WO1996013241A1 - Recipient pour perfusion - Google Patents
Recipient pour perfusion Download PDFInfo
- Publication number
- WO1996013241A1 WO1996013241A1 PCT/JP1995/002215 JP9502215W WO9613241A1 WO 1996013241 A1 WO1996013241 A1 WO 1996013241A1 JP 9502215 W JP9502215 W JP 9502215W WO 9613241 A1 WO9613241 A1 WO 9613241A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- container
- guide
- cap
- engagement
- medicine container
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1462—Containers with provisions for hanging, e.g. integral adaptations of the container
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2006—Piercing means
- A61J1/201—Piercing means having one piercing end
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2006—Piercing means
- A61J1/2017—Piercing means having three or more piercing ends
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2048—Connecting means
- A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding
Definitions
- the present invention relates to an infusion container, and more particularly, to a dry drug such as a powder formulation or a lyophilized drug, and a solution thereof, which is stored in a closed state, and the dry drug is stored in the container immediately before use.
- the present invention relates to an infusion container for aseptically mixing a dissolution solution and supplying it as an infusion solution.
- the vial containing the dried drug is connected in series to the dissolution solution container containing the dissolving solution so that the two containers can be aseptically connected during use.
- the proposed ring fluid container has been proposed (Japanese Unexamined Patent Publication No. Sho 61-501111, Japanese Unexamined Patent Publication No. Hei 2-12777, Japanese Unexamined Utility Model Publication No. 633-1356442). Gazettes).
- Japanese Patent Application Publication No. Sho 61-5011129 discloses a capsule in which a capsule containing a drug container and a solution container containing a solution are connected by a tube.
- the drug container and the dissolving solution container are communicated by a communicating means provided therein, so that the drug and the dissolving solution are aseptically mixed.
- JP -As shown in Fig. 21, as shown in Fig. 21, a hub is provided in the middle between the drug container 1 1 2 and the solution container 1 1 1 1 containing the solution.
- a hollow puncture needle 1 17 having a cutting edge at both ends is interposed, and the puncture needle 1 17 first penetrates the drug container 1 1 2, and then penetrates the dissolution solution container 1 ⁇ 1.
- the communication between the agent container 1 1 2 and the dissolving solution container 1 1 1 is ensured and easy, and mixing of the drug and the dissolving solution after the communication can be performed aseptically in a short time.
- the one disclosed in Japanese Utility Model Laid-Open Publication No. 63-1353652 is provided with an appropriately removable sabot ring, which is a cylindrical member, at the seal of the mouth of the dissolving solution container.
- a double-ended needle is attached to the ring so that it can slide up and down freely.When the double-ended needle is slid downward, the lower needle pierces the seal at the mouth of the solution container. is there.
- These ring fluid containers basically need to connect the medicine container and the dissolution solution container in a divided state, and to provide a means for mixing the medicine and the solution in both containers at the time of use at the connection part.
- the entire length (length in the connection direction) of the wheel fluid container is inevitably long, the cost of transporting the wheel is high, and it is difficult to secure a storage space.
- hospitals have the inconvenience of having to raise the hangers in order to get enough head for natural dropping.
- all of these wheel fluid containers are directly integrated with vials, which are a single flow form of dry medicine, and are highly versatile in that sense.
- these conventional liquid containers are described in, for example,
- the infusion container disclosed in 6 1-5 0 1 1 2 9 has a large number of parts and requires time and effort to break the broken member by hand to open the passage, and the broken part is incompletely broken. In such a case, there is a drawback that the liquid does not pass easily and the dissolution takes time.
- the container for wheel fluid disclosed in Japanese Patent Application Laid-Open No. 2-12777 is disclosed in Japanese Patent Application Publication No. Although it is considerably improved as compared with the liquid container of -5011129, the parts such as the communication order regulating means are complicated and the number of parts as a whole is large. Further, the container for wheel fluid disclosed in Japanese Utility Model Application Laid-Open No.
- 63-1353652 has a small number of parts and is relatively easy to operate, but requires a relatively large force for communication. After mixing the drug and the dissolving solution, remove the sabottling and double-ended needle to invert the dissolving solution container, and after removing the double-ended needle, attach a ring fluid set etc. to the seal at the mouth of the dissolving solution container. Since it is necessary to perform the operation, the operation is troublesome and the mixed chemical may leak when the double-ended needle is removed.
- a second object of the present invention is to reduce the total length of the liquid container, thereby reducing the transportation cost, facilitating storage in hospitals and the like, and further adapting to the age of mass transportation, and Easy to handle To be
- ADVANTAGE OF THE INVENTION communication with the medicine container sealed by the stopper whose mouth part can be penetrated, the vial guide holding this medicine container, and the medicine container which was liquid-tightly closed with the medicine liquid outlet and thin film.
