WO2020027500A1 - Puce fluidique modulaire et système d'écoulement de fluide la comprenant - Google Patents

Puce fluidique modulaire et système d'écoulement de fluide la comprenant Download PDF

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Publication number
WO2020027500A1
WO2020027500A1 PCT/KR2019/009272 KR2019009272W WO2020027500A1 WO 2020027500 A1 WO2020027500 A1 WO 2020027500A1 KR 2019009272 W KR2019009272 W KR 2019009272W WO 2020027500 A1 WO2020027500 A1 WO 2020027500A1
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WIPO (PCT)
Prior art keywords
fluid chip
modular fluid
housing
modular
chip
Prior art date
Application number
PCT/KR2019/009272
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English (en)
Korean (ko)
Inventor
이문근
이석재
배남호
이태재
이경균
박유민
Original Assignee
한국과학기술원
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020190088805A external-priority patent/KR102294916B1/ko
Application filed by 한국과학기술원 filed Critical 한국과학기술원
Priority to CN201980048036.8A priority Critical patent/CN113195100A/zh
Priority to US17/056,416 priority patent/US11618018B2/en
Priority to EP19843210.6A priority patent/EP3778026A4/fr
Publication of WO2020027500A1 publication Critical patent/WO2020027500A1/fr

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/028—Modular arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0874—Three dimensional network
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts

Definitions

  • the present invention relates to a modular fluid chip and a fluid flow system including the same, and more particularly, a modular fluid chip capable of realizing a fluid flow system having various structures by connecting a plurality of fluid chips capable of performing different functions to each other. And a fluid flow system including the same.
  • Lab-on-a-chip (LOC) technology is in the spotlight to overcome the shortcomings of conventional diagnostic techniques.
  • Lab-on-a-chip technology is a convergence technology of NT, IT, and BT. It uses all the pre-treatment and analysis steps such as dilution, mixing, reaction, separation, and quantification of a sample using a technology such as MEMS or NEMS on one chip. Say skills to help.
  • Such microfluidic devices using Lab-on-a-Chip technology can analyze and diagnose the flow of a fluid sample flowing through the reaction channel or the reaction of the fluid sample and the reagent supplied to the reaction channel, as well as the control of the fluid sample.
  • Many of the units required for analysis are built on small chips of several centimeters size, made of glass, silicon or plastic, so that the various steps of processing and manipulation can be carried out on one chip.
  • the microfluidic device includes a chamber capable of confining a small amount of fluid, a reaction channel through which the fluid can flow, a valve that can control the flow of the fluid, and various functional units capable of receiving a fluid and performing a predetermined function. And the like.
  • the conventional microfluidic device is manufactured to have a function associated with a plurality of microfluidic devices according to experimental purposes, even if a problem occurs or changes in one function, the whole device must be newly manufactured, and thus, manufacturing cost This increase, of course, there was a problem that management is not easy.
  • microfluidic device is difficult to change the design, it is not compatible with other microfluidic device has a problem that can not perform other experiments other than the specified experiment.
  • the conventional microfluidic device has a limited size and specification that can be manufactured, and thus cannot be structurally expanded. Therefore, after only a part of the experiment is performed, the entire experimental results must be predicted to derive accurate experimental data. There was no problem.
  • an object of the present invention is to connect a plurality of fluid chips capable of performing different functions as needed to connect the fluid flow system of various structures without constraints of shape or size. It can be implemented, through which a variety of accurate experimental data can be obtained, as well as providing a modular fluid chip and a fluid flow system including the same can replace only the fluid chip of the part in the case of deformation or breakage of a specific part It is.
  • Modular fluid chip according to a first embodiment of the present invention for solving the above problems is a modular fluid chip, a body including at least one first hole through which fluid flow; And a housing accommodating the body therein, the housing including a second hole in which the fluid flows in correspondence with the at least one first hole, and a fluid connection part connectable to another modular fluid chip. .
  • the body is formed in the form of a module capable of performing one function, and can be selectively replaced in the housing.
  • the other modular fluid chip may include a body capable of performing a function different from the one function.
  • the housing may be connected to the other modular fluid chip in a horizontal or vertical direction, and when the housing and the other modular fluid chip are connected in a horizontal or vertical direction, the first hole and the second hole may be connected to the other module.
  • the first and second holes provided in the mold fluid chip may be aligned with and communicate with each other.
  • the body may further include a fluid channel in communication with the first hole and in which the fluid flows.
  • the fluid channel has a straight channel, a streamline channel, a channel having at least one well, a channel having a valve, a channel having at least one branch, a cross channel, a Y-shaped channel, a channel having a sensor, and an electrical output. It may include any one of a channel and a channel having an optical output.
  • the first hole, the second hole and the fluid channel are formed in a circular, oval or polygonal shape in cross section, and the first hole, the second hole and the fluid channel are in a range of a circle having a diameter of 10 nm or more and 1 cm or less. It may be formed in a preset size.
  • the housing may be formed of at least one material of ceramic, metal and polymer.
  • the coupling unit may further include a coupling unit for coupling with another modular fluid chip, and the coupling unit may include a magnetic material.
  • the coupling unit may comprise convex or concave portions corresponding to each other.
  • the coupling unit may include a fastening portion connectable with the other modular fluid chip.
  • the cover may be coupled to the housing to surround the body and formed of a transparent material.
  • An imaging unit disposed on the cover; And a light source disposed in the housing or the cover.
  • the temperature control unit for heating or cooling the body may further include a.
  • the modular fluid chip according to the second embodiment of the present invention is a modular fluid chip, the body including at least one first hole through which the fluid flow; A housing containing the coupling unit receivable therein and connectable with another modular fluid chip; And a fluid connector received in the housing and including a third hole aligned with the first hole.
  • the fluid connector when connected to the other modular fluid chip, is in close contact with the fluid connector provided in the other modular fluid chip to form an interface, the fluid leakage between the housing and the other modular fluid chip You can block.
  • the fluid connection may be formed of an elastomer.
  • the fluid connector may be disposed on at least one of an outer side of the housing and an inner side of the housing.
  • the fluid connection may be provided with a convex portion or a recess that can be coupled to the housing.
  • the fluid connector may include a seating portion accommodated outside the housing and connectable with the other modular fluid chip; And a convex portion accommodated inside the housing and connectable with the body.
  • An O-ring disposed between the seating portion and the convex portion may be connected to the seating portion and the convex portion.
  • the modular fluid chip according to the third embodiment of the present invention is a modular fluid chip, the body including at least one first hole through which the fluid flow; A housing accommodating the body therein, the housing including a second hole in which the fluid flows in correspondence with the at least one first hole, the housing including a fluid connector connectable with another modular fluid chip; And at least one sensor capable of detecting a signal generated from the fluid.
  • the at least one sensor may detect at least one of an electrical signal, a fluorescence signal, an optical signal, an electrochemical signal, a chemical signal, and a spectroscopy signal.
  • the at least one sensor may be formed of any one material of a metal, an organic-inorganic composite, and an organic conductor.
  • the at least one sensor includes at least one of Au, Mg, Ti, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, Al, Zr, Nb, Mo, Ru, Ag, and Sn. It may be formed of a metal electrode.
  • the at least one sensor may be formed of an organic electrode including at least one material of a conductive polymer and carbon.
  • the at least one sensor may be formed of an organic-inorganic composite electrode in which at least one material of the metal electrode and at least one material of the organic electrode are mixed.
  • the at least one sensor may be formed of a material having transparency to detect at least one of a fluorescence signal, an optical signal, and a spectroscopy signal.
  • the modular fluid chip according to the fourth embodiment of the present invention is a modular fluid chip, the housing; And at least one coupling part provided in the housing to be coupled to another modular fluid chip.
  • the coupling part may include at least one protrusion protruding from the outer surface of the housing and at least one receiving groove provided on the outer surface of the housing.
  • the protrusion and the accommodation groove may be alternately arranged along the circumference of the housing.
  • the protrusion and the accommodation groove may be provided in a shape corresponding to each other.
  • the protrusion may include an inclined surface formed at one end thereof.
  • the coupling part may further include a plurality of magnetic members.
  • the plurality of magnetic members may be disposed inside the protrusion and the receiving groove.
  • the plurality of magnetic members may be installed on an outer surface of the housing along a circumference of the housing and may be disposed at different positions from the protrusion and the receiving groove.
  • the coupling part may include a shielding member disposed on one side of the magnetic member and configured to block a magnetic force of the magnetic member.
  • a body accommodated in the housing wherein when the housing is connected to the other modular fluid chip, the housing is arranged in a flow path provided in the other modular fluid chip and provided in the other modular fluid chip. At least one flow passage communicating with the flow passage may be formed.
  • the modular fluid chip according to the fifth embodiment of the present invention is a modular fluid chip including at least one flow path, connected to another modular fluid chip flow path provided in the other modular fluid chip It includes; connecting member configured to communicate with.
  • a body including the at least one flow passage therein and configured to be connected to the other modular fluid chip through the connection member.
  • connection member may be configured to be coupled to the body and coupled to a body provided in the other modular fluid chip.
  • connection member may be configured to be connected to a body provided in the other modular fluid chip through another connection member provided in the other modular fluid chip.
  • It may further include a housing for receiving the body and the connecting member.
  • the connecting member may include a flange portion protruding from an outer surface thereof, and the housing may include a flange receiving groove which receives and supports the flange portion to limit the flow of the connecting member.
  • connection member may include a first body and a second body having different materials, and the first body may have a hollow tube shape to communicate with the flow path, and the second body may have the first body. It can be combined to wrap around the body.
  • the second body may have a higher hardness than the first body.
  • connection member may include an inclined surface formed at both ends thereof.
  • the body may include a coupling groove communicating with the at least one flow passage, and the connection member may be inserted into the coupling groove to communicate with the at least one flow passage.
  • the hermetic part may include a potential parallel part configured to be press-fitted between the body and the connection member; A back parallel part configured to pressurize the potential parallel part and to be press-fitted between the potential parallel part and the connection member; And a pressurizing part fastened to the body and configured to pressurize the rear part parallel part.
  • connection member may be integrally formed with the body.
  • the body may comprise a glass or wood material.
  • the coupling part may further include a fastening part installed in the housing and the other modular fluid chip, the fastening part configured to convert the rotational motion into a linear motion when mutually coupled to closely contact the housing and the other modular fluid chip. can do.
  • the tightening unit the shaft portion is provided with a fastening portion that can be fastened to the housing on one side, the projection portion is provided on the other side;
  • a cam part installed in the other modular fluid chip to receive the catching part inward, and to rotate in the circumferential direction when the external force is applied, and pressurize the catching part accommodated in the inner side to linearly move the catching part in the axial direction. It can include;
  • a fluid flow system including a modular fluid chip includes a first modular fluid chip capable of implementing a first function; And at least one second modular fluid chip capable of implementing a second function different from the first function and connectable to the first modular fluid chip in at least one of horizontal and vertical directions.
  • Each of the first modular fluid chip and the second modular fluid chip may include: a body including at least one first hole through which fluid may flow; And a housing accommodating the body therein, the housing including a second hole and a coupling unit aligned with the at least one first hole and in which the fluid flows.
  • a body including at least one first hole through which fluid may flow
  • a housing accommodating the body therein, the housing including a second hole and a coupling unit aligned with the at least one first hole and in which the fluid flows.
  • the housing provided in the first modular fluid chip and the housing provided in the second modular fluid chip may have the same shape or the same size specification.
  • Each of the first modular fluid chip and the second modular fluid chip may further include a fluid connector including a third hole aligned with the first hole and the second hole.
