WO1991017163A1 - IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY - Google Patents

IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY Download PDF

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Publication number
WO1991017163A1
WO1991017163A1 PCT/US1991/002997 US9102997W WO9117163A1 WO 1991017163 A1 WO1991017163 A1 WO 1991017163A1 US 9102997 W US9102997 W US 9102997W WO 9117163 A1 WO9117163 A1 WO 9117163A1
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Prior art keywords
compound
het
fluoro
product
preparation
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PCT/US1991/002997
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English (en)
French (fr)
Inventor
Anthony Marfat
James Frederick Eggler
Kevin Cooper
Michael Jonathan Fray
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Pfizer Inc.
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Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Priority to RO92-01395A priority Critical patent/RO109450B1/ro
Priority to JP3509156A priority patent/JPH0678340B2/ja
Priority to FI925053A priority patent/FI925053L/fi
Priority to EP91909431A priority patent/EP0533695B1/en
Priority to DE69104481T priority patent/DE69104481T2/de
Priority to BR919106433A priority patent/BR9106433A/pt
Publication of WO1991017163A1 publication Critical patent/WO1991017163A1/en
Priority to BG097059A priority patent/BG97059A/bg
Priority to NO924290A priority patent/NO924290D0/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Definitions

  • the present invention is directed to azabenz- imidazoles of formula I, which as inhibitors of platelet activating factor (PAF) and of LTD 4 receptor binding sites are useful in the treatment or prevention of asthma, arthritis, psoriasis and a wide range of inflammatory disorders.
  • PAF platelet activating factor
  • R a is 2-pyridyl, 2-quinolyl, 2-pyrazinyl,
  • PCT/US89/00975 Publication No. WO 89/08653 describes the preparation of 1-carbamylbenzylimidazo[4,5-c]- pyridines useful as PAF antagonists.
  • the present invention comprises compounds of the formula
  • B is -NHCH 2 -, -CH 2 O-, -CH(CH 3 )O-, -C(CH 3 ) 2 O-, -O-,
  • R 1 and R 2 are each hydrogen.
  • Het is
  • R 6-fluoro; A is -CH 2 O- ; W is
  • B is -CH(CH 3 )O-, wherein Het is
  • R is 5-fluoro; A is -CH 2 O; W is
  • R is hydrogen; A is -CH 2 O-; W is
  • B is -CH(CH 3 )O-, wherein Het is
  • R is 5-fluoro; A is -(CH 2 ) 2 -; W is
  • B is -CH 2 O-, wherein Het is where R is 5,6-difluoro; A is -CH 2 O-; W is
  • R is 7-chloro; A is -(CH 2 ) 2 -; W is
  • R 6-fluoro ;
  • A is -CH 2 O- ;
  • W is
  • the present invention includes a pharmaceutical composition for administration to a mammal which comprises a platelet activating factor inhibiting and leukotriene D4 receptor blocking amount of a compound of formula I and a pharmaceutically acceptable carrier.
  • the present invention also includes a method of inhibiting platelet activating factor and blocking leukotriene D4 receptors in a mammal in need of such treatment which comprises administering to said mammal a platelet activating factor inhibiting and leukotriene D4 receptor blocking amount of a compound of formula I.
  • a platelet activating factor inhibiting and leukotriene D4 receptor blocking amount of a compound of formula I Preferred is a method wherein the mammal is a human suffering from asthma, arthritis, psoriasis, shock, gastrointestinal ulcers, myocardial infarction or a stroke.
  • the PAF antagonists of the present invention are also useful in preventing rejection in organ transplants.
  • the compounds of the present invention are very unique in that they possess the capacity to both inhibit PAF and block LTD4
  • This coupling is carried out by reacting the appropriate acid with approximately an equimolar amount of 1-hydroxybenzotriazole and dicyclohexylcarbodiimide, to form in situ an activated ester, and subsequently reacting said ester with the desired amine.
