WO1997004789A1 - Comprimes contenant une resine echangeuse d'anions - Google Patents
Comprimes contenant une resine echangeuse d'anions Download PDFInfo
- Publication number
- WO1997004789A1 WO1997004789A1 PCT/JP1996/002189 JP9602189W WO9704789A1 WO 1997004789 A1 WO1997004789 A1 WO 1997004789A1 JP 9602189 W JP9602189 W JP 9602189W WO 9704789 A1 WO9704789 A1 WO 9704789A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- exchange resin
- anion exchange
- tablet
- coating
- tablet according
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Definitions
- the present invention relates to an anion exchange resin useful as a cholesterol-lowering agent, and more particularly to an anion exchange resin represented by the following general formula (I):
- R represents an aralkyl group having 1 to 10 carbon atoms or an alkyl group having 1 to 20 carbon atoms
- R 2 and R 3 each independently represent the same or different lower alkyl having 1 to 4 carbon atoms.
- R represents a hydrogen atom or a lower alkyl group having 1 to 4 carbon atoms;
- X represents a physiologically acceptable counter ion;
- n represents an integer of 1 to 3; and
- p represents an average. fi indicates a degree of polymerization of 100 to 100, 000.
- the present invention relates to a tablet containing a non-crosslinked anion exchange resin and a coated tablet as an uncoated tablet, and more particularly to a high content of a main component so as to be easy to take and a small number of tablets to be taken.
- the present invention relates to a coated tablet having excellent stability.
- the present invention also relates to a method for producing the tablet and the coated tablet.
- Cross-linked cholestyramine which is used as a conventional cholesterol-lowering agent, places a heavy burden on the patient (8 g to 16 g per day), and when used! Due to the inconvenience of taking it turbidly, intensive research has been conducted on tableting and coating of anion exchange resin. For example, when agglomerates of cholestyramine resin having a water content of 8 to 14% are compressed into tablets to prevent swelling in the mouth, the cholestyramine tablets are treated with polyethylene glycol without solvent. Method of coating with hot melt of stearic acid and
- an imidazole-based anion exchange resin Japanese Patent Application Laid-Open No. 60-2095323 is also used for tableting by containing a certain amount of water (Japanese Patent Application Laid-Open No. 2-28666). No. 21), a method of coating an uncoated tablet containing a certain amount of water with a hydroxib or vircell orifice (Japanese Patent Application No. 4-320155) (Japanese Unexamined Patent Application Publication No. A method of tableting with a certain amount of water and silicon dioxide contained therein (Japanese Patent Application Laid-Open No. 7-97330) has been reported.
- R 2 and R 3 each independently represent the same or different and represent a lower alkyl group having 1 to 4 carbon atoms;
- R 4 represents a hydrogen atom or a lower alkyl group having 1 to 4 carbon atoms;
- p represents an average degree of polymerization of 10 to 100, 000.
- a non-crosslinked anion exchange resin is extremely useful as a cholesterol-lowering agent (W093 / 13781). Since this anion exchange resin is a non-cross-linked, linear polymer, it does not swell and expand in volume as seen in a cross-linked polymer such as cholestyramine, and a feeling of abdominal swelling accompanying it. There are no side effects such as constipation. It is also an anion exchange resin that has a large effective bile acid adsorption amount per unit weight and is extremely useful.
- the dose of the compound represented by the general formula (I) varies depending on the patient and the condition thereof.
- the dose is generally 0.1 to 9 g per day, preferably 0.1 to 5 g per day, and is relatively large.
- excipients and the like are contained in a large amount in the tablet so as not to give a feeling of astringency, there is also a problem that the number of tablets to be administered at one time becomes too large.
- R> represents an aralkyl group having 1 to 10 carbon atoms or an alkyl group having 1 to 20 carbon atoms, and R 2 and R 3 independently represent the same or different and have 1 to 4 carbon atoms.
- R 4 represents a hydrogen atom or a lower alkyl group having 1 to 4 carbon atoms;
- X represents a physiologically acceptable counter ion;
- n represents an integer of 1 to 3; Denotes an average degree of polymerization of 10 to: a degree of polymerization of L0, 000.
