WO2001019406A2 - Amphiphilic prodrugs - Google Patents

Amphiphilic prodrugs Download PDF

Info

Publication number
WO2001019406A2
WO2001019406A2 PCT/US2000/024520 US0024520W WO0119406A2 WO 2001019406 A2 WO2001019406 A2 WO 2001019406A2 US 0024520 W US0024520 W US 0024520W WO 0119406 A2 WO0119406 A2 WO 0119406A2
Authority
WO
WIPO (PCT)
Prior art keywords
prodrug
etoposide
therapeutic compound
formula
oligomer
Prior art date
Application number
PCT/US2000/024520
Other languages
English (en)
French (fr)
Other versions
WO2001019406A3 (en
Inventor
Nnochiri N. Ekwuribe
Tatyana A. Dyakonov
Christopher H. Price
Original Assignee
Nobex Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BR0013948-3A priority Critical patent/BR0013948A/pt
Application filed by Nobex Corporation filed Critical Nobex Corporation
Priority to JP2001523037A priority patent/JP2003509385A/ja
Priority to CA002384645A priority patent/CA2384645A1/en
Priority to NZ517681A priority patent/NZ517681A/en
Priority to EP00964949A priority patent/EP1212099A2/en
Priority to IL14855800A priority patent/IL148558A0/xx
Priority to MXPA02002712A priority patent/MXPA02002712A/es
Priority to HU0204110A priority patent/HUP0204110A3/hu
Priority to AU75756/00A priority patent/AU7575600A/en
Priority to KR1020027003276A priority patent/KR20020059398A/ko
Publication of WO2001019406A2 publication Critical patent/WO2001019406A2/en
Publication of WO2001019406A3 publication Critical patent/WO2001019406A3/en
Priority to NO20021213A priority patent/NO20021213L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
PCT/US2000/024520 1999-09-13 2000-09-07 Amphiphilic prodrugs WO2001019406A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
IL14855800A IL148558A0 (en) 1999-09-13 2000-09-07 Amphiphilic prodrugs
JP2001523037A JP2003509385A (ja) 1999-09-13 2000-09-07 両親媒性プロドラッグ
CA002384645A CA2384645A1 (en) 1999-09-13 2000-09-07 Amphiphilic prodrugs
NZ517681A NZ517681A (en) 1999-09-13 2000-09-07 Amphiphilic prodrugs
EP00964949A EP1212099A2 (en) 1999-09-13 2000-09-07 Amphiphilic prodrugs
BR0013948-3A BR0013948A (pt) 1999-09-13 2000-09-07 Prodroga, composição farmacêutica, e, método de tratamento de um paciente mamìfero
MXPA02002712A MXPA02002712A (es) 1999-09-13 2000-09-07 Profarmacos anfifilicos.
KR1020027003276A KR20020059398A (ko) 1999-09-13 2000-09-07 양성 친화성 프로드럭
AU75756/00A AU7575600A (en) 1999-09-13 2000-09-07 Amphiphilic prodrugs
HU0204110A HUP0204110A3 (en) 1999-09-13 2000-09-07 Amphiphilic prodrugs, process for preparation and use of pharmaceutical compositions containing them
NO20021213A NO20021213L (no) 1999-09-13 2002-03-12 Amfifile prodroger

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US15364999P 1999-09-13 1999-09-13
US60/153,649 1999-09-13
US09/474,915 US6713454B1 (en) 1999-09-13 1999-12-31 Prodrugs of etoposide and etoposide analogs
US09/474,915 1999-12-31

Publications (2)

Publication Number Publication Date
WO2001019406A2 true WO2001019406A2 (en) 2001-03-22
WO2001019406A3 WO2001019406A3 (en) 2002-01-17

Family

ID=26850733

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/024520 WO2001019406A2 (en) 1999-09-13 2000-09-07 Amphiphilic prodrugs

Country Status (17)