  • activated esters can be used in place of that formed by 1-hydroxybenzotriazole.
  • diimides other than dicyclohexylcarbodiimide can also be employed with similar results.
  • reaction time is dependent on reaction temperature. At room temperature the reaction proceeds in 12-72 hours, while under heating at 50-75°C the reaction is complete in 30 minutes to a few hours.
  • the product is isolated by quenching the reaction with water followed by extraction with a water immiscible solvent such as ethyl acetate. Purification of the product is by recrystallization, HPLC or flash column chromatography.
  • B is -CH 2 O-, -CH(CH 3 )O-, C(CH 3 ) 2 O-, -O- or -OCH 2 - are prepared by coupling the following fragments:
  • the reaction is conveniently carried out by reacting about equimolar amounts of the two hydroxy reagents with an equimolar amount, plus a 10-20% excess, of triphenylphosphine and an equimolar amount, plus a 50% excess of diethyl azodicarboxylate in a reaction-inert solvent such as dry tetrahydrofuran.
  • a reaction-inert solvent such as dry tetrahydrofuran.
  • the reaction is usually carried out under nitrogen or some inert gas at rooo temperature. Reaction time under these conditions is about from 12-24 hours, while shorter reaction times can be achieved by gently heating the reaction.
  • the product can be obtained by removing the reaction solvent and purifying the residue by
  • Het-A-W-CH 2 X + HO(CH 2 ) p where X Cl or Br and p is 0 or 1.
  • the reaction is conducted in a water-miscible aprotic solvent such as dimethylformamide,
  • an alkali metal hydride in a molar amount equal to the alcohol being alkylated can be used in place of the carbonate.
  • the product is isolated by diluting the reaction mixture with water followed by extraction of the product with a water-immiscible solvent such as ethyl acetate or chloroform. Purification of the product is carried out by recrystallization or chromatography.
  • the olefin is shaken with 5% palladium-on-charcoal in a hydrogen atmosphere at a pressure of about 30 psi in a reaction-inert solvent of miethanol-tetrahydrofuran at room temperature for 12-24 hours.
  • the product is isolated by filtering the spent catalyst and removing the solvent.
  • the product can be purified by means already mentioned.
  • the product is isolated by removing the acid catalyst with a base wash followed by removal of the solvent. Purification is by previously described means.
  • a reducing agent such as sodium borohydride or sodium cyanoborohydride.
  • reaction-inert solvent such as methanol containing about an equivalent amount of the reducing agent.
  • the reaction can be conducted at room temperature for a reaction time of several hours.
  • the product is isolated by the addition of a water immiscible solvent such as ethyl acetate followed by aqueous washings and removal of the appropriate
  • ester dissolved in methanol containing at least an equimolar amount of an aqueous alkali metal hydroxide, such as sodium
  • the product is isolated by removal of the solvent, addition of water to the residue and precipitation of the product by adjustment of the pH with aqueous acid. Purification is by conventional means.
  • the solvent is removed and the residual product wherein A is a cis olefin is purified by conventional means.
  • the compounds of formula I form pharmaceutically acceptable acid addition salts.
  • Said pharmaceutically-acceptable acid addition salts include, but are not limited to, those with HCl, HBr, HNO 3 , H 2 SO 4 , H 3 PO 4 , CH 3 SO 3 H, p-CH 3 C 6 H 4 SO 3 H, CH 3 CO 2 H, gulconic acid, tartaric acid, maleic acid and succinic acid.
  • those compounds of the formula (I) which contain a further basic nitrogen it will, of course, be possible to form diacid addition salts
  • Said pharmaceutically- acceptable cationic salts include, but are not limited to, those of sodium, potassium, calcium, magnesium, ammonia, N,N'-dibenzylethylenediamine, N-methyl- glucamine (meglumine), ethanolamine and diethanolamine.
