WO2001008594A1 - Prothese pour hernie - Google Patents

Prothese pour hernie Download PDF

Info

Publication number
WO2001008594A1
WO2001008594A1 PCT/US2000/020728 US0020728W WO0108594A1 WO 2001008594 A1 WO2001008594 A1 WO 2001008594A1 US 0020728 W US0020728 W US 0020728W WO 0108594 A1 WO0108594 A1 WO 0108594A1
Authority
WO
WIPO (PCT)
Prior art keywords
cord
protector
layer
opening
hernia
Prior art date
Application number
PCT/US2000/020728
Other languages
English (en)
Inventor
Enrico Nicolo
Original Assignee
C.R. Bard, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by C.R. Bard, Inc. filed Critical C.R. Bard, Inc.
Priority to DE60018571T priority Critical patent/DE60018571T8/de
Priority to JP2001513332A priority patent/JP4233254B2/ja
Priority to EP00950878A priority patent/EP1200010B1/fr
Priority to AU63912/00A priority patent/AU777027B2/en
Priority to CA002379215A priority patent/CA2379215C/fr
Publication of WO2001008594A1 publication Critical patent/WO2001008594A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes

Definitions

  • the present invention relates to a prosthesis for hernia repair.
  • the present invention relates to a prosthesis for hernia repair configured to protect a cord passing through the prosthesis, such as the spermatic cord when the prosthesis is employed in an inguinal hernia repair.
  • the prosthetic fabric may come into contact with sensitive tissue or organs potentially leading to postoperative adhesions between the mesh and the sensitive tissue or organs.
  • the prosthetic fabric may come into direct contact with the spermatic cord.
  • Postoperative adhesions between the mesh and the spermatic cord and/or erosion of the mesh into the cord, were they to occur, could potentially affect spermatic cord structure and function. For example, tissue ingrowth could potentially result in infertility, pain or other detrimental effects due to strangulation of the spermatic cord.
  • the composite In the repair of ventral hernias and in chest wall reconstruction, the composite is positioned with the barrier relative to the region of potential adhesion, such as the abdominal viscera.
  • Other configurations of composite prostheses can be found in U.S. Patent Nos. 5,725,577 and 5,743,917, both of which are also assigned to C.R Bard, Inc. International Publication No. WO 97/35533, by the present Applicant and also assigned to C.R. Bard, Inc., proposed a universal composite prosthesis in which one side of a layer of mesh material is completely covered with a layer of barrier material. The mesh material promotes biological tissue ingrowth while the barrier material retards biological tissue adherence thereto.
  • the prosthesis may be utilized for various surgical procedures, including ventral hernia repair and inguinal hernia repair.
  • the present invention is a prosthesis and a method for mending a tissue or muscle wall defect, and has particular application in inguinal canal repairs near the spermatic cord.
  • the prosthesis comprises a layer of repair fabric having a cord opening therethrough that is adapted to receive a cord-like structure, such as the spermatic cord, when the prosthesis is implanted at the repair site.
  • the prosthesis also includes a cord protector that is attachable to the repair fabric at the cord opening to isolate the cord-like structure from at least the fabric in proximity to the cord opening.
  • the repair fabric may be formed from a material which is susceptible to the formation of adhesions with sensitive tissue and organs.
  • the cord protector may be formed from material which inhibits the formation of adhesions with sensitive tissue and organs.
  • the repair fabric includes first and second surfaces and an opening having an edge that is defined by a portion of the layer of repair fabric.
  • the cord protector covers a substantial portion of the edge to isolate the substantial portion of the edge from the cord-like structure.
  • a layer of mesh fabric has a keyhole opening therethrough, and the cord protector extends about the keyhole opening and overlaps a portion of the layer of mesh fabric on opposing first and second surfaces thereof at least proximate the keyhole opening.
  • the cord protector is adapted to receive the cord-like structure therethrough so that the layer of fabric is isolated from the cord-like structure by the cord protector at least proximate the keyhole opening.
  • the cord protecting material may extend away from the opening edge on the first surface and/or the second surface of the repair fabric. Additionally, the cord protector may extend substantially farther away from the opening edge on one of the first and second surfaces than on the other of the first and second surfaces. Further, the cord protector may substantially cover one of the first and second surfaces.
  • the prosthesis may be provided as a composite in which the cord protector is pre- attached to the repair fabric. Alternatively, the cord protector may be configured as an insert that is separate from and attachable to a prosthesis by a surgeon. This allows a surgeon to either retrofit a barrier-less inguinal hernia prosthesis or to employ an implantable repair fabric that may have various tissue or muscle wall defect repair applications.
  • a cord protector for use with a hernia prosthesis having a cord opening therethrough that is adapted to receive a cord-like structure.
  • the cord protector includes a cord protecting insert that inhibits the formation of adhesions with sensitive tissue and organs.
