WO2000029002A3 - Transplantation intra-uterine de cellules embryonnaires mesenchymateuses humaines - Google Patents

Transplantation intra-uterine de cellules embryonnaires mesenchymateuses humaines Download PDF

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Publication number
WO2000029002A3
WO2000029002A3 PCT/US1999/026927 US9926927W WO0029002A3 WO 2000029002 A3 WO2000029002 A3 WO 2000029002A3 US 9926927 W US9926927 W US 9926927W WO 0029002 A3 WO0029002 A3 WO 0029002A3
Authority
WO
WIPO (PCT)
Prior art keywords
stem cells
mesenchymal stem
human mesenchymal
transplantation
utero transplantation
Prior art date
Application number
PCT/US1999/026927
Other languages
English (en)
Other versions
WO2000029002A2 (fr
Inventor
Mark Thiede
Alan Flake
Original Assignee
Osiris Therapeutics Inc
Mark Thiede
Alan Flake
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osiris Therapeutics Inc, Mark Thiede, Alan Flake filed Critical Osiris Therapeutics Inc
Priority to CA002348514A priority Critical patent/CA2348514A1/fr
Priority to JP2000582048A priority patent/JP2002529509A/ja
Priority to EP99972103A priority patent/EP1128836A2/fr
Priority to AU14780/00A priority patent/AU1478000A/en
Publication of WO2000029002A2 publication Critical patent/WO2000029002A2/fr
Publication of WO2000029002A3 publication Critical patent/WO2000029002A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention se rapporte à des cellules embryonnaires mésenchymateuses destinées à une transplantation intra-utérine. Ces cellules embryonnaires mésenchymateuses peuvent être utilisées dans une méthode de traitement d'un foetus, ou dans une méthode de greffe de cellules embryonnaires mésenchymateuses, ou encore dans une méthode de préparation d'un organe en vue de sa transplantation.
PCT/US1999/026927 1998-11-13 1999-11-12 Transplantation intra-uterine de cellules embryonnaires mesenchymateuses humaines WO2000029002A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002348514A CA2348514A1 (fr) 1998-11-13 1999-11-12 Transplantation intra-uterine de cellules embryonnaires mesenchymateuses humaines
JP2000582048A JP2002529509A (ja) 1998-11-13 1999-11-12 ヒト間葉幹細胞の子宮内移植で胎児を処置し間葉幹細胞を移植し移植器官を調製する方法と調製された雑種器官
EP99972103A EP1128836A2 (fr) 1998-11-13 1999-11-12 Transplantation intra-uterine de cellules embryonnaires mesenchymateuses humaines
AU14780/00A AU1478000A (en) 1998-11-13 1999-11-12 (in utero) transplantation of human mesenchymal stem cells

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10835798P 1998-11-13 1998-11-13
US60/108,357 1998-11-13

Publications (2)

Publication Number Publication Date
WO2000029002A2 WO2000029002A2 (fr) 2000-05-25
WO2000029002A3 true WO2000029002A3 (fr) 2000-10-05

Family

ID=22321740

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/026927 WO2000029002A2 (fr) 1998-11-13 1999-11-12 Transplantation intra-uterine de cellules embryonnaires mesenchymateuses humaines

Country Status (5)