- non-crosslinked anion-exchange resin is able to produce industrial tablets by tableting a mixture of cholesterol-lowering agent and at least silicon dioxide and microcrystalline cellulose without adding water.
- the present inventors have found that the above-mentioned problems can be overcome by using the tablet as a plain tablet and coating it with a coating agent containing cellulose. That is, the present invention relates to a pharmaceutical composition comprising an anion exchange resin, silicon dioxide, crystalline cellulose, and a pharmaceutically acceptable carrier.
- the present invention also relates to a tablet containing an anion exchange resin, which is obtained by adding at least silicon dioxide and crystalline cellulose to an anion exchange resin and tableting a mixture to which water has not been added.
- the present invention relates to an anion exchange resin comprising at least silicon dioxide and a crystal cell.
- the present invention relates to a method for producing a tablet containing anion-exchanged resin, which is obtained by compressing a mixture to which loin is added and water is not added.
- the present invention relates to a non-crosslinked type obtained by adding at least silicon dioxide and crystalline cellulose to a compound represented by the general formula (I) and tableting a mixture to which water has not been added. And a tablet containing the anion exchange resin. Further, the present invention provides a non-crosslinked anion exchange compound obtained by adding at least silicon dioxide and crystalline cellulose to the compound represented by the general formula (I) and tableting a mixture to which water has not been added. The present invention relates to a method for producing a tablet containing a resin.
- the uncoated tablet of the present invention comprises an anion exchange resin, which is difficult to form into a tablet to which water is added due to its strong hygroscopicity, in particular, a non-crosslinked anion exchange resin represented by the general formula (I). It is a plain tablet made into a tablet without adding the same, and it is difficult to directly apply the above-mentioned known tableting method for a plain tablet containing a certain amount of water to the plain tablet of the present invention having a high hygroscopicity. Met.
- the present inventors have applied uncoated tablets having strong hygroscopicity to a coating agent containing cellulose to reduce the annoyance of the anion exchange resin, especially the compound represented by the general formula (I).
- a coating agent containing cellulose to reduce the annoyance of the anion exchange resin, especially the compound represented by the general formula (I).
- the present invention provides a plain tablet obtained by tableting a mixture obtained by adding at least silicon dioxide and crystalline cellulose to an anion exchange resin without adding water.
- the present invention relates to a coating tablet containing an anion exchange resin, which is coated with a coating agent, and a method for producing the same. More specifically, the present invention provides a compound represented by the general formula (I):
- R represents an aralkyl group having 1 to 10 carbon atoms or an alkyl group having 1 to 20 carbon atoms, and R 2 and R 3 independently represent the same or different and have 1 to 4 carbon atoms.
- R 4 represents a hydrogen atom or a lower alkyl group having 1 to 4 carbon atoms;
- X represents a physiologically acceptable counter ion;
- n represents an integer of 1 to 3; Represents an average degree of polymerization of 10 to 100, 000.
- Tablets obtained by tableting a mixture obtained by adding at least silicon dioxide and microcrystalline cellulose to a non-crosslinked anion exchange resin without adding water and
- the present invention relates to a coating tablet containing a non-crosslinked anion-exchange resin coated with a coating agent containing celluloses, and a method for producing the same.
- the preparation of the present invention is also characterized in that the content of the excipient is extremely small, that is, the preparation of a high drug content is enabled.
- the preparation of the present invention is sufficiently compatible with continuous production and also with industrial production.
- the anion exchange resin of the present invention a non-crosslinked anion exchange resin is preferable, and a compound represented by the general formula (I) is particularly preferable.
- the substituent Hi of the compound represented by the general formula (I) of the present invention has a carbon number? Or an alkyl group having 1 to 20 carbon atoms, and the aryl group of the aralkyl group may have a substituent, but is preferably an unsubstituted one. May be linear or branched. More specifically, a benzyl group, a phenylethyl group, a methyl group, an ethyl group, an n-propyl group, an iso-propyl group, a hexyl group, a dodecyl group, an octadecyl group, an eicosyl group which may have a substituent, and the like. And more preferably a benzyl group, a methyl group, a hexyl group, a dodecyl group, and an octadecyl group.