  • the holes provided in the first modular fluid chip and the holes provided in the second modular fluid chip communicate with the holes provided in the first modular fluid chip and the holes provided in the second modular fluid chip.
  • the change in the fluid pressure is minimized at the portion to be formed, and may have a shape such that the composition of the fluid or the shape of the fine droplets is maintained.
  • the alignment of the holes provided in the first modular fluid chip and the holes provided in the second modular fluid chip may be configured to be horizontal or perpendicular to the fluid channel formed in the body.
  • a fluid chip capable of performing a single function in the form of a module by forming a fluid chip capable of performing a single function in the form of a module, a plurality of structures without restriction of shape or size by connecting a plurality of fluid chips capable of performing different functions as necessary to each other It is possible to implement a fluid flow system of the present invention, thereby obtaining various and accurate experimental data, and in the case of deformation or breakage of a specific part, it is possible to replace only the fluid chip of the corresponding part, thereby reducing manufacturing and maintenance costs.
  • a housing connectable to another modular fluid chip and a body that is selectively replaceable in the housing by forming a channel therein, respectively, in a modular form, the position of the section selected as needed in one fluid flow system, and The shape of the channel can be easily changed, and through this, the experimental conditions can be changed quickly, allowing for more various experiments than the conventional fluid flow system for a set time, and in case of failure or damage, replace only the housing or the body of the corresponding area quickly. can do.
  • the holes of each fluid chip communicate with each other in an aligned state, and the interface between the modular fluid chip and the other modular fluid chip close to each other to form an interface.
  • FIG. 1 is a perspective view illustrating a fluid flow system in which a modular fluid chip according to an embodiment of the present invention is connected in a horizontal direction.
  • FIG. 2 is a perspective view showing a state in which the cover of the modular fluid chip according to the embodiment of the present invention is separated.
  • FIG. 3 is an exploded perspective view of FIG. 2.
  • FIG. 4 to 6 schematically illustrate various embodiments of channels formed in the body of a modular fluid chip according to an embodiment of the present invention.
  • FIG. 7 is a plan view of a modular fluid chip according to an embodiment of the present invention.
  • FIG. 8 is a cross-sectional view of portions “A”, “B” and “C” of FIG. 7.
  • FIGS. 9 to 10 are exploded perspective views showing a modified embodiment of the coupling unit having a magnetic in the modular fluid chip according to an embodiment of the present invention.
  • FIGS. 11A and 11B are perspective views illustrating a fluid flow system in which a modular fluid chip according to an embodiment of the present invention is vertically connected.
  • 12A, 12B, 12C, and 12D are perspective views illustrating a modular fluid chip according to an embodiment of the present invention to which a vertical connection structure is applied.
  • FIGS. 12A, 12B, 12C, and 12D are exploded perspective views of FIGS. 12A, 12B, 12C, and 12D.
  • FIG. 14A is a perspective view illustrating a state in which a coupling unit having a magnetic body is installed outside the cover in FIG. 12B
  • FIG. 14B is a perspective view illustrating a state in which a coupling unit having a magnetic body is further installed in a housing of FIG. 12C.
  • FIGS. 15A and 15C schematically illustrate a cross-section of a state in which a modular fluid chip is connected in a vertical direction. It is a figure shown.
  • 16 to 20 schematically illustrate a state in which a coupling structure that is physically coupled to a modular fluid chip according to an embodiment of the present invention is applied.
  • 21 is an exploded perspective view illustrating a state in which an imaging unit and a light source are applied to a modular fluid chip according to an exemplary embodiment of the present invention.
  • FIG. 22 is an exploded perspective view illustrating a state in which a temperature controller is applied to a modular fluid chip according to an exemplary embodiment of the present invention.
  • FIG. 23 is a perspective view illustrating a state in which a fluid connector is applied to a modular fluid chip according to an exemplary embodiment of the present invention.
  • FIG. 24 is an exploded perspective view of FIG. 23.
  • 25 is a perspective view illustrating a state in which a modular fluid chip according to an embodiment of the present invention is connected to another modular fluid chip.
  • FIG. 26 is a cross-sectional view taken along the line A′-A ′ of FIG. 25.
  • 27 to 32 are views illustrating a state in which various embodiments of the fluid connector are applied to the modular fluid chip according to the embodiment of the present invention.
  • FIG 33 is a perspective view schematically showing a state in which a sensor is installed in a modular fluid chip according to an embodiment of the present invention.
  • FIG. 34 is a plan view of a fluid flow system implemented through a modular fluid chip according to another embodiment of the present invention.
  • 35 is a perspective view of a modular fluid chip according to another embodiment of the present invention.
  • 36 is a plan view illustrating a modular fluid chip according to another embodiment of the present invention.
  • FIG. 37 is an exploded perspective view showing a modular fluid chip according to another embodiment of the present invention.
  • FIG. 38 is a cross-sectional view taken along the line B-B of FIG. 35.
  • 39 to 41 schematically illustrate a modified embodiment of a connecting member applied to a modular fluid chip according to another embodiment of the present invention.
  • FIG. 42 is a view schematically illustrating a state where an airtight part is installed on an outer surface of a connection member applied to a modular fluid chip according to another exemplary embodiment of the present disclosure.
  • FIG 43 is a view schematically illustrating a state in which a magnetic member applied to a modular fluid chip according to another embodiment of the present invention is disposed at a position different from the protrusion and the receiving groove.
  • FIG. 44 is a view schematically illustrating a process in which a modular fluid chip is connected with another modular fluid chip through a fastener according to another embodiment of the present invention.
  • the terms “comprises” or “having” are intended to indicate that there is a feature, number, step, action, component, part, or combination thereof described on the specification, and one or more other features. It is to be understood that the present invention does not exclude the possibility of the presence or the addition of numbers, steps, operations, components, components, or a combination thereof.
  • a component When a component is said to be “connected” or “connected” to another component, it may be directly connected to or connected to that other component, but it may be understood that another component may be present in the middle. Should be.
  • a component is said to be “directly connected” or “directly connected” to another component, it should be understood that there is no other component in between.
  • module or “unit” for the components used in the present specification performs at least one function or operation.
  • the “module” or “unit” may perform a function or an operation by hardware, software, or a combination of hardware and software.
  • a plurality of “modules” or a plurality of “parts” other than “modules” or “parts” to be executed in specific hardware or executed in at least one processor may be integrated into at least one module. Singular expressions include plural expressions unless the context clearly indicates otherwise.
  • a modular fluid chip 1 (hereinafter referred to as a 'modular fluid chip 1') according to an embodiment of the present invention is formed in a module shape capable of performing one function. And connected with other modular fluid chips 2 to implement the fluid flow system 1000 of various structures.
  • the fluid flow system 1000 implemented through the modular fluid chip 1 may be used to collect a sample from a fluid, such as a liquid sample including body fluid, blood, saliva, skin cells, sample crush, gene or protein from the sample, etc. Amplification, antigen-antibody reactions, affinity chromatography and electrical sensing, electrochemical sensing, and capacitor type electricals using polymerase chain reaction including extraction, filtering, mixing, storage, valves, RT-PCR, etc. Analysis / detection processes, such as sensing, optical sensing with or without fluorescent materials, may be performed.
  • a fluid such as a liquid sample including body fluid, blood, saliva, skin cells, sample crush, gene or protein from the sample, etc.
  • Analysis / detection processes such as sensing, optical sensing with or without fluorescent materials, may be performed.
  • the modular fluid chips 1, 2 are shown to perform a function for fluid movement, the fluid flow system 1000, for example, the fluid enters, the cells in the fluid is broken, After filtering, the gene may be amplified and configured to allow a series of processes to allow fluorescent material to be observed and observed in the amplified gene.
  • the fluid flow system 1000 implemented through the modular fluid chip 1 may implement Factory-on-a-chip technology through connection with another fluid flow system 1000. have. This allows not only to simultaneously perform fluid analysis and diagnosis on different fluids in each fluid flow system 1000, but also to perform all experiments related to fluids that can be performed using the fluid flow system 1000 (e.g., Chemical reactions, material synthesis, etc.) may be simultaneously performed through the plurality of fluid flow systems 1000.
  • This allows not only to simultaneously perform fluid analysis and diagnosis on different fluids in each fluid flow system 1000, but also to perform all experiments related to fluids that can be performed using the fluid flow system 1000 (e.g., Chemical reactions, material synthesis, etc.) may be simultaneously performed through the plurality of fluid flow systems 1000.
  • modular fluid chip 1 may be connected to the other modular fluid chip 2 in a horizontal direction (X-axis and Y-axis directions) to implement one fluid flow system 1000.
  • the present modular fluid chip 1 is connected to another modular fluid chip 2 along the X and Y axis directions, which are shown in the horizontal direction in the drawing, and has a single fluid flow and analysis section.
  • Fluid flow system 1000 may be implemented. Accordingly, the fluid can move freely in the X and Y axis directions.
  • the other modular fluid chip 2 may be connected in an amount of between 1 and 10,000 in the X and Y axis directions about the present modular fluid chip 1.
  • Modular fluid chip 1 according to various embodiments of the present invention will be described in more detail.
  • the modular fluid chip 1 according to the first embodiment of the present invention includes a body 11.
  • the body 11 is formed in the form of a module capable of performing one function and is accommodated inside the housing 12 and may be selectively replaced with the housing 12 as necessary.
  • the body 11 may be formed in a shape corresponding to the inner surface of the housing 12 in which the accommodation space is formed, and may be formed at the same height as the housing 12 based on the Z axis direction of the drawing.
  • the body 11 may be manufactured using techniques such as MEMS, 3D printing, injection molding, CNC machining, imprinting, polymer casting, or the like.
  • the body 11 when the body 11 is coupled to the housing 12, the body 11 may be fixed at a predetermined position and may be formed in a polyhedral structure so as to be in surface contact with the inner surface of the housing 12.
  • the body 11 may be formed to have a transparency or a part of the transparency so as to visually check the flow of the fluid flowing from the outside to the inside.
  • the body 11 may be formed of at least one of an amorphous material such as glass, wood, a polymer resin, a metal, and an elastomer, or a combination thereof.
  • part of the body 11 may be made of an elastomeric material.
  • a portion in which the fluid flows or contacts with other parts of the body 11 may be formed of an elastomeric material.
  • the body 11 When the body 11 is partially formed of an elastomeric material, the body 11 may be manufactured through heterogeneous injection.
  • the body 11 is formed with a first hole 111 to guide the flow of the fluid.
  • the first hole 111 communicates with the second hole 121 of the housing 12, which will be described later, and the fluid channel 112, which will be described later, formed inside the body 11.
  • the first hole 111 may be formed in a predetermined section from the outer surface of the body 11 toward the inside of the body 11, and may be formed in a section having a smaller size than the section in which the fluid channel 112 is formed.
  • the first hole 111 may be formed in a shape corresponding to the second hole 121 provided in the housing 12 and the fluid channel 112 provided in the body 11. Therefore, the first hole 111 may prevent a phenomenon in which the pressure of the fluid is increased or the flow of the fluid is unstable between the housing 12 and the body 11 during the flow of the fluid.
  • the first hole 111 may have a circular cross section or may have a polygon or ellipse shape although not shown in the drawing.
  • the shape of the first hole 111 is not limited thereto and may be formed in various shapes within a limit of 10 nm or more and 1 Cm or less.
  • the first and second holes 111 and 121 having a shape and size corresponding to each other to form a straight fluid path with each other have a predictable flow rate when the fluid is moved from one module to another module.