  • the cord protecting insert is constructed and arranged to be attached to at least a portion of the opening edge of the opening edge to isolate the cord-like structure from at least the opening edge of the hernia prosthesis.
  • the cord protecting insert may include a backbone member.
  • the cord protecting insert may include a flexible tube having a slot along a length thereof that is adapted to receive a portion of the hernia prosthesis along the cord opening.
  • Fig. la is a perspective view of a prosthesis according to a first embodiment of the present invention
  • Fig. lb is a cross-sectional view of a portion of the prosthesis taken along section line
  • Fig. 2a is a perspective view of a prosthesis according to a second embodiment of the present invention.
  • Fig. 2b is a cross-sectional view of a portion of the prosthesis taken along section line II-II in Fig. 2a;
  • Fig. 3a is a perspective view of a prosthesis according to a third embodiment of the present invention.
  • Fig. 3b is a cross-sectional view of a portion of the prosthesis taken along section line III-III in Fig. 3a;
  • Fig. 4a is an exploded plan view of a barrier-less prosthesis and a separate cord protecting insert according to a fourth embodiment of the present invention
  • Fig. 4b is a cross-sectional view of the cord protecting insert taken along section line
  • Fig. 5a is a perspective view of a cord protecting insert according to another embodiment of the present invention.
  • Fig. 5b is a cross-sectional view of the cord protecting insert taken along a helical line V-V in Fig. 5a;
  • Fig. 6a illustrates another embodiment of a prosthesis utilizing the cord protecting insert of Figs. 5a and 5b;
  • Fig. 6b illustrates a further embodiment of a prosthesis utilizing the cord protecting insert of Figs. 5a and 5b
  • Fig. 7a is a plan view of a cord protecting insert according to another embodiment of the present invention.
  • Fig. 7b is a cross-sectional view of a portion of the cord protecting insert taken along section line VII-VII in Fig. 7a.
  • Figs, la- lb illustrate one embodiment of a prosthesis 10 which is particularly suited for inguinal hernia repair.
  • the prosthesis 10 includes a layer of repair fabric 12 formed of a material which is susceptible to the formation of adhesions with sensitive tissue and organs.
  • a barrier layer 14 Opposed from the layer of repair fabric 12 is a barrier layer 14 generally formed of a material which inhibits the formation of adhesions with sensitive tissue and organs..
  • the prosthesis 10 is configured with a cord opening or keyhole 18 therethrough for receipt of the spermatic cord for inguinal hernia repair.
  • the barrier layer 14 extends through and surrounds the cord opening 18 and covers the opening edge to isolate the spermatic cord from the opening edge of the fabric.
  • the barrier layer 14 may be configured to overlap one or both surfaces of the layer of repair fabric 12 in the area around the cord opening 18. As illustrated, the barrier layer 14 covers one surface of the layer of repair fabric 12 and overlaps a portion of the other surface of the fabric in close proximity to the cord opening 18.
  • the overlapping of the layer 12 around the cord opening 18 by the barrier layer 14 may enhance the isolation of the spermatic cord from the layer of repair fabric as it passes through the prosthesis.
  • This construction provides a composite prosthesis in which the surgeon does not have to fold the prosthesis at the edges during an inguinal hernia operation in order to place the barrier layer 14 in the desired position.
  • the layer of repair fabric 12 and/or the barrier layer 14 may be configured to suit a particular repair procedure and/or provide particular adhesion/adhesion resistance characteristics.
  • the barrier layer may be configured to cover selected portions of the fabric so as to enhance tissue adhesion to particular portions of the prosthesis while limiting the incidence of tissue adhesion at other portions of the prosthesis to the spermatic cord and/or other sensitive tissue and organs in the repair region.
  • Figs. 2a-2b illustrate another embodiment of a prosthesis 20 for inguinal hernia repairs.
  • the prosthesis 20 includes a layer of repair fabric 12, a barrier layer 14 and a cord opening 18 for the spermatic cord.
  • the barrier layer 14 is configured to overlie selected portions of the fabric 12.
  • the barrier layer 14 surrounds the opening 18 and extends farther away from the opening 18 along a portion of one surface of the fabric 12 along which the spermatic cord may contact the prosthesis.
  • the barrier layer 14 acts as a cord protector that may be provided in those areas of the prosthesis 20 expected to contact the spermatic cord.
  • the prosthesis 30 includes a layer of mesh fabric 12, a barrier layer 14 and a cord opening for receipt of the spermatic cord. As illustrated, the barrier layer 14, or the cord protector, is limited to overlying portions of the fabric in close proximity to the opening 18.
  • This configuration would be expected to increase tissue adhesion to the prosthesis while limiting cord adhesion in the vicinity of the opening.
  • the layer of repair fabric 12 is formed of a polyolefm material, such as a sheet of knitted polypropylene monofilament mesh fabric.
  • a polyolefm material such as a sheet of knitted polypropylene monofilament mesh fabric.
  • BARD MESH available from C.R. Bard, Inc.
  • the polypropylene mesh promotes rapid tissue ingrowth into and around the mesh structure.
