WO1998017236A1 - Preparations orales contenant du verre cristallise biologiquement actif - Google Patents

Preparations orales contenant du verre cristallise biologiquement actif Download PDF

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Publication number
WO1998017236A1
WO1998017236A1 PCT/JP1997/003843 JP9703843W WO9817236A1 WO 1998017236 A1 WO1998017236 A1 WO 1998017236A1 JP 9703843 W JP9703843 W JP 9703843W WO 9817236 A1 WO9817236 A1 WO 9817236A1
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WO
WIPO (PCT)
Prior art keywords
crystallized glass
oral
weight
bioactive
glass
Prior art date
Application number
PCT/JP1997/003843
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English (en)
Japanese (ja)
Inventor
Tamae Inoue
Akiyoshi Osaka
Original Assignee
Sunstar Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP32387196A external-priority patent/JP3816999B2/ja
Application filed by Sunstar Inc. filed Critical Sunstar Inc.
Priority to AU47232/97A priority Critical patent/AU4723297A/en
Publication of WO1998017236A1 publication Critical patent/WO1998017236A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
    • A61K6/69—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/20—Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/70—Preparations for dentistry comprising inorganic additives
    • A61K6/71—Fillers
    • A61K6/77—Glass

Definitions

  • the present invention relates to a bioactive crystallized glass-containing oral composition, and more particularly to an oral composition that forms a hydroxyapatite film on a tooth surface.
  • bioactive glasses can be broadly classified into bioactive crystallized glass containing crystals such as apatite-wollastonite in the glass and ordinary bioactive glass containing no such crystals.
  • bioactive crystallized glass containing crystals such as apatite-wollastonite in the glass
  • ordinary bioactive glass containing no such crystals for example, Japanese Patent Publication No. Sho 62-10939 discloses a crystallized glass containing avatitate and wollastonite crystals, and the apatite crystals are chemically bonded to bone. It is stated that wollastonite crystals can increase the mechanical strength of glass.
  • Japanese Patent Publication No. 1-550204 discloses a glass containing apatite or a crystal of avatitate and aluminum orthophosphate, and these crystal phases have a bone growth. It is described as stimulating.
  • Japanese Patent Application Laid-Open Nos. Hei 3-149570 and Hei 5-31166 disclose artificial bones and artificial joints obtained by coating bioactive crystallized glass on a metal such as titanium. Imprint materials such as are disclosed.
  • Japanese Patent Publication No. 54-423384 discloses a bone cement made of a methacrylate resin and crystallized glass having an abatite crystal.
  • Japanese Unexamined Patent Publication No. 2-255555 / 15 discloses that using bioactive glass, regardless of inorganic material, metal material, and organic material, bone repair material, implantable medical device, medical device A method is disclosed in which a bioactive abatite film similar to bone in a living body is formed on the surface of all materials used in the living body, such as products and artificial organs.
  • a film-forming agent in the field of oral preparations, a film-forming agent is known, and a technique for forming a film using a silicone derivative to suppress stains and dental caries (Japanese Patent Application Laid-Open No. 2-1990985) Japanese Patent Application Laid-Open No. HEI 3-38517), a technique of coating tooth surfaces using fluoroalkyl phosphates to suppress plaque dust, A technique of forming a thin film on the tooth surface using tines to inhibit plaque formation (Japanese Patent Application Laid-Open No. HEI 4-134025) and the like are disclosed.
  • antibacterial agents are blended with a varnish base composed of natural resin and ethanol, and a technology for antibacterial preparations having long-term activity (Japanese Patent Application Laid-Open No. 5-5088383) has been developed.