  • Some conventional microfluidic flow devices transfer fluid through a tube. In the case of a device using a tube, there may be a difference in the width of the channel or a space in the channel at the portion where the tube and the device are connected to cause vortex in the fluid. These vortices not only cause a drastic change in flow velocity but can also change the shape of the droplets. Alternatively, physical impacts on the materials in the fluid or impede the movement of the materials.
  • the arrangement of the first holes 111 of the body 11 and the second holes 121 of the housing 12 in the same width and in a straight line is not only a function of ensuring a connection between the modules, but also a stable flow velocity of the fluid. Enables stable movement of materials and materials
  • the housing 12 and the second hole 121 of the housing 12 can ensure the stability of the above-described fluid no matter what function or shape the module in the module system of the present application.
  • fluid channel 112 may be formed in the body 11.
  • the fluid channel 112 may be in communication with the at least one first hole 111 to enable flow of the fluid.
  • the fluid channel 112 may have a polygonal cross section or may have a circular or elliptical shape although not shown in the drawing.
  • the shape of the fluid channel 112 is not limited thereto, and the fluid channel 112 may be formed in various shapes within a limit of 10 nm or more and 1 Cm or less.
  • the fluid channel 112 may be configured to guide the flow of the fluid in various directions as well as to perform one preset function on the fluid in flow.
  • the inner side of the body 11 has a straight fluid channel 112 (FIGS. 4A and 4B) and a streamlined fluid channel 112 (FIG. 4C).
  • fluid channel with sensor At least one of a fluid channel (not shown) having an electrical output unit and a fluid channel (not shown) having an optical output unit may be formed.
  • the fluid channel 112 is not necessarily limited thereto, and may be changed and applied to various structures and shapes, and may be made through a combination of the aforementioned channels.
  • another modular fluid chip 2 connected to the modular fluid chip 1 may have a body capable of performing a function different from one function of the body 11 of the modular fluid chip 1. 11) may be included.
  • fluid channels 112 may be formed in the body 11 of the modular fluid chip 1 and the body 11 of the other modular fluid chip 2.
  • the plurality of modular fluid chips 1 connected to each other to implement the present fluid flow system 1000 may perform different functions with respect to the fluid flowing therein.
  • the plurality of modular fluid chips 1 connected to each other may be formed to perform only one function.
  • one fluid chip 1 includes the Y-shaped fluid channel 112 to perform a function for mixing
  • the other fluid chip 1 connected thereto is the above-described Y-shaped fluid channel.
  • Different types of fluid channels 112 and 112 may be provided to perform other functions.
  • the modular fluid chip 1 according to the first embodiment of the present invention includes a housing 12.
  • the housing 12 is formed in a frame structure in which an accommodation space is formed, and is configured to accommodate the body 11 inside.
  • the second hole 121 enables fluid to flow in correspondence with at least one first hole 111 provided in the body 11. ) Is formed.
  • the second hole 121 is formed at at least one position along the circumference of the housing 12, and communicates with the first hole 111 of the body 11 to fluid in at least one of an X-axis direction and a Y-axis direction. To guide the flow.
  • the second hole 121 is formed in a shape corresponding to the first hole 111 provided in the body 11 so that the pressure of the fluid increases between the housing 12 and the body 11 when the fluid flows. Unstable flow of fluid can be prevented.
  • the second hole 121 may have a circular cross section or may be formed in a polygon or ellipse shape although not shown in the drawing.
  • the shape of the second hole 121 is not limited thereto, and the second hole 121 may be formed in various shapes within a limit of 10 nm or more and 1 Cm or less.
  • the housing 12 may be formed of at least one material of ceramic, metal, and polymer.
  • the ceramic means a material composed of oxides, carbides, and nitrides formed by combining metal elements with oxygen, carbon, and nitrogen, such as silicon, aluminum, titanium, and zirconium, and the housing 12 is formed of any one of the above-described ceramic materials.
  • the ceramic material may be formed, or may be formed of a ceramic mixture in which at least one ceramic material is mixed.
  • the metal is named as metal in the chemical periodic table such as Au, Mg, Ti, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, Al, Zr, Nb, Mo, Ru, Ag, Sn, etc.
  • An element made of an element, and the housing 12 may be formed of any one of the above metal materials, or may be formed of a metal mixture in which at least one metal material is mixed.
  • the polymer means a material composed of COC, PMMA, PDMS, PC, TIPP, CPP, TPO, PET, PP, PS, PEEK, Teflon, PI, PU, and the like, and the housing 12 is the polymer material described above.
  • the polymer material may be formed of any one of the above, or may be formed of a polymer mixture mixed with at least one kind.
  • the housing 12 may be formed of a mixture of the above-described ceramics, metals and polymers. However, the housing 12 is not necessarily limited thereto, and may be formed of more various materials.
  • the housing 12 may be formed of a material similar to the body 11 described above, or may be formed of a material different from the body 11.
  • the housing 12 formed of at least one material of ceramics, metals and polymers, and the body 11 formed of at least one material of a polymer resin, an amorphous material, a metal and an elastomer, If necessary, they may be formed of similar materials or may be formed of different materials.
  • the housing 12 and the body 11 may maximize the adhesion of the surface contact portion to prevent mutual separation, as well as to prevent the leakage of fluid at the connection portion.
  • the housing 12 is formed separately from the body 11, but also for the purpose of ensuring a stable flow of the fluid when the modular fluid chips 1 are connected as described above, the modular fluid chip 1 There is also a purpose to provide convenience in modularizing them. That is, since the position of the second hole 121 of the housing 12 is standardized, when the body 11 is designed and manufactured, it is only required to manufacture it so as to have a standardized entrance or exit hole or the first hole 111. Interfacing or fluidic connections may be secured. In addition, when only the body 11 is newly manufactured and coupled to the housing 12, a module having a new function may be assembled.
  • the housing 12 also includes a fluid connection 17.
  • the fluid connection 17 is configured to connect the present modular fluid chip 1 with another modular fluid chip 2.
  • the fluid connection unit 17 may be formed in a sheet or pad form and may be detachably installed on the outer surface of the housing 12.
  • a mounting groove 123 corresponding to the fluid connecting portion 17 may be formed on the outer surface of the housing 12 to allow the fluid connecting portion 17 to be seated thereon.
  • a third hole 171 may be formed in the fluid connection unit 17 to correspond to the first hole 111 and the second hole 121.
  • the fluid connection unit 17 may be configured to form an interface upon contact with the other fluid connection unit 17.
  • the fluid connection portion 17 may be formed of an elastomeric material that is elastically deformable to form an interface at the contact portion upon contact with the other fluid connection portion 17.
  • one surface of the fluid connection portion 17 may be provided with a pressure-sensitive adhesive layer on one surface of the other fluid connection portion 17 in contact with the other fluid connection portion 17.
  • the fluid connection unit 17 is not limited thereto, and may be changed and applied to various forms or various materials within the conditions capable of performing the same function.
  • the fluid connection part 17 may be integrally provided on the outer surface of the housing 12 through heterogeneous injection when the housing 12 is manufactured, and may have a circular or polygonal ring shape having a hole in the center thereof, or It may be formed in a plate-shaped stopper shape.
  • the fluid connecting portion 17 may be made of at least one of a polymer resin, an amorphous material, and a metal, and may be chlorinated polyethylene, ethylene propylene dimethyl, silicone rubber, acrylic resin, amide resin, epoxy resin, phenol resin, poly It may include at least one of ester resin, polyethylene resin, ethylene-propylene rubber, polyvinyl butyral resin, polyurethane resin and nitrile-butadiene rubber.
  • the fluid connection 17 provided in the present modular fluid chip 1 has a different modular fluid chip. (2) is in close contact with the fluid connecting portion 17 provided to form an interface, through which the connection between the modular fluid chip (1) and the other modular fluid chip (2) completely hermetic leaking fluid You can block.
  • the inner surface of each housing 12 provided in the present modular fluid chip 1 and the other modular fluid chip 2 has a coupling unit to be described later having a magnetic so as to maximize the adhesion of the fluid connecting portion 17 ( 122) may be further arranged.
  • the fluid connection unit 17 may be disposed on at least one of an outer side and an inner side of the housing 12.
  • the fluid connection part 17 disposed outside the housing 12 is in close contact with another fluid connection part 17 to form an interface
  • the fluid connection part 17 disposed inside the housing 12 is In close contact with the body 11, an interface may be formed.
  • the coupling unit 122 having magnetic properties may be provided around the fluid connection part 17 disposed inside the housing 12. Accordingly, the sealing performance of the fluid connecting portion 17 disposed outside the housing 12 can be maximized to improve the airtight performance between the present modular fluid chip 1 and the other modular fluid chip 2.
  • the fluid connecting portion 17 may be formed in a structure that can be coupled to the housing 12.
  • a protruding portion 173 may be formed in the fluid connecting portion 17 to protrude a predetermined length from an outer surface and to be inserted into a seating groove 123 formed in the housing 12. Accordingly, the fluid connection portion 17 is more stably coupled to the housing 12 so that the flow can be restricted. Furthermore, even when the present modular fluid chip 1 is coupled with another modular fluid chip 2, the housing Departure from (12) can be prevented.
  • the fluid connection portion 17 may be formed in the groove-shaped recessed portion recessed from the outer surface to be coupled to the projection formed in the housing 12.
  • the coupling structure provided in the fluid connection unit 17 is not necessarily limited thereto, and may be changed and applied to various shapes.
  • fluid connection portion 17 may be in direct communication with the body 11 to be connected to another modular fluid chip 2.
  • the fluid connection part 17 may be accommodated in the housing 12 and may be in close contact with the outer surface of the body 11 through the housing 12. Accordingly, the third hole 171 provided in the fluid connection portion 17 directly communicates with the first hole 111 provided in the body 11 to enable the flow of the fluid.
  • the fluid connecting portion 17 installed through the housing 12 is in close contact with the fluid connecting portion 17 of the other modular fluid chip 2 on one side to form an interface, and on the other side of the body 11.
  • the point at which the fluid may leak may be minimized, thereby stably allowing the flow of the fluid.
  • the fluid connecting portion 17 is seated in a seating groove 123 formed on the outer surface of the housing 12 and connected to another modular fluid chip 2 from the seating portion 172 and from one surface of the seating portion 172. It may include a convex portion 173 protrudes a predetermined length and penetrates the housing 12 and is in close contact with the outer surface of the body 11 to form an interface.
  • the inner surface of the housing 12 may be provided with a recess 1231 formed in a shape corresponding to the outer surface of the convex portion 173 to support the convex portion 173.
  • a circumference of the convex portion 173 may further include a coupling unit 122 to be described later having magnetic properties to maximize the adhesion of the seating portion 172.
  • the fluid connection portion 17 is in direct communication with the body 11, it may be formed in a plurality of divided structures.
  • the fluid connection portion 17 may include a seating portion 172, a convex portion 173, and an O-ring.
  • the seating portion 172 may be seated in a seating groove 123 formed on the outer surface of the housing 12 and may be in close contact with another modular fluid chip 2 to form an interface.
  • the convex portion 173 may be separated from the seating portion 172 and accommodated in the concave portion 1231 provided inside the housing 12, and may be in close contact with the outer surface of the body 11 to form an interface.
  • the O-ring 174 is disposed between the seating portion 172 and the convex portion 173 to connect the seating portion 172 and the convex portion 173 to each other, and the present modular fluid chip 1 and the other modular fluid chip.
  • the O-ring 174 is formed of an elastic body, a plastic, or a metallic material, and another hole communicating with the third hole 171 formed in the seating portion 172 and the convex portion 173 is formed inside the O-ring 174. Can be formed.
  • fluid connection 17 is not necessarily limited thereto and may be modified and applied in various forms.
  • the modular fluid chip 1 according to the first embodiment of the present invention may further include a coupling unit 122.
