WO2000003997A1 - Derives de thiobenzimidazole - Google Patents
Derives de thiobenzimidazole Download PDFInfo
- Publication number
- WO2000003997A1 WO2000003997A1 PCT/JP1999/003799 JP9903799W WO0003997A1 WO 2000003997 A1 WO2000003997 A1 WO 2000003997A1 JP 9903799 W JP9903799 W JP 9903799W WO 0003997 A1 WO0003997 A1 WO 0003997A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- thiobenzimidazole derivatives
- human chymase
- thiobenzimidazole
- derivatives
- preventives
- Prior art date
Links
- KSAPYRIVHFAQGR-UHFFFAOYSA-N 1-sulfanylbenzimidazole Chemical class C1=CC=C2N(S)C=NC2=C1 KSAPYRIVHFAQGR-UHFFFAOYSA-N 0.000 title abstract 2
- 101000909983 Homo sapiens Chymase Proteins 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL345540A PL203730B1 (pl) | 1998-07-15 | 1999-07-14 | Pochodna tiobenzimidazolu, kompozycja farmaceutyczna i jej zastosowanie |
SK21-2001A SK212001A3 (en) | 1998-07-15 | 1999-07-14 | Thiobenzimidazole derivatives |
JP2000560104A JP3923255B2 (ja) | 1998-07-15 | 1999-07-14 | チオベンズイミダゾール誘導体 |
IL14086299A IL140862A (en) | 1998-07-15 | 1999-07-14 | Thiobenzimidazole derivatives and pharmaceutical compositions containing the same |
EP99929832A EP1097926A4 (en) | 1998-07-15 | 1999-07-14 | THIOBENZIMIDAZOLE DERIVATIVES |
NZ509207A NZ509207A (en) | 1998-07-15 | 1999-07-14 | Thiobenzimidazole derivative compounds, and usage as chymase activity inhibitors |
AU46519/99A AU758789B2 (en) | 1998-07-15 | 1999-07-14 | Thiobenzimidazole derivatives |
EEP200100022A EE04904B1 (et) | 1998-07-15 | 1999-07-14 | Tiobensimidasooli derivaadid ja farmatseutiline kompositsioon |
HU0103256A HUP0103256A3 (en) | 1998-07-15 | 1999-07-14 | Thiobenzimidazole derivatives and pharmaceutical compositions containing the compounds |
CA002336909A CA2336909C (en) | 1998-07-15 | 1999-07-14 | Thiobenzimidazole derivatives which are useful as inhibitors of human chymase activity |
BR9912098-4A BR9912098A (pt) | 1998-07-15 | 1999-07-14 | Derivado de tiobenzimidazol, composição farmacêutica, e, agente preventivo e/ou terapêutico |
IS5807A IS5807A (is) | 1998-07-15 | 2001-01-12 | Þíóbensimídasólafleiður |
HR20010030A HRP20010030A2 (en) | 1998-07-15 | 2001-01-12 | Thiobenzimidazole derivatives |
NO20010193A NO318957B1 (no) | 1998-07-15 | 2001-01-12 | Tiobenzimidazol-derivater og farmasoytiske preparater inneholdene disse |
UA2001021023A UA70953C2 (uk) | 1998-07-15 | 2001-09-17 | Похідні тіобензімідазолу та фармацевтична композиція, що їх містить |
US10/963,710 US7268145B2 (en) | 1998-07-15 | 2004-10-14 | Thiobenzimidazole derivatives |
US11/129,508 US20050267148A1 (en) | 1998-07-15 | 2005-05-16 | Benzimidazole derivative |
US11/797,975 US20070275995A1 (en) | 1998-07-15 | 2007-05-09 | Thiobenzimidazole derivatives |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10/200250 | 1998-07-15 | ||
JP20025098 | 1998-07-15 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09743483 A-371-Of-International | 1999-07-14 | ||
US10/963,710 Continuation US7268145B2 (en) | 1998-07-15 | 2004-10-14 | Thiobenzimidazole derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2000003997A1 true WO2000003997A1 (fr) | 2000-01-27 |
Family
ID=16421274
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP1999/003799 WO2000003997A1 (fr) | 1998-07-15 | 1999-07-14 | Derives de thiobenzimidazole |
Country Status (22)
Country | Link |
---|---|
US (2) | US7268145B2 (ja) |
EP (1) | EP1097926A4 (ja) |
JP (1) | JP3923255B2 (ja) |
KR (1) | KR100903531B1 (ja) |
CN (1) | CN1187337C (ja) |
AU (1) | AU758789B2 (ja) |
BG (1) | BG65514B1 (ja) |
BR (1) | BR9912098A (ja) |
CA (1) | CA2336909C (ja) |
EE (1) | EE04904B1 (ja) |
HR (1) | HRP20010030A2 (ja) |
HU (1) | HUP0103256A3 (ja) |
ID (1) | ID26899A (ja) |
IL (1) | IL140862A (ja) |
IS (1) | IS5807A (ja) |
NO (1) | NO318957B1 (ja) |
NZ (1) | NZ509207A (ja) |
PL (1) | PL203730B1 (ja) |
RU (1) | RU2237663C2 (ja) |
SK (1) | SK212001A3 (ja) |
TR (1) | TR200100047T2 (ja) |
WO (1) | WO2000003997A1 (ja) |