Country Link
US (3) US6713454B1 (US07119074-20061010-C00048.png)
EP (1) EP1212099A2 (US07119074-20061010-C00048.png)
JP (1) JP2003509385A (US07119074-20061010-C00048.png)
KR (1) KR20020059398A (US07119074-20061010-C00048.png)
CN (1) CN1390143A (US07119074-20061010-C00048.png)
AU (1) AU7575600A (US07119074-20061010-C00048.png)
BR (1) BR0013948A (US07119074-20061010-C00048.png)
CA (1) CA2384645A1 (US07119074-20061010-C00048.png)
CZ (1) CZ2002928A3 (US07119074-20061010-C00048.png)
HU (1) HUP0204110A3 (US07119074-20061010-C00048.png)
IL (1) IL148558A0 (US07119074-20061010-C00048.png)
MX (1) MXPA02002712A (US07119074-20061010-C00048.png)
NO (1) NO20021213L (US07119074-20061010-C00048.png)
NZ (1) NZ517681A (US07119074-20061010-C00048.png)
PL (1) PL354261A1 (US07119074-20061010-C00048.png)
RU (1) RU2002109595A (US07119074-20061010-C00048.png)
WO (1) WO2001019406A2 (US07119074-20061010-C00048.png)

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001019407A2 (en) * 1999-09-13 2001-03-22 Nobex Corporation Taxane prodrugs
EP1274460A1 (en) * 2000-04-15 2003-01-15 Kolon Industries, Inc. Aqueous-prodrug compound comprising moiety of paclitxel or derivatives thereof, method of preparing same and pharmaceutical composition comprising same
US6541508B2 (en) 1999-09-13 2003-04-01 Nobex Corporation Taxane prodrugs
WO2004035037A2 (en) * 2002-10-21 2004-04-29 Ramot At Tel Aviv University Ltd. Derivatives of n-phenylanthranilic acid and 2-benzimidazolon as potassium channel and/or cortical neuron activity modulators
US7119074B2 (en) 1999-09-13 2006-10-10 Nobex Corporation Treatment of cancers, tumors and malignancies using amphiphilic prodrugs
US7632866B2 (en) 2002-10-21 2009-12-15 Ramot At Tel Aviv University Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators
US8008435B2 (en) * 1999-10-04 2011-08-30 Nektar Therapeutics Polymer stabilized neuropeptides
US8188222B2 (en) 2006-11-08 2012-05-29 Nippon Kayaku Kabushiki Kaisha High molecular weight derivative of nucleic acid antimetabolite
US8323669B2 (en) 2006-03-28 2012-12-04 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of taxane
US8334364B2 (en) 2006-11-06 2012-12-18 Nipon Kayaku Kabushiki Kaisha High-molecular weight derivative of nucleic acid antimetabolite
US8703878B2 (en) 2007-09-28 2014-04-22 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of steroids
US8765815B2 (en) 2007-09-20 2014-07-01 Ramot At Tel-Aviv University Ltd. N-phenyl anthranilic acid derivatives and uses thereof
US8808749B2 (en) 2009-05-15 2014-08-19 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of bioactive substance having hydroxy group
US8920788B2 (en) 2008-03-18 2014-12-30 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of physiologically active substances
US9018323B2 (en) 2010-11-17 2015-04-28 Nippon Kayaku Kabushiki Kaisha Polymer derivative of cytidine metabolic antagonist
US9149540B2 (en) 2008-05-08 2015-10-06 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of folic acid or folic acid derivative
US9346923B2 (en) 2011-09-11 2016-05-24 Nippon Kayaku Kabushiki Kaisha Method for manufacturing block copolymer
US9434822B2 (en) 2004-09-22 2016-09-06 Nippon Kayaku Kabushiki Kaisha Block copolymer, micelle preparation, and anticancer agent containing the same as active ingredient