  • the coupling unit 122 may be configured to couple the present modular fluid chip 1 to another modular fluid chip 2 along the horizontal direction (X-axis and Y-axis directions). Can be.
  • the coupling unit 122 is accommodated in the housing 12 or integrally provided in the housing 12 so that the modular fluid chip 1 viewed along the horizontal direction (X-axis and Y-axis directions) can be replaced with other modules. At the same time as the horizontal connection to the mold fluid chip 2, the modular fluid chip 1 can be automatically aligned and secured to the other modular fluid chip 2.
  • the plurality of modular fluid chips 1 and 2 connected along the horizontal direction may implement one fluid flow system 1000 having a plurality of fluid flow sections and a fluid analysis section.
  • the coupling unit 122 may include a magnetic material.
  • the coupling unit 122 is made of a magnetic material having one side of the S pole and the other side of the N pole, and may be installed inside the housing 12. Through this, the present modular fluid chip 1 connected to the other modular fluid chip 2 may be in surface contact with the other modular fluid chip 2.
  • the coupling unit 122 may be installed outside the housing 12.
  • a mounting groove 123 in which the coupling unit 122 may be seated may be formed on an outer surface of the housing 12. Therefore, the coupling unit 122 installed on the outside of the housing 12 may maximize the binding force between the present modular fluid chip 1 and the other modular fluid chip 2.
  • the coupling unit 122 is not limited thereto, and may be modified in various structures.
  • the coupling unit 122 may be provided at both the inside and the outside of the housing 12, and may be formed in a form that can change the direction of polarity as necessary.
  • the coupling unit 122 may include at least one of various magnetic materials capable of implementing the same function as well as a magnetic material such as a permanent magnet.
  • the second hole of the other modular fluid chip 2 ( 121 and the second hole 121 of the modular fluid chip 1 may be disposed at a position having the same central axis as the second hole 121 of the modular fluid chip 1 so as to be aligned and communicated.
  • the housing 12 may be formed with a mounting groove 123 to which the coupling unit 122 can be seated.
  • the coupling unit 122 accommodated in the mounting groove 123 may be formed in a shape corresponding to the mounting groove 123 so that the coupling unit 122 is exposed to the outside of the housing 12 so as not to interfere with other components.
  • the coupling unit 122 provided in the modular fluid chip 1 may be formed in a structure that can be directly connected to the coupling unit 122 provided in the other modular fluid chip 2.
  • the coupling unit 122 included in the modular fluid chip 1 and the coupling unit 122 of the other modular fluid chip 2 corresponding thereto may have convex portions 1223 or corresponding to each other. It may include a recess 1224.
  • the convex portion 1223 and the concave portion 1224 may be formed in a concave-convex shape corresponding to each other.
  • the convex portion 1223 and the concave portion 1224 may be formed in a column or polygonal column shape so as to prevent the separation or flow of each modular fluid chip at the time of mutual coupling.
  • the coupling unit 122 provided in the modular fluid chip 1 may include a fastening part 1225 connectable to another modular fluid chip 2.
  • the coupling unit 122 included in the modular fluid chip 1 has a hook-shaped fastening part 1225 at an end thereof to be coupled with another modular fluid chip 2.
  • a fastening groove 1226 corresponding to the fastening part 1225 provided in the modular fluid chip 1 may be formed in the other modular fluid chip 2.
  • the coupling unit 122 included in the modular fluid chip 1 includes a bolt-shaped fastening part 1225 having threads formed on an outer circumferential surface thereof so as to be coupled with another modular fluid chip 2.
  • a fastening groove 1226 corresponding to the fastening part 1225 provided in the modular fluid chip 1 may be formed in the other modular fluid chip 2.
  • the coupling unit 122 included in the modular fluid chip 1 includes a fastening portion 1225 having a pin shape having a ' ⁇ ' shape and the other modular fluid chip 2. Can be combined.
  • a fastening groove 1226 into which the pin-shaped fastening part 1225 may be inserted may be formed in the modular fluid chip 1 and the other modular fluid chip 2.
  • the coupling unit 122 provided in the modular fluid chip 1 may be coupled to another modular fluid chip 2 through a bolt-shaped coupling part 1225.
  • the modular fluid chip 1 and the other modular fluid chip 2 may be formed with a fastening groove 1226 to which the bolt-shaped fastening part 1225 can be fastened.
  • the modular fluid chip 1 according to the first embodiment of the present invention may further include a cover 13.
  • the cover 13 may be coupled to at least one of the upper and lower portions of the housing 12 along a vertical direction (Z-axis direction) to protect the body 11.
  • the cover 13 may be formed in a shape corresponding to the housing 12, and may be formed of a transparent material so that the body 11 may be identified from the outside when coupled to the housing 12.
  • an optical or electrical cable (not shown) may be mounted inside the cover 13 as necessary.
  • cover 13 and the housing 12 may be further provided with a fastening means 131 for interconnection.
  • each of the cover 13 and the housing 12 may be provided with a coupling portion projecting outward from one surface, and an insertion groove into which the coupling portion provided at the relative position can be inserted.
  • the coupling portion formed in the cover 13 and the coupling portion formed in the housing 12 may be formed in the same or different forms.
  • the fastening means 131 provided in the cover 13 and the housing 12 is not limited thereto, and may be applied to various structures that can be fastened to each other.
  • the present modular fluid chip 1 may be connected to the other modular fluid chip 2 in a vertical direction to implement one fluid flow system 1000.
  • the modular fluid chip 1 is connected to another modular fluid chip 2 along a vertical direction (Z-axis direction) and includes a plurality of fluid flow sections and a fluid analysis section.
  • One fluid flow system 1000 may be implemented.
  • the modular fluid chip 1 is connected to another modular fluid chip 2 along the horizontal direction (X axis direction) and vertical direction (Z axis direction).
  • Other forms of fluid flow system 1000 may be implemented.
  • the second hole 121 provided in the housing 12 of the modular fluid chip 1 may communicate with the second hole 121 provided in the housing 12 of the other modular fluid chip 2. Can be.
  • the modular fluid chip 1 is shown connected to another modular fluid chip 2 only in the X-axis direction, but the modular fluid chip 1 is in the X-axis direction. In addition, it may be connected to another modular fluid chip 2 along the Y-axis direction or along the X- and Y-axis directions.
  • the present modular fluid chip 1 is configured to be connected to other modular fluid chips 2 along the horizontal and vertical directions, thereby generating a flow path of the fluid in various directions.
  • the plurality of modular fluid chips 2 connected to each other to form the fluid flow system 1000 may be connected in quantities ranging from 1 to 10,000 in at least one of a horizontal direction and a vertical direction.
  • the present modular fluid chip 1 connected to another modular fluid chip 2 along the vertical direction (Z-axis direction) is another modular type without the cover 13 being coupled. It can be coupled to the fluid chip (2).
  • the second hole 121 provided in the housing 12 is the second hole 121 provided in the other modular fluid chip 2 disposed above and below the modular fluid chip 1. It may be formed in a structure that can guide the flow of the.
  • the modular fluid chip 1 connected to another modular fluid chip 2 along the vertical direction (Z-axis direction) includes a body 11 and a housing 12. At least one second hole 121 formed in the housing 12 communicates with the first hole 111 formed in the body 11 and is disposed in parallel with the fluid channel 112. It may include a vertical portion 1212 in communication with the horizontal portion 1211 and bent vertically in the housing 12 to communicate with the outer space of the housing 12.
  • the housing 12 may be provided with a plurality of coupling units 122 capable of connecting another modular fluid chip 2 disposed above and below the housing 12 to the modular fluid chip 1. .
  • Each of the plurality of coupling units 122 is formed of a magnetic material having one side of the S pole and the other side of the N pole, and may be installed in the mounting groove 123 provided on the upper and lower surfaces of the housing 12.
  • the plurality of coupling units 122 may be formed with through holes communicating with each of the vertical parts 1212 provided in the housing 12.
  • the through hole may be formed in a shape corresponding to the vertical portion 1212 and may have the same central axis as the vertical portion 1212.
  • the present modular fluid chip when the housing 12 of the present modular fluid chip 1 and the other modular fluid chip 2 are connected in the horizontal or vertical direction, the present modular fluid chip
  • the first hole 111 and the second hole 121 provided in (1) are aligned with and communicate with the first hole 111 and the second hole 121 provided in the other modular fluid chip 2. Can be.
  • the above-described modular fluid chip 1 may be formed in a structure capable of connecting with another modular fluid chip 2 in a state in which the cover 13 is coupled to the housing 12.
  • the cover 13 has an extension hole communicating with the vertical portion 1212 of the second hole 121 formed in the housing 12 and communicating with another modular fluid chip 2. 132 may be formed.
  • housing 12 and the cover 13 each include a plurality of modular fluid chips 2 that can be connected to the modular fluid chip 1 with another modular fluid chip 2 disposed above and below the modular fluid chip 1.
  • Coupling unit 122 may be provided.
  • the plurality of coupling units 122 may be formed of a magnetic material having one side of the S pole and the other side of the N pole, and may be installed in the housing 12 and the cover 13.
  • the plurality of coupling units 122 may include a first magnetic part 1221 provided on the upper and lower surfaces of the housing 12, and an inner surface of each cover 13 coupled to the upper and lower sides of the housing 12. It may include a second magnetic portion 1222 to be installed in.
  • one side of the second magnetic portion 1222 provided on the cover 13 is connected to the first magnetic portion 1221 provided on the housing 12 by magnetic force, and the other side of the second magnetic portion 1222 is another module.
  • the second magnetic part 1222 provided on the cover 13 of the mold fluid chip 2 may be connected by a magnetic force.
  • the housing 12 and the cover 13 may be provided with a mounting groove 123 in which the first magnetic part 1221 and the second magnetic part 1222 are accommodated.
  • first magnetic part 1221 may have a through hole communicating with the vertical part 1212 provided in the housing 12.
  • the through hole formed in the first magnetic part 1221 may be formed in a shape corresponding to the vertical part 1212 and may have the same central axis as the vertical part 1212.
  • the second magnetic part 1222 may have a through hole communicating with the extension hole 132 provided in the cover 13.
  • the through hole formed in the second magnetic part 1222 may have a shape corresponding to the extension hole 132 and may have the same central axis as the extension hole 132.
  • cover 13 coupled to the upper side of the housing 12 and the cover 13 coupled to the lower side of the housing 12 have other modular fluid chips connected to the upper side and the lower side of the present modular fluid chip 1.
  • a coupling structure that can be combined with (2) may be further provided.
  • the cover 13 disposed on the upper side of the housing 12 is formed with a protrusion 133 that can be engaged with the groove 134 provided in the other modular fluid chip 2, and the lower side of the housing 120.
  • the cover 13 may be formed with a groove portion 134 that can be coupled to the protrusion 133 provided in the other modular fluid chip 2.
  • the protrusion 133 and the groove portion 134 correspond to each other. It may be formed in a shape.
  • the magnetic coupling type unit 122 may be installed on the outside of the cover 13. Can be.
  • the coupling unit 122 in the form of a magnetic body is formed in the form of a tablet (tablet) as shown in (a) of Figure 14a, or is formed in the form of a panel (panel) as shown in (b) of Figure 14a It may be installed on the outer surface of the cover 13.
  • a seating groove 123 in which the coupling unit 122 may be seated may be formed on the outer surface of the cover 13.
  • the modular fluid chip 1 connected to another modular fluid chip 2 along the vertical direction (Z-axis direction) includes a fluid channel 112 formed in the body 11. It may be formed of a structure capable of guiding the flow of the fluid to the fluid channel 112 of the other modular fluid chip (2) disposed above and below the modular fluid chip (1).