  • the mesh fabric may be formed from multifilament yarns and that woven, molded and other suitable methods of forming prosthetic mesh materials may be employed. It is to be appreciated that any suitable materials promoting fibroplasia may be used as would be apparent to one of skill in the art.
  • the barrier layer 14 is formed from a fluoropolymer material such as polytetrafluoroethylene (PTFE).
  • PTFE polytetrafluoroethylene
  • a fluoropolymer material such as polytetrafluoroethylene (PTFE).
  • PTFE polytetrafluoroethylene
  • ePTFE expanded polytetrafluoroethylene
  • GORETEX available from W.L. Gore & Associates, Inc.
  • FEP fluorinated ethylene propylene
  • TFE tetrafluoroethylene
  • ETFE ethylene tetrafluoroethylene
  • silicone elastomer such as SILASTIC Rx Medical Grade Sheeting (Platinum Cured) distributed by Dow Corning Corporation, TEFLON mesh, and microporous polypropylene sheeting (CELGARD). It is also contemplated that a polyethylene terephthalate, such as
  • DACRON and MYLAR may be employed as a barrier material.
  • Autogenous, heterogenous and xenogeneic tissue also are contemplated including, for example, pericardium and small intestine submucosa.
  • Absorbable materials such as oxidized, regenerated cellulose (Intercede (TC7)) may be employed for some applications. It is to be appreciated that any suitable adhesion resistant materials may be used as would be apparent to one of skill in the art.
  • a surgeon may find it desirable to employ a cord protector that can be readily attached to a hernia repair prosthesis that is initially provided with no adhesion resistant barrier.
  • Figs. 4a-4b illustrate one embodiment of a prosthesis utilizing a separable cord protecting insert 40 which is attachable to a barrier-less inguinal hernia patch 42 formed with a layer of repair fabric 12 that is susceptible to the formation of adhesions with sensitive tissue and organs.
  • the patch 42 includes a cord opening 18 for receipt of the spermatic cord.
  • the cord protecting insert 40 is adapted to overlap and surround the opening 18 in a manner similar to the prosthesis 30 discussed above.
  • the separable or attachable cord protecting insert 40 includes an outer barrier layer 14 and a support member or backbone 44 which can be used to maintain the shape of the cord protecting insert 40.
  • the backbone 44 can also be utilized to provide the cord protecting insert 40 with sufficient rigidity that allows it to frictionally engage the patch 42.
  • any suitable arrangement as would be apparent to one of skill may be employed to attach the cord protecting insert to the fabric.
  • biological adhesives may also be utilized to bond the cord protecting insert 40 to the barrier- less prosthesis 42.
  • the cord protecting insert 40 allows existing hernia patches 42 to be easily modified to provide spermatic cord protection.
  • the cord protecting insert may be constructed in a manner that allows it to be readily attachable to repair fabric.
  • the cord protecting insert 50 includes a long flexible tube having a slot along the length of the tube for receipt of a portion of the fabric along a keyhole or opening of a hernia patch.
  • the cord protecting insert 50 may include a backbone 54 in the form of a spiral thread or wire extending along the inside of the cord protecting insert 50.
  • the spiral threads forming the backbone 54 are discontinuous due to the slot in the tube. It is to be appreciated that the cord protecting insert may employ any suitable configuration.
  • the flexible cord protecting insert 50 may be particularly suited to retrofitting hernia repair patches having a cord opening of various configurations.
  • Fig. 6a illustrates the cord protecting insert 50 attached along the opening edge of a hernia patch 62 provided with a cord opening 18 having a keyhole shape.
  • Fig. 6b illustrates the cord protecting insert 50 attached along the opening edge of a hernia patch 62' with a cord opening 18 having an additional flap 64 provided for receipt of the spermatic cord.
  • the cord protecting attributes of the cord protecting insert 50 make the receipt of the spermatic cord onto the flap 64 a viable possibility.
  • the cord protecting insert may employ any configuration suitable for providing desired cord protection characteristics.
  • Figs. 7a-7b illustrate another embodiment of a cord protecting insert 70 that may be attached to a barrier- less hernia patch.
  • the cord protecting insert 70 is similar in shape to the barrier layer 14 of hernia patch 20 illustrated in Figs. 2a-2b discussed above.
  • the cord protecting insert 70 is adapted to fit around a cord opening 18 of a hernia patch and includes a barrier layer 14 and a backbone 74 which is adapted to give the appropriate rigidity to the cord protecting insert 70 and provide for easy attachment to a barrier-less hernia patch.
  • the cord protecting insert 70 includes an extension that is configured to overlie one side of the patch in a position likely to engage the spermatic cord.
  • the separable cord protecting inserts of Figs. 4-7 provide protective characteristics similar to those of the barrier layers 14 employed with the composite prostheses illustrated in Figs. 1-3.
  • the barrier layers 14 of Figs. 1-3 may be considered as cord protecting inserts that are integral with the prosthesis formed by the layer of repair fabric 12.
  • the separate cord protecting inserts of Figs. 4-7 allow for retrofitting existing barrier-less hernia prosthetics.
  • cord protecting inserts may be formed of a material not requiring a separate backbone or supporting member.
  • inguinal hernia patches having alternative shapes may also be contemplated within the scope of the present invention.