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6703381B1 (en) * 1998-08-14 2004-03-09 Nobex Corporation Methods for delivery therapeutic compounds across the blood-brain barrier
DE60205470T2 (de) * 2002-03-28 2006-05-24 Council Of Scientific And Industrial Research Analoge von 4-beta-1''-[(2''-(substitutierte-benzoyl)anilin]-podophyllotoxin zur verwendung als antikrebs-agentia 4-beta-1"-∫2"-(substituted benzoyl) anilino∫ podophyllotoxin analogues useful as anticancer agents
US7648962B2 (en) * 2002-11-26 2010-01-19 Biocon Limited Natriuretic compounds, conjugates, and uses thereof
EP1569683B1 (en) * 2002-11-26 2010-03-03 Biocon Limited Modified natriuretic compounds, conjugates, and uses thereof
SI1583562T1 (sl) * 2003-01-06 2011-10-28 Angiochem Inc AngioPep-1, sorodne spojine in njihove uporabe
US7140522B2 (en) * 2003-06-26 2006-11-28 Spencer Forrest, Inc. Applicator for hair building solids
US20060182692A1 (en) * 2003-12-16 2006-08-17 Fishburn C S Chemically modified small molecules
CN102895666B (zh) * 2003-12-16 2015-08-19 尼克塔治疗公司 化学改性的小分子
NZ548195A (en) * 2004-01-14 2011-01-28 Gilead Sciences Inc Lipid-based dispersions useful for drug delivery
US8329958B2 (en) 2004-07-02 2012-12-11 Biocon Limited Combinatorial synthesis of PEG oligomer libraries
WO2006076471A2 (en) * 2005-01-12 2006-07-20 Nobex Corporation Bnp conjugates and methods of use
US20090016959A1 (en) * 2005-02-18 2009-01-15 Richard Beliveau Delivery of antibodies to the central nervous system
ES2383901T5 (es) * 2005-02-18 2015-02-25 Angiochem Inc. Polipéptidos de aprotinina para transportar un compuesto a través de la barrera sangre-cerebro
CN101262890B (zh) 2005-07-15 2015-08-26 安吉奥化学公司 抑肽酶多肽作为载体在药物缀合物中的用途
JP5173199B2 (ja) * 2006-01-16 2013-03-27 株式会社アイ・ティー・オー 創傷治癒用高分子組成物
WO2007135910A1 (ja) * 2006-05-18 2007-11-29 Nippon Kayaku Kabushiki Kaisha ポドフィロトキシン類の高分子結合体
CA2664852A1 (en) * 2006-10-03 2008-04-10 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of resorcinol derivatives
US9365634B2 (en) * 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
RU2518240C2 (ru) * 2008-04-18 2014-06-10 Ангиочем Инк. Композиция, на основе гидрофобных агентов и способ ее получения(варианты)
US20100075926A1 (en) * 2008-07-23 2010-03-25 Li-Huei Tsai Activation of histone deacetylase 1 (hdac1) protects against dna damage and increases neuronal survival
BRPI0920121A2 (pt) 2008-10-15 2019-09-24 Angiochem Inc conjugados de etoposida e doxorubicina para liberação de fármaco
JP2012505637A (ja) 2008-10-15 2012-03-08 アンジオケム，インコーポレーテッド Ｇｌｐ−１アゴニストのコンジュゲート及びその使用
JP5759379B2 (ja) * 2008-12-05 2015-08-05 アンジオケム インコーポレーテッド ニューロテンシンまたはニューロテンシンアナログおよびその使用