- the substituents R 2 and R 3 are each independently the same or different and are lower alkyl groups having 1 to 4 carbon atoms, which may be linear or branched. More specifically, a methyl group, an ethyl group, an n-bromo group, an iso-bromo group, an n-butyl group, an iso-butyl group and the like are mentioned, and a methyl group is more preferable. Can be.
- the substituent R may be a hydrogen atom or a lower alkyl group having 1 to 4 carbon atoms, and the lower alkyl group may be linear or branched. More specifically, a hydrogen atom, a methyl group, an ethyl group, an n-propyl group, an iso-propyl group, an n-butyl group, an iso-butyl group and the like are mentioned, and more preferably, a hydrogen atom or Mention may be made of methyl groups.
- the counter ion X is not particularly limited as long as it is a physiologically acceptable counter ion, but inorganic salts such as halogen, sulfate, carbonate, acetate, brobionate, malonate, ascorbate, Examples include organic acid salts such as glucuronate, glutamate, sulfonate, and phosphate.Halogen, sulfate, and phosphate are preferred, and chloride ion and bromine are more preferred. And halogen such as fluorine ion.
- the compound represented by the general formula (I) of the present invention can be produced by preparing a quaternary ammonium salt of a corresponding monomer, and polymerizing this in the presence of a polymerization initiator such as a radical polymerization agent.
- a polymerization initiator such as a radical polymerization agent.
- Specific examples of the compound represented by the general formula (I) of the present invention include the following.
- Particularly preferred compounds include poly (acryloyloxethyl), poly (dimethyl-benzyl-benzylammonium chloride).
- the content of the anion exchange resin of the present invention in particular, the compound represented by the general formula (I) is 50 to 95% by weight, preferably 70 to 90% by weight, based on the total weight of the uncoated tablet. %, More preferably 75-90% by weight.
- the silicon dioxide and microcrystalline cellulose used in the present invention are not particularly limited as long as they are allowed to be taken orally.Pharmaceuticals for oral administration, which have precedents for use, are industrially preferable. .
- Silicon dioxide is intended to impart fluidity, and examples thereof include hydrous silicon dioxide (alias: white carbon) and silicon dioxide (alias: silica gel or kaic anhydride). It is preferable to use fine particulate silicon dioxide or light anhydrous silicic acid, which is not water-containing.
- the silicon dioxide used has an apparent specific gravity of 70 g / l to 20 g / l, preferably 50 g / l to 20 g / l, and is a light material having a small apparent specific gravity. Preference is given to caffeic anhydride.
- the added amount is 0.01 to 5% by weight, preferably 0.1 to 3% by weight, more preferably 0.1 to 1% by weight of the total weight of the uncoated tablet.
- Microcrystalline cellulose is preferred as the microcrystalline cellulose, with an average particle size of 5 to 50 microns, preferably 10 to 50 microns, more preferably 10 to 30 microns. Crystalline cellulose is preferred.
- the amount added is 0.1 to 30% by weight, preferably 1 to 30% by weight, more preferably 10 to 30% by weight of the total weight of the uncoated tablet.
- the silicon dioxide used in the present invention in particular, light caustic anhydride, the powder fluidity is improved as the content thereof increases and as the apparent specific gravity (kaza density) of the silicon dioxide decreases.
- tableting properties seem to decrease.
- the tableting property improves as the content increases and as the average particle size of the crystalline cellulose decreases, but on the other hand, the powder flowability increases. There is a decrease. In microcrystalline cellulose, when the content exceeds 30 parts, the tablet weight greatly increases. The use of more than 30 parts of crystalline cellulose in the compound represented by the general formula (I) is not particularly useful, so lactose should be used when a larger amount of excipient is required.
- the present invention relates to an anion exchange resin, preferably a non-crosslinked anion exchange resin represented by the general formula (I), having an apparent specific gravity of 70 g / l or less. 20 g / l, preferably 50 g / l to 20 g / l, light caustic anhydride with small apparent specific gravity, and average particle size of 50 micron to 10 micron, preferably
- the present invention relates to a tablet containing an anion exchange resin obtained by tableting a mixture containing at least 30 micron to 10 micron microcrystalline cellulose and not adding water, and a method for producing the same.