  • the modular fluid chip 1 connected to another modular fluid chip 2 along the vertical direction (Z-axis direction) includes a body 11 and a housing 12.
  • the fluid channel 112 formed in the body 11 may include a horizontal part 1121 disposed in parallel to the second hole 121 formed in the housing 12, and one side and the other end of the horizontal part 1121. It may include a vertical portion 1122 which is in communication with the upper portion and vertically bent toward the lower side in communication with the external space.
  • the body 11 may be provided with a plurality of coupling units 122 capable of connecting another modular fluid chip 2 disposed above and below the housing 12 to the present modular fluid chip 1. .
  • Each of the plurality of coupling units 122 is formed of a magnetic material having one side of the S pole and the other side of the N pole, and may be installed in the mounting groove 113 provided on the upper and lower surfaces of the body 11.
  • the plurality of coupling units 122 may be formed with through holes communicating with each vertical portion 1122 provided in the body 11.
  • the through hole may be formed in a shape corresponding to the vertical portion 1122, and may have the same central axis as the vertical portion 1122.
  • the present modular fluid chip 1 when the housing 12 of the present modular fluid chip 1 and the other modular fluid chip 2 are connected in the horizontal or vertical direction, the present modular fluid chip 1
  • the fluid channel 112 provided in the body 11 of the may be aligned with and in communication with the fluid channel 112 provided in the other modular fluid chip 2.
  • the above-described modular fluid chip 1 may be formed in a structure capable of connecting with another modular fluid chip 2 in a state in which the cover 13 is coupled to the housing 12.
  • the cover 13 has an extension hole communicating with the vertical portion 1122 of the fluid channel 112 provided in the body 11 and communicating with another modular fluid chip 2.
  • 132 may be formed.
  • the body 11 and the cover 13 each have a plurality of modular fluid chips 2 which are arranged above and below the modular fluid chip 1, which can be connected to the modular fluid chip 1.
  • Coupling unit 122 may be provided.
  • the plurality of coupling units 122 may be formed of a magnetic material having one side of the S pole and the other side of the N pole, and may be installed on the body 11 and the cover 13.
  • the plurality of coupling units 122 may include a first magnetic part 1221 provided on the top and bottom surfaces of the body 11, a second magnetic part 1222 installed on the outer surface of each cover 13, and an angle. It may include a third magnetic portion 1227 installed on the inner surface of the cover 13.
  • the third magnetic part 1227 installed on the inner surface of the cover 13 is connected to the first magnetic part 1221 provided on the body 11 by magnetic force
  • 1222 may be connected to the second magnetic portion 1222 provided on the cover 13 of the other modular fluid chip 2 by magnetic force.
  • the body 11 is provided with a seating groove 113 in which the first magnetic part 1221 is seated, and the cover 13 is seated in which the second magnetic part 1222 and the third magnetic part 1227 are seated. Grooves 135 may be formed.
  • the first magnetic part 1221 may have a through hole communicating with the vertical part 1122 of the fluid channel 112 provided in the body 11.
  • the through hole formed in the first magnetic part 1221 may be formed in a shape corresponding to the vertical part 1122 and may have the same central axis as the vertical part 1122.
  • the second magnetic part 1222 and the third magnetic part 1227 may have a through hole communicating with the extension hole 132 provided in the cover 13.
  • the through holes formed in the second magnetic part 1222 and the third magnetic part 1227 may be formed in a shape corresponding to the extension hole 132 and may have the same central axis as the extension hole 132.
  • a coupling unit 122 in the form of a magnetic body is formed on the upper and lower surfaces of the housing 12. More can be installed.
  • the coupling unit 122 in the form of a magnetic body is formed in the form of a tablet (tablet) as shown in (a) of Figure 14b, or is formed in the form of a panel (panel) as shown in (b) of Figure 14b It may be installed on the upper and lower surfaces of the housing 12.
  • a mounting groove 123 in which the coupling unit 122 may be seated may be formed on the upper and lower surfaces of the housing 12.
  • the modular fluid chip 1 may further include an image capturing unit 14, a light source 15, and a temperature controller 16.
  • the modular fluid chip 1 is disposed on the cover 13 to capture an entirety or a part of a channel through which a fluid flows, and an imaging unit 14, and a housing 12 or a cover ( 13 may further include a light source 15 for irradiating predetermined light to the channel side.
  • the modular fluid chip 1 may be installed in the housing 12 or the cover 13 to heat or cool the body 11 to a predetermined temperature. It may further include.
  • the temperature controller 16 may be applied as a Peltier device or a resistance device.
  • the temperature controller 16 may be formed in a channel structure that directly supplies a gas or air having a predetermined temperature to the channel.
  • the temperature controller 16 is not necessarily limited thereto, and may be changed and applied to various structures and shapes.
  • the modular fluid chip 1 may further include a gas supply unit (not shown) and a circulator (not shown).
  • the gas supply part supplies the gas at the set temperature to the gap between the body 11 and the housing 12 or the body 11 and the cover 13, or supplies the gas at the set temperature to the inside of the body 11 so that the body ( 11) can be heated or cooled to a preset temperature.
  • the circulator is connected to the first hole 111 of the body 11 and transmits pressure to the first hole 111 and the fluid channel 112 by using a pressure difference through a pumping action, thereby working the fluid. It can move stably in the direction.
  • each configuration for describing the modular fluid chip 1 according to the second embodiment of the present invention is used for the convenience of description while explaining the modular fluid chip 1 according to the first embodiment of the present invention.
  • the same reference numerals are used, and the same or redundant descriptions will be omitted.
  • the modular fluid chip 1 according to the second embodiment of the present invention includes a body 11.
  • the body 11 is formed with at least one first hole 111 to guide the flow of the fluid.
  • the first hole 111 is in communication with the fluid channel 112 formed inside the body 11 and the third hole 171 formed in the fluid connecting member 17 to be described later. Guide the flow of fluid in at least one direction.
  • the first hole 111 may be formed in a shape corresponding to the third hole 171 formed in the fluid connector 17 and the fluid channel 112 provided in the body 11.
  • fluid channel 112 may be formed in the body 11.
  • the fluid channel 112 may be in communication with the at least one first hole 111 to enable flow of the fluid.
  • the fluid channel 112 may be configured to guide the flow of the fluid in various directions as well as to perform one preset function for the fluid in flow.
  • the modular fluid chip 1 according to the second embodiment of the present invention includes a housing 12.
  • the housing 12 is configured to receive the body 11 and the fluid connection 17 therein.
  • the housing 12 also includes a coupling unit 122.
  • Coupling unit 122 may be configured to couple the present modular fluid chip 1 to another modular fluid chip 2 along the horizontal direction (X-axis and Y-axis directions).
  • the coupling unit 122 is accommodated in the housing 12 or integrally provided in the housing 12 so that the modular fluid chip 1 viewed along the horizontal direction (X-axis and Y-axis directions) can be replaced with other modules.
  • the present modular fluid chip 1 can be automatically aligned and fixed to the other modular fluid chip 2.
  • the coupling unit 122 may include a magnetic material.
  • the coupling unit 122 is made of a magnetic material having one side of the S pole and the other side of the N pole, and may be installed inside or outside the housing 12.
  • the coupling unit 122 may be formed in a structure that can be directly connected to the coupling unit 122 provided in the other modular fluid chip (2).
  • the coupling unit 122 included in the modular fluid chip 1 and the coupling unit 122 of the other modular fluid chip 2 corresponding thereto may have convex portions 1223 or corresponding to each other. It may include a recess 1224.
  • the coupling unit 122 included in the modular fluid chip 1 has a hook-shaped fastening part 1225 at an end thereof to be coupled with another modular fluid chip 2.
  • a fastening groove 1226 corresponding to the fastening part 1225 provided in the modular fluid chip 1 may be formed in the other modular fluid chip 2.
  • the coupling unit 122 included in the modular fluid chip 1 includes a bolt-shaped fastening part 1225 having threads formed on an outer circumferential surface thereof so as to be coupled with another modular fluid chip 2.
  • a fastening groove 1226 corresponding to the fastening part 1225 provided in the modular fluid chip 1 may be formed in the other modular fluid chip 2.
  • the coupling unit 122 included in the modular fluid chip 1 includes a fastening portion 1225 having a pin shape having a ' ⁇ ' shape and the other modular fluid chip 2. Can be combined.
  • a fastening groove 1226 into which the pin-shaped fastening part 1225 may be inserted may be formed in the modular fluid chip 1 and the other modular fluid chip 2.
  • the coupling unit 122 provided in the modular fluid chip 1 may be coupled to another modular fluid chip 2 through a bolt-shaped coupling part 1225.
  • the modular fluid chip 1 and the other modular fluid chip 2 may be formed with a fastening groove 1226 to which the bolt-shaped fastening part 1225 can be fastened.
  • the modular fluid chip 1 according to the second embodiment of the present invention includes a fluid connection 17.
  • the fluid connector 17 may be formed in the form of a sheet or pad, and may be detachably installed in the housing 12.
  • the housing 12 may be formed with a seating groove 123 to accommodate the fluid connector 17.
  • a third hole 171 that is aligned with the first hole 111 may be formed in the fluid connector 17.
  • fluid connection 17 may be configured to form an interface upon contact with the other fluid connection 17.
  • the fluid connector 17 is formed of an elastomeric material that can be elastically deformed to form an interface at a contact portion upon contact with another fluid connector 17 provided in another modular fluid chip 2. can do.
  • one surface of the fluid connector 17 may be provided with a pressure-sensitive adhesive layer on one surface of the other fluid connector 17 when contacted with the other fluid connector 17.
  • the fluid connector 17 is not limited thereto, and may be changed and applied to various forms or various materials within the conditions capable of performing the same function.
  • the fluid connector 17 may be integrally provided on the outer surface of the housing 12 through heterogeneous injection when the housing 12 is manufactured, and has a circular or polygonal ring shape in which a hole is formed in a central portion thereof. Or it may be formed in a plate-shaped stopper shape.
  • the fluid connector 17 may be made of at least one of a polymer resin, an amorphous material, and a metal, and may be chlorinated polyethylene, ethylene propylene dimethyl, silicone rubber, acrylic resin, amide resin, epoxy resin, phenol resin, It may include at least one of polyester resin, polyethylene resin, ethylene-propylene rubber, polyvinyl butyral resin, polyurethane resin and nitrile-butadiene rubber.
  • the fluid connection 17 provided in the modular fluid chip 1 is connected to the other modular fluid chip 2. It is in close contact with the provided fluid connector 17 to form an interface, through which the connection between the modular fluid chip 1 and the other modular fluid chip 2 can be completely airtight to prevent leakage of fluid. .
  • the fluid connection 17 may be disposed on at least one of an outer side and an inner side of the housing 12.
  • the fluid connector 17 disposed outside the housing 12 may be in close contact with the other fluid connector 17 to form an interface, and the fluid connector disposed inside the housing 12 may be formed in an interface. 17 may be in close contact with the body 11 to form an interface.
  • the fluid connection 17 may be formed in a structure that can be coupled to the housing 12.
  • a protruding portion 173 may be formed on the fluid connector 17 to protrude a predetermined length from an outer surface and to be inserted into a seating groove 123 formed in the housing 12. Accordingly, the fluid connector 17 is more stably coupled to the housing 12, thereby restricting the flow, and even when the present modular fluid chip 1 is coupled with another modular fluid chip 2, Deviation from the housing 12 can be prevented.
  • the fluid connection 17 may be formed in the groove-shaped recessed portion is recessed from the outer surface to be coupled to the projection formed in the housing 12.
