WO2000062918A2 - Module microreacteur - Google Patents

Module microreacteur Download PDF

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Publication number
WO2000062918A2
WO2000062918A2 PCT/DE2000/001213 DE0001213W WO0062918A2 WO 2000062918 A2 WO2000062918 A2 WO 2000062918A2 DE 0001213 W DE0001213 W DE 0001213W WO 0062918 A2 WO0062918 A2 WO 0062918A2
Authority
WO
WIPO (PCT)
Prior art keywords
microreactor
modules
elements
module according
microreactor module
Prior art date
Application number
PCT/DE2000/001213
Other languages
German (de)
English (en)
Other versions
WO2000062918A3 (fr
Inventor
Wolfgang Ehrfeld
Holger LÖWE
Frank Michel
Astrid Lohf
Christian Hofmann
Original Assignee
INSTITUT FüR MIKROTECHNIK MAINZ GMBH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by INSTITUT FüR MIKROTECHNIK MAINZ GMBH filed Critical INSTITUT FüR MIKROTECHNIK MAINZ GMBH
Publication of WO2000062918A2 publication Critical patent/WO2000062918A2/fr
Publication of WO2000062918A3 publication Critical patent/WO2000062918A3/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/56—Labware specially adapted for transferring fluids
    • B01L3/565—Seals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00421—Means for dispensing and evacuation of reagents using centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00495—Means for heating or cooling the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00801—Means to assemble
    • B01J2219/0081—Plurality of modules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00871—Modular assembly
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00889—Mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00905—Separation
    • B01J2219/00909—Separation using filters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B01J2219/00952—Sensing operations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/028—Modular arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00326—Analysers with modular structure