- the present invention relates to a non-crosslinked anion exchange resin represented by the general formula (I): Fat, silicon dioxide having an apparent specific gravity of 50/1 to 20/1, preferably 40 g / l to 20 g / 1 and a small apparent specific gravity, and an average particle size of 50 microns to 10 microns
- the present invention relates to a tablet containing 50 to 95% by weight, preferably 70 to 90% by weight, and more preferably 75 to 90% by weight, and a method for producing the tablet.
- the present invention provides a coated tablet containing a non-crosslinked anion exchange resin obtained by coating the tablet with a coating agent containing cellulose, and a method for producing the same.
- a coating agent containing cellulose e.g., silicon dioxide and crystalline cellulose
- components conventionally used in tableting should be added to the tablets before coating as uncoated tablets of the present invention in a range not to impair the object of the present invention.
- disaccharides such as lactose (lactose), sucrose, dextrose, mannite, sorbitol or monosaccharides and excipients such as starch such as potato starch, wheat starch, corn starch, rice starch, etc.
- -Lubricants such as inorganic substances such as calcium phosphate and calcium sulfate, higher fatty acids and their metal salts (eg, stearate, magnesium stearate), higher alcohols, talc, synthetic aluminum silicate, starch, Sodium or calcium salt of carboxymethyl cellulose, disintegrants such as methylcellulose, carboxymethylstatite, sodium alginate, starch, sucrose, gelatin, arabia gum, methylcellulose, carboxymethylcellulose sodium Lithium, polyvinyl rubylodon, polymethylbi A binder such as rolidone can be added as necessary.
- the uncoated tablet to be the uncoated tablet of the present invention can be produced by mixing the respective components and tableting this mixture. The order of addition of each component is not particularly limited. First, microcrystalline cellulose and silicon dioxide are mixed, and then the compound represented by the general formula (I) is gradually and preferably gradually added, and if necessary, other components are added to the mixture. I prefer to do that.
- the punch pressure during tableting is not particularly limited, but is preferably 2 tons or less.
- the cellulose contained in the coating agent used in the coating step of the present invention is not particularly limited as long as it is pH-independent and water-soluble. Specifically, for example, hydroxybile bilcellulose, hydroxybile virmethylcellulose, methylcellulose and the like are mentioned, and hydroxybyl virmethylcellulose is preferable.
- these celluloses may be used alone, but if necessary, a small amount of wax, titanium oxide, talc, low-substituted hydroxybile bilcellulose, polyethylene glycol, citrate It can also be used with Lietil added. It is preferable to add polyethylene glycol (macrogol) from the viewpoints of the strength of the obtained coating film, economy and the like.
- the concentration of the cellulose in the coating solution is not preferred because the amount of the coated cellulose is too high when the concentration is too high, and may be less than 20% by weight. Preferably, it is more preferably about 6 to 15% by weight.
- polyethylene glycol (macrogol) When polyethylene glycol (macrogol) is added, its concentration is preferably about 1 to 50% by weight, more preferably about 5 to 40% by weight, based on celluloses.
- an acid-soluble film agent can be used as a coating agent.
- getylamino methacrylate polyvinyl acetal acetylaminoacetate (AEA), dimethylaminoethyl methacrylate-methyl methacrylate copolymer (trade name: Eudragit E (methyl methacrylate) Butyl methacrylate 'dimethylaminoethyl methacrylate copolymer))
- cellulose acetate Coating agents that dissolve in gastric acid such as acetate N, N-di-n-butylhydroxyl mouth ether (CABP) can be used.
- CABP N-di-n-butylhydroxyl mouth ether
- the method of coating is not particularly limited, but spray coating is preferred.
- the amount of coating is preferably such that the coating film itself is coated in an amount of 1 to 10% by weight based on the tablet (uncoated tablet). In coatings intended for masking astringency, the effect is exhibited at 1% by weight or more, but coating at 10% by weight or more is not particularly useful, and is about 3% by weight. Coating is most preferred. When coating, it is preferable to measure the water content of the uncoated tablet and continue coating until no increase in water is observed. Next, the present invention will be described in more detail with reference to Examples, but it is apparent that the present invention is not limited to the following Examples without departing from the gist thereof.
- Example 1 Example 1
- the total amount of compound 1 is divided into four parts, each of which is divided into five minutes and added to the above mixture and mixed.
- the total amount of compound 1 is divided into 4 parts, each of which is divided into 5 minutes and added to the above mixture and mixed.