  • the coupling structure provided in the fluid connector 17 is not necessarily limited thereto, and may be changed and applied to various shapes.
  • fluid connector 17 may be in direct communication with the body 11 to be connected to another modular fluid chip 2.
  • the fluid connector 17 may be accommodated in the housing 12 and may be in close contact with the outer surface of the body 11 through the housing 12. Accordingly, the third hole 171 provided in the fluid connector 17 directly communicates with the first hole 111 provided in the body 11 to allow the flow of the fluid.
  • the fluid connecting member 17 installed through the housing 12 is in close contact with the fluid connecting member 17 of the other modular fluid chip 2 on one side to form an interface, and the body 11 on the other side. As it forms an interface in close contact with the outer surface of the), it is possible to minimize the point at which the fluid can leak, thereby enabling a stable flow of the fluid.
  • the fluid connector 17 may be seated in a seating groove 123 formed on the outer surface of the housing 12 and connected to another modular fluid chip 2, and one surface of the seating portion 172. It may include a convex portion 173 protruding from the predetermined length from the through to the housing 12, and in close contact with the outer surface of the body 11 to form an interface.
  • the inner surface of the housing 12 may be provided with a recess 1231 formed in a shape corresponding to the outer surface of the convex portion 173 to support the convex portion 173.
  • the fluid connection 17 is in direct communication with the body 11, it may be formed in a plurality of divided structures.
  • the fluid connector 17 may include a seating portion 172, a convex portion 173, and an O-ring.
  • the seating portion 172 may be seated in a seating groove 123 formed on the outer surface of the housing 12 and may be in close contact with another modular fluid chip 2 to form an interface.
  • the convex portion 173 may be separated from the seating portion 172 and accommodated in the concave portion 1231 provided inside the housing 12, and may be in close contact with the outer surface of the body 11 to form an interface.
  • the O-ring 174 is disposed between the seating portion 172 and the convex portion 173 to connect the seating portion 172 and the convex portion 173 to each other, and the present modular fluid chip 1 and the other modular fluid chip.
  • the O-ring 174 is formed of an elastic body, a plastic, or a metallic material, and another hole communicating with the third hole 171 formed in the seating portion 172 and the convex portion 173 is formed inside the O-ring 174. Can be formed.
  • fluid connection 17 is not necessarily limited thereto and may be modified and applied in various forms.
  • each configuration for describing the modular fluid chip 1 according to the third embodiment of the present invention is used for the convenience of description while explaining the modular fluid chip 1 according to the first embodiment of the present invention.
  • the same reference numerals are used, and the same or redundant descriptions will be omitted.
  • the modular fluid chip 1 according to the third embodiment of the present invention includes a body 11.
  • the body 11 is formed with at least one first hole 111 to guide the flow of the fluid.
  • the first hole 111 communicates with the second hole 121 of the housing 12, which will be described later, and the fluid channel 112, which will be described later, formed inside the body 11.
  • the first hole 111 may be formed in a shape corresponding to the second hole 121 provided in the housing 12 and the fluid channel 112 provided in the body 11.
  • fluid channel 112 may be formed in the body 11.
  • the fluid channel 112 may be in communication with the at least one first hole 111 to enable flow of the fluid.
  • the fluid channel 112 may be configured to guide the flow of the fluid in various directions as well as to perform one preset function for the fluid in flow.
  • the modular fluid chip 1 according to the third embodiment of the present invention includes a housing 12.
  • the housing 12 is formed in a frame structure in which an accommodating space is formed, and is configured to accommodate the body 11 therein.
  • the second hole 121 enables fluid to flow in correspondence with at least one first hole 111 provided in the body 11. ) Is formed.
  • the housing 12 also includes a fluid connection 17.
  • the fluid connection 17 is configured to connect the present modular fluid chip 1 with another modular fluid chip 2.
  • the fluid connector 17 may be formed in a sheet or pad form and may be detachably installed on the outer surface of the housing 12.
  • a seating groove 123 corresponding to the fluid connector 17 may be formed on the outer surface of the housing 12 to allow the fluid connector 17 to be seated thereon.
  • a third hole 171 may be formed in the fluid connector 17 to correspond to the first hole 111 and the second hole 121.
  • the fluid connection 17 may be configured to form an interface upon contact with the other fluid connection 17.
  • the fluid connector 17 may be formed of an elastomeric material that is elastically deformable to form an interface at a contact portion when contacting the other fluid connector 17.
  • one surface of the fluid connector 17 may be provided with a pressure-sensitive adhesive layer on one surface of the other fluid connector 17 when contacted with the other fluid connector 17.
  • the fluid connector 17 is not limited thereto, and may be changed and applied to various forms or various materials within the conditions capable of performing the same function.
  • the fluid connector 17 may be integrally provided on the outer surface of the housing 12 through heterogeneous injection when the housing 12 is manufactured, and has a circular or polygonal ring shape in which a hole is formed in a central portion thereof. Or it may be formed in a plate-shaped stopper shape.
  • the fluid connector 17 may be made of at least one of a polymer resin, an amorphous material, and a metal, and may be chlorinated polyethylene, ethylene propylene dimethyl, silicone rubber, acrylic resin, amide resin, epoxy resin, phenol resin, It may include at least one of polyester resin, polyethylene resin, ethylene-propylene rubber, polyvinyl butyral resin, polyurethane resin and nitrile-butadiene rubber.
  • the fluid connection 17 provided in the present modular fluid chip 1 is a different modular fluid. It is in close contact with the fluid connector 17 provided in the chip 2 to form an interface, through which the connection between the modular fluid chip 1 and the other modular fluid chip 2 is completely hermetically sealed. Leakage can be blocked.
  • the coupling unit to be described later having a magnetic to maximize the adhesion of the fluid connector 17 on the inner surface of each housing 12 provided in the modular fluid chip 1 and the other modular fluid chip 2 122 may be further disposed.
  • the fluid connection 17 may be disposed on at least one of an outer side and an inner side of the housing 12.
  • the fluid connector 17 disposed outside the housing 12 may be in close contact with the other fluid connector 17 to form an interface, and the fluid connector disposed inside the housing 12 may be provided. 17 may be in close contact with the body 11 to form an interface.
  • the fluid connection 17 may be formed in a structure that can be coupled to the housing 12.
  • a protruding portion 173 may be formed in the fluid connector 17 to protrude a predetermined length from an outer surface and to be inserted into a seating groove 123 formed in the housing 12.
  • the fluid connection 17 may be formed in the groove-shaped recessed portion is recessed from the outer surface to be coupled to the projection formed in the housing 12.
  • the coupling structure provided in the fluid connector 17 is not necessarily limited thereto, and may be changed and applied to various shapes.
  • fluid connector 17 may be in direct communication with the body 11 to be connected to another modular fluid chip 2.
  • the fluid connector 17 may be accommodated in the housing 12 and may be in close contact with the outer surface of the body 11 through the housing 12. Accordingly, the third hole 171 provided in the fluid connector 17 directly communicates with the first hole 111 provided in the body 11 to allow the flow of the fluid.
  • the fluid connecting member 17 installed through the housing 12 is in close contact with the fluid connecting member 17 of the other modular fluid chip 2 on one side to form an interface, and the body 11 on the other side. As it forms an interface in close contact with the outer surface of the), it is possible to minimize the point at which the fluid can leak, thereby enabling a stable flow of the fluid.
  • the fluid connection 17 is in direct communication with the body 11, it may be formed in a plurality of divided structures.
  • the fluid connector 17 may include a seating portion 172, a convex portion 173, and an O-ring.
  • the seating portion 172 may be seated in a seating groove 123 formed on the outer surface of the housing 12 and may be in close contact with another modular fluid chip 2 to form an interface.
  • the convex portion 173 may be separated from the seating portion 172 and accommodated in the concave portion 1231 provided inside the housing 12, and may be in close contact with the outer surface of the body 11 to form an interface.
  • the O-ring 174 is disposed between the seating portion 172 and the convex portion 173 to connect the seating portion 172 and the convex portion 173 to each other, and the present modular fluid chip 1 and the other modular fluid chip.
  • the modular fluid chip 1 according to the third embodiment of the present invention may further include at least one sensor 18.
  • At least one sensor 18 is installed inside the body 11 in which the fluid channel 112 is formed, is connected to the fluid channel 112 through a microchannel, and the fluid is connected to the fluid channel 112. When is flowing, it is possible to detect a signal generated from the fluid.
  • the at least one sensor 18 may be configured to detect at least one of an electrical signal, a fluorescence signal, an optical signal, an electrochemical signal, a chemical signal, and a spectroscopy signal.
  • the at least one sensor 18 may be formed of any one material of a metal, an organic-inorganic composite, and an organic conductor.
  • the at least one sensor 18 includes at least one of Au, Mg, Ti, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, Al, Zr, Nb, Mo, Ru, Ag, and Sn.
  • a metal electrode containing one material or formed of an organic electrode containing at least one material of the conductive polymer and carbon, or at least one of the materials constituting the metal electrode and the material constituting the organic electrode
  • At least one material may be formed of a mixed organic-inorganic composite electrode.
  • the at least one sensor 18 may be formed of a material having transparency to detect at least one of a fluorescence signal, an optical signal, and a spectroscopy signal.
  • the at least one sensor 18 is an electrode installed inside the body 11 and connected to the fluid channel 112, as shown in FIG. 33A, and electrically connected to and external to the electrode. It can include a USB port that can be connected to a USB connector.
  • the fixing pin and the external connection device may be connected to each other, and may include a connection line (CONTACT LINE) for transmitting a signal sensed through the fixing pin to the external connection device.
  • CONTACT LINE connection line
  • the at least one sensor 18 is not limited thereto, and may be changed and applied in various forms.
  • each configuration for describing the modular fluid chip 1 according to the fourth embodiment of the present invention is used for the convenience of description while describing the modular fluid chip 1 according to the first embodiment of the present invention.
  • the same reference numerals are used, and the same or redundant descriptions will be omitted.
  • the modular fluid chip 1 according to the fourth embodiment of the present invention includes a housing 12.
  • the housing 12 is formed in a frame structure in which an accommodation space is formed, and is configured to accommodate the body 11 to be described later.
  • the housing 12 is configured to communicate the body 11 accommodated inside with the body 11 provided in the other modular fluid chip 2.
  • the housing 12 may be composed of a plurality of parts that can be divided and assembled.
  • the housing 12 has a lower part configured to support the lower surface of the body 11 and an upper part configured to support the circumferential surface of the body 11 coupled to the lower part and exposed to the outside of the lower part. It can be configured as.
  • the lower body may be formed with a receiving groove for receiving the lower side of the body 11
  • the upper body may be formed through holes for exposing the upper surface of the body 11 to the outer space.
  • the plurality of parts constituting the housing 12 may be coupled to each other using magnetic.
  • a magnetic material that can be coupled to each other may be provided on an upper surface of the lower part and a lower surface of the upper part corresponding thereto.
  • the plurality of parts are not necessarily coupled using magnetism, and may be coupled to each other through various coupling methods.
  • the modular fluid chip 1 according to the fourth embodiment of the present invention includes a coupling portion 122.
  • the coupling part 122 is provided in the housing 12 and is configured to couple the present modular fluid chip 1 with another modular fluid chip 2.
  • Coupling portion 122 may be formed in a form that can connect the present modular fluid chip 1 to the other modular fluid chip (2) in various directions and at various angles.
  • the coupling part 122 includes at least one protrusion 1223 protruding from the outer surface of the housing 12, and at least one receiving groove 1224 provided at the outer surface of the housing 12. It may include.