Landscapes

  • Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention se rapporte à une prothèse et à un procédé de réparation d'un tissu ou d'une paroi musculaire présentant un défaut, tel qu'une hernie inguinale, près d'une structure de type cordon, telle que le cordon spermatique. Cette prothèse comporte une couche de tissu de réparation présentant une ouverture qui est conçue pour recevoir une structure de type cordon lorsque la prothèse est implantée au niveau du site de réparation. Cette prothèse comporte également un protecteur de cordon qui peut être fixé au tissu de réparation au niveau de l'ouverture dans le but d'isoler la structure de type cordon du tissu se trouvant à proximité de l'ouverture. Le tissu de réparation peut être constitué d'une matière qui est susceptible de former des adhésions avec du tissu ou des organes sensibles. Le protecteur de cordon peut être fabriqué dans une matière qui empêche la formation d'adhésion avec du tissu ou des organes sensibles. Ce protecteur de cordon peut recouvrir une partie d'au moins une des première et seconde surfaces du tissu de réparation. Ce cordon protecteur peut faire saillie à partir du bord de l'ouverture sur une distance sensiblement plus longue sur l'une des première et seconde surfaces que sur l'autre de ces première et seconde surfaces. Ce protecteur de cordon peut être conçu comme une pièce rapportée distincte du tissu de réparation et susceptible d'être attachée à celui-ci. Ce cordon protecteur peut également être intégré au tissu de réparation pour former une prothèse composite.
PCT/US2000/020728 1999-07-28 2000-07-28 Prothese pour hernie WO2001008594A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE60018571T DE60018571T8 (de) 1999-07-28 2000-07-28 Hernienprothese
JP2001513332A JP4233254B2 (ja) 1999-07-28 2000-07-28 ヘルニア用人工補装具
EP00950878A EP1200010B1 (fr) 1999-07-28 2000-07-28 Prothese pour hernie
AU63912/00A AU777027B2 (en) 1999-07-28 2000-07-28 Hernia prosthesis
CA002379215A CA2379215C (fr) 1999-07-28 2000-07-28 Prothese pour hernie

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14606199P 1999-07-28 1999-07-28
US60/146,061 1999-07-28

Publications (1)

Publication Number Publication Date
WO2001008594A1 true WO2001008594A1 (fr) 2001-02-08

Family

ID=22515702

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/020728 WO2001008594A1 (fr) 1999-07-28 2000-07-28 Prothese pour hernie

Country Status (8)

Country Link
US (2) US6497650B1 (fr)
EP (1) EP1200010B1 (fr)
JP (1) JP4233254B2 (fr)
AU (1) AU777027B2 (fr)
CA (1) CA2379215C (fr)
DE (1) DE60018571T8 (fr)
ES (1) ES2234642T3 (fr)
WO (1) WO2001008594A1 (fr)

Cited By (23)