  • Technology relating to polymer preparations comprising a release acryl polymer, a drug, and a release controlling agent to give sustained release of the drug Japanese Patent Application Laid-Open No. 3-128316
  • chelating capping agents disclose a technique in which a dental primer varnish in which is dissolved in a volatile solvent gives good adhesion to the tooth surface.
  • a technique for retaining bioactive crystallized glass on the tooth surface to form hydroxyapatite on the tooth surface there is no disclosure of a technique for retaining bioactive crystallized glass on the tooth surface to form hydroxyapatite on the tooth surface.
  • an object of the present invention is to provide a bioactive crystallized glass-containing oral composition that can form an excellent hydroxyapatite film on a tooth surface and effectively prevent dental caries.
  • an object of the present invention is to allow the bioactive crystallized glass to stay on the tooth surface to form hydroxyapatite on the tooth surface.
  • bioactive crystallized glass is a material capable of forming a hydroxyapatite film on the tooth surface, but when incorporated into an oral composition, the bioactive crystallized glass itself remains on the tooth surface.
  • an object of the present invention is to allow bioactive crystallized glass to stay on the tooth surface to effectively form hydroxyapatite on the tooth surface.
  • the present inventors have conducted intensive studies to solve the above-mentioned problems, and as a result, by blending a bioactive crystallized glass having a specific composition into an oral composition, a high-density coating can be uniformly applied to the tooth surface in a short time.
  • the inventors have found that a droxypatite film can be formed, and have completed the present invention.
  • the present inventor has found that by blending bioactive crystallized glass, a film-forming substance, and an organic solvent, the bioactive crystallized glass can be retained on the tooth surface for a long period of time to form a uniform hydroxyapatite film. This led to the completion of the present invention. Furthermore, the present inventors improved the retention of the bioactive crystallized glass on the tooth surface by blending the bioactive crystallized glass and the tooth-surface-adhering polymer into the oral tissue, and uniformly coated the bioactive crystallized glass on the tooth surface. They have found that a hydroxyapatite film can be formed, and have completed the present invention.
  • the oral composition characterized by formulating a bioactive glass-ceramics consisting of P 2 0 5 in.
  • bioactive crystallized glass N a 2 0, K 2 0, L i 2 0, T i 0, A 1 0, B a 0, Z r 0, F, N b 2 0 5 the 1 containing L a 2 0 3, T a 3 0, Y 0, S r O, B a O, Z n 0 and one Ru is selected from the group consisting of Mg 0 or two or more inorganic compounds 2.
  • the composition for oral cavity according to item 1. 3.
  • the bioactive crystallized glass forms one or more crystals selected from the group consisting of apatite, wollastonite, magnesium titanate, aluminum orthophosphate, diopside, and mica. 3.
  • composition for oral cavity according to any one of the above items 1 to 3, wherein the size of the bioactive crystallized glass is less than 32 mesh paths.
  • the tooth-adhering polymer is soluble in water, alcohol, or a wetting agent, and the compounding amount is 0.01 to 5% by weight based on the total amount of the composition. Oral composition.
  • the composition for oral cavity which can solve the above-mentioned problem and form a hydroxyapatite film