  • the at least one protrusion 1223 and the at least one receiving groove 1224 may be formed in a shape corresponding to each other, and may be alternately arranged along the circumference of the housing 12.
  • the protrusion 1223 and the receiving groove 1224 provided on one surface of the housing 12 may be disposed at positions symmetrical with each other along a horizontal or vertical direction.
  • the protrusions 1223 and the receiving grooves 1224 provided on one surface of the housing 12 may be provided in plural numbers, and may be disposed at equal intervals in a horizontal or vertical direction.
  • the plurality of protrusions 1223 and the receiving grooves 1224 provided on one surface of the housing 12 may be alternately arranged along the arrangement direction, or may be arranged in a state separated by types.
  • the protrusion 1223 and the receiving groove 1224 are not necessarily limited thereto, and may be changed and applied in various forms.
  • the at least one protrusion 1223 and the at least one receiving groove 1224 provided in the modular fluid chip 1 may include the protrusions 1223 and the receiving groove 1224 provided in the other modular fluid chip 2. When combined with, it may be configured to align the projection 1223 and the receiving groove 1224 provided in the other modular fluid chip (2).
  • At least one protrusion 1223 and at least one receiving groove 1224 inclined surface for guiding the projection 1223 and the receiving groove 1224 provided in the other modular fluid chip 2 to a predetermined position. 122a may be formed.
  • the inclined surface 122a may be formed at the ends of the protrusion 1223 and the receiving groove 1224.
  • the coupling part 122 may further include a plurality of magnetic members 1221.
  • the plurality of magnetic members 1221 may be formed of a magnetic material having one side of an S pole and the other side of an N pole, and may be disposed inside the housing 12.
  • the plurality of magnetic members 1221 may be disposed inside the protrusion 1223 and the receiving groove 1224 provided in the housing 12.
  • the magnetic member 1221 disposed inside the protrusion 1223 has the same central axis as the protrusion 1223
  • the magnetic member 1221 disposed inside the receiving groove 1224 is the same as the receiving groove 1224. It may have a central axis.
  • the magnetic member 1221 disposed inside the protrusion 1223 and the magnetic member 1221 disposed inside the receiving groove 1224 have a polarity direction in consideration of coupling with another modular fluid chip 2. These may be arranged to be opposite to each other.
  • the present modular fluid chip 1 and another modular fluid chip 2 are connected, the present modular fluid chip 1 and the other modular fluid chip 2 are connected to the present modular fluid chip 1 and Through the binding force of the magnetic members 1221 provided in the other modular fluid chip (2) can be maintained in close contact with each other.
  • the plurality of magnetic members 1221 are not necessarily disposed inside the protrusions 1223 and the receiving grooves 1224 provided in the housing 12, and may be disposed at various positions as necessary.
  • a plurality of magnetic members 1221 may be installed on the outer surface of the housing 12 along the circumference of the housing 12, and may be disposed at different positions from the protrusion 1223 and the receiving groove 1224. .
  • the plurality of magnetic members 1221 are disposed inside the protrusion 1223 and the receiving groove 1224 provided in the housing 12, as well as the protrusion 1223 and the receiving groove 1224. It may be arranged in a different position than).
  • the coupling part 122 may further include a shielding member 124.
  • the shielding member 124 may be disposed on one side of the magnetic member 1221 to block the magnetic force of the magnetic member 1221.
  • the shielding member 124 may affect the magnetic force of the magnetic member 1221 acting toward the flow path 112 to reduce the magnetic force or block the magnetic force. Accordingly, it is possible to prevent the abnormality in the flow of the fluid by the magnetic force or the abnormality in the function of the modular fluid chip 1.
  • the shielding member 124 may be made of a conductive material or a magnetic material.
  • the shielding member 124 may be formed of an alloy using iron, nickel, chromium, and copper.
  • the shielding member 124 is not limited thereto and may be changed and applied to various materials or structures capable of performing the same function.
  • the coupling part 122 may further include a tightening part 160.
  • the fasteners 160 are installed in the housing 12 of the present modular fluid chip 1 and the housing 12 of the other modular fluid chip 2, respectively, and have a separate tool. It is coupled to each other through the modular fluid chip 1 and the other modular fluid chip 2 can be in close contact.
  • the tightening unit 160 may convert the rotational motion into a linear motion to bring the modular fluid chip 1 into close contact with another modular fluid chip 2.
  • the fastener 160 installed in the other modular fluid chip 2 performs a rotary motion through a tool and is coupled to the fastener 160 installed in the other modular fluid chip 2.
  • the tightening unit 160 installed in the modular fluid chip 1 performs the linear motion through the tightening unit 160 of the other modular fluid chip 2 which performs the rotational movement. Can be moved to the other modular fluid chip 2 side.
  • the tightening unit 160 may include a shaft portion 161 and a cam portion 162.
  • the shaft portion 161 may be formed in a rod shape having a preset length.
  • One side of the shaft portion 161 is provided with a fastening portion 1611 that can be fastened to the housing 12 of the modular fluid chip 1 (or the housing 12 of the other modular fluid chip 2),
  • the other side of the shaft portion 161 may be provided with a projection 1616 of the projection shape.
  • the cam part 162 is installed in another modular fluid chip 2 (or the housing 12 of this modular fluid chip 1), accommodates the catching part 1612 inward, and external force by a tool.
  • the locking portion 1612 may be linearly moved along the axial direction by pressing the locking portion 1612 accommodated in the circumferential direction while rotating along the circumferential direction.
  • the housing 12 of the other modular fluid chip 2 communicates with the space in which the cam portion 162 is accommodated, and communicates with the first insertion hole into which the shaft portion 161 can be inserted and the space in which the cam portion 162 is accommodated.
  • a second insertion hole into which the tool can be inserted may be formed.
  • the tightening unit 160 is a modular fluid chip viewed through the cam portion 162 performing a rotational movement through a tool and the shaft portion 161 performing a linear movement by the rotational movement of the cam portion 162. (1) and the other modular fluid chip 2 can be combined more firmly.
  • the modular fluid chip 1 according to the fourth embodiment of the present invention may further include a body 11.
  • the body 11 may be formed in a replaceable module shape and accommodated inside the housing 12. Therefore, the body 11 can be selectively replaced as needed.
  • At least one flow path 112 may be formed inside the body 11 to guide the flow of the fluid in various directions.
  • the flow path 112 is aligned with the flow path 112 provided in the other modular fluid chip when the housing 12 is connected to another modular fluid chip 2 and the flow path 112 provided in the other modular fluid chip. Can be communicated.
  • the body 11 is not necessarily formed with only the flow path 112, and may be provided with various functional units as necessary.
  • the body 11 may be provided with various functional units such as a quantitative chamber, a gene extraction chamber, a waste chamber, a mixing chamber, a buffer chamber, a valve, and the like.
  • the present modular fluid chip 1 may perform various functions such as not only guiding the flow of the fluid, but also mixing or dispensing the fluid.
  • a coating layer may be further formed in the flow path 112 of the modular fluid chip 1.
  • a coating layer of hydrophobic or hydrophilic material may be further formed in the flow path 112 of the modular fluid chip 1.
  • the type of the coating layer described above may be selectively applied to the present modular fluid chip 1 according to the type of the fluid, thereby improving the flow performance of the fluid.
  • the coating layer is not necessarily formed only in the flow path 112, and may be further formed in various functional parts such as a quantitative chamber, a gene extraction chamber, a waste chamber, a mixing chamber, a buffer chamber, a valve, and the like as necessary.
  • each configuration for explaining the modular fluid chip 1 according to the fifth embodiment of the present invention for convenience of description the modular fluid chip 1 according to the first and fourth embodiments of the present invention
  • the same reference numerals are used to describe the same reference numerals, and the same or redundant descriptions will be omitted.
  • the modular fluid chip 1 according to the fifth embodiment of the present invention includes a connecting member 17.
  • the connecting member 17 is connected to the connecting member 17 provided in the other modular fluid chip 2 so that the at least one flow path 112 provided in the modular fluid chip 1 is connected to another modular fluid chip ( It can communicate with the flow path 112 provided in the body 11 of 2).
  • connection member 17 may be formed in a tube shape having a flow path therein, and may be detachably installed on an outer surface of the body 11 to be described later.
  • the outer surface of the body 11 may be in communication with the flow path 112 provided in the body 11 may be formed with a coupling groove 113 into which a part of the connecting member 17 can be inserted. Therefore, when the connection member 17 is inserted into the coupling groove 113, the flow path provided in the connection member 17 may be aligned with the flow path 112 provided in the body 11 to communicate with each other.
  • the coupling groove 113 may be formed in a shape corresponding to the outer surface of the connection member 17.
  • connection member 17 may be accommodated and supported in the housing 12 to be described later.
  • the housing 12 may correspond to the outer surface of the connecting member 17, the receiving groove for supporting the outer surface of the connecting member 17 may be formed.
  • connection member 17 may be configured to form an interface at the contact portion when contacting the body 11 and the other connection member 17.
  • connection member 17 may be formed of an elastomeric material that is elastically deformable to form an interface at the contact portion when contacting the body 11 and the other connection member 17.
  • one side and the other side of the connection member 17 may be provided with an adhesive layer.
  • the connecting member 17 is not limited thereto, and may be changed and applied to various forms or various materials within the conditions capable of performing the same function.
  • the connecting member 17 may be integrally formed on the outer surface of the body 11 through heterogeneous injection to form an interface only on one side when the body 11 is manufactured.
  • the connecting member 17 may be made of at least one of a polymer resin, an amorphous material, and a metal, and may be chlorinated polyethylene, ethylene propylene dimethyl, silicone rubber, acrylic resin, amide resin, epoxy resin, phenol resin, poly It may include at least one of ester resin, polyethylene resin, ethylene-propylene rubber, polyvinyl butyral resin, polyurethane resin and nitrile-butadiene rubber.
  • connection member 17 is in close contact with the body 11 to form an interface
  • the other side of the connection member 17 is in close contact with the connection member 17 provided in the other modular fluid chip 2 and is interfaced.
  • connecting member 17 may be configured to directly connect the present modular fluid chip 1 with another modular fluid chip 2.
  • the connecting member 17 coupled to the body 11 of the modular fluid chip 1 does not go through the connecting member 17 provided in the other modular fluid chip 2, and the other module is not connected to the module 11. It can be directly coupled to the body 11 of the mold fluid chip 2.
  • connection member 17 is in close contact with the body 11 of the modular fluid chip 1 to form an interface
  • the other side of the connection member 17 is the body of the other modular fluid chip 2 ( 11) by close contact to form an interface, it is possible to minimize the leakage point of the fluid.
  • connecting member 17 may be configured to limit the flow in the axial direction when accommodated in the housing 12.
  • the connecting member 17 may include a flange portion 17a that protrudes radially from the outer surface and is supported on the inner surface of the housing 12.
  • the housing 12 may be formed with a flange receiving groove 122b for receiving and supporting the flange portion 17a to limit the flow of the connecting member 17 in the axial direction of the connecting member 17.
  • the flange receiving groove 122b may be formed in a shape corresponding to the flange portion 17a.
  • the flange portion 17a is supported on the inner surface of the housing 12 to fix the connecting member 17 at a predetermined position. You can.
  • connection member 17 may be formed in a structure that can minimize the deformation in the axial direction when coupled with the connection member 17 provided in the other modular fluid chip (2).
  • connection member 17 may include a plurality of bodies made of different materials.
  • connection member 17 may include a first body 17b and a second body 17c having different materials.
  • the first body 17b may have a hollow tube shape so as to be in communication with the flow path 112 provided in the body 11.
  • the second body 17c may be coupled to surround the circumference of the first body 17b.
