WO1997030724A1 - Rt-pa zur prävention des nachstars nach kataraktoperation - Google Patents
Rt-pa zur prävention des nachstars nach kataraktoperation Download PDFInfo
- Publication number
- WO1997030724A1 WO1997030724A1 PCT/EP1997/000756 EP9700756W WO9730724A1 WO 1997030724 A1 WO1997030724 A1 WO 1997030724A1 EP 9700756 W EP9700756 W EP 9700756W WO 9730724 A1 WO9730724 A1 WO 9730724A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fibrosis
- rtpa
- prevention
- proliferation
- posterior capsule
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
Definitions
- the present invention relates to the use of rt-PA for the prevention of postoperative proliferation of lens tissue on the posterior capsule wall (fibrosis) in the case of extracapsular cataract extraction.
- the fibrosis of the posterior capsule wall also called connective tissue proliferation, is the most common late complication of extracapsular cataract extraction (Z. Prakt. Augenheilkd. 15, 488 (1994)). In 35-51% of cases, follow-up treatment is necessary within 5 years.
- cystoid macular edema and rubeosis iridis MC Boschi et al., New Trends Ophthalmol., 9 (1), 55-57 (1994); D. Altamirano et al., Klin. Monatbl. Augenheilkd., 204 (5), 286-287 (1994)).
- t-PA is the main cause of the episcleral fibrosis (discoloration) of the filter pad after trabeculectomy (glaucoma operation) for the failure of this therapy, significantly decreased.
- a drainage fistula (filter cushion) is placed through the conjunctiva, which, however, clogs up again as a result of fibroblast proliferation.
- the authors cite the inhibition of the formation of a primary fibrin / fibronectin matrix as a probable cause for the successful prevention of this complication by t-PA, which may function as a framework for the subsequent fibrosis.
- EP-A-0 318 801 describes that rt-PA prevents the formation of adhesions of organs or parts of organs after invasive interventions in the chest or abdominal cavity.
- the present invention thus relates to the use of rt-PA for the prevention of the fibrosis of the posterior capsule wall known as the afterstar after extracapsular cataract extraction.
- the reduction in fibrosis is associated with an improvement in vision.
- Another object of the invention is the use of rt-PA for the manufacture of a medicament for the prevention of the night star.
- isoforms or mutants derived therefrom can also be used, provided that they have comparable fibrinolytic activity.
- Isoforms or mutants are understood to mean those forms which, in addition to the native structure, contain one or more amino acids, differ in the amino acid sequence with respect to one or more amino acids from the naturally occurring t-PA (ie have a heterologous amino acid sequence), or in which one or more amino acids which are present in the natural t-PA are not present, and their glycosylated and non-glycosylated derivatives.
- Rt-PA is applied postoperatively, with an amount of 1-20 ⁇ g preferably instilled into the anterior chamber by paracentesis or administered subconjunctivally.
- rt-PA is present as a lyophilisate for the solution, an aqueous arginine / polysorbate buffer being used as the solvent.
- concentration of the effective dose after reconstitution of the solution is 1-20 ⁇ g rt-PA in 0.01-0.1 ml per injection.
- a suitable medicament for the prevention of the fibrosis of the posterior capsule wall known as the afterstar after extracapsular cataract extraction contains for example in one unit the fibrinolytic rt-PA as a lyophilisate in an amount of 0.10-0.50 mg, preferably together with stabilizers or buffers such as arginine, phosphoric acid and Polysorbate 80, and in a second unit as a diluent, 2 to 6 ml of an aqueous 0.1-0.3 M arginine / polysorbate buffer, advantageously prefilled into a syringe, so that after reconstitution of the rt-PA solution, the fibrinolytic in a concentration from 0.05 to 0.2 mg / ml.
- a dose of 1-20 ⁇ g rt-PA is applied from this solution by injection of a corresponding volume of the reconstituted solution.
- the lyophilisate preferably contains 0.3 mg of rt-PA and 3 ml of 0.2M arginine / phosphate buffer with a pH of 7.3 are preferably used as diluent.
- the preferred application amount is 10 ⁇ g rt-PA in 100 ⁇ l of the buffer mentioned.
- the effect of a single dose of rt-PA on the incidence of fibrosis of the posterior capsule wall after extracapsular cataract extraction was examined in a clinical study.
- the investigations were carried out in a randomized, double-blind, parallel group study.
- the dose unit of 10 ⁇ g rt-PA was available as a solution in 100 ⁇ l 0.2 M arginine buffer, and 100 ⁇ l 0.2 M arginine buffer alone was used as placebo.
- the lyophilisate then has the following composition
- diluent 3 ml of sterile 0 2 M arginine / phosphate buffer are filled into a 3 ml syringe as diluent.