  • the bioactive crystallized glass can be retained on the tooth surface, and effective formation of hydroxyapatite on the tooth surface can be achieved, which is excellent in preventing caries. . Further, according to the present invention, the bioactive crystallized glass stays on the tooth surface by the action of the tooth surface-adhering polymer, and effective formation of hydroxyapatite on the tooth surface can be achieved.
  • the crystals contained in the bioactive crystallized glass used in the present invention are apatites such as wollastonite, hydroxyapatite or oxyfluorapatite, magnesium titanate, aluminum orthophosphate, diopside. And at least one selected from the group consisting of mica such as phlogopite and iron mica, and those containing 1 to 80% by weight with respect to the whole glass are preferred, and 50 to 8% by weight. 0% by weight is most preferred. If the amount of crystals in the glass is less than 1% by weight, the effective effect of each crystal will not be exhibited, while if it exceeds 80% by weight, the apatite-forming ability will decrease, which is not preferable.
  • one or more of these bioactive crystallized glasses may be combined in an amount of 0.001 to 50% by weight based on the total amount of the oral composition. it can. If the amount is less than 0.001% by weight, no apatite is formed on the tooth surface, while if it exceeds 50% by weight, the tooth surface is damaged, which is not preferable.
  • Et al is, the bioactive crystallized glass used in the present invention, N a 2 0, K 2 0, L i 0, T i 0 2, A l 2 0 3, Mg O, B 2 0 3, Z r 0 2, F, n b 2 ⁇ 5, L a 2 0, T a 2 0 5, Y 2 0 3, S r O, B a O and Z n 1 kind or 2 O is the group or al selection consisting of More than one inorganic compound can be included.
  • N a 2 0, K 2 0, L i 0 and B 2 0 3 is a TeiTorusei the glass
  • a 1 0, M g O, Z r 0 2 and F act to regulate apatite reactivity
  • S r O, B a 0 and Z n 0 is the performance of the glass Acts to regulate.
  • These inorganic compounds can be contained in an amount of 0 to 30% by weight based on the whole bioactive crystallized glass.
  • the bioactive crystallized glass used in the present invention has a shape such as a spherical shape, a bead shape, a granular shape, and a granular shape.
  • a shape such as a spherical shape, a bead shape, a granular shape, and a granular shape.
  • Japanese Patent Publication No. 62-10939 Japanese Patent Publication No. It can be produced by the method disclosed in JP-A-2004-204.
  • the bioactive crystallized glass those having less than 32 mesh paths are preferably used, and 65 mesh paths are particularly preferred. If the size is more than 32 mesh passes, it is not preferable because the feeling of use of the oral composition is impaired.
  • composition for oral cavity of the present invention can be prepared by a conventional method using toothpaste, toothpaste, jewel, ointment, mouthwash, chewing gum, dental floss, patch, sealant, glass ionomer, vanish, It can be in the form of a troche, gargle tablet, oral pasta, foam, film-forming agent or liniment, but is preferably used as a dentifrice or mouthwash because of its usability. Used.
  • the abrasive may be calcium diphosphate / dihydrate and anhydride, calcium phosphate, calcium tertiary phosphate, calcium carbonate, calcium pyrophosphate , Aluminum hydroxide, alumina, maleic anhydride, silica gel, aluminum gayate, insoluble sodium metaphosphate, magnesium tertiary phosphate, magnesium carbonate, calcium sulfate, polymethacrylate Methyl acrylate, bentonites, zirconium gaylate, synthetic resins, and the like can be used.
  • abrasives may be used alone or in combination of two or more.
  • the compounding amount is usually 5 to 90% by weight based on the whole composition, and 5 to 60% for toothpaste. % By weight.
  • foaming agent examples include mainly nonionic surfactants and anionic surfactants.
  • nonionic surfactant examples include sugar or fatty acid ester of sugar alcohol.
  • the fatty acid residues each have 12 to 18 carbon atoms, Those having a degree of tellurization of 1.1 to 2.5, preferably 1.2 to 1.9 can be used.