Definitions

  • the invention relates to an icroreactor module with reactor elements such as fluid channels, reaction chambers, heating devices, mixing devices and the like, wherein a number of microreactor modules of the same and different types can be assembled to form a microreactor system which is connected to one another via fluid channels.
  • Such systems can be used, for example, for individual operations, such as carrying out chemical, biochemical and physicochemical reactions, distilling, mixing, separating, etc., or for setting up an entire chain of operations up to a miniaturized chemical factory.
  • a chemical microreactor is known from EP-A-0 688 242, which consists of a number of superimposed, thin, structured plates. The plates are connected to one another.
  • the microreactor can comprise a whole number of operating units such as mixers, distributors, heat exchangers, separators and reaction chambers and can be provided with sensors, valves, pumps and the like. Although several of these known microreactors can be arranged in parallel or in series, the microreactor is above all a complete reaction unit for a complete process.
  • the individual components of the modular microsystem constructed in this way must be mechanically, fluidically, optically, thermally and, if necessary, also electrically connected to one another at interfaces. In order to be able to replace individual modules, the connections should be detachable.
  • Detachable connections such as plug connections, screw connections and the like are known in many fields of technology.
  • the parts to be connected are fed towards one another in the axial direction, aligned with one another and compressed and held together by force-applying parts. So far, however, little attention has been paid to the detachable connection of microreactor modules in microsystems.
  • the object of the invention is to design the microreactor modules mentioned at the outset in such a way that the microreactor modules can be connected in one or more dimensions.
  • the connection should preferably be releasable.
  • the microreactor module according to the invention which comprises reactor elements such as fluid channels, reaction chambers, heating or cooling devices, mixing or separating devices, optical and electrical elements and the like, can be assembled to form a microsystem.
  • a connection system with connection elements which, when put together, form at least two microreactor modules to form a system.
  • the fluid channels preferably connect the modules directly to one another.
  • the modules are directly connected to one another via these channels, ie usually without fluid detours outside the modules.
  • the connecting elements are designed as male and female elements. In this way a reverse connection of the modules can be prevented. In some cases, however, it may be desirable to connect a module to other modules in both the one and the opposite flow direction as required. In such cases, the connecting element is gender-neutral.
  • the connecting elements on the microreactor modules are preferably hook-shaped or dovetail-shaped elements which engage with one another in such a way that a relative movement of the microreactor modules perpendicular to the connecting axis is possible with a spacing of the microreactors from one another, the play between the two microreactor modules being canceled by clamping elements can be inserted into an opening formed by recesses in the connecting elements.
  • the connecting elements can be connected in one piece to the module or can also be attached to the module by means of screws or a similar element or also by means of welding and the like.
  • the connecting elements from grooves in the Mi kroreaktormodulen exist, wherein each two microreactor modules are connected by profile pieces which can be used in the cavity formed by two opposite grooves.
  • connection system for microreactor modules has the advantage that individual modules can be removed from the system without having to disassemble the entire structure.
  • the required connections of electrical, fluidic and other types are possible in a rectangular or cube-shaped configuration of the microreactor module in all 6 spatial directions. In principle, however, other configurations are also possible.
  • Such reactor modules can contain all the operational elements necessary for the construction of a chemical plant, such as reaction rooms, which can be heated or cooled if necessary, in which the substances to be reacted come into contact with each other with vigorous agitation, as well as small stirrers or pumps, distillation elements, microscopic separation gels, centrifuges, for example also fluidic spiral centrifuges or light sources, such as light-conducting glass fibers.
  • Such modules can also contain elements for controlling, regulating, detecting and controlling processes. In this way, systems for manufacturing a wide variety of substances can be assembled. Since only extremely small quantities are converted in such systems, the substances can be heated, cooled or separated in fractions of a second, for example.
  • the module reactors are thus suitable for both mixing, heating, cooling, elec- trip-induced and optically induced with light operations, eg. B. also for measuring and controlling reactions by means of optical detectors, for centrifuging, filtering and for changing physical and chemical States of substances. This is particularly the case because long distances between the individual process steps are eliminated, since the individual reactors are located directly next to one another.
  • microreactor module according to the invention can easily be combined with a so-called fluid circuit board, the fluidic equivalent for the electrical circuit boards of electrical engineering.
  • the microreactor modules are for use with