  • compounds of formula I have the potential for containing cis-trans olefins, cis-trans-conformational structures and asymmetric carbon atoms. All these potential isomers are considered within the scope of the present
  • leukotrienes the other to several oxidative products called leukotrienes, which are designated by letter number combinations such as B4, C4, D4 and E4.
  • the first step in this oxidative pathway is the oxidation of arachidonic acid under the influence of
  • 5-lipoxygenase enzyme an enzyme which is inhibited by many of the compounds (I) of the present invention, thus blocking the synthesis of all leukotrienes.
  • Supplementing this enzyme inhibitory activity is the general ability of the present compounds to antagonize peptidyl leukotrienes (e.g., block LTD4 receptors), and to antagonize platelet activating factor (e.g., block PAF receptors).
  • peptidyl leukotrienes e.g., block LTD4 receptors
  • platelet activating factor e.g., block PAF receptors
  • RBL-1 cells maintained in monolayer form are grown for 1 or 2 days in spinner culture in Minimum Essential Medium (Eagle) with Earl's Salts plus 15% Fetal Bovine Serum
  • the cells are washed one time with RPMI 1640 (GIBCO) and resuspended in RPMI 1640 plus 1 microM glutathione to a cell density of 1 x 10 cells/ml.
  • a volume of 0.5 ml of the cell suspension is incubated at 30°C with 0.001 ml of dimethylsulfoxide solution of drug for 10 minutes.
  • the reaction is started by a simultaneous addition of 0.005 ml (14C)-arachidonic acid in ethanol and 0.002 ml A23187 in dimethylsulfoxide to give final concentrations of 5.0 and 7.6 microM, respectively. After a 5 minute incubation at 30°C, the reaction is stopped by the addition of
  • Quantitation is accomplished with a Berthold Radioactivity Monitor equipped with a built-in integrator and a 0.2 ml flow cell mixing 2.4 ml/minute Omnifluor (NEN) with column effluent. Integration units for each product are calculated at a percentage of total integration units, and then compared to the average control levels. The results are expressed as "Percent of Control" and are plotted vs the log of drug concentration. The IC 50 values are estimated by graphical inspection.
  • the platelet activating factor (PAF) receptor assay tests the ability of a compound to compete with radiolabeled PAF for specific PAF receptor sites on rabbit platelet homogenate.
  • the blood mixture is 4 parts blood: 1 part 4% sodium citrate (v/v), and is obtained by heart puncture from normal, approximately 8-month old New Zealand white rabbits.
  • the blood mixture is delivered overnight on wet ice (approx. 8°C).
  • the blood mixture is centrifuged at 514 g for 10 minutes.
  • the supernatant platelet-rich plasma is gently laid over Ficoll-Paque (Pharmacia) at a ratio of 9 parts plasma:2 parts Ficoll (v/v).
  • the plasma/Ficoll mixture is centrifuged at 856 g for 20 minutes.
  • the platelet layer is collected and washed in a buffer containing 150 mM NaCl, 10 mM Tris and 1 mM EDTA
  • the platelet pellet is resuspended in about 10 ml of sodium-free buffer. This suspension is quick-frozen in a methanol/dry ice bath and thawed quickly three times before being frozen again for storage in 1 ml aliquots at -70°C. Protein concentration of the suspension is determined by a Bio-Rad assay.
  • BSA bovine serum albumin
  • NSB cpm non-specific binding
  • Percent specific binding is graphed as a function of compound concentration.
  • lC 50 is that concentration at which 50% SB occurs.
  • the IC 50 is calculated using the logistic dose-response (Hill plot) option of the VAX Biostat utility.
  • the inhibitory constant (Ki) is calculated by using the formula
  • Ki (IC 50 )/[1 + (L/Kd)]
  • the leukotriene D4 (LTD4) receptor assay tests the ability of a compound to compete with radiolabeled LTD4 for specific LTD4 receptor sites on guinea pig lung membranes.
