WO2002015857A1 - Composition orale - Google Patents

Composition orale Download PDF

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Publication number
WO2002015857A1
WO2002015857A1 PCT/JP2001/007148 JP0107148W WO0215857A1 WO 2002015857 A1 WO2002015857 A1 WO 2002015857A1 JP 0107148 W JP0107148 W JP 0107148W WO 0215857 A1 WO0215857 A1 WO 0215857A1
Authority
WO
WIPO (PCT)
Prior art keywords
sodium
particles
oral composition
colored
acid
Prior art date
Application number
PCT/JP2001/007148
Other languages
English (en)
Japanese (ja)
Inventor
Daisuke Uno
Takayuki Oniki
Original Assignee
Lion Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lion Corporation filed Critical Lion Corporation
Priority to AU2001278788A priority Critical patent/AU2001278788A1/en
Priority to KR10-2003-7002483A priority patent/KR20030040411A/ko
Publication of WO2002015857A1 publication Critical patent/WO2002015857A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A23G4/064—Chewing gum characterised by the composition containing organic or inorganic compounds containing inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention relates to an oral composition for removing a colored pellicle.
  • the present inventors have conducted intensive studies in order to respond to the above demand, and as a result, have found that the linear water-soluble polyphosphate has an average particle size of 50 to 1, m and a collapse strength of 10 to 20. It was found that the combined use of 0 g and Z particles significantly improved the effect of removing tooth stains (colored pellicles) colored by tobacco and tea astringent. That is, it has been known that a linear water-soluble polyphosphate such as sodium pyrophosphate has been used as a component for removing stains on teeth (Japanese Patent Application Laid-Open No.
  • Hei 9-19796 / 66 It is also known to incorporate the above particles into a composition for oral cavity (Japanese Unexamined Patent Publication (Kokai) No. Hei 10-182,389, Japanese Patent Application Laid-Open No. 7-55040). No. 1-2999211, Japanese Unexamined Patent Publication No. Hei. 4-238416, Japanese Translation of PCT International Publication No. 10-5505843) is a linear water-soluble polyphosphate, and the above particles. Even if each is used alone The effect of removing colored pellicles is low even when particles having a particle diameter outside the above-mentioned average particle size range or the disintegration strength range are used. The present inventors have found that a remarkable colored pellicle removing effect can be obtained when an acid salt is used in combination with particles having the above-mentioned specific average particle size and disintegration strength.
  • the linear water-soluble polyphosphate used in the oral composition of the present invention has the following general formula (1)
  • M n + 2 P n 0 3 n + 1 (1) ( and ⁇ , M represents a N a or K, n is an integer of 2 or more.)
  • sodium metaphosphate and potassium metaphosphate are particularly preferred.
  • the blending amount of the above polyphosphate is preferably 0.1 to 10% (mass percentage, the same applies hereinafter), particularly preferably 1 to 6% of the whole composition. If the amount is too small, an excellent effect of removing colored pellicles cannot be obtained. If the amount is too large, the taste of the composition may deteriorate.
  • particles having an average particle size of 50 to 1, OOOM and a breaking strength of 10 to 200 g / particle are used in combination with the polyphosphate.
  • those obtained by forming a water-insoluble powder into granules without or with the use of a binder can be used, and in particular, those without a binder are preferred.
  • Water-insoluble powders include dibasic calcium phosphate, tribasic calcium phosphate, insoluble calcium metaphosphate, silica, aluminum hydroxide, magnesium phosphate, red iron oxide, calcium carbonate, calcium pyrophosphate, zeolite, and aluminosilicate Salts, magnesium carbonate, zirconosilicate, calcium sulfate, and the like, and mixtures thereof can be used, and silica is particularly preferable.
  • the particles used in the present invention have an average particle diameter of 50 to 1, as described above, preferably 100 to 700 m, more preferably 200 to 400 m / xm. belongs to.
  • the disintegration strength is 10 to 200 g / piece, preferably 30 to 100 g / piece, and more preferably 50 to 80 gZ pieces. Particles having an average particle size of less than 50 m and particles having a disintegration strength of less than 10 g ia do not have an excellent effect of removing colored pellicles, and particles having an average particle size of more than 100 m and disintegration strength Particles higher than 20 Og / particle cause foreign body sensation and discomfort in the oral cavity.
  • the collapse strength is the maximum stress value (g) per piece when the particles are immersed in water for 60 seconds and then pressed under the conditions of a plunger diameter of 10 mm and a compression speed of 1 OmmZmin. You.
  • the mixing amount of the above particles is preferably 0.1% to 10%, particularly preferably 1% to 5% of the whole composition. If the amount is too small, an excellent effect of removing colored pellicles cannot be obtained, and if the amount is too large, the usability may be reduced.