  • the fluid circuit board has corresponding connecting elements that match the reactor module.
  • the fluid circuit board itself has conductor elements with which the reactor modules can be provided with reaction fluids, cooling or heating fluids or also mechanical elements or also electrical current or voltage. You can also optical line elements such. B. glass fibers.
  • the fluid circuit board is designed such that the reactor modules are not or not exclusively arranged in direct contact with one another, but also communicate with one another via the lines arranged in the fluid circuit boards.
  • FIG. 1 shows a perspective view of a microreactor module
  • FIGS. 7 (a) and 7 (b) further alternative clamping elements for the connection according to FIG. 4;
  • FIG. 1 of the drawing shows a microreactor module 10 in the form of a cube, which is provided for a microsystem composed of many such modules with partly different functions.
  • the modules can each be separate functional units for complete processes or functional units for sub-processes, such as mixing, heating, cooling, centrifuging, filtering for electrical-optical operations or detections or also for a change in the physical or chemical state.
  • Other modules in turn can only contain fluid channels or signal lines or can only be termination modules which, for example, terminate fluid lines or lead them out of the system.
  • the cube shape shown is not absolutely necessary for the microreactor modules; for example, the modules can also have a rectangular shape.
  • the microreactor module 10 can be designed in one piece, but it is preferably composed of at least 2 parts 11, which are in particular releasably connected to one another.
  • the structures required for the respective function of the module are formed in at least one part, such as fluid channels, cavities for reaction chambers and the like.
  • the parts 11 are screwed together by means of screws 12 in the embodiment shown.
  • the parts can also be connected to one another in any other way.
  • Some of the side surfaces of the microreactor module 10 have fluid channel openings 14, 16, via which fluids are supplied to the module 10 from the outside or via which the fluids are discharged from the module 10 to the outside.
  • the opening 14 is surrounded by an annular groove 17 which receives an elastic sealing element such as an O-ring or the like.
  • the opening 16 is not surrounded by such an annular groove.
  • the (not shown) sealing element in the annular groove 17 is compressed when another, second module is arranged on the side face of the first module 10 with the opening 14 and pressed in such a way that the side faces of both modules abut one another. If the second module has a fluid channel opening 16 without an annular groove opposite the opening 14 in the first module 10, this results in an externally sealed fluid connection between the modules.
  • bushings 18 for electrical connections, optical viewing windows for monitoring reactions and / or also accesses for introduction or to the Removal of substances, for example also from catalysts and the like, can be provided.
  • a system can also have modules with pure connection and connection functions with measurement and control technology, with actuators, pumps and / or valves.
  • the microsystem is constructed from a number of such and similar modules, which can be arranged one-dimensionally (linear), two-dimensionally (in one plane) and three-dimensionally (spatially).
  • the modules can be held together by screwing the individual modules together, by screwing them with through screws, or by screwing or clamping them into solid shapes.
  • Figures 2 (a) through 2 (c) show some such arrangements.
  • the microreactor modules 10 which are located in a frame 60, are pressed together by screws 62, which act on clamping wedges 64.
  • FIG. 2 (b) shows an arrangement in which the microreactor modules 10 are pressed into the frame 60 by a toggle lever device 66, and FIG.
  • FIG. 2 (c) shows an arrangement in which this is done by an eccentric device 68.
  • FIG. 2 (d) shows a top view of a microsystem arranged in two dimensions, comprising a number of microreactor modules 10, which is held together with tensioning screws 70.
  • Module cubes can be arranged that contain their own elements or elements that support the reactions.
  • the first embodiment of a microreactor module 100 shown in FIG. 3 (a) has a connection system with hook-shaped connection elements 120, 122 on the microreactor module 100.
  • the connecting elements 120, 122 can be formed integrally or in one piece with the microreactor module 100. However, they can also be screwed, glued, welded or the like. his.
  • the connecting element 122 is attached to the side of the microreactor module 100 that lies opposite the side with the connecting element 120 and is designed to be complementary to the connecting element 120.
  • FIG. 3 (b) shows a preferred embodiment of the connection from FIG. 3 (a), in which the hook-shaped connecting elements 120a, 120b have recesses 121a, 121b and recesses 124a and 124b lying on the corner.
  • the recesses 124a, 124b on the corner are arranged in such a way that they have an internal thread for screwing in a screw, the internal threads for the adjacent connecting elements 120a and 120b being arranged such that the screws act as clamping elements 128 from opposite sides can be turned.
  • further connection elements 120, 122 can be provided on the other opposite sides of the microreactor module 100.
  • the microreactor module 100 consists of parts 111 which are held together by screws 112. Fluid channel openings 114 and 116 with or without a surrounding annular groove 117 are located in the rare walls of the microreactor module 100.
  • the first connecting element 120 of the microreactor module 100 consists of two mutually spaced, hook-shaped or L-shaped parts cut towards one another and the second connecting element 122 consists of a T-shaped undercut part.