  • fatty acid ester of the sugar or sugar alcohol examples include sucrose fatty acid ester, maltose fatty acid ester, maltitol fatty acid ester, maltotriethyl fatty acid ester, maltote tritol
  • fatty acid esters examples include fatty acid esters, maltopentitol fatty acid esters, maltohexitol fatty acid esters, maltohexyl fatty acid esters, sorbitan fatty acid esters, lactose fatty acid esters, and lactinose fatty acid esters.
  • nonionic surfactants include polyoxyethylene, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, and the like.
  • nonionic surfactants may be used alone or in combination of two or more.
  • the amount of the nonionic surfactants is usually from 0.01 to 40% by weight based on the whole composition. And preferably 0.01 to 30% by weight.
  • anionic surfactant examples include higher alkyl sulfates having an alkyl group of 8 to 18 carbon atoms, such as sodium lauryl sulfate and sodium myristyl sulfate. Water-soluble salts, alpha-sulfur refinsulfonate salts, higher fatty acid sodium monoglyceride monosulfate, ⁇ -methylamine-palmitoyl tauride salt, ⁇ -long chain acetyl basic amino acid salts and the like. These anionic surfactants may be used alone or in combination of two or more.
  • the compounding amount is usually 0.0001 to 10% by weight based on the whole composition, It is preferably 0.01 to 5% by weight.
  • binder examples include cellulose derivatives such as carboxymethylcellulose, alkaline metal alginates such as sodium alginate, propylene glycol alginate, xanthan gum, tragacanth gum, karaya gum, and arabia gum. , Gums such as carrageenan, polyvinyl alcohol, and sodium polyacrylate Synthetic binders such as rubber, carboxyvinyl polymer, and polyvinylpyrrolidone; and inorganic binders such as silica gel, aluminum silica gel, bi-gum, and labonite. These compounds may be used alone or in combination of two or more. The compounding amount is usually 0.001 to 5% by weight based on the whole composition.
  • menthol carvone, phenol, eugenol, methyl salicylate, limonene, osimene, n-decyl alcohol, citronellol, ⁇ -tervineol, methyl acetate, citronellyl acetate, methyl Eugenol, Sionaire, linalool, ethyl linalool, penilin, thymol, spare mint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimentum oil, Flavoring agents such as diatom oil, perilla oil, winter green oil, clove oil, and eucalyptus oil may be used alone or in combination of two or more.
  • the amount of the flavoring agent is usually based on the total amount of the composition. 0.1 to 10% by weight, preferably 0.05 to 5% by weight.
  • saccharin sodium In addition, saccharin sodium, acetylfirm calcium, stepioside, neohesporidildihydrochalcone, glycyrrhizin, perillaltin, thaumatin, aspartyl phenylalanalanine methyl ester, ⁇ -methoxy cinnamamic aldehyde, etc.
  • the sweetener may be used alone or in combination of two or more. The amount of the sweetener is usually 0.01 to 5% by weight based on the whole composition.
  • dosage forms such as dentifrices or mouthwashes include sorbitol, glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, polypropylene glycol, and xylitol.
  • a wetting agent such as tut, mulch or lacquet may be used alone or in combination of two or more kinds.
  • the compounding amount is usually 1 to 70% by weight based on the whole composition. is there.
  • ⁇ regulators such as sodium hydrogen phosphate, cunic acid, sodium citrate, fungicides such as chlorhexidine gluconate, cetylpyridinium chloride, triclosan, dextranase, Enzymes such as amylase, protease, mutanase, lysozyme, and lytic enzyme (Litechenzyme), and alkaloids such as monofluorophosphate sodium phosphate and monofluorophosphate phosphate.
  • fungicides such as chlorhexidine gluconate, cetylpyridinium chloride, triclosan, dextranase
  • Enzymes such as amylase, protease, mutanase, lysozyme, and lytic enzyme (Litechenzyme)
  • alkaloids such as monofluorophosphate sodium phosphate and monofluorophosphate phosphate.
