WO1999030580A1 - Verfahren und vorrichtung zur verbesserung der wirksamkeit von wirkstoffen, die mindestens aus mineralstoffen bestehen - Google Patents
Verfahren und vorrichtung zur verbesserung der wirksamkeit von wirkstoffen, die mindestens aus mineralstoffen bestehen Download PDFInfo
- Publication number
- WO1999030580A1 WO1999030580A1 PCT/DE1998/003702 DE9803702W WO9930580A1 WO 1999030580 A1 WO1999030580 A1 WO 1999030580A1 DE 9803702 W DE9803702 W DE 9803702W WO 9930580 A1 WO9930580 A1 WO 9930580A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- activated
- rings
- active ingredients
- granolometry
- active ingredient
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
- B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
- B02C13/00—Disintegrating by mills having rotary beater elements ; Hammer mills
- B02C13/20—Disintegrating by mills having rotary beater elements ; Hammer mills with two or more co-operating rotors
- B02C13/205—Disintegrating by mills having rotary beater elements ; Hammer mills with two or more co-operating rotors arranged concentrically
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
Definitions
- the invention relates to a method for improving the
- the invention relates to a device for improving the effectiveness of active ingredients from minerals suitable for human consumption.
- the invention also relates to a powder made of zeolites for human consumption.
- the object of the present invention is therefore to specify methods, devices and products with the aid of which a replacement of chemical products in the field of human nutrition is possible.
- This object is achieved in that, in the process for improving the effectiveness of active ingredients which consist at least of minerals, the active ingredients are subjected to tribomechanical activation, in which the surface of the treated active ingredients is enlarged and their structure is destabilized to increase the chemical potential.
- the device for improving the effectiveness of active substances from minerals suitable for human consumption at least three rows of rings are driven in opposite directions for the tribomechanical activation of the minerals, and blade-like projections are fastened on each ring row.
- This device is capable of tribochemically activating minerals so that they have a much wider range of possibilities for interfering with human life processes than before.
- This activation consists in mechanically interfering with the integrity of the crystal lattice present in the mineral substances. This results in damage which is also noticeable externally in the form of an activation, for example of an electrical type.
- a powder made of zeolites for human consumption has a grain size of less than 20 ⁇ m and is activated by tribomechanics.
- a powder has a very far-reaching influence on the well-being of a person. Among other things, it strengthens the immune system against certain types of cancer, for example lung cancer, colon cancer, skin cancer and the like. a. In addition, it stabilizes the blood circulation and leads to a significant improvement in venous tension and the permeability of the veins. It also achieves success in the remediation of rheumatic diseases and has a positive diaretic effect and a revitalization of the kidney function. Finally, it is successfully used in the rehabilitation of periodontitis by adding toothpaste. It eliminates stressful situations, neuroses and sleep disorders. A variety of other fields of application are known.
- FIG. 1 a side view of an activator
- FIG. 2 a side view of a runner, consisting of three rows of rings,
- FIG. 3 a plan view of a rotor according to the section line III-III in FIG. 2,
- FIG. 4 an enlarged partial section of three rows of wreaths arranged side by side
- FIG. 5 a system sketch of a silo and wind screening system
- Figure 6 a system sketch of a cross flow classifier
- Figure 7 a system sketch of a classification line with cross flow classifier.
- the centerpiece of a system 1 for activating active substances is an activator 2 in which the active substance is mechanically activated by intensive mechanical stress and thus by material breakage (tribomechanical activation). These activations are a result of the action of impact and / or friction, the particles 3 of which are to be activated. These effects result in spatial disturbances and the associated energetic disturbances of atomic and molecular structures, errors in the structure of the crystal lattice, deformations of the crystal lattice, breakage of the connections, installation in the lattice, formation of free radicals and electrons, an increase in displacements etc. Shattering the material body or grain.
- Such disturbances occur in a very short time span of 10 3 to 10 ° sec. In surface layers of the particles 3. Secondary effects penetrate very deeply into the particles. These disturbances put the particles in an activated state.
- Such activated particles 4 have a free energy that appears to the outside world, which manifests itself in a very wide range in activity, for example as chemical binding energy. This enables the creation of new compositions and reactions that would otherwise only be possible with large pressure applications.
- the activated state of such particles 4 can be proven both by physical methods as well as by X-ray radiography and by morphological examinations.
- reactions based on such a tribomechanical activity follow different laws than thermodynamically determined transformations. They are largely independent of the temperature. The reaction rate depends rather on the intensity of the mechanical load and the activity achieved thereby.
- the particles 3 to be activated and thus also the activated particles 4 are mostly of mineral origin. Zeolites are particularly suitable for the production of active ingredients for human consumption. In the agricultural sector, calcite is very often activated and used for the production of fertilizers.