- a pressurized and deformable synthetic resin solution container having a mouth at both ends thereof and surrounding the communication port and having a concentric guide portion provided concentrically with the communication port;
- a communicating means that is vertically slidably accommodated in the guide of the container and communicates the inside of the solution container with the inside of the drug container, and the vial guide is accommodated and the opening of the guide is rotatable. It is equipped with a cab for sealing.
- the inner wall of the cap, the inner wall of the guide section, and the vial guide are provided with a medicine container pushing-down means for cooperatively moving the medicine container downward, and rotating the cap.
- the vial guide moves downward without rotating by the drug container pressing means, reaches the communication means, pierces the stopper at the mouth of the drug container held by the vial guide, and is accompanied by the communication means.
- the container for wheel fluid having a communication order control and wholesale mechanism that controls the communication order so as to penetrate the thin film at the communication port of the solution container and communicate the drug container and the solution container is formed.
- the lower end of the guide may be embedded in the solution container, and a communication port may be formed in the lower end.
- the vial guide was connected to a medicine container mouth holding portion for holding the mouth of the medicine container, and extended upward along the medicine container from the medicine container mouth holding portion to the outer corner of the bottom surface of the medicine container.
- a plurality of movable rib members stopped, a beveled surface formed at the upper end of the movable rib member and slidable along a cam formed on an inner wall of the cap, and a replaceable rib member It is preferable to comprise a flexible claw that extends downwardly in connection with the lower end of the guide and is slidably fitted to the inner wall of the guide.
- the medicine container depressing means includes a beveled surface portion and a flexible claw piece of the vial guide, a cam provided on the inner wall of the cap, and a vertically running groove provided on the inner wall of the guide portion. It is preferable to be composed.
- the communication means is preferably a double-ended needle having a hub in the middle.
- the communication sequence control mechanism includes a pressing engagement portion formed on the outer peripheral portion of the hub and displaceable in the radial direction of the hub, and an engagement formed on the longitudinal groove and engaging with the pressing engagement portion. It is preferable to have a step and a control rod provided on the outer wall of the vial guide for holding the medicine container opening.
- the control unit prevents the pressing engagement portion engaged with the engaging step portion from moving inward in the radial direction of the hub when the vial guide is moved downward, and presses the engagement portion.
- the longitudinal groove of the guide portion deforms the flexible claw piece of the vial guide to the ⁇ side to thereby form the flexible rib member. It is preferable to provide a sliding surface for releasing the lock at the outer corner at the bottom of the medicine container.
- the cap removing means includes an annular projection formed on the upper end edge of the guide portion, a projection formed on the upper portion of the annular projection, and an annular projection formed on the inner peripheral wall thereof and capable of engaging with the annular projection.
- a ring having an open end and a closed end formed on the other side of the groove; and a rib formed on the inner peripheral wall of the cap and introduced from the open end and engaged with the closed end.
- the claw piece 6 6 of the vial guide 6 externally fitted to the medicine container 1 has the longitudinal groove 4 4 of the guide section 4.
- the beveled surface 65 of the vial guide 6 fits into the cam 5 6 of the cap 5 (Fig. 13). It is fitted.
- the cam 56 rotates and the beveled surface 65 of the vial guide 6 slides along the cam 56. Since the vial guide 6 does not rotate with the cap 5 due to the engagement of the claw piece 6 6 and the longitudinal groove 44, the claw piece 6 slides along the cam 56 of the cap 5. Move down.
- the communication means since the communication means has such a communication order control function, the communication means is pierced first by the rubber stopper 12 of the mouth 11 of the medicine container.
- the communication order is regulated so that the thin film 47 of the communication port 45 is formed later. Therefore, leakage of the solution into the guide portion 4 during communication is prevented.
- the vial guide 6 moves downward, the vial guide 6 is guided to the flexible claw piece 6 6 that moves along the longitudinal groove 44 of the guide portion 4.
- the sliding surface 46 formed in the longitudinal groove 44 has an opposing taper surface that contracts downward (FIG. 20)
- the claw piece 6 6 that moves downward gradually moves inward. Is transformed into With the deformation of the nail piece 66, the upper end of the grindable rib member 62 connected to the nail piece 66 is gradually deformed outward. Thereby, the locking of the outer corner of the bottom surface of the medicine container 1 is released. Therefore, the used medicine container 1 can be easily removed from the vial guide 6.
- the upper end of the control rod 6 3 of the vial guide 6 is pinched by the pressing engagement portion 38 moved inward in the radial direction of the hub 34, and the vial guide 6 is fixed to the double-ended needle 3.
- the drug container 1 can be removed from the upper puncture needle 35. Therefore, the hand is not hurt by the lower puncture needle 36 when removing the medicine container 1.