EP2373789A4 (en) 2008-12-17 2012-08-29 Angiochem Inc MEMBRANTYP-1 MATRIX METALLOPROTEINASE INHIBITORS AND THEIR USE
WO2010121379A1 (en) 2009-04-20 2010-10-28 Angiochem Inc Treatment of ovarian cancer using an anticancer agent conjugated to an angiopep-2 analog
AU2010268726A1 (en) 2009-07-02 2012-01-19 Angiochem Inc. Multimeric peptide conjugates and uses thereof
CA2779497A1 (en) 2009-10-30 2011-05-05 Massachusetts Institute Of Technology The use of ci-994 and dinaline for the treatment of memory/cognition and anxiety disorders
US9561285B2 (en) * 2010-01-22 2017-02-07 Ascendis Pharma As Carrier-linked carbamate prodrug linkers
SA111320200B1 (ar) 2010-02-17 2014-02-16 ديبيوفارم اس ايه مركبات ثنائية الحلقة واستخداماتها كمثبطات c-src/jak مزدوجة
WO2011141891A1 (en) 2010-05-12 2011-11-17 Debio Recherche Pharmaceutique S.A. Use of cycloundecadepsipeptide compounds
EP2624869A4 (en) * 2010-10-08 2015-11-04 Univ Virginia Commonwealth PRODRUGS USING A CONTAINER CONTROLLED ABSORPTION MECHANISM
WO2012149540A1 (en) 2011-04-28 2012-11-01 The Broad Institute Inc Inhibitors of histone deacetylase
TR201901856T4 (tr) 2011-07-22 2019-03-21 Massachusetts Inst Technology Sınıf I histon deasetilazların (HDAC'ler) aktivatörleri ve kullanımları.
US8993614B2 (en) 2012-03-15 2015-03-31 F. Hoffmann-La Roche Ag Substituted pyrrolidine-2-carboxamides
EP2852439A1 (en) 2012-05-23 2015-04-01 Stemergie Biotechnology SA Inhibitors of the activity of complex (iii) of the mitochondrial electron transport chain and use thereof
WO2014100438A1 (en) 2012-12-20 2014-06-26 The Broad Institute, Inc. Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors
CA2989400A1 (en) 2015-06-15 2016-12-22 Angiochem Inc. Ang1005 for the treatment of leptomeningeal carcinomatosis
WO2016205631A1 (en) 2015-06-17 2016-12-22 Massachusetts Institute Of Technology Serotonin 2c receptor antagonists to prevent and treat stress-related trauma disorders
JP2020533992A (ja) 2017-09-18 2020-11-26 マサチューセッツ インスティテュート オブ テクノロジー サイクリン依存性キナーゼ５（ｃｄｋ５）阻害性ペプチド
CN112266409B (zh) * 2020-10-28 2022-05-13 南开大学 依托泊苷自组装纳米纤维多肽、制备方法及应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996023794A1 (en) * 1995-01-30 1996-08-08 Enzon, Inc. High molecular weight polymer-based prodrugs
WO1997033552A1 (en) * 1996-03-12 1997-09-18 Pg-Txl Company, L.P. Water soluble paclitaxel prodrugs
WO1998007713A1 (en) * 1996-08-20 1998-02-26 Enzon, Inc. High molecular weight polymer-based prodrugs
WO1999030727A1 (en) * 1997-12-17 1999-06-24 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
WO2000064486A2 (en) * 1999-04-28 2000-11-02 Vectramed, Inc. Enzymatically activated polymeric drug conjugates
WO2001019407A2 (en) * 1999-09-13 2001-03-22 Nobex Corporation Taxane prodrugs