- magnesium stearate is weighed, put into a mixer and mixed for 1 minute.
- the coating method is the same as in Example 1 until drying, and 5 g of Carnaupalow is further added. The operation is performed at a rotation speed of 5 rpm for 5 minutes.
- the total amount of compound 1 is divided into four parts, each of which is divided into five minutes and added to the above mixture and mixed.
- magnesium stearate is weighed, put into a mixer and mixed for 1 minute.
- the total amount of compound 1 is divided into four parts, each of which is divided into five minutes and added to the above mixture and mixed.
- magnesium stearate is weighed, put into a mixer and mixed for 1 minute.
- the following mixing apparatus was used for mixing the components.
- the total amount of compound 1 is divided into four parts, each of which is divided into five minutes and added to the above mixture and mixed.
- magnesium stearate is weighed, put into a mixer and mixed for 1 minute.
- the following mixing apparatus was used for mixing the components.
- the tableting step and the coating step were performed in the same manner as in Example 1.
- the total amount of compound 1 is divided into 4 parts, each of which is divided into 5 minutes and added to the above mixture and mixed.
- magnesium stearate is weighed, put into a mixer and mixed for 1 minute.
- the tableting step and the coating step were performed in the same manner as in Example 1.
- the tableting step and the coating step were performed in the same manner as in Example 1.
- the powder fluidity was the variation in the uncoated tablet weight, and the compressibility was indicated by the frequency of chipping and cracking of the tablets obtained with a tableting pressure of 2 tons or less during coating.
- This product was highly hygroscopic and increased in weight during the abrasion test, showing compressibility in this appearance test. Table 1 shows the test results.
- Comparative Example 2 Small Crack on surface ⁇ Comparative Example 3 Small Crack on surface, chipped on edge ⁇ Comparative Example 4 Small Crack on surface, chipped on edge Mu Comparative Example 5 Medium None ⁇ Comparative Example 6 Large
- Comparative Example 4 shows a formulation without the addition of crystalline cellulose
- Comparative Example 5 shows a formulation without the addition of light caustic anhydride
- Comparative Example 6 shows a formulation without the addition of both.
- crystalline cellulose is not added, the tableting property (compressibility) is significantly reduced, and cracks are observed on the tablet surface.
- the powder fluidity is reduced and the variation in tablet weight becomes very large.
- the tablet weight varies greatly, cracks and chips often occur, and the tabletability is poor.
- Comparative Example 2 shows a formulation containing crystalline cellulose having an average particle size of 40 microns
- Comparative Example 3 shows a formulation containing crystalline cellulose having an average particle size of 120 microns.
- a light caustic anhydride having an apparent specific gravity (kaza density) of 30 g / 1 was treated. Even if the average particle size of the microcrystalline cellulose to be added is large, tableting can be performed by adding a material having a small apparent specific gravity (kaza density) of light anhydrous kaic anhydride (Example 2).
- This comparative example shows that when a substance having a large apparent specific gravity (dense density) of an acid is added, cracking and chipping increase and the tableting property also becomes unfavorable.
- a tablet having a high drug content can be produced by using light caustic anhydride having a small apparent specific gravity (kaza density) and crystalline cellulose having a small average particle size.
- kaza density small apparent specific gravity
- crystalline cellulose having a small average particle size.
- the tablet formulation of the present invention enables stable direct tableting only in the mixing step without the granulation step, and is sufficiently compatible with continuous production.
- the tablet changes its shape when the water content exceeds 7%, and deliquesces when it absorbs moisture.
- the increase in stability due to the coating was compared with the change in shape after storage for 20 minutes at 60 ° C and 90% relative humidity.
- the bitterness when the mouth was included for 30 seconds was compared.
- Table 2 shows the test results.
- the pharmaceutical composition and tablet of the present invention are superior to conventional oral cholesterol-lowering agents containing an anion exchange resin in terms of dosage and method of administration, and furthermore, in the production. They also have significant advantages such as not requiring a granulation step. Further, by coating the obtained tablet with celluloses, it is possible to obtain a screened tablet that can be taken without feeling astringency of the drug.