- a cap removing means for removing the cap from the guide portion can be used. 10 to 17, a specific example of the structure and operation of the cap removing means will be described.
- the cap removing means is constituted by the cooperation of the guide portion 4, the engagement ring 7 and the cap 5.
- the guide part 4 is formed at the upper edge.
- An annular projection 48 and a protrusion 49 formed on the projection 48 are provided.
- the engagement ring 7 has an engagement protrusion 72 formed on the inner peripheral wall thereof and engageable with the annular protrusion 48, a rotation prevention protrusion 75 formed on the upper portion of the engagement protrusion 72, A groove 77 formed on the outer peripheral wall in the circumferential direction, an open end 71 on one side of the groove 77 and opened to the upper end side of the outer peripheral wall, and a groove 77 formed on the other side of the groove. It has a closed end (stop projection 74).
- the cap 5 has a rib 58 introduced to the inner peripheral wall from the open end 71 and engaged at the closed end.
- the cap 5 When the cap 5 is rotated in one direction at the upper edge of the guide 4, the cap 5 is engaged with the closed end 7 4 of the engagement ring 7 and rotates together with the engagement ring 7. Then, when the cap 5 is rotated in the opposite direction, the rotation preventing projections 75 of the engagement ring 7 engage with the projections 49 on the upper edge of the guide portion 4 and the ribs 58 are closed ends.
- the cap 5 can be removed from the guide part 4 by moving relatively from the (locking projection 74) to the open end 71.
- the dissolving solution container is provided with a cylindrical guide portion surrounding the communication port with the drug container and concentrically around the communication port, and preferably the lower end portion of the guiding portion is the dissolving solution. Since it is buried integrally in the container, the overall length of the wheel fluid container (the length in the direction of connection between the drug container and the solution container) can be shortened in comparison with conventional containers. This facilitates storage in hospitals, etc., and also provides compactness suitable for transport and lowers transport costs. Further, as shown in the conventional example of FIG. 21, the bottom portion of the guide portion 126 and the communication port of the solution container 111 are not formed separately, but in the present invention, the lower end portion is formed. Since the guide part 4 having the communication port 45 formed therein is integrally formed as a part of the solution container 2, a complicated structure for sealingly connecting the two parts can be omitted and the parts can be omitted. The score can be reduced.
- hospitals can secure heads for spontaneous dropping of wheel fluid without using expensive stands.
- the upper end of the flexible rib member 62 of the vial guide 6 is pushed out to release the lock at the outer corner of the bottom surface of the drug container 1. Therefore, it is easy to remove the medicine container 1 from the vial guide 6.
- it is easy to separate and discard after use, and a wheel fluid container excellent in disposability is provided.
- FIG. 1 is a cross-sectional view of a principal part of a ring fluid container according to an embodiment of the present invention
- FIG. 2 is a cross-sectional view of a principal part of the drug container of FIG. 1
- FIG. 3 is a cross-sectional view of the double-ended needle of FIG. 4 is a bottom view of FIG. 3
- FIG. 5 is a side view of FIG. 3
- FIG. 6 is a front view of the vial guide of FIG. 1
- FIG. FIG. 8 is a side view of the vial guide of FIG. 6,
- FIG. 8 is a plan view of the vial guide of FIG. 6,
- FIG. 9 is a bottom view of the vial guide of FIG. 6, and
- FIG. Guy FIG. 11 is a plan view of FIG. 10, and FIG.
- FIG. 2 is a front view of the cap of FIG. 1
- FIG. 13 is a side sectional view of the cap of FIG. 12
- FIG. 14 is a bottom view of the cap of FIG. Yes
- FIG. 15 is a plan view of the cap of FIG. 1
- FIG. 16 is a plan view of the engagement ring
- FIG. 17 is a portion of the engagement ring of FIG.
- FIG. 18 is a side view including a cross section.
- FIG. 18 is an explanatory diagram showing an initial state in the operation of the double-ended needle and the engagement arm of FIG.
- FIG. 9 is a diagram corresponding to FIG. 18 showing a state where the double-ended needle is pushed down
- FIG. 20 is a diagram corresponding to FIG. 18 showing a state where the double-ended needle is further pushed down
- FIG. 21 is a diagram corresponding to FIG.
- FIG. 2 is a sectional view of a main part of a conventional wheel fluid container corresponding to FIG. BEST MODE FOR CARRYING OUT THE INVENTION
- the container for wheel fluid mainly comprises a drug container 1, a dissolution solution container 2, a double-ended needle 3, a guide part 4, a cap 5, a vial guide 6, and the like.
- the guide 4 has a lower end integrally buried in the solution container 2, an open end at the upper end thereof is sealed with a cap 5, and a double-ended needle 3 is provided in the guide 4.