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US611107A (en) * 1898-09-20 Method of forming tobacco into wrappers
ATE28864T1 (de) 1982-07-23 1987-08-15 Ici Plc Amide-derivate.
US4567253A (en) 1984-02-03 1986-01-28 Tony Durst 2-Substituted derivatives of podophyllotoxin and etoposide
US5122614A (en) 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
US5324844A (en) 1989-04-19 1994-06-28 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
US5411947A (en) 1989-06-28 1995-05-02 Vestar, Inc. Method of converting a drug to an orally available form by covalently bonding a lipid to the drug
DE3935016A1 (de) 1989-10-20 1991-04-25 Behringwerke Ag Glycosyl-etoposid-prodrugs, verfahren zu ihrer herstellung und ihre anwendung in kombination mit funktionalisiertem tumorspezifischen enzym-konjugaten
US5219564A (en) 1990-07-06 1993-06-15 Enzon, Inc. Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
US5407683A (en) 1990-06-01 1995-04-18 Research Corporation Technologies, Inc. Pharmaceutical solutions and emulsions containing taxol
AU4406793A (en) 1992-06-04 1993-12-30 Clover Consolidated, Limited Water-soluble polymeric carriers for drug delivery
US5602112A (en) 1992-06-19 1997-02-11 Supergen, Inc. Pharmaceutical formulation
IT1256345B (it) 1992-08-20 1995-12-01 Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione
US5614549A (en) * 1992-08-21 1997-03-25 Enzon, Inc. High molecular weight polymer-based prodrugs
WO1994005282A1 (en) 1992-09-04 1994-03-17 The Scripps Research Institute Water soluble taxol derivatives
US5817321A (en) 1992-10-08 1998-10-06 Supratek Pharma, Inc. Biological agent compositions
IT1256450B (it) 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
US5298643A (en) 1992-12-22 1994-03-29 Enzon, Inc. Aryl imidate activated polyalkylene oxides
US5349001A (en) 1993-01-19 1994-09-20 Enzon, Inc. Cyclic imide thione activated polyalkylene oxides
US5321095A (en) 1993-02-02 1994-06-14 Enzon, Inc. Azlactone activated polyalkylene oxides
US5439686A (en) 1993-02-22 1995-08-08 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
WO1994020453A1 (en) 1993-03-09 1994-09-15 Enzon, Inc. Taxol polyalkylene oxide conjugates of taxol and taxol intermediates
US5547981A (en) 1993-03-09 1996-08-20 Enzon, Inc. Taxol-7-carbazates
US5681811A (en) * 1993-05-10 1997-10-28 Protein Delivery, Inc. Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same
JPH0782291A (ja) 1993-09-13 1995-03-28 Microbial Chem Res Found 水溶性アンスラサイクリン誘導体
US5824701A (en) 1993-10-20 1998-10-20 Enzon, Inc. Taxane-based prodrugs
US5965566A (en) 1993-10-20 1999-10-12 Enzon, Inc. High molecular weight polymer-based prodrugs
US5622986A (en) 1993-10-20 1997-04-22 Enzon, Inc. 2'-and/or 7-substituted taxanes
US5605976A (en) 1995-05-15 1997-02-25 Enzon, Inc. Method of preparing polyalkylene oxide carboxylic acids
US5919455A (en) 1993-10-27 1999-07-06 Enzon, Inc. Non-antigenic branched polymer conjugates
US5643575A (en) 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
US5618528A (en) 1994-02-28 1997-04-08 Sterling Winthrop Inc. Biologically compatible linear block copolymers of polyalkylene oxide and peptide units
US5730990A (en) 1994-06-24 1998-03-24 Enzon, Inc. Non-antigenic amine derived polymers and polymer conjugates
US5547027A (en) * 1994-07-14 1996-08-20 Dowell, A Division Of Schlumberger Technology Corporation Low temperature, low rheology synthetic cement
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US5756593A (en) 1995-05-15 1998-05-26 Enzon, Inc. Method of preparing polyalkyene oxide carboxylic acids
WO1997038727A1 (fr) 1996-04-15 1997-10-23 Asahi Kasei Kogyo Kabushiki Kaisha Composite medicamenteux
US5795909A (en) 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
DE19636889A1 (de) * 1996-09-11 1998-03-12 Felix Dr Kratz Antineoplastisch wirkende Transferrin- und Albuminkonjugate zytostatischer Verbindungen aus der Gruppe der Anthrazykline, Alkylantien, Antimetabolite und Cisplatin-Analoga und diese enthaltende Arzneimittel
CA2265476A1 (en) 1996-09-12 1998-03-19 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
IL133585A0 (en) 1997-06-20 2001-04-30 Baker Norton Pharma Soluble prodrugs of paclitaxel
US6011042A (en) 1997-10-10 2000-01-04 Enzon, Inc. Acyl polymeric derivatives of aromatic hydroxyl-containing compounds
US6111107A (en) 1997-11-20 2000-08-29 Enzon, Inc. High yield method for stereoselective acylation of tertiary alcohols
US6180095B1 (en) 1997-12-17 2001-01-30 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
US5965119A (en) 1997-12-30 1999-10-12 Enzon, Inc. Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents
JP2002512640A (ja) 1998-03-23 2002-04-23 コンジュケム，インコーポレーテッド 持続性治療薬の局所送達
US6153655A (en) 1998-04-17 2000-11-28 Enzon, Inc. Terminally-branched polymeric linkers and polymeric conjugates containing the same
US6703381B1 (en) 1998-08-14 2004-03-09 Nobex Corporation Methods for delivery therapeutic compounds across the blood-brain barrier
US6309633B1 (en) 1999-06-19 2001-10-30 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
US6593292B1 (en) 1999-08-24 2003-07-15 Cellgate, Inc. Compositions and methods for enhancing drug delivery across and into epithelial tissues
US6713454B1 (en) 1999-09-13 2004-03-30 Nobex Corporation Prodrugs of etoposide and etoposide analogs
US6541508B2 (en) 1999-09-13 2003-04-01 Nobex Corporation Taxane prodrugs

