Giving a fragrance note As perfumes, for example, mixtures of natural and synthetic fragrances.
• Natural fragrances are extracts of bleeds, stems and leaves. Fruits Fruit peel, roots, wood, Kr Autern and grazers, needles and twigs as well as resins and balsams. Animal raw materials are also suitable, such as civet and castoreum. Typical synthetic fragrance compounds are products of the ester, ether, aldehyde, ketone, alcohol and hydrocarbon type.
• Fragrance compounds are of the ester type eg benzyl acetate, p-tert-butylcyclohexyl acetate, linalyl acetate, phenylethyl acetate, lmalyl benzoate, benzyl formate, allyl cyclohexyl propionate, styrallyl propionate and benzyl salicylate
• ethers include benzyl ethyl ether, for the aldehydes alkali atoms z. Citronellyloxyacetaldehyde, cyclamenaldehyde, hydroxycitronellal, lilial and bourgeonal, to the ketones e.g.
• Usable film formers for example, chitosan, microcrystalline chitosan, quaternized chitosan, polyvinyl pyrrolidone, vinyl pyrrolidone-vinyl acetate copolymers, polymers of the acrylic acid series, quaternary cellulose derivatives, collagen, hyaluronic acid or compounds thereof and the like
• Methyl compounds such as in particular trimethylolethane, trimethylolpropane, trimethylolbutane, pentaerythritol and dipentaerythritol;
• the ethers include, for example, benzylethylether, the aldehydes, for example, the linear alkanals having 8 to 18 carbon atoms, citral, citronellal, citronellyloxyacetalonone, lilydialonaldehyde, cyclamenaldehyde, cyclamenaldehyde, cyclamenaldehyde, cyclamenaldehyde, cyclamenaldehyde, cyclamenaldehyde, cyclamenaldehyde, cyclamen
• the hydrocarbons mainly include the terpenes and balsams, but mixtures of different fragrances
• perfume oils e.g. sage oil, camomile oil, clove oil, melissa oil, mint oil, cinnamon leaf oil, linden blossom oil, juniper berry oil, vetiverol, oliban oil, galbanumol L abolanumol and lavandin
• perfume oils e.g. sage oil, camomile oil, clove oil, melissa oil, mint oil, cinnamon leaf oil, linden blossom oil, juniper berry oil, vetiverol, oliban oil, galbanumol L abolanumol and lavandin
• sage oil e.g. sage oil, camomile oil, clove oil, melissa oil, mint oil, cinnamon leaf oil, linden blossom oil, juniper berry oil, vetiverol, oliban oil, galbanumol L abolanumol and lavandin
• sage oil e.g. sage oil, camomile oil, clove oil, melissa oil, mint
• the dyes which can be used are those which are suitable and approved for cosmetic purposes, such as are listed, for example, in the publication "Cosmetic Dyes” by the Dye Commission of the German Research Foundation, Verlag Chemie, Weinheim, 1984, pp. 81-106. These dyes are usually used in concentrations from 0.001 to 0.1% by weight, based on the mixture as a whole
• the brown colored extract was obtained at an initial temperature of 185 ° C and a final temperature of 80 ° C, optionally after adding an auxiliary such as mannitol (1/2 auxiliary, 1/2 extracted material or 1/10 excipient and 9/10 extracted material) spray dried.
• an auxiliary such as mannitol (1/2 auxiliary, 1/2 extracted material or 1/10 excipient and 9/10 extracted material) spray dried.
• Table 1 Information on alcoholic and aqueous-alcoholic extracts from Waltheria indica

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• Health & Medical Sciences (AREA)
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• Public Health (AREA)
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• Animal Behavior & Ethology (AREA)
• Epidemiology (AREA)
• Birds (AREA)
• Engineering & Computer Science (AREA)
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• Biotechnology (AREA)
• Emergency Medicine (AREA)
• Mycology (AREA)
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• General Chemical & Material Sciences (AREA)
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• Medicinal Chemistry (AREA)
• Chemical Kinetics & Catalysis (AREA)
• Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
• Chemical & Material Sciences (AREA)
• Bioinformatics & Cheminformatics (AREA)
• Organic Chemistry (AREA)
• Cosmetics (AREA)
• Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
• Medicines Containing Plant Substances (AREA)
• Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

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• 2000
  • 2000-02-07 EP EP00440033A patent/EP1121926A1/de not_active Withdrawn
• 2001
  • 2001-01-27 CN CN01804653A patent/CN1398179A/zh active Pending
  • 2001-01-27 KR KR1020027010186A patent/KR100748056B1/ko not_active Expired - Fee Related
  • 2001-01-27 BR BR0108056-3A patent/BR0108056A/pt not_active Application Discontinuation
  • 2001-01-27 DE DE50104294T patent/DE50104294D1/de not_active Expired - Lifetime
  • 2001-01-27 AU AU44111/01A patent/AU4411101A/en not_active Abandoned
  • 2001-01-27 EP EP20010916957 patent/EP1253906B1/de not_active Expired - Lifetime
  • 2001-01-27 US US10/203,228 patent/US20030152536A1/en not_active Abandoned
  • 2001-01-27 JP JP2001556233A patent/JP2003521505A/ja active Pending
  • 2001-01-27 WO PCT/EP2001/000884 patent/WO2001056541A1/de not_active Ceased
  • 2001-01-27 ES ES01916957T patent/ES2231464T3/es not_active Expired - Lifetime

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