WO1997012035A3 - Animaux transgeniques pour xenotransplantation avec limitation du rejet induit par des anticorps - Google Patents
Animaux transgeniques pour xenotransplantation avec limitation du rejet induit par des anticorps Download PDFInfo
- Publication number
- WO1997012035A3 WO1997012035A3 PCT/US1996/015255 US9615255W WO9712035A3 WO 1997012035 A3 WO1997012035 A3 WO 1997012035A3 US 9615255 W US9615255 W US 9615255W WO 9712035 A3 WO9712035 A3 WO 9712035A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- transgenic animals
- cells
- antibody
- organs
- tissues
- Prior art date
Links
- 241001465754 Metazoa Species 0.000 title abstract 5
- 230000009261 transgenic effect Effects 0.000 title abstract 5
- 206010052779 Transplant rejections Diseases 0.000 title abstract 4
- 238000002689 xenotransplantation Methods 0.000 title 1
- 239000004074 complement inhibitor Substances 0.000 abstract 4
- 210000000056 organ Anatomy 0.000 abstract 4
- 229940124073 Complement inhibitor Drugs 0.000 abstract 3
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 238000002054 transplantation Methods 0.000 abstract 2
- 102100022002 CD59 glycoprotein Human genes 0.000 abstract 1
- 101000897400 Homo sapiens CD59 glycoprotein Proteins 0.000 abstract 1
- 241000288906 Primates Species 0.000 abstract 1
- QIGJYVCQYDKYDW-SDOYDPJRSA-N alpha-D-galactosyl-(1->3)-D-galactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@H]1[C@@H](O)[C@@H](CO)OC(O)[C@@H]1O QIGJYVCQYDKYDW-SDOYDPJRSA-N 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 230000024203 complement activation Effects 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 230000008105 immune reaction Effects 0.000 abstract 1
- 230000010354 integration Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/108—Swine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
- A01K2267/025—Animal producing cells or organs for transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Animal Husbandry (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MXPA98002434A MXPA98002434A (es) | 1995-09-27 | 1996-09-23 | Animales transgenicos para xenotrasplante con rechazo reducido de anticuerpos mediados. |
BR9610843A BR9610843A (pt) | 1995-09-27 | 1996-09-23 | Animais transgênicos para xenotransplante com reduzida rejeição mediada por anticorpo |
AU71170/96A AU727546B2 (en) | 1995-09-27 | 1996-09-23 | Transgenic animals for xenotransplantation with reduced antibody-mediated rejection |
IL12379196A IL123791A0 (en) | 1995-09-27 | 1996-09-23 | Transgenic animals for xenotransplantation with reduced antibody-mediated rejection |
EP96932320A EP0853665A2 (fr) | 1995-09-27 | 1996-09-23 | Animaux transgeniques pour xenotransplantation avec limitation du rejet induit par des anticorps |
JP51354297A JP2001517924A (ja) | 1995-09-27 | 1996-09-23 | 抗体媒介性拒絶反応を低減させた異種移植のためのトランスジェニック動物 |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US446195P | 1995-09-27 | 1995-09-27 | |
US60/004,461 | 1995-09-27 | ||
US08/675,773 | 1996-07-03 | ||
US08/675,773 US6166288A (en) | 1995-09-27 | 1996-07-03 | Method of producing transgenic animals for xenotransplantation expressing both an enzyme masking or reducing the level of the gal epitope and a complement inhibitor |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1997012035A2 WO1997012035A2 (fr) | 1997-04-03 |
WO1997012035A3 true WO1997012035A3 (fr) | 1997-06-12 |
Family
ID=26673032
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1996/015255 WO1997012035A2 (fr) | 1995-09-27 | 1996-09-23 | Animaux transgeniques pour xenotransplantation avec limitation du rejet induit par des anticorps |
Country Status (10)
Country | Link |
---|---|
US (1) | US6166288A (fr) |
EP (1) | EP0853665A2 (fr) |
JP (1) | JP2001517924A (fr) |
CN (1) | CN1278299A (fr) |
AU (1) | AU727546B2 (fr) |
BR (1) | BR9610843A (fr) |
CA (1) | CA2233040A1 (fr) |
IL (1) | IL123791A0 (fr) |
MX (1) | MXPA98002434A (fr) |
WO (1) | WO1997012035A2 (fr) |
Families Citing this family (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6331658B1 (en) * | 1993-04-20 | 2001-12-18 | Integris Baptist Medical Center, Inc. | Genetically engineered mammals for use as organ donors |
US6231608B1 (en) * | 1995-06-07 | 2001-05-15 | Crosscart, Inc. | Aldehyde and glycosidase-treated soft and bone tissue xenografts |
WO1997044449A1 (fr) * | 1996-05-17 | 1997-11-27 | Nippon Meat Packers, Inc. | Promoteurs d'inhibiteurs complementaires porcins |