  • the T-shaped connecting element 122 is pushed behind the two hook-shaped parts of the first connecting element 120 by a relative movement of the two modules parallel to the side walls of the modules on which the connecting elements 120, 122 are located, until the two The modules are exactly opposite each other and any fluid channel openings 114 or 116 are exactly aligned with each other. This alignment can be facilitated by stops on the connection elements 120, 122 (not shown).
  • connection constructed from the two connecting elements 120, 122 has a clear play, so that the two connecting elements 120, 122 of the two modules to be connected can be pushed into one another, while the modules themselves are held a sufficient distance 130 so that the seal m of the annular groove 117 around the fluid channel opening 114 on a fluid channel 115 is not damaged by shearing during assembly (FIG. 4 (a)).
  • the connecting elements 120, 122 have cutouts 124, 126 on their inner sides (cf. Fig. 3), which run parallel to the abutting side walls of the modules 100 and which, when two modules are assembled, lie opposite one another.
  • clamping elements 128 are introduced into the cutouts 124, 126, which cancel out the play between the two modules 100 and apply the sealing force required for the fluid seal.
  • the tensioning elements 128 can be designed differently.
  • 5 (a) shows a cylindrical clamping element 128 and
  • FIG. 5 (b) shows a conical clamping element 128 in the form of corresponding pins or wedges which enter the essentially cylindrical opening formed by the recesses 124, 126 are hammered in, the cylindrical tensioning element 128 preferably being provided with a tip for easier insertion.
  • conical screws can also be used as the tensioning element 128.
  • the clamping element 128 has a cylinder-shaped recess with an internal thread.
  • FIG. 6 (a) and 6 (b) show clamping elements 128 in the form of screws which insert a wedge (FIG. 6 (a)) or two wedges (FIG. 6 (b)) into the recesses 124, Push or pull 126 formed opening.
  • dowel-like slotted sleeves can also be used as clamping elements 128.
  • the tensioning element 128 of FIG. 7 (a) consists of a sleeve slotted at the end, which is provided with a conical internal thread and into which a screw is screwed.
  • a sleeve can be easily manufactured by first slitting solid material into which an internal thread is then cut. The sleeve expands so that a conical internal thread is created.
  • FIG. 7 (b) shows a variant in which the sleeve of the tensioning element 128 is slit four times in the middle, for example.
  • the sleeve expands accordingly in the middle.
  • FIG. 8 shows a connection system for the microreactor modules 100, in which the connection elements 140, 142 for the sliding connection are dovetail-shaped or undercut (FIG. 8 (a)).
  • a clamping element 128 adapted to it can then be inserted into the opening formed by recesses 144, 146 in the connecting elements 140, 142, such as an eccentric clamping element 128, which is rotated to clamp the two modules 100 together (FIG. 8 (b ), Fig. 8 (c)).
  • the connection system is designed such that the rectangular or cube-shaped housing geometry of the microreactor modules 100 is essentially retained.
  • grooves 150 with an undercut are formed in the side walls of the microreactor modules 100, that is to say in the cube or rectangular body of the modules 100. Two of the grooves 150 are preferably provided in each side wall.
  • the groove 150 in each of the side walls of the microreactor module 100 has a T shape. If two modules 100 are placed next to one another, the grooves 150 lie opposite one another and a cavity is formed in a double T shape. The two modules 100 are connected by a profile piece 152 inserted into the cavity, the cross section of which corresponds to the cross section of the cavity from the two opposite grooves 150. One end of the profile piece 152 can be shaped conically for easier insertion.
  • the grooves 150 have a dovetail shape, so that when two modules 100 are put together, a double dovetail is formed, into which a profile piece 152 with a corresponding cross section is inserted.
  • microreactor modules described preferably have a standard grid dimension, for example a grid dimension of 25 mm, which is relatively widespread in modular systems.
  • the material for the microreactor modules is selected as required, for example plastic, steel, stainless steel or also coated material or a composite material.
  • the described microreactor modules can be combined with fluid circuit boards.
  • fluid circuit boards are the equivalent of the known circuit boards for electrical circuits, and the microreactor modules correspond to the components applied to the circuit boards for specific functions in the circuit.
  • the microreactors on the fluid circuit boards can thus ensure defined conditions in certain process steps, for example ensure exact temperature and mixing ratios and the like.
  • By bringing reactants together specific reactions can also be brought about in the microreactors, the products of which are then carried on again in the fluid circuit board.
  • Fluid circuit boards can also be used, for example, to feed several parallel microreactor process lines evenly. Similarly, the products from such a system can be collected via a fluid circuit board.
  • the microreactor modules In order to be able to fulfill their function, the microreactor modules must be mechanically and fluidly connected to the fluid circuit board. This can be done via direct connections between the modules and the circuit board or via separate lines. There is also the possibility of using connection modules that route channels in the printed circuit board to certain reactor modules.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micromachines (AREA)