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WO2003094787A1 (fr) * 2002-05-10 2003-11-20 C.R. Bard, Inc. Tissu de reparation prothetique
WO2003094786A1 (fr) * 2002-05-10 2003-11-20 C.R. Bard, Inc. Tissu de reparation prothetique
US6736854B2 (en) 2002-05-10 2004-05-18 C. R. Bard, Inc. Prosthetic repair fabric with erosion resistant edge
EP1491159A3 (fr) * 2000-09-14 2005-01-19 C.R. Bard, Inc. Prothèse implantable
WO2008002549A2 (fr) * 2006-06-26 2008-01-03 Gore Enterprise Holdings, Inc. Pièce pour réparation du tissu facile à utiliser
WO2010093333A1 (fr) * 2009-02-11 2010-08-19 Nanyang Technological University Prothèse chirurgicale multicouche
US7785334B2 (en) 2002-08-02 2010-08-31 C.R. Bard, Inc. Implantable prosthesis
US8317808B2 (en) 2008-02-18 2012-11-27 Covidien Lp Device and method for rolling and inserting a prosthetic patch into a body cavity
US8753359B2 (en) 2008-02-18 2014-06-17 Covidien Lp Device and method for deploying and attaching an implant to a biological tissue
US8758373B2 (en) 2008-02-18 2014-06-24 Covidien Lp Means and method for reversibly connecting a patch to a patch deployment device
US8808314B2 (en) 2008-02-18 2014-08-19 Covidien Lp Device and method for deploying and attaching an implant to a biological tissue
US8888811B2 (en) 2008-10-20 2014-11-18 Covidien Lp Device and method for attaching an implant to biological tissue
US8906045B2 (en) 2009-08-17 2014-12-09 Covidien Lp Articulating patch deployment device and method of use
US9034002B2 (en) 2008-02-18 2015-05-19 Covidien Lp Lock bar spring and clip for implant deployment device
US9044235B2 (en) 2008-02-18 2015-06-02 Covidien Lp Magnetic clip for implant deployment device
US9072586B2 (en) 2008-10-03 2015-07-07 C.R. Bard, Inc. Implantable prosthesis
US9301826B2 (en) 2008-02-18 2016-04-05 Covidien Lp Lock bar spring and clip for implant deployment device
US9393002B2 (en) 2008-02-18 2016-07-19 Covidien Lp Clip for implant deployment device
US9393093B2 (en) 2008-02-18 2016-07-19 Covidien Lp Clip for implant deployment device
US9398944B2 (en) 2008-02-18 2016-07-26 Covidien Lp Lock bar spring and clip for implant deployment device
WO2016154478A1 (fr) * 2015-03-24 2016-09-29 Hexagon Health, Inc. Implant à mailles spécifiques au genre muni d'une barrière pour la réparation d'une hernie inguinale
US9833240B2 (en) 2008-02-18 2017-12-05 Covidien Lp Lock bar spring and clip for implant deployment device
US9999424B2 (en) 2009-08-17 2018-06-19 Covidien Lp Means and method for reversibly connecting an implant to a deployment device

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US8366787B2 (en) * 2000-08-04 2013-02-05 Depuy Products, Inc. Hybrid biologic-synthetic bioabsorbable scaffolds
EP1416866A4 (fr) 2001-07-16 2007-04-18 Depuy Products Inc Dispositifs a base de matieres biologiquement derivees d'origine naturelle
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EP1592361A2 (fr) * 2003-02-11 2005-11-09 C.R. Bard, Inc. Prothese implantable et son procede d'utilisation
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FR2977789B1 (fr) 2011-07-13 2013-07-19 Sofradim Production Prothese pour hernie ombilicale
FR2977790B1 (fr) 2011-07-13 2013-07-19 Sofradim Production Prothese pour hernie ombilicale
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US9005308B2 (en) 2011-10-25 2015-04-14 Covidien Lp Implantable film/mesh composite for passage of tissue therebetween
FR2985170B1 (fr) 2011-12-29 2014-01-24 Sofradim Production Prothese pour hernie inguinale
US10206769B2 (en) 2012-03-30 2019-02-19 Covidien Lp Implantable devices including a film providing folding characteristics
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JP2003505191A (ja) 2003-02-12
ES2234642T3 (es) 2005-07-01
DE60018571D1 (en) 2005-04-14
AU6391200A (en) 2001-02-19
EP1200010A1 (fr) 2002-05-02
US7156804B2 (en) 2007-01-02
CA2379215C (fr) 2007-01-09
EP1200010B1 (fr) 2005-03-09
AU777027B2 (en) 2004-09-30
US20030083543A1 (en) 2003-05-01
DE60018571T8 (de) 2006-04-27
US6497650B1 (en) 2002-12-24
DE60018571T2 (de) 2006-01-05
CA2379215A1 (fr) 2001-02-08
JP4233254B2 (ja) 2009-03-04

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