  • the second body 17c may be formed of a material having a higher hardness than the first body 17b.
  • the first body 17b may be formed of an elastic material
  • the second body 17c may be formed of an elastic body having a higher hardness than the first body 17b, or a material such as metal or plastic.
  • the second body 17c is not necessarily limited thereto, and may be applied to various materials.
  • the first body 17b and the second body 17c may be separately manufactured and combined with each other, or may be integrally manufactured through heterogeneous injection.
  • the present modular fluid chip 1 and the other modular fluid chip 2 are coupled to each other and a load is applied to the connecting member 17 in the axial direction, the first body (via the second body 17c) It is possible to minimize the deformation of the 17b), through which the fluid can be stably passed by minimizing the deformation of the flow path provided in the connecting member 17.
  • inclined surfaces 17d may be formed at both ends of the connection member 17.
  • the connecting member 17 when the connecting member 17 is inserted into the coupling groove 113 of the body 11, the edge of the end of the connecting member 17 is prevented from contacting the inner surface of the body 11, thereby, the connection Insertion of the member 17 can be made easy.
  • the connecting member 17 is The modular fluid chip 1 and the other modular fluid chip 2 may be completely in close contact with each other by being compressed in the coupling groove 113 to fill the free space.
  • the modular fluid chip 1 according to the fifth embodiment of the present invention may further include a body (11).
  • the body 11 may be formed in a replaceable module shape and accommodated inside the housing 12 to be described later.
  • at least one flow path 112 may be formed inside the body 11 to guide the flow of the fluid in various directions.
  • the body 11 is not necessarily formed with only the flow path 112, and may be provided with various functional units as necessary.
  • the body 11 may be provided with various functional units such as a quantitative chamber, a gene extraction chamber, a waste chamber, a mixing chamber, a buffer chamber, a valve, and the like.
  • the body 11 may be formed of at least one of an amorphous material such as glass, wood, a polymer resin, a metal, and an elastomer, or a combination thereof.
  • an amorphous material such as glass, wood, a polymer resin, a metal, and an elastomer, or a combination thereof.
  • the body 11 may be connected to another modular fluid chip 2 through the aforementioned connection member 17.
  • the body 11 may be provided with a coupling groove 113 communicating with at least one flow path 112 and into which a part of the connection member 17 is inserted. Accordingly, the connection member 17 may communicate with at least one flow path 112 provided in the body 11 through the coupling groove 113.
  • the flow path 112 provided in the body 11 and the flow path provided in the connecting member 17 are different from each other. It may be aligned with the flow path 112 provided in the fluid chip.
  • the modular fluid chip 1 according to the fifth embodiment of the present invention may further include a housing 12.
  • the housing 12 may be formed in a frame structure in which an accommodation space is formed, to accommodate the body 11 and the connection member 17 therein.
  • the housing 12 may be composed of a plurality of parts that can be divided and assembled.
  • the housing 12 is configured to support a lower part configured to support a lower surface of the body 11 and a peripheral surface of the body 11 coupled to the lower part and exposed to the outside of the lower part. It may be composed of an upper part.
  • modular fluid chip 1 may further include an airtight portion 19.
  • the airtight part 19 is press-fitted between the body 11 and the connecting member 17 to seal the body 11 and the connecting member 17, and the connecting member 17 to the body 11. ) Can be fixed.
  • the airtight portion 19 may include a potential parallel portion 191, a rear side parallel portion 192, and a pressing portion 193 formed in a ring shape.
  • the potential parallel part 191 may be disposed between an inner surface of the body 11 forming the coupling groove 113 and an outer surface of the connection member 17 inserted into the coupling groove 113.
  • the dislocation parallel part 191 moves toward the coupling groove 113 along the inclined surface 11a provided on the inner surface of the body 11, and is disposed between the body 11 and the connecting member 17. Can be press-fitted.
  • the rear side parallel portion 192 may be disposed between the inner surface of the potential parallel portion 191 and the outer surface of the connecting member 17.
  • the rear side parallel part 192 presses the potential parallel part 191 when an external force is applied in the axial direction, and along the inclined surface 191a provided on the inner surface of the potential parallel part 191 toward the coupling groove 113. It may move and be press-fitted between the potential parallel part 191 and the connection member 17.
  • the pressing unit 193 may be fastened to the body 11 and disposed at the rear of the rear side parallel unit 192, and may press the rear side parallel unit 192 forward or release the pressurization during rotation.
  • a fluid flow system 1000 including a modular fluid chip according to an embodiment of the present invention (hereinafter referred to as a 'fluid flow system 1000') will be described.
  • each component for explaining the fluid flow system 1000 is the same reference numerals used while describing the modular fluid chip 1 according to the first embodiment of the present invention for the convenience of description, and the same reference numerals are used. Or duplicate descriptions will be omitted.
  • the fluid flow system 1000 may collect a sample from a fluid such as a body fluid or blood, extract a gene from a sample, and amplify and analyze the polymerase chain reaction.
  • a diagnostic fluid flow system 1000 comprising a first modular fluid chip 1 capable of implementing a first function, a second function different from the first function, and horizontal to the first modular fluid chip 1.
  • at least one second modular fluid chip 2 connectable in at least one of the vertical directions.
  • the second modular fluid chip 2 does not necessarily implement a different function from that of the first modular fluid chip 1, and may be applied to implement the same function as the first modular fluid chip 1 as necessary. Can be.
  • the first modular fluid chip 1 and the second modular fluid chip 2 each include a body 11 including at least one first hole 111 through which fluid can flow.
  • the housing 12 provided in the first modular fluid chip 1 and the housing 12 provided in the second modular fluid chip 2 may be formed in the same shape or the same size specification.
  • the holes 111 and 121 provided in the first modular fluid chip 1 and the first modular fluid chip 1 are connected to each other.
  • the holes 111 and 121 provided in the two-modular fluid chip 2 communicate with each other, and the holes 111 and 121 and the second modular fluid chip 2 provided in the first modular fluid chip 1 communicate with each other.
  • Portions of the holes 111 and 121 provided in the communication portion may be formed in sizes and shapes corresponding to each other.
  • the holes 111 and 121 provided in the first modular fluid chip 1 and the holes 111 and 121 provided in the second modular fluid chip 2 are the first modular fluid chip 1.
  • the change in the fluid pressure is minimized, and the composition of the fluid or the shape of the fine droplets is reduced. It may have a shape to be maintained.
  • the holes 111 and 121 provided in the first modular fluid chip 1 and the holes 111 and 121 provided in the second modular fluid chip 2 are fluid channels 112 formed in the body 11. Can be aligned horizontally or vertically).
  • the apparatus may further include a fluid connector 17 including three holes 171.
  • a fluid chip capable of performing one function in a module form by forming a fluid chip capable of performing one function in a module form, connecting a plurality of fluid chips capable of performing different functions as necessary to various shapes without restriction of shape or size
  • the fluid flow system 1000 of the structure can be implemented, and various and accurate experimental data can be obtained, and only the fluid chip of the corresponding part can be replaced in case of deformation or breakage of a specific part, thereby reducing manufacturing and maintenance costs. can do.
  • a housing 12 connectable to another modular fluid chip 2 and a fluid channel 112 therein are formed to form a replaceable body 11 in the housing 12 in a modular form, respectively. Accordingly, it is possible to easily change the position of the selected section and the shape of the fluid channel as needed in one fluid flow system 1000, and through this it is possible to quickly change the experimental conditions through the conventional fluid flow system 1000 for a set time Compared to the above, various experiments are possible, and in case of failure or damage, only the housing 12 or the body 11 of the corresponding part can be quickly replaced.
  • the holes of each fluid chip communicate with each other in an aligned state, and the modular fluid chip 1 and the other modular fluid chip ( By providing the fluid connection body 17 which is in close contact with each other to form an interface at the connection part of 2), it blocks the leakage of fluid at the connection part when the fluid flows, minimizes the change in the fluid pressure, and furthermore, The shape of the fine droplets can be maintained.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

L'invention concerne une puce fluidique modulaire et un système d'écoulement de fluide la comprenant, la puce fluidique modulaire étant capable de mettre en œuvre le système d'écoulement de fluide de diverses structures sans restreindre la forme ou la taille en connectant une pluralité de puces fluidiques capables de réaliser différentes fonctions, selon les besoins. La puce fluidique modulaire comprend : un corps qui comprend au moins un premier trou à travers lequel un fluide peut s'écouler; et une partie de raccordement de fluide qui est apte à recevoir le corps à l'intérieur de celui-ci, comprend un second trou, correspondant à l'au moins un premier trou, à travers lequel un fluide peut s'écouler, et peut être relié à d'autres puces fluidiques modulaires.
PCT/KR2019/009272 2018-07-28 2019-07-25 Puce fluidique modulaire et système d'écoulement de fluide la comprenant WO2020027500A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN201980048036.8A CN113195100A (zh) 2018-07-28 2019-07-25 模块化流体芯片和包括该模块化流体芯片的流体流动系统
US17/056,416 US11618018B2 (en) 2018-07-28 2019-07-25 Modular fluid chip and fluid flow system comprising same
EP19843210.6A EP3778026A4 (fr) 2018-07-28 2019-07-25 Puce fluidique modulaire et système d'écoulement de fluide la comprenant

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20180088227 2018-07-28
KR10-2018-0088227 2018-07-28
KR10-2019-0088805 2019-07-23
KR1020190088805A KR102294916B1 (ko) 2018-07-28 2019-07-23 모듈형 유체 칩 및 이를 포함하는 유체 유동 시스템

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WO2020027500A1 true WO2020027500A1 (fr) 2020-02-06

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IT202100006980A1 (it) * 2021-03-23 2022-09-23 Sanchip Soc A Responsabilita Limitata Dispositivo lab-on-a-chip modulare per l'analisi di fluidi
DE102021203617A1 (de) * 2021-04-13 2022-10-13 Robert Bosch Gesellschaft mit beschränkter Haftung L-Kartusche

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WO2000062918A2 (fr) * 1999-04-16 2000-10-26 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Module microreacteur
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US20090132204A1 (en) * 2006-06-28 2009-05-21 Koninklijke Philips Electronics N.V. Disposable assay device with removables modules and remote data transfer system
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KR20170049564A (ko) * 2014-09-08 2017-05-10 이노베이티브 서모어낼리틱 인스트루먼츠 카게 모듈식 반응기

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WO2015090339A1 (fr) * 2013-12-18 2015-06-25 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Micro-système fluidique et son procédé de fabrication
KR101670826B1 (ko) * 2014-05-30 2016-11-10 한국과학기술원 미세유체 유동블럭과 이의 제조방법
EP3190172A3 (fr) * 2016-01-07 2017-08-30 Vanderbilt University Interconnexions de perfusion multiples des constructions tissulaires techniques et microbioréacteurs, multi-microformulateurs et leurs applications
US10343159B2 (en) * 2016-09-16 2019-07-09 Massachusetts Institute Of Technology Systems, devices, and methods for microfluidics using modular blocks

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WO2000062918A2 (fr) * 1999-04-16 2000-10-26 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Module microreacteur
KR20050057222A (ko) * 2002-09-06 2005-06-16 에피겜 리미티드 모듈화된 마이크로유체 시스템
US20090132204A1 (en) * 2006-06-28 2009-05-21 Koninklijke Philips Electronics N.V. Disposable assay device with removables modules and remote data transfer system
US20090156966A1 (en) * 2007-11-13 2009-06-18 Heinz Kontschieder Modular sensor cassette
KR20170049564A (ko) * 2014-09-08 2017-05-10 이노베이티브 서모어낼리틱 인스트루먼츠 카게 모듈식 반응기

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