  • LTD4 leukotriene D4
  • the guinea pigs are stunned by a blow to the back of the neck, and exsanguinated by cutting the carotid artery.
  • the chest cavity is opened and the lungs are removed, rinsed in 50 mM Tris buffer (pH 7.0) and placed in clean buffer.
  • 50 mM Tris buffer pH 7.0
  • all tissue and buffer are kept on ice throughout the preparation, and all centrifugation is carried out at 4°C. Bronchi and connective tissue are trimmed from the lungs.
  • the tissue is weighed and placed in 50 ml polycarbonate tubes with buffer at a ratio of 1 gm tissue/3 ml buffer.
  • the tissue is homogenized by a Tekmar Tissumizer at full speed for 30 seconds and centrifuged in a Sovall SS-34 rotor at
  • the reaction tubes are incubated at 25°C for 30 minutes.
  • Four ml of cold Tris buffer + 10 microM MgCl are added to each tube.
  • the contents are quickly filtered through a Whatman GF/C filter with a Yeda separation device.
  • the filter is washed 3X with 4 ml Tris-MgCl 2 buffer.
  • the filter is transferred to a scintillation vial. Ultrafluor scintillation fluid is added.
  • the vial is capped, vortexed and counted for 3 hours. Percent specific binding is calculated using the formula
  • % SB (X - NSB)/(TB - NSB) ,
  • NSB cpm non-specific binding
  • Percent specific binding is graphed as a function of compound concentration. IC 50 is that concentration at which 50% SB occurs. Ki is calculated by using the formula
  • mice CDI males, all approximately the same weight (approximately 26 grams), 12 per group.
  • EES 5% ethanol, 5% emulphor, 90% saline. Stored at room temperature.
  • Drugs For routine screening at 50 mg/kg, 20 mg drug is dissolved in 4 ml EES, using sonication in a sonicator bath or grinding in a Ten Broeck grinder to dissolve drug if necessary. If solubility is still a problem, the drug is used as a suspension.
  • PAF Platelet Activating Factor
  • untreated controls This is usually about 0.028 g/kg (a 1 to 2034 dilution from stock).
  • the solution is prepared in glass containers and is used with glass syringes to minimize surface adhesion by the PAF. It is kept at room temperature.
  • Phenidone is used at 25 mg/kg (its approximate ED 50).
  • Method 45 minutes before PAF injection, mice are treated orally with drug using 0.1 ml/10 grams body weight. Thirty-five to 40 minutes later they are placed under a heat lamp to dilate the caudal vein for PAF injection. PAF is injected i.v. at 0.1 ml/10 grams body weight, and death follows usually within 30 minutes, rarely after 60 minutes. Results are
  • mice are acclimated to the room before testing, and if room noise and temperature are kept moderate and constant.
  • the heat lamp distance should be calibrated so as to permit vasodilation without visible stress to the mice. Fasting the mice should be avoided.
  • the time for oral dosing can be changed.
  • Intravenous drug dosing is possible by coinjecting the drug with PAF in the same volume and vehicle as described above.
  • PAF is prepared at twice the desired concentration in saline with BSA and Propranolol as above, and the drug is prepared at twice the desired concentration in the same vehicle.
  • the two preparations are mixed in equal volumes immediately before injection.
  • a compound of the formula (I) is given a PAF inhibiting and leukotriene D4 receptor blocking amount of about 0.5-50 mg/kg/day, in single or divided daily doses.
  • a more preferred dosage range is 2-20 mg/kg/day, although in particular cases, at the discretion of the attending physician, doses outside the broader range may be required.
  • the preferred route of administration is generally oral, but parenteral administration (e.g., intramuscular, intravenous, intradermal) will be preferred in special cases, e.g., where oral absorption is impaired as by disease, or the patient is unable to swallow.