Abstract

L'invention concerne un module microréacteur (100) comportant des éléments de réacteur tels que des conduites de fluide, des chambres de réaction, des dispositifs de chauffage, des dispositifs de mélange et autres. L'invention vise à constituer un microsystème à partir d'un certain nombre de modules microréacteurs (100) de type identique et différent. A cet effet, le module microréacteur selon l'invention comporte des éléments de liaison (120, 122) qui, lors de la liaison de deux modules microréacteurs (100), constituent une liaison de forme telle que les conduites de fluide menant d'un module à l'autre sont reliées l'une à l'autre de manière étanche vers l'extérieur.
PCT/DE2000/001213 1999-04-16 2000-04-14 Module microreacteur WO2000062918A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19917330.3 1999-04-16
DE1999117330 DE19917330B4 (de) 1999-04-16 1999-04-16 Mikroreaktormodul

Publications (2)

Publication Number Publication Date
WO2000062918A2 true WO2000062918A2 (fr) 2000-10-26
WO2000062918A3 WO2000062918A3 (fr) 2001-02-01

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ID=7904860

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2000/001213 WO2000062918A2 (fr) 1999-04-16 2000-04-14 Module microreacteur

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DE (1) DE19917330B4 (fr)
WO (1) WO2000062918A2 (fr)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE20201753U1 (de) 2002-02-05 2002-04-11 Ehrfeld Mikrotechnik GmbH, 55234 Wendelsheim Modulares Mikroreaktorsystem
US7468165B2 (en) 2001-11-06 2008-12-23 Sebastian Oberbeck Microreactor system
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CN107626271A (zh) * 2017-11-07 2018-01-26 菲立化学工程（上海）有限公司 一种微通道反应器
WO2020027500A1 (fr) * 2018-07-28 2020-02-06 한국과학기술원 Puce fluidique modulaire et système d'écoulement de fluide la comprenant
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US7468165B2 (en) 2001-11-06 2008-12-23 Sebastian Oberbeck Microreactor system
DE20201753U1 (de) 2002-02-05 2002-04-11 Ehrfeld Mikrotechnik GmbH, 55234 Wendelsheim Modulares Mikroreaktorsystem
US7795359B2 (en) 2005-03-04 2010-09-14 Novartis Ag Continuous process for production of polymeric materials
US8381798B2 (en) 2007-03-29 2013-02-26 Fujifilm Corporation Micro fluid device having piping to control fluid temperature
US8262992B2 (en) 2007-11-13 2012-09-11 Roche Diagnostics Operations, Inc. Modular sensor cassette
GB2475835A (en) * 2009-11-27 2011-06-08 Magna Parva Ltd Sample Processing System
EP3155261A4 (fr) * 2014-06-10 2018-01-17 University of Southern California Éléments discrets destinés à la microfluidique 3d
AU2015274693B2 (en) * 2014-06-10 2019-01-03 Reolab, Inc. Discrete elements for 3D microfluidics
CN107626271A (zh) * 2017-11-07 2018-01-26 菲立化学工程（上海）有限公司 一种微通道反应器
WO2020027500A1 (fr) * 2018-07-28 2020-02-06 한국과학기술원 Puce fluidique modulaire et système d'écoulement de fluide la comprenant
US11618018B2 (en) 2018-07-28 2023-04-04 Korea Advanced Institute Of Science And Technology Modular fluid chip and fluid flow system comprising same
US11666902B2 (en) 2018-07-28 2023-06-06 Korea Advanced Institute Of Science And Technology Modular fluidic chip and fluidic flow system comprising same
CN112805568A (zh) * 2018-10-01 2021-05-14 勃林格殷格翰维特梅迪卡有限公司 用于测试样品的分析仪

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