- a vial guide 6 holding the mouth 11 of the medicine container 1 facing downward is accommodated so as to be able to slide downward.
- the medicine container 1 is attached to a container mouth holding portion 60 formed below the vial guide 6 in the figure so that the mouth 11 is held.
- the cap 5 when the cap 5 is rotated clockwise, the medicine container 1 is lowered together with the vial guide 6. Then, the double-ended needle 3 penetrates the rubber stopper 12 of the medicine container 1 and the thin film 47 of the communication port 45 formed at the lower end of the guide part 4, and the containers 1 and 2 are connected. It is configured as follows.
- the medicine container i is generally made of glass, and as shown in FIG. 2, its mouth 11 is sealed with a self-sealing sealing member that can be pierced by a double-ended needle 3 such as a rubber stopper 12. Further, the rubber member 12 is further fastened around the body portion 15 by a cover member 13 covered with aluminum or the like, and is fixed to the mouth portion 11 of the container 1.
- a commercially available drug container can be used as the drug container 1.
- the top surface of the cover member 13 is removed, and the puncture needle of the double-ended needle 3 is a rubber stopper 1 2
- a through hole 14 is formed at a position where the body 15 of the puncture body is punctured.
- the medicine container 1 is made of synthetic resin, and the ribs 62 of the vial guide 6 and the flexible nail pieces 66 as shown in FIG. 1 are provided on the outer wall of the container body, even if the vial guide 6 is omitted. Good, but it is difficult to form these protruding members in the medicine container when made of glass as in this example, so it is preferable to form the vial guide 6 with synthetic resin and attach the medicine container 1 in this. I like it.
- dry preparations such as powder preparations and freeze-dried preparations are contained in the preparation container 1, but are omitted in the drawings. Specifically, the following are examples of dry preparations:
- Antibiotics include cefabrina sodium, ceftizoxim natrium, cefotiamam hydrochloride, cefmenoxime hydrochloride, cefacetrinatridium, cefamolinatrium sodium, Cephalolysine, Ceftiotaximnatrium, Cefotetannat Lithium, Ceph Opera Bunna Torium, Cefsloginna Torium, Ceftebournatridium, Cefvilamidonatonium, Cephmetaburunatridium, Cephloquinnatridium, Cephocresulfate, etc.
- Ceph antibiotics as well as penicillin antibiotics such as ampicillin sodium, potassium lupenicillin sodium, sulpenicillin sodium, and ticarcillin sodium.
- penicillin antibiotics such as ampicillin sodium, potassium lupenicillin sodium, sulpenicillin sodium, and ticarcillin sodium.
- antitumor agents include mitomycin C, fluorouracil, tegafur, and shiburabin.
- Antiulcer agents include famotidine, ranitidine hydrochloride and cimetidine.
- the vial guide 6 for accommodating and holding the medicine container 1 as shown in FIG. 1 and for moving the medicine container 1 downward so that it does not rotate is usually made of a polyethylene resin-volume port. It is integrally molded with synthetic resins such as pyrene resin, polyester resin, polyvinyl chloride resin, polycarbonate resin, and acrylonitrile butadiene styrene (ABS) resin. As shown in FIGS. 6 to 9, the vial guide 6 mainly includes a medicine container mouth holding portion 60 and a pair of flexible rib members 62.
- the mouth holding portion 60 is a cylindrical member having an inner diameter capable of fitting the outer peripheral surface of the cover member 13 of the medicine container 1, and has a bottom surface for the double-ended needle 3 larger than the through hole 14 of the medicine container 1.
- a piercing opening 61 is formed.
- a pair of opposing control rods 63 are formed on the outer peripheral surface of the mouth holding part 60.
- the control member 63 is a straight bar having a size of several mm that can be inserted into a hole 34 a of the hub 34 described later, and is formed integrally with the mouth holding portion 10.
- the lower end of the control unit 63 extends slightly below the bottom surface of the mouth holding unit 60 (downward in the figure).
- the upper end of the wholesaler 6 3 is located above the body of the rubber stopper 1 2 (the part pierced by the upper puncture needle 35) when the medicine container 1 is held in the vial guide 6. are doing.
- a supporting portion that extends from the mouth holding portion 60 is formed along the shoulder portion of the medicine container 1, and is further opposed to the upper edge of the supporting portion.
- Flexible rib members 62 are arranged to extend upward.
- the rib member 62 extends slightly above the height of the body of the medicine container 1 in the prone position attached to the vial guide 6.
- a medicine container locking claw 64 is formed which can lock the outer corner of the bottom surface of the medicine container 1 stored in the vial guide 6.