Cited By (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001053272A1 (fr) * | 2000-01-17 | 2001-07-26 | Teijin Limited | Inhibiteurs de chymase humaine |
WO2001053291A1 (fr) * | 2000-01-17 | 2001-07-26 | Teijin Limited | Derives benzimidazoles |
WO2002066457A1 (fr) * | 2001-02-22 | 2002-08-29 | Teijin Limited | Derive benzo[b]thiophene et procede de production correspondant |
WO2004007464A1 (ja) * | 2002-07-10 | 2004-01-22 | Sumitomo Pharmaceuticals Co., Ltd. | イミダゾール誘導体 |
WO2004101551A1 (ja) * | 2003-05-14 | 2004-11-25 | Teijin Pharma Limited | ベンズイミダゾール誘導体の結晶及びその製造方法 |
WO2005018672A1 (ja) * | 2003-08-22 | 2005-03-03 | Teijin Pharma Limited | キマーゼ阻害剤を有効成分として含有する薬剤 |
WO2006052026A1 (ja) * | 2004-11-12 | 2006-05-18 | Teijin Pharma Limited | ベンズイミダゾール誘導体の酸性塩及びその結晶 |
US7176320B2 (en) | 2000-01-17 | 2007-02-13 | Teijin Limited | Benzimidazole derivative |
JP2007119483A (ja) * | 2001-02-22 | 2007-05-17 | Teijin Ltd | ベンゾ[b]チオフェン誘導体、およびその製造方法 |
US7268145B2 (en) | 1998-07-15 | 2007-09-11 | Teijin Pharma Limited | Thiobenzimidazole derivatives |
JP2008510760A (ja) * | 2004-08-26 | 2008-04-10 | アクテリオン ファーマシューティカルズ リミテッド | 2−スルファニル−ベンゾイミダゾール−1−イル−酢酸誘導体 |
WO2008153129A1 (ja) * | 2007-06-14 | 2008-12-18 | Teijin Pharma Limited | 尿酸値低下剤 |
JP2009519291A (ja) * | 2005-12-15 | 2009-05-14 | エフ.ホフマン−ラ ロシュ アーゲー | 新規な縮合ピロール誘導体 |
WO2009133964A1 (ja) * | 2008-04-28 | 2009-11-05 | 国立大学法人九州大学 | 酸化ストレス抑制剤 |
US7618977B2 (en) | 2000-02-22 | 2009-11-17 | Asubio Pharma Co., Ltd. | Method of treating dermatitis comprising administering a chymase inhibitor |
WO2010047982A1 (en) | 2008-10-22 | 2010-04-29 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
WO2010051206A1 (en) | 2008-10-31 | 2010-05-06 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
WO2011106273A1 (en) | 2010-02-25 | 2011-09-01 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
WO2012116145A1 (en) | 2011-02-25 | 2012-08-30 | Merck Sharp & Dohme Corp. | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
US8394969B2 (en) | 2008-09-26 | 2013-03-12 | Merck Sharp & Dohme Corp. | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
US8563746B2 (en) | 2008-10-29 | 2013-10-22 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
WO2014022528A1 (en) | 2012-08-02 | 2014-02-06 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
WO2014031465A1 (en) | 2012-08-22 | 2014-02-27 | Merck Sharp & Dohme Corp. | Novel azabenzimidazole tetrahydropyran derivatives |
WO2014139388A1 (en) | 2013-03-14 | 2014-09-18 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
WO2015051725A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
WO2015095256A1 (en) | 2013-12-19 | 2015-06-25 | Merck Sharp & Dohme Corp. | Antidiabetic substituted heteroaryl compounds |
US9290517B2 (en) | 2012-08-22 | 2016-03-22 | Merck Sharp & Dohme Corp. | Azabenzimidazole hexahydrofuro[3,2-b]furan derivatives |
US9394285B2 (en) | 2013-03-15 | 2016-07-19 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
US9527839B2 (en) | 2012-08-22 | 2016-12-27 | Merck Sharp & Dohme Corp. | Benzimidazole tetrahydropyran derivatives |
US9540364B2 (en) | 2012-08-22 | 2017-01-10 | Merck Sharp & Dohme Corp. | Benzimidazole tetrahydrofuran derivatives |
US9556193B2 (en) | 2012-08-22 | 2017-01-31 | Merck Shapr & Dohme Corp. | Benzimidazole hexahydrofuro[3,2-b]furan derivatives |
US9868733B2 (en) | 2012-08-22 | 2018-01-16 | Merck Sharp & Dohme Corp. | Azabenzimidazole tetrahydrofuran derivatives |
US10519115B2 (en) | 2013-11-15 | 2019-12-31 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007119478A (ja) * | 1998-07-15 | 2007-05-17 | Teijin Ltd | チオベンズイミダゾール誘導体 |
JP4339371B2 (ja) * | 2007-03-22 | 2009-10-07 | 株式会社ソニー・コンピュータエンタテインメント | 情報処理装置および情報処理方法 |
KR101435496B1 (ko) * | 2012-10-22 | 2014-08-28 | 한국과학기술연구원 | 미토콘드리아 기능 조절제로서의 벤즈이미다졸 유도체 |
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DE69622148T2 (de) | 1995-09-28 | 2002-10-31 | Suntory Limited, Osaka | Chinazozin derivate und deren verwendung |
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