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Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE69619139T DE69619139T2 (de) | 1995-08-02 | 1996-08-02 | Ein amonenaustauscherharz enthaltende tabletten |
EP96925987A EP0878198B1 (en) | 1995-08-02 | 1996-08-02 | Tablets containing an anion exchange resin |
DK96925987T DK0878198T3 (da) | 1995-08-02 | 1996-08-02 | Tabletter indeholdende en anionbytterharpiks |
AT96925987T ATE212852T1 (de) | 1995-08-02 | 1996-08-02 | Ein amonenaustauscherharz enthaltende tabletten |
CA002228472A CA2228472C (en) | 1995-08-02 | 1996-08-02 | Tablets containing anion exchange resin |
US09/000,314 US6022533A (en) | 1995-08-02 | 1996-08-02 | Tablets containing anion exchange resin |
AU66305/96A AU723249B2 (en) | 1995-08-02 | 1996-08-02 | Tablets containing anion exchange resin |
HK98114166A HK1012849A1 (en) | 1995-08-02 | 1998-12-21 | Tablets containing anion exchange resin |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP22692695 | 1995-08-02 | ||
JP7/226926 | 1995-08-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1997004789A1 true WO1997004789A1 (fr) | 1997-02-13 |
Family
ID=16852774
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP1996/002189 WO1997004789A1 (fr) | 1995-08-02 | 1996-08-02 | Comprimes contenant une resine echangeuse d'anions |
Country Status (14)
Country | Link |
---|---|
US (1) | US6022533A (ja) |
EP (1) | EP0878198B1 (ja) |
KR (1) | KR19990035884A (ja) |
CN (1) | CN1079236C (ja) |
AT (1) | ATE212852T1 (ja) |
AU (1) | AU723249B2 (ja) |
CA (1) | CA2228472C (ja) |
DE (1) | DE69619139T2 (ja) |
DK (1) | DK0878198T3 (ja) |
ES (1) | ES2170864T3 (ja) |
HK (1) | HK1012849A1 (ja) |
PT (1) | PT878198E (ja) |
TW (1) | TW438608B (ja) |
WO (1) | WO1997004789A1 (ja) |
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WO1998016237A1 (en) * | 1996-10-15 | 1998-04-23 | Hisamitsu Pharmaceutical Co., Inc. | Anion exchange resin-containing tablets |
WO1998044933A1 (fr) * | 1997-04-04 | 1998-10-15 | Chugai Seiyaku Kabushiki Kaisha | Preparations polymeres se fixant au phosphate |
WO2001076635A1 (fr) * | 2000-04-10 | 2001-10-18 | Shionogi & Co., Ltd. | Preparations destinees a la prevention de diarrhee liee aux acides biliaires |
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EP2152277A1 (en) * | 2007-04-27 | 2010-02-17 | Genzyme Corporation | Amido-amine dendrimer compositions |
EP2217215A1 (en) * | 2007-12-14 | 2010-08-18 | Genzyme Corporation | Coated pharmaceutical compositions |
US20110142952A1 (en) * | 2008-06-20 | 2011-06-16 | Harris David J | Pharmaceutical Compositions |
CN117500923A (zh) | 2021-04-07 | 2024-02-02 | 巴特尔纪念研究院 | 用于鉴定和使用非病毒载体的快速设计、构建、测试和学习技术 |
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DE4121127A1 (de) * | 1991-06-26 | 1993-01-14 | Rettenmaier & Soehne Gmbh & Co | Hilfsstoff zur trockenen direkttablettierung und verfahren zur herstellung desselben |
US5800809A (en) * | 1992-01-14 | 1998-09-01 | Hisamitsu Pharmaceutical Co, Inc | Non-crosslinked acrylic polymers and non-crosslinked anion exchange resins |
DE69326231T2 (de) * | 1992-01-14 | 1999-12-30 | Hisamitsu Pharmaceutical Co., Inc. | Cholesterinspiegelsenkendes mittel |
US5709880A (en) * | 1995-07-10 | 1998-01-20 | Buckman Laboratories International, Inc. | Method of making tabletized ionene polymers |