- the surface of the treated active ingredients is enlarged and their structure destabilized to increase the chemical potential. This increases the capacity of the active substances to exchange ions with ions of other substances.
- the kinetic energy is applied to the individual particles 3, these mutually influence one another by means of non-plastic deformation. This converts the kinetic energy into an energy of molecular motion.
- the active ingredient has a granolometry of 0 to 20 ⁇ .
- This granolometry depends on at least one influencing variable. It can be determined depending on a size of the starting grain 3. In addition, it can be dependent on the degree of acceleration with which the active substance is acted on. Further influencing variables for the granolometry are the collision angle at which the particles 3 collide. Finally, the granolometry also depends on the intensity of the friction with which the individual particles 3 rub against one another. In addition, the granolometry can also depend on the number of collisions with which particles 3 meet each other.
- the particles 3 have a grain size of 0 to 4.0 mm and enter an inlet funnel 5 into a central part 6 of the activator 2.
- This consists of two rotors 7, 8, of which the rotor 7 is smaller than the rotor 8.
- the large rotor 8 has two rings 9, 10 arranged parallel to one another, of which the ring 9 as the inner ring is directly adjacent to the central part 6 in the direction of a circumference 11 of the rotors, while the outer ring 10 is adjacent to the outer circumference 1 of the rotor 8 is.
- a ring 12 Arranged between the inner ring 9 and the outer ring 10 is a ring 12 fastened to the smaller rotor 7, the inner edge 13 of which is directly adjacent to an outer edge 14 of the inner ring 9.
- an outer edge 15 of the ring 12 adjacent to the outer ring 10 is an inner edge facing the central part 6
- the large rotor 8 is fastened on a shaft 17, by means of which it is rotated.
- the small rotor 7 is fixed on a shaft 18 which is connected to the shaft
- Fan blades 21 are attached to the rings 9, 12, 10, each of which favors acceleration of the particles 3 to be activated in the desired direction.
- the fan blades 21 each run in the longitudinal direction 22, in which in the direction of rotation of the individual rings 9, 12, 10 the longitudinal direction 22 is arranged obliquely to the direction of rotation 23 of the individual rings 9, 12, 10, specifically in the manner that a rear edge 24 provided on the rear of each fan blade 21 in the direction of rotation 23 faces an area smaller and an opposite front edge 25 faces an area of higher rotational acceleration.
- the particles 3 passing between two fan blades 21 adjacent to one another on a ring 9, 11, 10 receive an acceleration in the direction of the next larger ring 11, 10.
- an angle 27 is fixed, with the aid of which the appropriately aligned fan blades 21 bring about an optimal acceleration of the particles 3.
- a deflector part 28 can also be fastened to the fan blades 21 of the outer ring 10, said deflector part being connected to the corresponding fan blade 21 in a predetermined direction.
- the deflector part 28 has a direction directed towards the circumference 11, which maintains an angle 29 to be defined with the direction of the fan blade.
- the deflector part 28 has a precisely defined length 30, which either extends to the circumference 11 of the outer ring 10 or even beyond. The length of a part 31 projecting beyond the circumference 11 can be calculated such that at its end 32 projecting beyond the circumference 11 the activated particles 4 each have the desired signs of detachment.
- the fan blades 21 can consist of one or more parts 33, depending on the desired activation. In this case, angles 34 can be provided between several parts 33 of a fan blade 21, the size of which influence the acceleration of the particles 3 to be achieved on a ring 9, 11, 10. Constellations are conceivable in which higher accelerations on the inner rings 9, 12 due to the fan blades 21 fastened there Particles are brought in as by the fan blades 21 which are fixed on the outer ring 11. This can achieve a streamlined guide 35 by multiple kinks, so that the mediated impact energy is comparatively low along these fan blades 21 fastened on the outer ring 11, but the acceleration of the particles 3 before leaving the outer circumference 11 is very high.
- a stock 36 of particles accumulates between the individual parts 33 in the course of the rotation, which hardens there under the influence of the centrifugal acceleration constantly acting on them.
- This stock 36 forms a homogeneous sliding surface on which particles are deflected little but accelerated to a very high degree.
- the activated particles 4 leaving the outer ring 10 via the circumference 11 collect in a housing 37 of the activator 2 surrounding the rotors 7, 8 and pass through an outlet 38 provided in this housing 37 to a foot station 39 of an elevator 40, in which the activated parts are sucked in due to a negative pressure generated in a negative pressure generator 41. They arrive in a distribution room 42, from which they can be called up as required.
- the two shafts 17, 18 are each driven by motors 43, 44 in opposite directions of rotation.