- the drug container locking claws 64 are bent at substantially right angles inward from the upper ends of the rib members 62. Thus, the user can attach and detach the medicine container 1 to and from the mouth holding portion 60 while pushing the rib members 62 outward.
- a beveled surface 65 is formed as a beveled surface.
- the pair of inclined surfaces 65 are slidable on a cam 56 formed on an inner peripheral portion of the cap 5 described later.
- a flexible claw piece 66 extending downward from the mouth holding portion 60 ⁇ so as to be continuous with the rib member 62 is formed.
- the grindable claw piece 66 is a flat member having substantially the same bird as the rib member 62, and is composed of two branched protruding pieces. The distance between the two projecting pieces is determined by the guide section 4 described later. It is configured to be slightly wider than the width of the engaging step 4I. The lower end of the claw piece 66 extends near the upper end of the control rod 63.
- the rib member 62 and the claw piece 66 are part of the vial guide 6 formed integrally with the resin, when the claw piece 66 is pressed in the radial direction, the medicine container locking claw 64 is simultaneously moved in the radial direction. Is displaced. That is, when the claw pieces 66 are pressed inward in the radial direction, the rib members 62 are pressed outward in the radial direction.
- the guide part 4 is integrally formed of the same synthetic resin as the vial guide 6 as a part of the solution container 2, and has an open end and a lower end as upper ends as shown in FIGS. 10 and 11. It has a partition 42 as a part. Close to the open end side, a ring-shaped projection 48 is formed for coupling with the cap 5 via the cable removing means shown in FIG. 1, and furthermore, on the upper part of the ring-shaped projection 48. A pair of protrusions 49 are formed, and a pair of opposed longitudinal grooves 44 running vertically from the partition wall 42 toward the open end are formed on the inner wall of the guide portion 4.
- the longitudinal groove 44 engages with the flexible claw 66 of the vial guide 6 to lower the vial guide 6 without rotating it.
- the longitudinal groove 44 has an engaging step 41 for controlling the order of penetration by the double-ended needle 3 described later.
- a sliding surface 46 described later is formed in the longitudinal groove 44 near the engaging step portion 41.
- Circumferential projections 48 are projections that engage with engagement projections 72 of engagement ring 7 described later as cap removing means, and projections 49 are rotation prevention projections of engagement ring 7 described later. 7 It has a function to prevent the engagement ring 7 from rotating counterclockwise by engaging with the engagement ring 5.
- the partition wall 42 has a communication port 45 with a dissolving solution container formed in the center in a concave step shape.
- the communication port 45 has a thin film 47 as a closed membrane that can be pierced by lowering a double-ended needle 3 (a lower puncture needle 36) described later at the bottom.
- the annular projection 48 is unnecessary.
- the open end of the guide 4 and the scar 5 of the cap 5 (FIG. 12)
- a complementary undercut may be provided at the lower ends of the caps, and the caps 5 may be joined so that the cap 5 can rotate.
- the double-ended needle 3 used as the communication means is arranged between the drug container 1 and the dissolution solution container 2 as shown in Fig. 1, and is usually stainless steel (SUS 304 is preferred). Or it is composed of a synthetic resin power nut and a synthetic resin hub. When sharpness is important, stainless steel is preferred, but in view of disposal problems and the fact that it can be molded, a double-ended needle made of synthetic resin is preferred.
- the synthetic resin for example, high-hardness polyethylene such as high-density polyethylene, ABS resin, and polycarbonate resin are preferable.
- the double-ended needle 3 penetrates the rubber 12 of the mouth 11 of the medicine container 1 that has descended, and further descends with the medicine container 1 to form a communication port 4 5 formed at the lower end of the guide 4.
- the hub 34, the upper puncture needle 35 piercing the rubber stopper 11 of the medicine container 1, and the guide so that the thin film 47 of the drug can be pierced.
- Under section 4 It comprises a lower puncture needle 36 penetrating the thin film 47 of the communication port 45 formed at the end, and preferably engages with the longitudinal groove 44 of the guide part 4 at the tip of the hub 34.
- An engagement arm 37 for suppressing the downward movement of the double-ended needle 3 is provided.
- a pressing engagement portion 38 that can be engaged with the engagement step portion 41 is formed.
- the pressing engagement portion 38 engages with the longitudinal groove 44 at the tip jaw 39.
- the upper puncture needle 35 is formed on a sharp edge in the center, and the lower puncture needle 36 is formed on a pure edge.
- the shape of the cutting edge is not particularly limited.
- the base of the knob 34 is formed with a hole 34a into which the lower end of the wholesaler 63 of the vial guide 6 is inserted.
- the hole 34 a acts as a stopper for the vial guide 6.
- the dissolving solution container 2 is generally a press-deformable container formed of a relatively soft synthetic resin such as polyethylene resin, polypropylene resin, polyester resin, etc.