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1996
- 1996-07-26 TW TW085109202A patent/TW438608B/zh active
- 1996-08-02 KR KR1019980700545A patent/KR19990035884A/ko active IP Right Grant
- 1996-08-02 WO PCT/JP1996/002189 patent/WO1997004789A1/ja active IP Right Grant
- 1996-08-02 ES ES96925987T patent/ES2170864T3/es not_active Expired - Lifetime
- 1996-08-02 AT AT96925987T patent/ATE212852T1/de not_active IP Right Cessation
- 1996-08-02 US US09/000,314 patent/US6022533A/en not_active Expired - Fee Related
- 1996-08-02 CN CN96195992A patent/CN1079236C/zh not_active Expired - Fee Related
- 1996-08-02 CA CA002228472A patent/CA2228472C/en not_active Expired - Fee Related
- 1996-08-02 AU AU66305/96A patent/AU723249B2/en not_active Ceased
- 1996-08-02 EP EP96925987A patent/EP0878198B1/en not_active Expired - Lifetime
- 1996-08-02 DE DE69619139T patent/DE69619139T2/de not_active Expired - Fee Related
- 1996-08-02 DK DK96925987T patent/DK0878198T3/da active
- 1996-08-02 PT PT96925987T patent/PT878198E/pt unknown
-
1998
- 1998-12-21 HK HK98114166A patent/HK1012849A1/xx not_active IP Right Cessation
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JPS567719A (en) * | 1979-06-21 | 1981-01-27 | Pharmacia Ab | Drug for prevention and remedy of infection |
JPH01172324A (ja) * | 1987-12-15 | 1989-07-07 | Armour Internatl Co | コレスチラミン組成物及びその製造法 |
JPH02286621A (ja) * | 1989-04-26 | 1990-11-26 | Mitsubishi Kasei Corp | 経口コレステロール低下剤 |
JPH0797330A (ja) * | 1993-08-03 | 1995-04-11 | Mitsubishi Chem Corp | 経口コレステロール低下剤 |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998016237A1 (en) * | 1996-10-15 | 1998-04-23 | Hisamitsu Pharmaceutical Co., Inc. | Anion exchange resin-containing tablets |
US6197290B1 (en) | 1996-10-15 | 2001-03-06 | Hisamitsu Pharmaceutical Co., Inc. | Anion exchange resin-containing tablets |
US6673605B2 (en) | 1997-03-05 | 2004-01-06 | Japan Science & Technology Corporation | Established cell line of microglia |
WO1998044933A1 (fr) * | 1997-04-04 | 1998-10-15 | Chugai Seiyaku Kabushiki Kaisha | Preparations polymeres se fixant au phosphate |
US6383518B1 (en) | 1997-04-04 | 2002-05-07 | Chugai Seiyaku Kabushiki Kaisha | Phosphate-binding polymer preparations |
JP2009173687A (ja) * | 1997-04-04 | 2009-08-06 | Chugai Pharmaceut Co Ltd | リン酸結合性ポリマー製剤 |
JP2013010803A (ja) * | 1997-04-04 | 2013-01-17 | Chugai Pharmaceut Co Ltd | リン酸結合性ポリマー製剤 |
WO2001076635A1 (fr) * | 2000-04-10 | 2001-10-18 | Shionogi & Co., Ltd. | Preparations destinees a la prevention de diarrhee liee aux acides biliaires |
Also Published As
Publication number | Publication date |
---|---|
CA2228472C (en) | 2003-06-17 |
AU723249B2 (en) | 2000-08-24 |
AU6630596A (en) | 1997-02-26 |
US6022533A (en) | 2000-02-08 |
EP0878198B1 (en) | 2002-02-06 |
ATE212852T1 (de) | 2002-02-15 |
CN1192150A (zh) | 1998-09-02 |
DK0878198T3 (da) | 2002-04-22 |
EP0878198A4 (ja) | 1998-11-18 |
KR19990035884A (ko) | 1999-05-25 |
EP0878198A1 (en) | 1998-11-18 |
ES2170864T3 (es) | 2002-08-16 |
PT878198E (pt) | 2002-06-28 |
TW438608B (en) | 2001-06-07 |
HK1012849A1 (en) | 1999-08-13 |
CN1079236C (zh) | 2002-02-20 |
CA2228472A1 (en) | 1997-02-13 |
DE69619139T2 (de) | 2002-10-31 |
DE69619139D1 (de) | 2002-03-21 |
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