  • the oral composition of the present invention can be prepared and applied as toothpaste, dentifrice such as liquid toothpaste, dental cream, dental whitening pack, mouthwash, dental whitening solution, etc.
  • Ordinary components according to the type can be blended.
  • an abrasive, a binder, a thickener, a surfactant, a sweetener, a fragrance and the like can be blended in a usual amount.
  • abrasives include calcium hydrogen phosphate dihydrate, calcium tertiary phosphate, calcium carbonate, calcium pyrophosphate, aluminum hydroxide, silicic anhydride, aluminum silicate, insoluble sodium metaphosphate,
  • magnesium phosphate, magnesium carbonate, calcium sulfate, bentonite, zirconium silicate, polymethyl methacrylate, and other synthetic resins can be blended within a range that does not impair the effects of the present invention.
  • binder examples include cellulose derivatives such as carrageenan, sodium carboxymethylcellulose, methylcellulose, and hydroxyethylcellulose; alginic acid derivatives such as sodium alginate and propylene dalicol alginate; One or two of gums such as xanthan gum, suelan gum, tragacanth gum, and karaya gum; synthetic binders such as polyvinyl alcohol, sodium polyacrylate, and carboxyvinyl polymer; and inorganic binders such as silica gel, pea gum, and labonite. More than one species may be included.
  • cellulose derivatives such as carrageenan, sodium carboxymethylcellulose, methylcellulose, and hydroxyethylcellulose
  • alginic acid derivatives such as sodium alginate and propylene dalicol alginate
  • One or two of gums such as xanthan gum, suelan gum, tragacanth gum, and karaya gum
  • synthetic binders such as polyvinyl alcohol,
  • one or more polyhydric alcohols such as glycerin, sorbitol, propylene glycol, polyethylene blend, alcohol, xylitol, maltitol, and lactitol may be blended.
  • an anionic surfactant such as sodium lauryl sulfate, a nonionic surfactant such as decaglyceryl perphosphate and myristate diethanolamide, and an amphoteric surfactant such as a bayonein-based surfactant can be blended.
  • an anionic surfactant such as sodium lauryl sulfate, a nonionic surfactant such as decaglyceryl perphosphate and myristate diethanolamide, and an amphoteric surfactant such as a bayonein-based surfactant can be blended.
  • the fragrance ingredients include menthol, anethol, carvone, eugenol, limonene, n-decyl alcohol, citronellol, ⁇ -terpineol, cineole, linalool, ethyl linalool, peniline, timole, peppermint oil, spearmint Flavors such as oil, Winyuichi green oil, T-shaped oil, and eucalyptus oil can be used alone or in combination.
  • sweeteners such as saccharin sodium, stepioside, dali tillitin, perillartin, and thaumatin can be used.
  • cationic fungicides such as chlorhexidine, benzethonium chloride, benzalkonium chloride, cetylpyridinium chloride, decanidium chloride, triclosan, hinokitiol, and piozole.
  • phenolic compounds dextranase, mutanase, lysozyme, amylase, protease, lytic enzymes, enzymes such as superoxide Day Sum synthetase, vitamin E, vitamins such as vitamin B 6, sodium Monofuruororin acid, Al forces such Monofuruororin acid Kariumu Li-metal monofluorophosphate, sodium fluoride, fluorides such as stannous fluoride, tranexamic acid, epsilon amino cabronic acid, aluminum chlorohydroxyl allantoin, dihydrocholesta Lumpur, glycyrrhizin acid, glycyrrhetinic acid, Pisaporo Ichiru, Guriserofo Sufeto, chlorophyll, sodium chloride, the active ingredient publicly known, such as water-soluble inorganic phosphoric acid compounds may be formulated alone or in combination.
  • the oral composition according to the present invention has an excellent colored pellicle removing effect. You.
  • the color difference is measured using the color of the hydroxyapatite pellet (hereinafter referred to as HAP) as a reference value (L0). Treat the measured HAP with saliva at 37 ° C for 30 minutes. After 3 minutes, rinse the HAP with deionized water, then remove the water droplets on the HAP.
  • HAP hydroxyapatite pellet
  • HAP was repeatedly immersed in 0.5% aqueous albumin solution ⁇ 3% Japanese tea + 1% coffee + 1% black tea extraction aqueous solution ⁇ 0.6% iron ammonium citrate aqueous solution for 1 hour each. This operation was continued for 50 cycles. Removed from the coloring liquid, dried at room temperature for one day, lightly brushed the surface of HAP in running water to remove weakly adhered coloring matter, air-dried again, and measured the color difference of the colored HAP produced (L1) . After applying the dentifrice to the toothbrush and brushing the surface of the prepared colored HAP 1,000 times, the color difference was measured (L2), and the colored pellicle removing effect was calculated by the following formula. 1) One (L0-L2)
  • Particle A average particle size 300 rn, crushing strength 60 gZ, silica particles
  • Particle B average particle size 10 m, collapse strength 60 g / piece, silica particles
  • Particle C average particle diameter 300 urn, decay strength 6 gZ, silica particles
  • the colored pellicle-removed particles were immersed in water for 60 seconds, and after 60 seconds, removed from the water and measured for the maximum stress when the plunger diameter was 1 Omm and the compression speed was 1 Omm / min. did.
  • Particle A 4.0% Sodium pyrophosphate 3.0 Sodium tririboliphosphate 4,0 Xanthan gum 0,2 Sodium polyacrylate 0,2 Butylparaben 0,
  • Particle A 1.0% sodium pyrophosphate 4.0 Ethanol 5 0 Glycerin 0 0