- the diluent has the following composition
- the product After reconstitution of the lyophilizate with 3 ml of the diluent, the product has the following composition
- solution 100 ⁇ l, which contain 0.01 mg rt-PA, are administered intraocularly.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97905042A EP0881909A1 (de) | 1996-02-22 | 1997-02-18 | Rt-pa zur prävention des nachstars nach kataraktoperation |
AU18741/97A AU1874197A (en) | 1996-02-22 | 1997-02-18 | Recombinant tissue plasminogen activator (RTPA) for preventing secondar y cataracts following cataract operations |
JP9529779A JP2000504737A (ja) | 1996-02-22 | 1997-02-18 | 白内障手術後における続発性白内障の予防のためのrt―PA |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19606551.8 | 1996-02-22 | ||
DE19606551A DE19606551C2 (de) | 1996-02-22 | 1996-02-22 | rt-PA zur Prävention des Nachstars nach Kataraktoperation |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1997030724A1 true WO1997030724A1 (de) | 1997-08-28 |
Family
ID=7786075
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1997/000756 WO1997030724A1 (de) | 1996-02-22 | 1997-02-18 | Rt-pa zur prävention des nachstars nach kataraktoperation |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0881909A1 (de) |
JP (1) | JP2000504737A (de) |
AR (1) | AR005949A1 (de) |
AU (1) | AU1874197A (de) |
CA (1) | CA2247460A1 (de) |
DE (1) | DE19606551C2 (de) |
WO (1) | WO1997030724A1 (de) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999039722A2 (en) * | 1998-02-04 | 1999-08-12 | Kiyoshi Okada | Compositions and methods for separating lens epithelial cells and preventing posterior capsular opacification |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0041449A1 (de) * | 1980-05-29 | 1981-12-09 | Pierre Fabre S.A. | Verwendung von ophthalmischen Zusammensetzungen, die einen Plasminogenaktivator enthalten, zur Reinigung von Kontaktlinsen |
EP0228862A2 (de) * | 1985-12-17 | 1987-07-15 | Genentech, Inc. | Stabilisierte Zusammensetzungen von menschlichen Aktivatoren des Gewebeplasminogens |
EP0540747A1 (de) * | 1991-04-22 | 1993-05-12 | Senju Pharmaceutical Co., Ltd. | Medizin zur intraokularen operation |
-
1996
- 1996-02-22 DE DE19606551A patent/DE19606551C2/de not_active Expired - Fee Related
-
1997
- 1997-02-18 EP EP97905042A patent/EP0881909A1/de not_active Withdrawn
- 1997-02-18 AU AU18741/97A patent/AU1874197A/en not_active Abandoned
- 1997-02-18 WO PCT/EP1997/000756 patent/WO1997030724A1/de not_active Application Discontinuation
- 1997-02-18 CA CA002247460A patent/CA2247460A1/en not_active Abandoned
- 1997-02-18 JP JP9529779A patent/JP2000504737A/ja active Pending
- 1997-02-21 AR ARP970100705A patent/AR005949A1/es unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0041449A1 (de) * | 1980-05-29 | 1981-12-09 | Pierre Fabre S.A. | Verwendung von ophthalmischen Zusammensetzungen, die einen Plasminogenaktivator enthalten, zur Reinigung von Kontaktlinsen |
EP0228862A2 (de) * | 1985-12-17 | 1987-07-15 | Genentech, Inc. | Stabilisierte Zusammensetzungen von menschlichen Aktivatoren des Gewebeplasminogens |
EP0540747A1 (de) * | 1991-04-22 | 1993-05-12 | Senju Pharmaceutical Co., Ltd. | Medizin zur intraokularen operation |
Non-Patent Citations (8)
Title |
---|
"DICTIONNAIRE VIDAL, 71. AUFLAGE", 1995, EDITIONS DU VIDAL, PARIS, FR, XP002032553 * |
DATABASE BIOSIS BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; KIM ET AL: "THE EFFECT OF TISSUE PLASMINOGEN ACTIVATOR ON THE RESOLUTION OF EXPERIMENTAL FIBRINOUS MEMBRANE FOLLOWING EXTRACAPSULAR CATARACT EXTRACTION IN RABBITS", XP002032555 * |
DATABASE MEDLINE FILE SERVER STN KARLSRUHE; STARCK ET AL: "LOW-DOSE INTRAOCULAR TISSUE PLASMINOGEN ACTIVATOR TREATMENT FOR TRAUMATIC TOTAL HYPHEMA, POSTCATARACT, AND PENETRATING KERATOPLASTY FIBRINOUS MEMBRANES", XP002032554 * |
J CATHOL MED COLL, vol. 44, no. 4, 1991, pages 1253 - 1262 * |
JOURNAL OF CATARACT AND REFRACTIVE SURGERY, vol. 21, no. 2, March 1995 (1995-03-01), pages 219 - 224 * |
SCHMITZ ET AL: "TISSUE PLASMINOGEN ACTIVATOR FOR THE TREATMENT OF POSTOPERATIVE INTRAOCULAR FIBRINOUS MEMBRANES FOLLOWING CATARACT SURGERY", GERMAN JOURNAL OF OPHTHALMOLOGY, vol. 4, no. 2, 1995, pages 75 - 79, XP000674541 * |
STRAUSS ET AL: "SUBCONJUNCTIVAL HIGH DOSE PLASMINOGEN ACTIVATOR IN RABBIT FILTRATION SURGERY", JOURNAL OF OCULAR PHARMACOLOGY, vol. 7, no. 1, 1991, pages 9 - 19, XP000674528 * |