  • Metal fluorides such as monofluorophosphate, sodium fluoride, stannous fluoride, vitamin ⁇ derivatives, tranexamic acid and epsilon aminocaproic acid, aluminum chlorohydroxide
  • Active ingredients such as silalanine toin, dihydrocholesterol, glycyrrhizin salts, glycyrrhetinic acid, glycerol phosphate, chlorophyll, sodium chloride, liposide peptides, and water-soluble inorganic phosphoric acid compounds May be used alone or in combination of two or more.
  • the tooth surface-adhering polymer used in the oral composition of the present invention may be any polymer as long as it is a polymer that imparts retention of the bioactive crystallized glass on the tooth surface.
  • the polymer include water, alcohol, and a wetting agent.
  • a natural polymer or a synthetic polymer soluble in at least one kind is exemplified.
  • natural polymers include cellulose derivatives such as carboxymethylcellulose, methylcellulose, ethylcellulose, hydroxypropylcellulose, hydroxyethylcellulose, cellulose acetate phthalate, and sodium alginate.
  • Examples include alkali metal alginate, propylene glycol alginate, gums such as xanthan gum, tragacanth gum, karaya gum, arabic gum and carrageenan, and gelatin.
  • Examples of synthetic polymers include non-ionic polymers such as polyvinylpyrrolidone and polyvinyl alcohol, epoxy vinyl polymer, methyl vinyl ether maleate copolymer, sodium polyacrylate and the like.
  • anionic copolymers such as methyl acrylate, methyl methacrylate copolymer, and aminoalkyl methacrylate copolymer.
  • the molecular weight of these polymers is preferably in the range of 50,000 to 50,000 in terms of number average molecular weight.
  • tooth-surface-adhering polymers may be used alone or in combination of two or more, and the compounding amount is 0.01 to 5% by weight based on the total amount of the composition. If the amount is less than 0.01% by weight, the effect of attaching the bioactive crystallized glass to the tooth surface is not obtained, which is not preferable. Further, when the amount is more than 5% by weight, the viscosity becomes too high, which is not preferable.
  • the oral coating composition of the present invention can be prepared by an aerosol, mist, It can be in the form of a brush, a brush or the like, and is applied to the tooth surface by a method of directly spraying on the tooth surface, a method using a tray, or a method of applying with a brush.
  • the oral composition and the coating composition of the present invention may further include an abrasive, a foaming agent, a flavoring agent, a sweetening agent, a binder, and a pH adjusting agent according to each dosage form.
  • a base such as an agent and a wetting agent, as well as a medicinal ingredient and the like can be appropriately compounded within a range that does not impair the effects of the present invention.
  • film-forming substance used in the coating agent of the present invention those known for film formation can be used.
  • natural resins such as silicone resin, rosin, sandalack, alkyd resin, copalite, Sumatran benzoate, polyvinyl alcohol, polyvinylpyrrolidone, polyurethane, and polystyrene Len, polymethylmethacrylate, vinyl acetate, polyvinyl chloride, polyacrylonitrile, vinyl lipidone z vinyl acetate polymer, vinylpyrrolidone Z dimethylethyla
  • Nonionic polymers such as methinoethyl methacrylate copolymer, carboxyvinyl polymer, methylvinyl ether / maleic acid ester copolymer, and acrylic acid ester / methyl ester
  • Anionic polymers such as acrylic acid ester copolymers, vinyl acetate copolymers, etc., dimethyl aryl ammonium chloride polymers Polymers, hydroxymethyl cellulose / dimethylphenylammonium chloride copolymers, vinylpyrrolidone quaternized dial