Country Link
EP (1) EP1128836A2 (fr)
JP (1) JP2002529509A (fr)
AU (1) AU1478000A (fr)
CA (1) CA2348514A1 (fr)
WO (1) WO2000029002A2 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1290443A1 (fr) * 2000-06-14 2003-03-12 Vistagen, Inc. Typage de toxicite au moyen de cellules souches mesenchymateuses
US20020012905A1 (en) 2000-06-14 2002-01-31 Snodgrass H. Ralph Toxicity typing using liver stem cells
WO2002040061A2 (fr) * 2000-11-15 2002-05-23 Osiris Therapeutics, Inc. Animaux immunocompetents, y compris sous forme d'implants xenogeniques de cellules embryonnaires mesenchymateuses
AU2002354101A1 (en) * 2001-12-06 2003-06-17 Sankyo Company, Limited Medicinal compositions containing human amnion-origin cells
JPWO2007125916A1 (ja) * 2006-04-24 2009-09-10 株式会社ステムセル研究所 移植用臓器の調製方法
EP2625263B1 (fr) 2010-10-08 2020-03-11 Terumo BCT, Inc. Procédés et systèmes configurables pour la culture et la récolte de cellules dans un système de bioréacteur à fibres creuses
JP6633522B2 (ja) 2013-11-16 2020-01-22 テルモ ビーシーティー、インコーポレーテッド バイオリアクターにおける細胞増殖
US11008547B2 (en) 2014-03-25 2021-05-18 Terumo Bct, Inc. Passive replacement of media
JP6830059B2 (ja) 2014-09-26 2021-02-17 テルモ ビーシーティー、インコーポレーテッド スケジュール化された細胞フィーディング
WO2017004592A1 (fr) 2015-07-02 2017-01-05 Terumo Bct, Inc. Croissance cellulaire à l'aide de stimuli mécaniques
EP3464565A4 (fr) 2016-05-25 2020-01-01 Terumo BCT, Inc. Expansion cellulaire
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
CN106806947A (zh) * 2017-01-13 2017-06-09 宁夏医科大学总医院 一种低免疫原性组织工程皮肤构建方法
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
CN117247899A (zh) 2017-03-31 2023-12-19 泰尔茂比司特公司 细胞扩增
US20200368286A1 (en) * 2017-08-23 2020-11-26 Wake Forest University Health Sciences In utero transplantation of factor viii-expressing cells for treatment of hemophilia
CA3135618A1 (fr) * 2019-04-02 2020-10-08 The General Hospital Corporation Procedes pour ameliorer la regeneration de lymphocytes t
CN113941032B (zh) * 2020-07-16 2023-04-07 北京中卫医正科技有限公司 一种间充质干细胞复合补片及其制备方法与应用
CN113215084B (zh) * 2021-06-11 2023-04-07 中国农业科学院兰州兽医研究所 一种羊胎儿皮肤成纤维细胞、其分离方法与应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026884A1 (fr) * 1993-05-14 1994-11-24 Biotechnology Research And Development Corporation Cellules souches embryonnaires destinees a la reproduction d'ongules chimeres et transgeniques
WO1997010348A1 (fr) * 1995-09-14 1997-03-20 The Regents Of The University Of California Procedes d'induction de types cellulaires selectionnes
WO1999046366A1 (fr) * 1998-03-13 1999-09-16 Osiris Therapeutics, Inc. Utilisations de cellules souches humaines mesenchymateuses non autologues

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996028967A1 (fr) * 1995-03-17 1996-09-26 Chihiro Koike Mammiferes transgeniques autres que des primates, ou des serotypes de primates superieurs ont ete exprimes par un transfert de genes etrangers et procede pour creer ceux-ci

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026884A1 (fr) * 1993-05-14 1994-11-24 Biotechnology Research And Development Corporation Cellules souches embryonnaires destinees a la reproduction d'ongules chimeres et transgeniques
WO1997010348A1 (fr) * 1995-09-14 1997-03-20 The Regents Of The University Of California Procedes d'induction de types cellulaires selectionnes
WO1999046366A1 (fr) * 1998-03-13 1999-09-16 Osiris Therapeutics, Inc. Utilisations de cellules souches humaines mesenchymateuses non autologues

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ALMEIDA-PORADA G ET AL: "Human bone marrow stromal cell progenitors are able to induce donor specific tolerance after in utero transplantation.", BLOOD, vol. 94, no. 10 SUPPL. 1 PART 1, 15 November 1999 (1999-11-15), 41th annual meeting of the American Society of Hematology, 3-7/12-1999, pages 40a, XP002139877 *
DEVINE S ET AL.: "Studies of mesenchymal stem cells in non-human primates: Evaluation of toxicity and engraftment", BLOOD, vol. 94, no. 10 Suppl. 1, 15 November 1999 (1999-11-15), 41th annual meeting of the American Society of Hematology, 3-7/12/1999, pages 391a, XP002139790 *
LIECHTY K W ET AL.: "Distribution and engraftment of human mesenchymal stem cells (MSC) after in utero transplantation in fetal sheep.", BLOOD, vol. 92, no. 10 Suppl. 1, 15 November 1998 (1998-11-15), 40th annual meeting of the American Society of Hematology, 4-8/12/1998, pages 117A, XP000914604 *
PEREIRA R F ET AL.: "Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage, and lung in irradiated mice", PROC. NAT'L. ACAD. SCI. USA, vol. 92, May 1995 (1995-05-01), pages 4857 - 4861, XP002139789 *
PROCKOP D J: "Marrow stromal cells as stem cells for nonhematopoietic tissues", SCIENCE, vol. 276, no. 5309, 4 April 1997 (1997-04-04), pages 71 - 74, XP002139788 *
SROUR E F ET AL.: "Sustained human hematopoiesis in sheep transplanted in utero during early gestation with fractionated adult human bone marrow cells", BLOOD, vol. 79, no. 6, 15 March 1992 (1992-03-15), pages 1404 - 1412, XP000569644 *

Also Published As

Publication number Publication date
WO2000029002A2 (fr) 2000-05-25
AU1478000A (en) 2000-06-05
CA2348514A1 (fr) 2000-05-25
JP2002529509A (ja) 2002-09-10
EP1128836A2 (fr) 2001-09-05

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