- the container is integrally buried, and the lower end of the container has a chemical solution outlet 21.
- the chemical solution outlet 21 has the same configuration as that of a normal bottle for ring fluid.For example, as shown in FIG. 1, a pressing member 23 is attached to a closing film 22 and attached to the same. A configuration in which a sealing member made of rubber 24 is covered is adopted. Attach the sealing member to the solution container 2
- the welding is performed by welding a flange 21 a formed on the outer wall of the chemical solution outlet 21 and a flange 23 a formed on the pressing member 23.
- the rubber stopper 24 of the dense needle member is not shown, but may be protected by a cover member such as a film so that the surface is not contaminated.
- the lower end of the guide portion 4 is integrally buried in the upper portion of the solution container 2, and the double-ended needle 3 and the mouth 11 side of the drug container 1 are inserted into the guide portion 4. Is set, and the cap 5 is airtightly attached to the open end of the guide 4 to complete the operation.
- the cap 5 seals the open end of the upper end of the guide part 4 and has a function as a medicine container depressing means for moving the medicine container 1 downward. As shown in 13, it is formed in a rectangular shape with the same synthetic resin as the guide portion 4.
- the top surface 52 of the cap 5 is preferably provided with a suspending means 53, and the cap 5 and the guide portion 4 are provided at the lower end of the side wall of the scar 55.
- a seal member mounting groove 51 for accommodating a seal member 54 (see Fig. 1) that hermetically seals the gap between the seal member 54 and the beveled surface 25 of the vial guide 6 is tightly attached to the inner wall of the scar 55. Thus, a sliding cam 56 is formed.
- the hanging means 53 may be provided with a hinge part 57 so that it can be folded up. If the cap removing means is adopted, as shown in Figs. 14 and 15, A rib 58 may be provided at the lower end of the inner surface of the scar 55 to engage with the groove of the engagement ring 7.
- Reference numeral 59 denotes a suspension hole.
- the cam 56 is a pair of helical steps facing each other on the wall of the scar 55.
- the spiral step is a semi-strip.
- the cam 56, the beveled surface 65 of the vial guide 6, the flexible claw piece 66, and the longitudinal groove 44 of the guide part 4 constitute a medicine container pressing means.
- a ridge that runs obliquely in a spiral may be used instead of the cam 56.
- the cap removing means removes the cap 5 from the guide part 4 so that the medicine container 1 and the double-ended needle 3 can be discarded separately, and the engagement ring 7 and the cap are removed. And a rib 58 formed on the inner peripheral surface.
- the engagement ring 7 is a member formed in a ring shape as shown in FIGS. 16 and 17, and has an engagement member which is rotatably engaged with the annular projection 48 of the guide portion 4 inside.
- a groove 77 is formed on the outer wall, which is engaged with a rib 58 on the inner wall at the lower end of the cap 5.
- the notch 73 of the groove forming the open end 71 has a shape in which the upper side wall constituting the groove 77 is cut off. That is, it is formed in a step shape, and the length of the rib 58 of the cap 5 is shorter than the length of the cut 73 of the groove.
- a locking projection 74 is provided as a closed end between the clockwise groove 77 and the groove cut 73, and when the cap 5 is turned clockwise, the rib 58 is engaged. Collision with 7 4 causes the engagement ring 7 to rotate with the cap 5 while the rib 5 8 of the cap 5 is in the groove 7 7, and then turns the cap 5 counterclockwise.
- the ribs 58 When turned in the direction, the ribs 58 come to the groove breaks 73. In this case, the ribs 5 8 Since the rib 5 is short, when the cap 5 is moved upward when the rib 58 reaches the groove cut 73, the cap 5 is disengaged from the engagement ring 7.
- the cap removal mechanism including the groove 77, the groove cut 73, and the locking projection 74 is formed outside the engagement ring 7.
- the boss removal mechanism may be formed inside the engagement ring 7 and may be combined with a protrusion (corresponding to the rib 58) formed on the outer wall at the lower end of the scar 55 of the cap 5.
- the cap removing means may be provided on the inner wall or the outer wall of the cap 5 so as to be combined with a similar projection provided on the outer wall or the inner wall of the engagement ring 7.
- a cap removing means or a projection is provided on the outer wall of the cap 5
- the cap 5 is engaged with the inclined surface 65 of the vial guide 6 when the cap 56 is engaged. Because Before use, the cap cannot be rotated counterclockwise.However, it is possible to remove the cap 5 by turning only the engagement ring 7 counterclockwise. It is necessary to provide a means so that step 5 cannot be removed.
- the container for liquid solution in FIG. 1 can be turned upside down and self-supported by folding the suspension means 53 of the cap 5, and can be self-supported even if the lower end of the solution container 2 is down. It can be done.