WEDRICH ET AL: "THE USE OF RECOMBINANT TISSUE PLASMINOGEN ACTIVATOR FOR INTRACAMERAL FIBINOLYSIS FOLLOWING CATARACT SURGERY", INTERNATIONAL OPHTHALMOLOGY, vol. 18, 1995, pages 277 - 280, XP000674530 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999039722A2 (en) * | 1998-02-04 | 1999-08-12 | Kiyoshi Okada | Compositions and methods for separating lens epithelial cells and preventing posterior capsular opacification |
WO1999039722A3 (en) * | 1998-02-04 | 1999-12-23 | Kiyoshi Okada | Compositions and methods for separating lens epithelial cells and preventing posterior capsular opacification |
Also Published As
Publication number | Publication date |
---|---|
AU1874197A (en) | 1997-09-10 |
AR005949A1 (es) | 1999-07-21 |
CA2247460A1 (en) | 1997-08-28 |
JP2000504737A (ja) | 2000-04-18 |
DE19606551A1 (de) | 1997-08-28 |
DE19606551C2 (de) | 2000-06-08 |
EP0881909A1 (de) | 1998-12-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69825906T2 (de) | Verwendung von angiostatische steroide in photodynamischer therapie | |
Jampel et al. | Trabeculectomy with 5-fluorouracil for adult inflammatory glaucoma | |
KR100889170B1 (ko) | 안구 건조의 치료에 있어서 리멕솔론의 용도 | |
DE69730476T2 (de) | Albumin als aktiver Bestandteil zur Behandlung von Bindehaut- und Hornhautverletzungen und von trockenen Augen | |
JPS62501002A (ja) | 高い眼圧の防止法、緑内障の処置及び高眼圧の処置 | |
Bartlett et al. | Safety and efficacy of loteprednol etabonate for treatment of papillae in contact lens-associated giant papillary conjunctivitis | |
EP0430200A1 (de) | Arzneimittel zur subkutanen oder intramuskulären Applikation enthaltend Polypeptide | |
EP0380560B1 (de) | Verwendung von tetracycline zur herstellung eines arzneimittels zum herabsetzen des augendrucks | |
WO1999038497A2 (en) | Ophthalmic composition | |
DE69836858T2 (de) | Verwendung von hyaluronidase zur herstellung eines augenpräparats zur glasskörperverflüssigung bei der behandlung von augenerkrankungen | |
McDONALD et al. | Hydrocortisone (compound F) in ophthalmology: Clinical and experimental studies | |
DE19606551C2 (de) | rt-PA zur Prävention des Nachstars nach Kataraktoperation | |
DE60027878T2 (de) | Verwendung des nervenwachstumfaktors zur herstellung eines arzneimittels zur behandlung von erkrankungen der innenaugegeweb | |
EP1380302B1 (de) | Heilmittel für erkrankungen der retina und der aderhaut die als aktive bestandteile steroide enthalten | |
DE69628430T2 (de) | Verwendung von lactoferrin zur prävention des nachoperativen astigmatismus | |
DE60304458T2 (de) | Verwendung eines l-ascorbinsäuresalzes zur herstellung einer pharmazeutischen zusammensetzung für die ophthalmische topische anwendung zur verbesserung des l-ascorbinsäurespiegels im auge | |
DE60213230T2 (de) | Verwendung von NF-Kappa.B Inhibitoren zur Behandlung von Augentrockenheit | |
US20030008853A1 (en) | Method for treating dry eye disorders | |
Behrens-Baumann et al. | Experimental study on drug therapy of “traction retinal detachment” after posterior penetrating eye injury in the rabbit | |
Gregersen et al. | The effect of indomethacin 1% ophthalmic suspension on the pupil during extracapsular cataract surgery | |
Ball | Effects of triamcinolone injection | |
EP0719556A2 (de) | Mittel zur Behandlung von Keratopathie | |
Lewis et al. | Aminozolamide suspension: the role of the vehicle in a topical carbonic anhydrase inhibitor | |
DE60225576T2 (de) | Verfahren zur unterdrückung der bildung von seromen mit faktor xiii | |
DD271268A5 (de) | Verfahren zur herstellung einer topisch anwendbaren pharmazeutischen zusammensetzung zur verhinderung von fibrinablagerungen oder verwachsungen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE HU IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG US UZ VN YU AM AZ BY KG KZ MD RU TJ TM |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): KE LS MW SD SZ UG AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 1997905042 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: 2247460 Country of ref document: CA Ref country code: CA Ref document number: 2247460 Kind code of ref document: A Format of ref document f/p: F |
|
WWP | Wipo information: published in national office |
Ref document number: 1997905042 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 1997905042 Country of ref document: EP |