  • One or more of these film-forming substances may be used in combination, and the compounding amount is 0.01 to 15% by weight based on the total amount of the coating agent. If the amount is less than 0.01% by weight, the film-forming ability is poor, and if the amount exceeds 15% by weight, the activity of the bioactive crystallized glass is unfavorably impaired.
  • organic solvent used in the present invention examples include ethyl acetate, dichloromethane, chloroform, alcohol, dioxane, siloxane, hexane, cyclohexane, and hexane. It is a volatile organic solvent such as sun, acetate, ether, petroleum ether, propylene carbonate and the like, and these may be used alone or in combination of two or more, and the compounding amount is 10 to 9 with respect to the total amount of the coating agent. 0% by weight, preferably 20 to 70% by weight.
  • [%] indicates% by weight.
  • Examples and comparative examples (formulations in which hydroxyapatite was replaced with bioactive crystallized glass, and formulations in which both components were not blended) were prepared by a conventional method and used for evaluation.
  • the mouthwash of Example 2 was added so as to be 1% in the whole saliva, and left at 37 ° C for 12 hours. As a result, crystals precipitated in the solution, and were analyzed by infrared spectroscopy and X-ray diffraction, and were confirmed to be hydroxyapatite. However, when the same operation was performed using a mouthwash having the above formulation except for the bioactive crystallized glass, no crystals were precipitated in the liquid.
  • the oral composition of the present invention forms a hydroxyapatite film on the tooth surface in a shorter time and more uniformly than the conventional oral composition.
  • Example 4 and Comparative Example 2 were applied to an acrylic plate in an amount of 0.1 g each and immersed in artificial saliva for 24 hours. Twenty-four hours later, it was confirmed by induction crystal plasma emission spectrometry that a hydroxyaperite was formed on the coating of Example 4.
  • Example 5 and Example 6 were applied to the extracted adult permanent tooth enamel with a brush.
  • the adult permanent teeth were immersed in whole saliva for one week.
  • a film was formed on adult permanent teeth even after one week, and hydroxyapatite was detected from compounds extracted from the film.
  • Comparative Example 3 was similarly applied to adult permanent teeth and immersed in whole saliva, no film remained after one week.
  • the oral composition of the present invention forms a film on the tooth surface and uniformly forms a hydroxyapatite film on the tooth surface.
  • a gel containing the tooth surface-adhering polymer was prepared by a conventional method (Examples? To 9 and Comparative Examples 4 to 6), and the bioactive crystallized glass was used as artificial saliva.
  • the solution was applied to an acrylic plate so as to have a concentration of 0.1%, and was allowed to stand at 37 ° C for 12 hours. The retention on the acrylic plate after 12 hours and the apatite conversion were evaluated based on the following criteria.
  • Inductively coupled plasma emission spectrometry was used for quantification of the apatite.
  • an oral composition effective for preventing dental caries which forms a hydroxyapatite film on the enamel surface of a tooth in a short time and uniformly.
  • a uniform hydroxyapatite film can be formed on the tooth surface, prevention of secondary caries and root caries, repair of defects such as wedge-shaped defects, relaxation of hyperesthesia, It is possible to provide an oral coating agent effective for aesthetic coating of the tooth surface. Furthermore, according to the present invention, it is possible to provide an oral composition effective for preventing dental caries, which forms a hydroxyapatite film on the enamel surface of a tooth in a short time and uniformly. The oral composition is also effective in preventing secondary caries and root caries, repairing defects such as wedge-shaped defects, alleviating hyperesthesia, and aesthetically coating tooth surfaces. .