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Inorganic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une composition orale destinée à l'élimination de pellicules décolorées, caractérisée en ce qu'elle renferme un ou plusieurs sels hydrosolubles linéaires de polyphosphate représentés par la formule générale (1) (dans laquelle M représente Na ou K ; et n représente un entier supérieur ou égal à 2) ainsi que des particules possédant un diamètre moyen compris entre 50 et 1'000 νm et une résistance à la rupture comprise entre 100 et 20 g/particule.
PCT/JP2001/007148 2000-08-23 2001-08-21 Composition orale WO2002015857A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001278788A AU2001278788A1 (en) 2000-08-23 2001-08-21 Oral composition
KR10-2003-7002483A KR20030040411A (ko) 2000-08-23 2001-08-21 구강용 조성물

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000-251890 2000-08-23
JP2000251890A JP2002068947A (ja) 2000-08-23 2000-08-23 口腔用組成物

Publications (1)

Publication Number Publication Date
WO2002015857A1 true WO2002015857A1 (fr) 2002-02-28

Family

ID=18741229

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2001/007148 WO2002015857A1 (fr) 2000-08-23 2001-08-21 Composition orale

Country Status (4)

Country Link
JP (1) JP2002068947A (fr)
KR (1) KR20030040411A (fr)
AU (1) AU2001278788A1 (fr)
WO (1) WO2002015857A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004010962A1 (fr) * 2002-07-31 2004-02-05 Bon-Gil Koo Composition liquide servant a proteger les cavites buccales et les dents des animaux domestiques et utilisation de cette composition dans des jouets pour animaux domestiques
CN104189773A (zh) * 2014-09-19 2014-12-10 徐德玲 一种用于骨折后止痛消肿的中药组合物

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5961013B2 (ja) * 2012-03-02 2016-08-02 花王株式会社 歯磨剤
JP7376976B2 (ja) * 2017-12-26 2023-11-09 小林製薬株式会社 タバコ臭消臭用口腔用組成物

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3767791A (en) * 1971-06-03 1973-10-23 Colgate Palmolive Co Dental cream containing abrasive agglomerates
JPH01299211A (ja) * 1988-05-25 1989-12-04 Kao Corp 歯磨剤
JPH04243816A (ja) * 1991-01-28 1992-08-31 Kao Corp 顆粒剤及びこれを含有する口腔用組成物
WO1996009033A1 (fr) * 1994-09-21 1996-03-28 Crosfield Limited Compositions granulaires

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3767791A (en) * 1971-06-03 1973-10-23 Colgate Palmolive Co Dental cream containing abrasive agglomerates
JPH01299211A (ja) * 1988-05-25 1989-12-04 Kao Corp 歯磨剤
JPH04243816A (ja) * 1991-01-28 1992-08-31 Kao Corp 顆粒剤及びこれを含有する口腔用組成物
WO1996009033A1 (fr) * 1994-09-21 1996-03-28 Crosfield Limited Compositions granulaires

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004010962A1 (fr) * 2002-07-31 2004-02-05 Bon-Gil Koo Composition liquide servant a proteger les cavites buccales et les dents des animaux domestiques et utilisation de cette composition dans des jouets pour animaux domestiques
CN104189773A (zh) * 2014-09-19 2014-12-10 徐德玲 一种用于骨折后止痛消肿的中药组合物

Also Published As

Publication number Publication date
JP2002068947A (ja) 2002-03-08
AU2001278788A1 (en) 2002-03-04
KR20030040411A (ko) 2003-05-22

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