- the claw pieces 6 6 of the vial guide 6 externally fitted to the medicine container 1 are fitted into the longitudinal grooves 44 of the guide part 4, and the vial guide 6
- the beveled surface 65 is fitted to the cam 56 of the cap 5.
- the control rod 63 provided in the container mouth holding portion 60 of the vial guide 6 moves the hub engaged with the engaging step portion 41 to the hub.
- the pressing engagement portion 38 of 34 is prevented from moving inward in the radial direction of the hub 34 so that the engagement between the pressing engagement portion 38 and the engaging step portion 41 is not released.
- the upper puncture needle 35 of the double-ended needle 3 fixed to the engagement step portion 41 receives and holds the container opening holder 60 moving downward. Penetrate the body 15 of the rubber stopper 1 2 of the drug container 1.
- the communication operation between the medicine container 1 and the solution container 2 can be achieved very easily by the rotation of the cap 5.
- the communication means is pierced by the rubber 12 of the mouth portion 11 of the drug container first, and the thin film 47 of the communication port 45 is performed later.
- the communication order is controlled so as to be performed. Therefore, leakage into the guide portion 4 at the time of communication is prevented.
- a cap removing means for removing the cap from the guide can be used. The operation of the cap removal means will be described (see Figs. 12 to 17).
- the cap 5 When the cap 5 is rotated in one direction at the upper edge of the guide 4, the cap 5 rotates together with the engagement ring 7 because the rib 58 is engaged with the locking projection 74.
- the rotation preventing projection 75 engages with the protrusion 4 9 on the upper edge of the guide 4, and the rib 58 extends from the locking projection 74.
- the cap 5 can be easily removed from the guide part 4 by relatively moving to the open end 71. Therefore, when the medicine container 1, the double-ended needle 3 and the like are taken out and discarded, the separation process can be easily performed.
- the medicine container 1 can also be removed from the vial guide 6.
- this removal means when the vial guide 6 moves downward, the vial guide 6 is guided by the flexible claw piece 66 moving along the longitudinal groove 44 of the guide portion 4.
- the sliding surface 46 formed in the longitudinal running groove 44 has an opposed tapered surface that contracts downward, the claw piece 6 6 that moves downward is gradually deformed inward.
- the upper ends of the rib members 62 connected to the nail pieces 66 are gradually deformed outward. Thereby, the locking of the outer corner of the bottom surface of the medicine container 1 is released. Therefore, the used medicine container 1 can be easily removed from the vial guide 6.
- the mixing operation is easy and time-consuming, and the drug and the dissolving solution can be aseptically mixed without any risk of leakage of the mixed drug solution. It is possible to provide an infusion container that can be used. Further, in the present invention, since the lower end of the guide is buried in the solution container, the overall length of the wheel fluid container (the length in the connection direction between the drug container and the solution container) is shortened. This facilitates storage in hospitals and other facilities, and also provides compactness suitable for transport.
- the order of piercing by the communicating means is controlled so that the rubber stopper at the mouth of the drug container is performed first and the thin film of the communicating port is performed later. Therefore, the communication between the drug container and the dissolving solution container can be reliably and easily performed, and the mixing of the drug and the dissolving solution after the communication can be performed aseptically in a short time. Since a complicated structure for performing the operation can be omitted and the number of parts can be reduced, a container for a wheel fluid can be provided at a low cost.
- the lower end of the guide portion is buried in the dissolving solution container, and a communication port is formed at the lower end, so that the Reduce the overall length of the container. This will reduce transport costs and make it easier to secure storage space.
- the vial guide includes a medicine container mouth holding portion, a pair of flexible rib members (obliquely cut surfaces) locked to the outer corners of the bottom surface of the medicine container, and a movable nail piece.
- the drug container can be easily removed from the vial guide when the used infusion container is discarded separately. At this time, if only the medicine container can be removed from the communication means, the hand does not have to be caught with a double-ended needle when removing the medicine container.
- the glass drug container can be easily separated from the synthetic resin part of the main body of the orbital fluid container.
- the drug container depressing means is composed of a cam, a longitudinal groove, a bevel, and a flexible claw, so that the vial guide is formed by rotating the cap. It can be moved downward without rotating. Therefore, the force required for communication is small.
- the communication sequence control mechanism includes a pressing engagement portion formed on the outer peripheral portion of the hub and displaceable in the radial direction of the hub, an engagement step portion formed on the longitudinal groove, and a vial guide. Since the control mechanism is provided on the outer wall of the medicine container mouth holding section, the control mechanism can be simplified without adding new members.
- the medicine container can be easily removed from the vial guide by a series of piercing operations by the communication means.
- the cap can be easily removed after use if the guide portion has the cap removing means. Therefore, separation and disposal becomes easy.