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  • Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une préparation orale caractérisée par le fait qu'elle contient du verre cristallisé biologiquement actif comprenant 25 à 60 % en poids de SiO2, 15 à 60 % en poids de CaO et 0 à 30 % en poids de P2O5, chaque pourcentage étant basé sur le verre cristallisé; une peinture à usage oral que l'on prépare en ajoutant à ladite préparation une substance filmogène et un solvant organique; et une autre préparation orale que l'on prépare en ajoutant à la préparation orale ci-dessus un polymère capable d'adhérer à la surface d'une dent.
PCT/JP1997/003843 1996-10-23 1997-10-23 Preparations orales contenant du verre cristallise biologiquement actif WO1998017236A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU47232/97A AU4723297A (en) 1996-10-23 1997-10-23 Oral preparations containing biologically active crystallized glass

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP8/299615 1996-10-23
JP29961596 1996-10-23
JP8/323868 1996-12-04
JP8/323871 1996-12-04
JP32387196A JP3816999B2 (ja) 1996-12-04 1996-12-04 生体活性ガラス含有口腔用塗布剤
JP32386896 1996-12-04

Publications (1)

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WO1998017236A1 true WO1998017236A1 (fr) 1998-04-30

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WO (1) WO1998017236A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001072145A1 (fr) * 2000-03-24 2001-10-04 Ustherapeutics, Llc Supplements nutritionnels prepares a partir de matieres bioactives
WO2010041073A1 (fr) * 2008-10-08 2010-04-15 Biofilm Limited Reminéralisation des dents
EP2401997A3 (fr) * 2004-11-16 2012-03-21 3M Innovative Properties Company Compositions dentaires avec un verre liberant du calcium et du phosphore
US8357515B2 (en) 2007-12-17 2013-01-22 Queen Mary & Westfield College Latency associated protein construct with aggrecanase sensitive cleavage site
CN104013993A (zh) * 2014-03-20 2014-09-03 胡方 一种具有诱导基因表达的骨生物修复制剂的制备方法
US9198842B2 (en) 2009-06-30 2015-12-01 Repregen Limited Multicomponent glasses for use in personal care products
US9233054B2 (en) 2004-11-16 2016-01-12 3M Innovative Properties Company Dental fillers including a phosphorus-containing surface treatment, and compositions and methods thereof
US10137061B2 (en) 2004-11-16 2018-11-27 3M Innovative Properties Company Dental fillers and compositions including phosphate salts

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5673015A (en) * 1979-11-15 1981-06-17 Dentaru Kagaku Kk Toothpaste composition
JPS6210939B2 (fr) * 1981-05-22 1987-03-09 Kyoto Daigaku Socho
JPH02255515A (ja) * 1989-03-29 1990-10-16 Univ Kyoto 生体活性水酸アパタイト膜のコーティング法
JPH09301839A (ja) * 1996-05-14 1997-11-25 Sunstar Inc 生体活性結晶化ガラス含有口腔用組成物

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5673015A (en) * 1979-11-15 1981-06-17 Dentaru Kagaku Kk Toothpaste composition
JPS6210939B2 (fr) * 1981-05-22 1987-03-09 Kyoto Daigaku Socho
JPH02255515A (ja) * 1989-03-29 1990-10-16 Univ Kyoto 生体活性水酸アパタイト膜のコーティング法
JPH09301839A (ja) * 1996-05-14 1997-11-25 Sunstar Inc 生体活性結晶化ガラス含有口腔用組成物

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495168B2 (en) 2000-03-24 2002-12-17 Ustherapeutics, Llc Nutritional supplements formulated from bioactive materials
WO2001072145A1 (fr) * 2000-03-24 2001-10-04 Ustherapeutics, Llc Supplements nutritionnels prepares a partir de matieres bioactives
US9233054B2 (en) 2004-11-16 2016-01-12 3M Innovative Properties Company Dental fillers including a phosphorus-containing surface treatment, and compositions and methods thereof
US10137061B2 (en) 2004-11-16 2018-11-27 3M Innovative Properties Company Dental fillers and compositions including phosphate salts
EP2401997A3 (fr) * 2004-11-16 2012-03-21 3M Innovative Properties Company Compositions dentaires avec un verre liberant du calcium et du phosphore
US9517186B2 (en) 2004-11-16 2016-12-13 3M Innovative Properties Company Dental compositions with calcium phosphorus releasing glass
US8957126B2 (en) 2004-11-16 2015-02-17 3M Innovative Properties Company Dental compositions with calcium phosphorus releasing glass
US9414995B2 (en) 2004-11-16 2016-08-16 3M Innovative Properties Company Dental fillers including a phosphorus-containing surface treatment, and compositions and methods thereof
US8357515B2 (en) 2007-12-17 2013-01-22 Queen Mary & Westfield College Latency associated protein construct with aggrecanase sensitive cleavage site
JP2012505192A (ja) * 2008-10-08 2012-03-01 ノバミン テクノロジー インコーポレイテッド 歯の再石灰化
WO2010041073A1 (fr) * 2008-10-08 2010-04-15 Biofilm Limited Reminéralisation des dents
US9198842B2 (en) 2009-06-30 2015-12-01 Repregen Limited Multicomponent glasses for use in personal care products
CN104013993A (zh) * 2014-03-20 2014-09-03 胡方 一种具有诱导基因表达的骨生物修复制剂的制备方法

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