  • the compounds of the present invention are:
  • compositions comprising at least one of the compound of the formula (I), together with a pharmaceutically acceptable vehicle or diluent.
  • Such compositions are generally formulated in a conventional manner utilizing solid or liquid vehicles or diluents as appropriate to the mode of desired administration: for oral
  • reaction mixture was diluted with ethyl acetate (75 ml) which was then washed with a saturated sodium bicarbonate solution (2 x 75 ml) and a brine solution (1 x 75 ml).
  • the solution was separated, dried over sodium sulfate and concentrated in vacuo to give 1.18 g of product as a yellow solid, which was further purified by chromatographing on 75 g of silica using 800 ml of 4% methanol-methylene chloride. The fractions containing the product were combined and concentrated to give 447 mg of a white foam.
  • the hydrochloride salt was prepared by treating an ethanol solution of the product with ethyl acetate saturated with hydrogen chloride, m.p. 160°C, dec.
  • the hydrochloride salt of the product was prepared by treating an ethanol solution of the product with ethyl acetate saturated with hydrogen chloride, m.p. 259-261°C.
  • Preparation B in 8 ml of dimethylformamide was added 78 mg of 60% sodium hydride. After stirring for 15 minutes, 650 mg of the product of Preparation P was added, and the reaction mixture stirred for 30 minutes. The reaction was diluted with water and extracted with ethyl acetate. The extracts were washed with water and a brine solution and dried over sodium sulfate.
  • triphenylphosphine (2.88 g) were dissolved in dry tetrahydrofuran (50 ml). Diethylazodicarboxylate
  • reaction was again cooled to -60°C and treated with 4.37 ⁇ l of triethylamine dropwise over a 5 minute period.
  • reaction mixture was then diluted with 75 ml of methylene chloride and washed with a saturated sodium bicarbonate solution (3 x
  • the reaction was diluted with water (1 1) and the pH adjusted to 8 with 3N sodium hydroxide.
  • the aqueous was extracted with ethyl acetate (3 x 500 ml), which was washed with water and a brine solution.
  • the organic phase was dried over sodium sulfate and concentrated to give 5.83 g of material.
  • the residue was chromatographed on 400 g of silica using 15% ethyl acetate - methylene chloride. The fractions containing the product were combined and concentrated to give 3.45 g of product.
  • 3-mercaptobenzyl alcohol and 2-chloromethyl-5-fluorobenzothiazole and 2-ethoxy- carbonyl-7-(5-fluorobenzothiazol-2-ylmethoxy)chroman, m.p. 109-112°C was prepared from 2-chloronethyl-5- fluorobenzothiazole and 2-ethoxycarbonyl-7-hydroxy- chroman.
  • triphenyl phosphonium chloride prepared by reacting 4.0 g of 2-chloromethyl-5-fluorobenzothiazole and 5.22 g of triphenylphosphine in 50 ml of toluene at reflux temperature for 17 hours), 7.61 ml of 1.6M n-butyl lithium solution in hexane and 2.0 g of methyl 3-formylbenzoate in 80 ml of dry tetrahydrofuran there was obtained 2.92 g of the titled product, m.p.
  • triphenyl 5-chlorobenzo- thiazol-2-ylmethyl phosphonium chloride was reacted with methyl 3-formylbenzoate to give methyl 3-(5- chlorobenzothiazol-2-yl-trans-ethenyl)benzoate, m.p. 168-169°C
  • triphenyl 5-fluorobenzothiazol-2-ylmethyl phosphonium chloride was reacted with ethyl
  • An alternate procedure for preparing this benzyl alcohol comprises condensing isophthalaldehyde with 2-methyl-5-fluorobenzothiazole in the presence of acetic anhydride and zinc chloride in hot xylene followed by the reduction of the 3-(5-fluorobenzo- thiazol-2-yl-trans-ethenyl)benzaldehyde product with sodium borohydride to provide the appropriate benzyl alcohol.