- the motors are connected to the activator 2 via couplings 45, 46 and gears 47, 48.
- the rotors 7, 8 are overhung on the shafts 17, 18, which are each mounted in bearings of the gears 47, 48.
- the speed of at least one of the rotors 7, 8 can be changed by a controller 49, so that the rotors 7, 8 can be operated at the same as well as at different speeds.
- the activated particles 4 pass from the distribution space 42 via a funnel 50 into a classifier 51, in which they are classified according to their size.
- a cross-flow classifier 52 has been found to be particularly favorable, in which the activated particles 4 are classed for coarse particles 53 and for finest-grain particles 54.
- the activated particles 4 enter this cross-flow classifier 52 in a mixture 55 of particles of all fractions through an inlet 56. They are sucked in an air stream 57 in the direction of a worm-like housing 58. This air flow 57 enters through an air tube 59. The mixture 55 loosens into the finest grain 54 and coarse grain 53.
- secondary air is blown into the housing 58 through a third inlet 60, which separates out the fine grain fractions 54.
- tertiary air 62 enters through a further opening 61, which again separates out fine particles 54 from the coarse fraction 53.
- the coarse particles 53 drop out of a lower opening 63 towards a collecting station.
- the fine fraction freed from the coarse particles 53 is accelerated upwards in a spiral. A further separation of the fractions takes place under the influence of centrifugal forces. Coarse particles circle along walls 64 of the housing 58 and finally reach the lower opening 63.
- parts of the fine fraction are carried along by the air flows of the air pipe 59 and the access 60 and passed to a centrifugal classification field 65. From there they reach its opening 66, from which they exit in the direction of cyclones 67, 68, 69, in which the finest particles are extracted from the fine fraction and transported in the direction of a filter bag 70.
- the cross-flow classifier 62 together with the cyclones 67, 68, 69 and the filter bag 70, forms a micro-classifier for separating the fine-grain particles 54.
- Tribomechanical excitation of calcites also creates a highly energetic active ingredient.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU20462/99A AU2046299A (en) | 1997-12-16 | 1998-12-16 | Method and device for improving the efficiency of active agents consisting at least of mineral substances |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19755921A DE19755921A1 (de) | 1997-12-16 | 1997-12-16 | Verfahren und Vorrichtung zur Verbesserung der Wirksamkeit von Wirkstoffen, die mindestens aus Mineralstoffen bestehen |
DE19755921.2 | 1997-12-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999030580A1 true WO1999030580A1 (de) | 1999-06-24 |
Family
ID=7852125
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DE1998/003702 WO1999030580A1 (de) | 1997-12-16 | 1998-12-16 | Verfahren und vorrichtung zur verbesserung der wirksamkeit von wirkstoffen, die mindestens aus mineralstoffen bestehen |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU2046299A (pt-PT) |
DE (1) | DE19755921A1 (pt-PT) |
WO (1) | WO1999030580A1 (pt-PT) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6288045B1 (en) | 2000-06-09 | 2001-09-11 | Lifelink Pharmaceuticals, Inc. | Epithelial cell cancer drug |
WO2005003032A1 (en) * | 2003-07-03 | 2005-01-13 | The University Court Of The University Of St Andrews | Zeolites for delivery of nitric oxide |
US20210322997A1 (en) * | 2017-02-24 | 2021-10-21 | Nanom Inc. | Apparatus and method for forming nanoparticles |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1107826A1 (de) * | 1999-04-26 | 2001-06-20 | Tihomir Lelas | Vorrichtung zum mikronisieren von materialien |
DE10200688A1 (de) * | 2002-01-10 | 2003-07-24 | Vip Domotec S A R L | Verfahren zum tribo-mechanischen Aktivieren von Silikatmineralien, nämlich natürlichen Zeotithen |
EP1839666A1 (de) * | 2006-02-15 | 2007-10-03 | Tihomir Lelas | Bluthochdruck-Mittel enthaltend tribomechanisch aktivierte Zeolithen |