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996023794A1 (en) * 1995-01-30 1996-08-08 Enzon, Inc. High molecular weight polymer-based prodrugs
WO1997033552A1 (en) * 1996-03-12 1997-09-18 Pg-Txl Company, L.P. Water soluble paclitaxel prodrugs
WO1998007713A1 (en) * 1996-08-20 1998-02-26 Enzon, Inc. High molecular weight polymer-based prodrugs
WO1999030727A1 (en) * 1997-12-17 1999-06-24 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
WO2000064486A2 (en) * 1999-04-28 2000-11-02 Vectramed, Inc. Enzymatically activated polymeric drug conjugates
WO2001019407A2 (en) * 1999-09-13 2001-03-22 Nobex Corporation Taxane prodrugs

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GREENWALD R.B. ET AL: "Drug delivery of anticancer agents: Water soluble 4-poly (ethylene glycol) derivatives of the lignan, podophyllotoxin." JOURNAL OF CONTROLLED RELEASE, (1999) 61/3 (281-294). , XP001014151 *

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7119074B2 (en) 1999-09-13 2006-10-10 Nobex Corporation Treatment of cancers, tumors and malignancies using amphiphilic prodrugs
WO2001019407A3 (en) * 1999-09-13 2002-01-17 Nobex Corp Taxane prodrugs
US6380405B1 (en) 1999-09-13 2002-04-30 Nobex Corporation Taxane prodrugs
US6541508B2 (en) 1999-09-13 2003-04-01 Nobex Corporation Taxane prodrugs
WO2001019407A2 (en) * 1999-09-13 2001-03-22 Nobex Corporation Taxane prodrugs
US8008435B2 (en) * 1999-10-04 2011-08-30 Nektar Therapeutics Polymer stabilized neuropeptides
US8440623B2 (en) 1999-10-04 2013-05-14 Nektar Therapeutics Polymer stabilized neuropeptides
EP1274460A1 (en) * 2000-04-15 2003-01-15 Kolon Industries, Inc. Aqueous-prodrug compound comprising moiety of paclitxel or derivatives thereof, method of preparing same and pharmaceutical composition comprising same
EP1274460A4 (en) * 2000-04-15 2005-06-29 Kolon Inc Aqueous PRODRUG COMPOUND WITH A PART OF PACLITAXEL OR ITS DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF
JP2006513154A (ja) * 2002-10-21 2006-04-20 ラモト アット テル アヴィヴ ユニヴァーシティ リミテッド カリウムチャネルおよび／または皮質ニューロン活性モジュレーターとしての、ｎ−フェニルアントラニル酸および２−ベンズイミダゾロンの誘導体
US7632866B2 (en) 2002-10-21 2009-12-15 Ramot At Tel Aviv University Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators
WO2004035037A3 (en) * 2002-10-21 2004-06-03 Univ Ramot Derivatives of n-phenylanthranilic acid and 2-benzimidazolon as potassium channel and/or cortical neuron activity modulators
US8278357B2 (en) 2002-10-21 2012-10-02 Ramot At Tel-Aviv University Ltd. Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators
WO2004035037A2 (en) * 2002-10-21 2004-04-29 Ramot At Tel Aviv University Ltd. Derivatives of n-phenylanthranilic acid and 2-benzimidazolon as potassium channel and/or cortical neuron activity modulators
US8618169B2 (en) 2002-10-21 2013-12-31 Ramot At Tel-Aviv University Ltd. Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators
US9434822B2 (en) 2004-09-22 2016-09-06 Nippon Kayaku Kabushiki Kaisha Block copolymer, micelle preparation, and anticancer agent containing the same as active ingredient
US8323669B2 (en) 2006-03-28 2012-12-04 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of taxane
US8334364B2 (en) 2006-11-06 2012-12-18 Nipon Kayaku Kabushiki Kaisha High-molecular weight derivative of nucleic acid antimetabolite
US8188222B2 (en) 2006-11-08 2012-05-29 Nippon Kayaku Kabushiki Kaisha High molecular weight derivative of nucleic acid antimetabolite
US8765815B2 (en) 2007-09-20 2014-07-01 Ramot At Tel-Aviv University Ltd. N-phenyl anthranilic acid derivatives and uses thereof
US9403756B2 (en) 2007-09-20 2016-08-02 Ramot At Tel-Aviv University Ltd. N-phenyl anthranilic acid derivatives and uses thereof
US8703878B2 (en) 2007-09-28 2014-04-22 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of steroids
USRE46190E1 (en) 2007-09-28 2016-11-01 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of steroids
US8920788B2 (en) 2008-03-18 2014-12-30 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of physiologically active substances
US9149540B2 (en) 2008-05-08 2015-10-06 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of folic acid or folic acid derivative
US8808749B2 (en) 2009-05-15 2014-08-19 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of bioactive substance having hydroxy group
US9018323B2 (en) 2010-11-17 2015-04-28 Nippon Kayaku Kabushiki Kaisha Polymer derivative of cytidine metabolic antagonist
US9346923B2 (en) 2011-09-11 2016-05-24 Nippon Kayaku Kabushiki Kaisha Method for manufacturing block copolymer