- the cap rotates in one direction at the upper edge of the guide, the cap rotates with the engagement ring with the rib engaged with the closed end, and the When the is rotated in the opposite direction, the anti-rotation protrusion engages with the protrusion on the upper edge of the guide, and the rib moves relatively from the closed end to the open end to remove the cap from the guide. If this is done, the vial guide can be securely removed from the cap.
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Closures For Containers (AREA)
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP95935583A EP0843992A4 (en) | 1994-10-31 | 1995-10-27 | CONTAINER FOR INFUSION |
US08/817,649 US5826713A (en) | 1994-10-31 | 1995-10-27 | Fluid vessel |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6/267069 | 1994-10-31 | ||
JP26706994A JPH08126683A (ja) | 1994-10-31 | 1994-10-31 | 輸液用容器 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996013241A1 true WO1996013241A1 (fr) | 1996-05-09 |
Family
ID=17439604
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP1995/002215 WO1996013241A1 (fr) | 1994-10-31 | 1995-10-27 | Recipient pour perfusion |
Country Status (5)
Country | Link |
---|---|
US (1) | US5826713A (ja) |
EP (1) | EP0843992A4 (ja) |
JP (1) | JPH08126683A (ja) |
TW (1) | TW290465B (ja) |
WO (1) | WO1996013241A1 (ja) |
Cited By (1)
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DE102009013211B4 (de) | 2009-03-17 | 2012-04-19 | Aap Biomaterials Gmbh | Vakuum-Mischvorrichtung für Knochenzement sowie Verfahren zum Mischen von Knochenzement |
SI2923688T1 (sl) | 2010-08-25 | 2017-07-31 | Baxalta GmbH | Sestav, ki omogoča uporabniku rekonstitucijo |
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EP3291786B1 (de) * | 2015-05-06 | 2019-07-10 | Kocher-Plastik Maschinenbau GmbH | Behälter-entnahmesystem |
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KR101982004B1 (ko) * | 2017-08-28 | 2019-05-24 | 김은자 | 약제 용기 및 약제 용기 결합형 수액 용기 |
WO2019187839A1 (ja) * | 2018-03-27 | 2019-10-03 | テルモ株式会社 | 医療器具 |
CN112739307A (zh) | 2018-09-24 | 2021-04-30 | 吴制药有限公司 | 输注系统 |
US11338082B2 (en) * | 2019-09-04 | 2022-05-24 | BloQ Pharma, Inc. | Variable rate dispenser with aseptic spike connector assembly |
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JPH0614976A (ja) * | 1992-04-10 | 1994-01-25 | Nissho Corp | 輸液用容器 |
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JPH05123377A (ja) * | 1991-05-29 | 1993-05-21 | Fujisawa Pharmaceut Co Ltd | 輸液装置 |
US5308347A (en) * | 1991-09-18 | 1994-05-03 | Fujisawa Pharmaceutical Co., Ltd. | Transfusion device |
US5352191A (en) * | 1991-10-25 | 1994-10-04 | Fujisawa Pharmaceutical Co., Ltd. | Transfusion device |
-
1994
- 1994-10-31 JP JP26706994A patent/JPH08126683A/ja active Pending
-
1995
- 1995-10-27 EP EP95935583A patent/EP0843992A4/en not_active Ceased
- 1995-10-27 WO PCT/JP1995/002215 patent/WO1996013241A1/ja not_active Application Discontinuation
- 1995-10-27 US US08/817,649 patent/US5826713A/en not_active Expired - Fee Related
- 1995-10-30 TW TW84111463A patent/TW290465B/zh active
Patent Citations (4)
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JPH04329956A (ja) * | 1991-04-30 | 1992-11-18 | Takeda Chem Ind Ltd | 個別密封容器に収容した薬剤の無菌保持混合装置 |
JPH04253863A (ja) * | 1991-06-21 | 1992-09-09 | Fujisawa Pharmaceut Co Ltd | 輸液容器 |
EP0565103A1 (en) | 1992-04-10 | 1993-10-13 | Nissho Corporation | Fluid container |
JPH0614976A (ja) * | 1992-04-10 | 1994-01-25 | Nissho Corp | 輸液用容器 |
Cited By (1)
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---|---|---|---|---|
CN113101986A (zh) * | 2020-06-17 | 2021-07-13 | 京东方科技集团股份有限公司 | 一种用于试剂存储和释放的装置以及微流控装置 |
Also Published As
Publication number | Publication date |
---|---|
TW290465B (ja) | 1996-11-11 |
EP0843992A4 (en) | 1998-12-09 |
EP0843992A1 (en) | 1998-05-27 |
US5826713A (en) | 1998-10-27 |
JPH08126683A (ja) | 1996-05-21 |
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