US6455037B1 (en) * | 1996-11-01 | 2002-09-24 | Mount Sinai School Of Medicine Of The City University Of New York | Cells expressing an αgala nucleic acid and methods of xenotransplantation |
US6011197A (en) | 1997-03-06 | 2000-01-04 | Infigen, Inc. | Method of cloning bovines using reprogrammed non-embryonic bovine cells |
AU7935598A (en) * | 1997-07-14 | 1999-02-10 | Nippon Meat Packers, Inc. | Transgenic mammals |
CA2248971A1 (fr) * | 1997-10-31 | 1999-04-30 | Kyowa Hakko Kogyo Co., Ltd. | Beta-1,3-n-acetylglucosaminyltransferase, adn l'encodant et son utilisation |
US6383732B1 (en) * | 1999-02-11 | 2002-05-07 | Crosscart, Inc. | Method of preparing xenograft heart valves |
GB9807520D0 (en) | 1998-04-09 | 1998-06-10 | Univ Wales Medicine | Modified biological material |
US6197294B1 (en) | 1998-10-26 | 2001-03-06 | Neurotech S.A. | Cell surface molecule-induced macrophage activation |
US6700037B2 (en) | 1998-11-24 | 2004-03-02 | Infigen, Inc. | Method of cloning porcine animals |
US6258998B1 (en) | 1998-11-24 | 2001-07-10 | Infigen, Inc. | Method of cloning porcine animals |
US6267786B1 (en) * | 1999-02-11 | 2001-07-31 | Crosscart, Inc. | Proteoglycan-reduced soft tissue xenografts |
WO2001000848A1 (fr) * | 1999-06-29 | 2001-01-04 | Kyowa Hakko Kogyo Co., Ltd. | Polypeptide utile |
US7414170B2 (en) | 1999-11-19 | 2008-08-19 | Kirin Beer Kabushiki Kaisha | Transgenic bovines capable of human antibody production |
US7074983B2 (en) | 1999-11-19 | 2006-07-11 | Kirin Beer Kabushiki Kaisha | Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin |
US7820878B2 (en) | 1999-11-19 | 2010-10-26 | Kyowa Hakko Kirin Co., Ltd. | Production of ungulates, preferably bovines that produce human immunoglobulins |
AU2001261650A1 (en) * | 2000-05-15 | 2001-11-26 | Geron Corporation | Ovine tissue for xenotransplantation |
EP1314352B1 (fr) * | 2000-08-25 | 2013-06-12 | Nippon Meat Packers, Inc. | Porcs transgeniques portant un gene codant beta-d-mannoside beta-1,4 n-acetylglucosaminyltransferase |
JP4955905B2 (ja) * | 2001-02-20 | 2012-06-20 | イントレキソン コーポレーション | キメラレチノイドx受容体および新規エクジソン受容体−ベースの誘導性遺伝子発現システムにおけるそれらの使用 |
US7126039B2 (en) | 2001-03-21 | 2006-10-24 | Geron Corporation | Animal tissue with carbohydrate antigens compatible for human transplantation |
CA2445945A1 (fr) * | 2001-04-30 | 2002-11-07 | Rbc Biotechnology, Inc. | Cellules et organes modifies destines a la xenotransplantation |
US20050108780A1 (en) * | 2002-01-24 | 2005-05-19 | Erasmus University | Intracellular antibodies for a retrovirus protein |
WO2004016742A2 (fr) | 2002-08-14 | 2004-02-26 | Immerge Biotherapeutics, Inc. | Cellules depourvues d'$g(a)(1,3)-galactosyltransferase, procedes de selection et porc depourvu d'$g(a)(1,3)-galactosyltransferase ainsi obtenu |
AU2003290689A1 (en) | 2002-11-08 | 2004-06-03 | Kyowa Hakko Kirin Co., Ltd. | Transgenic ungulates having reduced prion protein activity and uses thereof |
US7514593B2 (en) * | 2003-05-30 | 2009-04-07 | The University Of North Carolina At Chapel Hill | Animal model for chronic obstructive pulmonary disease and cystic fibrosis |
CA2528500A1 (fr) * | 2003-06-06 | 2004-12-16 | University Of Pittsburgh | Gene porcin de l'hydroxylase d'acide cmp-n-acetylneuraminique |
EP3184629A1 (fr) | 2003-06-20 | 2017-06-28 | Axiogenesis Ag | Découverte de médicaments à base de tissu produit in vitro |
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- 1996-09-23 MX MXPA98002434A patent/MXPA98002434A/es not_active Application Discontinuation
- 1996-09-23 CA CA002233040A patent/CA2233040A1/fr not_active Abandoned
- 1996-09-23 IL IL12379196A patent/IL123791A0/xx unknown
- 1996-09-23 WO PCT/US1996/015255 patent/WO1997012035A2/fr not_active Application Discontinuation
- 1996-09-23 EP EP96932320A patent/EP0853665A2/fr not_active Withdrawn
- 1996-09-23 CN CN96198555A patent/CN1278299A/zh active Pending
- 1996-09-23 JP JP51354297A patent/JP2001517924A/ja active Pending
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Also Published As
Publication number | Publication date |
---|---|
JP2001517924A (ja) | 2001-10-09 |
BR9610843A (pt) | 1999-07-13 |
AU727546B2 (en) | 2000-12-14 |
EP0853665A2 (fr) | 1998-07-22 |
AU7117096A (en) | 1997-04-17 |
US6166288A (en) | 2000-12-26 |
CN1278299A (zh) | 2000-12-27 |
IL123791A0 (en) | 1998-10-30 |
WO1997012035A2 (fr) | 1997-04-03 |
MXPA98002434A (es) | 2005-04-29 |
CA2233040A1 (fr) | 1997-04-03 |
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