WO2007056996A2 (de) * | 2005-11-15 | 2007-05-24 | Ljubicic, Mijo | Bluthochdruck-mittel enthaltend tribomechanisch aktivierte zeolithen |
DE102008022726A1 (de) | 2008-05-06 | 2009-11-12 | Winkler, Kurt, Dr. | Verfahren für den Kontakt einer Gasphase mit einer Flüssigkeit in Anwesenheit eines Feststoffes |
DE102009012774A1 (de) | 2008-07-11 | 2010-01-14 | Sanoviva Ag | Vorrichtung zur Strukturänderung von Mineralien und Verwendung von derart veränderten Mineralien |
WO2012064294A1 (en) | 2010-11-09 | 2012-05-18 | KAYA, Selçuk | Reduction of harmful smoke constituents, including a tobacco column and a filter element |
ES2744718T3 (es) | 2016-12-02 | 2020-02-26 | Jakob Hraschan | Composiciones de zeolita y procedimiento de producción de las mismas |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1296943B (de) * | 1965-05-29 | 1969-06-04 | Sviluppo Silicalcite S P A | Desintegrator |
US3894695A (en) * | 1973-07-05 | 1975-07-15 | Patentanstalt Neue Baustoffe | Disintegrator |
DD135616A1 (de) * | 1978-01-30 | 1979-05-16 | Romann Paudert | Verfahren zur herstellung eines phosphorduengemittels |
US4406409A (en) * | 1980-09-16 | 1983-09-27 | Joachim Durek | Disintegrator and method for the operation thereof |
EP0444392A2 (de) * | 1990-01-24 | 1991-09-04 | LOIDELSBACHER & PARTNER GESELLSCHAFT m.b.H. | Verfahren zur Herstellung von Düngemitteln oder Bodenhilfsstoffen aus mineralischen oder organischen Komponenten |
DE19548645A1 (de) * | 1995-12-14 | 1997-06-19 | Witega Angewandte Werkstoff Forschung Gemeinnuetzige Gmbh Adlershof | Verfahren zur Herstellung von hochwertigen Sekundärrohstoffen aus sortenreinem Abbruchmaterial von Bauwerken |
-
1997
- 1997-12-16 DE DE19755921A patent/DE19755921A1/de not_active Withdrawn
-
1998
- 1998-12-16 AU AU20462/99A patent/AU2046299A/en not_active Abandoned
- 1998-12-16 WO PCT/DE1998/003702 patent/WO1999030580A1/de active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1296943B (de) * | 1965-05-29 | 1969-06-04 | Sviluppo Silicalcite S P A | Desintegrator |
US3894695A (en) * | 1973-07-05 | 1975-07-15 | Patentanstalt Neue Baustoffe | Disintegrator |
DD135616A1 (de) * | 1978-01-30 | 1979-05-16 | Romann Paudert | Verfahren zur herstellung eines phosphorduengemittels |
US4406409A (en) * | 1980-09-16 | 1983-09-27 | Joachim Durek | Disintegrator and method for the operation thereof |
EP0444392A2 (de) * | 1990-01-24 | 1991-09-04 | LOIDELSBACHER & PARTNER GESELLSCHAFT m.b.H. | Verfahren zur Herstellung von Düngemitteln oder Bodenhilfsstoffen aus mineralischen oder organischen Komponenten |
DE19548645A1 (de) * | 1995-12-14 | 1997-06-19 | Witega Angewandte Werkstoff Forschung Gemeinnuetzige Gmbh Adlershof | Verfahren zur Herstellung von hochwertigen Sekundärrohstoffen aus sortenreinem Abbruchmaterial von Bauwerken |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6288045B1 (en) | 2000-06-09 | 2001-09-11 | Lifelink Pharmaceuticals, Inc. | Epithelial cell cancer drug |
WO2005003032A1 (en) * | 2003-07-03 | 2005-01-13 | The University Court Of The University Of St Andrews | Zeolites for delivery of nitric oxide |
JP2007526867A (ja) * | 2003-07-03 | 2007-09-20 | ザ ユニヴァーシティー コート オブ ザ ユニヴァーシティー オブ セント アンドリューズ | 一酸化窒素放出用ゼオライト |
EA014704B1 (ru) * | 2003-07-03 | 2011-02-28 | Ти Юниверсити Корт Оф Ти Юниверсити Оф Ст Эндрюс | Полностью или частично обезвоженный цеолитный материал для дозирования оксида азота |
JP4818108B2 (ja) * | 2003-07-03 | 2011-11-16 | ザ、ユニバーシティー、コート、オブ、ザ、ユニバーシティー、オブ、セント、アンドルーズ | 一酸化窒素放出用ゼオライト |
US8722103B2 (en) | 2003-07-03 | 2014-05-13 | University Court Of The University Of St. Andrews | Zeolites for delivery of nitric oxide |
US9402862B2 (en) | 2003-07-03 | 2016-08-02 | University Court Of The University Of St Andrews | Zeolites for delivery of nitric oxide |
US20210322997A1 (en) * | 2017-02-24 | 2021-10-21 | Nanom Inc. | Apparatus and method for forming nanoparticles |
US11607693B2 (en) * | 2017-02-24 | 2023-03-21 | Nanom Inc. | Apparatus and method for forming nanoparticles |
Also Published As
Publication number | Publication date |
---|---|
AU2046299A (en) | 1999-07-05 |
DE19755921A1 (de) | 1999-06-17 |
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