WO1999039722A3 - Compositions and methods for separating lens epithelial cells and preventing posterior capsular opacification - Google Patents

Compositions and methods for separating lens epithelial cells and preventing posterior capsular opacification Download PDF

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Publication number
WO1999039722A3
WO1999039722A3 PCT/IB1999/000905 IB9900905W WO9939722A3 WO 1999039722 A3 WO1999039722 A3 WO 1999039722A3 IB 9900905 W IB9900905 W IB 9900905W WO 9939722 A3 WO9939722 A3 WO 9939722A3
Authority
WO
WIPO (PCT)
Prior art keywords
epithelial cells
treating solution
lens
lens epithelial
compositions
Prior art date
Application number
PCT/IB1999/000905
Other languages
French (fr)
Other versions
WO1999039722A2 (en
Inventor
Kiyoshi Okada
Original Assignee
Kiyoshi Okada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kiyoshi Okada filed Critical Kiyoshi Okada
Priority to EP99918229A priority Critical patent/EP1053003A1/en
Priority to AU36242/99A priority patent/AU3624299A/en
Priority to JP2000530219A priority patent/JP2002502821A/en
Publication of WO1999039722A2 publication Critical patent/WO1999039722A2/en
Publication of WO1999039722A3 publication Critical patent/WO1999039722A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/484—Plasmin (3.4.21.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Posterior capsular opacification can be prevented by modulating focal contacts, which mediate adhesion between lens epithelial cells and the lens capsule, using a treating solution containing a focal contact-modulating substance or a proenzyme, such as Lys-plasminogen, which is introduced into the lens capsular bag during cataract surgery. To secure the passage of a treating solution between the lens epithelial cells, a calcium chelating agent, such as ethylenediamine tetraacetic acid (EDTA), is included in a treating solution. To limit the effect of the treating solution to lens epithelial cells prior to, during, and/or after capsulotomy, and inhibitor, such as φ-amino acid, can be introduced into the anterior chamber before the treating solution as a mixture with a viscoelastic material, such as sodium hyaluronate, or into the lens capsular bag without a viscoelastic material during capsulotomy.
PCT/IB1999/000905 1998-02-04 1999-02-02 Compositions and methods for separating lens epithelial cells and preventing posterior capsular opacification WO1999039722A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP99918229A EP1053003A1 (en) 1998-02-04 1999-02-02 Compositions and methods for separating lens epithelial cells and preventing posterior capsular opacification
AU36242/99A AU3624299A (en) 1998-02-04 1999-02-02 Compositions and methods for separating lens epithelial cells and preventing posterior capsular opacification
JP2000530219A JP2002502821A (en) 1998-02-04 1999-02-02 Pharmaceutical formulations for removing lens epithelial cells and preventing secondary cataract and methods of use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1771698A 1998-02-04 1998-02-04
US09/017,716 1998-02-04

Publications (2)

Publication Number Publication Date
WO1999039722A2 WO1999039722A2 (en) 1999-08-12
WO1999039722A3 true WO1999039722A3 (en) 1999-12-23

Family

ID=21784159

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1999/000905 WO1999039722A2 (en) 1998-02-04 1999-02-02 Compositions and methods for separating lens epithelial cells and preventing posterior capsular opacification

Country Status (4)

Country Link
EP (1) EP1053003A1 (en)
JP (1) JP2002502821A (en)
AU (1) AU3624299A (en)
WO (1) WO1999039722A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9844556B2 (en) 2015-03-25 2017-12-19 Megumi Honjo Preventive/therapeutic method and preventive/therapeutic agent for complications after cataract surgery
CN114613240B (en) * 2021-08-09 2023-07-14 首都医科大学附属北京同仁医院 Processing method of anterior capsule of isolated pig eyeball and capsulorhexis training model for cataract operation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0464727A2 (en) * 1990-06-29 1992-01-08 Santen Pharmaceutical Co., Ltd. Use of a composition for the preparation of a medicament for debridment of retained lens material
WO1997030724A1 (en) * 1996-02-22 1997-08-28 Alcon Pharmaceuticals, Ltd. Recombinant tissue plasminogen activator (rtpa) for preventing secondary cataracts following cataract operations

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0464727A2 (en) * 1990-06-29 1992-01-08 Santen Pharmaceutical Co., Ltd. Use of a composition for the preparation of a medicament for debridment of retained lens material
US5204331A (en) * 1990-06-29 1993-04-20 Santen Pharmaceutical Co., Ltd. Composition for debridement of retained lens materials
WO1997030724A1 (en) * 1996-02-22 1997-08-28 Alcon Pharmaceuticals, Ltd. Recombinant tissue plasminogen activator (rtpa) for preventing secondary cataracts following cataract operations

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J. PÖLLÄNEN ET AL.: "ULTRASTRUCTURAL LOCALIZATION OF PLASMA MEMBRANE-ASSOCIATED UROKINASE-TYPE PLASMINOGEN ACTIVATOR AT FOCAL CONTACTS.", THE JOURNAL OF CELL BIOLOGY, vol. 106, no. 1, January 1988 (1988-01-01), NEW YORK, N.Y., US, pages 87 - 95, XP002120028 *

Also Published As

Publication number Publication date
AU3624299A (en) 1999-08-23
EP1053003A1 (en) 2000-11-22
JP2002502821A (en) 2002-01-29
WO1999039722A2 (en) 1999-08-12

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