Also Published As

Publication number Publication date
US20040253206A1 (en) 2004-12-16
CA2384645A1 (en) 2001-03-22
MXPA02002712A (es) 2003-10-14
NO20021213L (no) 2002-05-13
NO20021213D0 (no) 2002-03-12
RU2002109595A (ru) 2003-11-27
AU7575600A (en) 2001-04-17
BR0013948A (pt) 2002-05-14
CN1390143A (zh) 2003-01-08
NZ517681A (en) 2004-01-30
EP1212099A2 (en) 2002-06-12
HUP0204110A2 (hu) 2003-04-28
HUP0204110A3 (en) 2003-08-28
CZ2002928A3 (cs) 2002-09-11
KR20020059398A (ko) 2002-07-12
US20040180840A1 (en) 2004-09-16
IL148558A0 (en) 2002-09-12
PL354261A1 (en) 2003-12-29
US7119074B2 (en) 2006-10-10
JP2003509385A (ja) 2003-03-11
US6713454B1 (en) 2004-03-30
WO2001019406A3 (en) 2002-01-17

Similar Documents

Publication Publication Date Title
US7119074B2 (en) Treatment of cancers, tumors and malignancies using amphiphilic prodrugs
CZ2002929A3 (cs) Amfifilní proléčiva
US20210154312A1 (en) Conjugates for treating diseases caused by psma expressing cells
US7846893B2 (en) Drug-polymer conjugates coupled to a peptidic carrier
US20050026996A1 (en) Taxane prodrugs
Sedlak Amphotericin B: from derivatives to covalent targeted conjugates

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 148558

Country of ref document: IL

Ref document number: 517681

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: IN/PCT/2002/00292/DE

Country of ref document: IN

Ref document number: 2384645

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: PA/a/2002/002712

Country of ref document: MX

Ref document number: 75756/00

Country of ref document: AU

Ref document number: 1020027003276

Country of ref document: KR

ENP Entry into the national phase

Ref document number: 2001 523037

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: PV2002-928

Country of ref document: CZ

WWE Wipo information: entry into national phase

Ref document number: 2000964949

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2002 2002109595

Country of ref document: RU

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 008155089

Country of ref document: CN

WWP Wipo information: published in national office

Ref document number: 2000964949

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1020027003276

Country of ref document: KR

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: PV2002-928

Country of ref document: CZ

WWP Wipo information: published in national office

Ref document number: 517681

Country of ref document: NZ

WWG Wipo information: grant in national office

Ref document number: 517681

Country of ref document: NZ

WWR Wipo information: refused in national office

Ref document number: PV2002-928

Country of ref document: CZ