  • reaction mixture was concentrated in vacuo and the residue partitioned between 300 ml of water and ethyl acetate (2 x 300 ml).
  • organic extracts were combined, washed with water and a brine solution and dried over sodium sulfate.
  • dimethylsulfoxide at -60°C was added a solution of .64 ml of oxalyl chloride in 20 ml of dry methylene chloride containing .74 ml of dimethylsulfoxide. After stirring at -60°C for 35 minutes the reaction mixture was allowed to warm to -35°C for 25 minutes. The mixture was again cooled to -60°C and 3.65 ml of triethylamine was added over a period of 5 minutes.
  • the reaction mixture was stirred at 0°C for 2 hours, was hydrolyzed by the addition of an ammonium chloride solution and was concentrated to a small volume in vacuo.
  • the residual suspension was added to 200 ml of water, the pH adjusted to 10 and the resulting mixture extracted with ethyl acetate (2 x 200 ml). The extracts were combined, washed with water and a brine solution and dried over magnesium sulfate. Removal in vacuo of the solvent gave 2 g of material which was chromatographed on silica gel to give 235 mg of pure product.
  • the mixture was diluted with 400 ml of ethyl acetate and washed with water (1 x 40 ml) and brine (1 x
  • Acetic anhydride (75 ml) containing 3.09 g of the product of Preparation FF2 was heated to reflux under nitrogen for 4 hours. The reaction was cooled to room temperature and concentrated in vacuo to dryness. The residue was chromatographed on 350 g of silica gel using 4% methanol in methylene chloride (v:v) to give 2.30 g of a product as a white foam and 1.96 g of an off-white foam. The latter material was used in the next reaction step without further purification.

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PCT/US1991/002997 1990-05-09 1991-05-01 IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY WO1991017163A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
RO92-01395A RO109450B1 (ro) 1990-05-09 1991-05-01 Derivati de imidazo (4,5-c) piridine, procedee de obtinere, compozitii care ii contin si metoda de tratament
JP3509156A JPH0678340B2 (ja) 1990-05-09 1991-05-01 喘息、関節炎および関連疾患の治療におけるアザベンジミダゾール
FI925053A FI925053L (fi) 1990-05-09 1991-05-01 Imidazo(4,5-c)pyridiner med paf-antagonistaktivitet
EP91909431A EP0533695B1 (en) 1990-05-09 1991-05-01 IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY
DE69104481T DE69104481T2 (de) 1990-05-09 1991-05-01 Imidazo[4,5-c]pyridine als paf antagonisten.
BR919106433A BR9106433A (pt) 1990-05-09 1991-05-01 Imidazo (4,5-c) piridinas com atividade antagonista ao paf
BG097059A BG97059A (bg) 1990-05-09 1992-11-06 Имидазо (4,5-с) пиридини, антагонисти на раf
NO924290A NO924290D0 (no) 1990-05-09 1992-11-06 Azabenzimidazoler for behandling av astma, artritt og lignende lidelser

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US52119990A 1990-05-09 1990-05-09
US521,199 1990-05-09

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WO1994004537A3 (en) * 1992-08-20 1994-10-27 Cytomed Inc Dual functional anti-inflammatory and immunosuppressive agents
WO1999058518A3 (en) * 1998-05-12 2000-01-20 American Home Prod Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6232322B1 (en) 1998-05-12 2001-05-15 American Home Products Corporation Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6310081B1 (en) 1999-05-10 2001-10-30 American Home Products Corporation Biphenyl sulfonyl aryl carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
US7196089B2 (en) 2003-01-29 2007-03-27 Asterand Uk Limited EP4 receptor antagonists
US7417068B2 (en) 2003-10-16 2008-08-26 Asterand Uk Limited EP4 receptor antagonists
CN105348182A (zh) * 2014-08-24 2016-02-24 复旦大学 2-烷氧基苯甲酰芳胺类化合物及其药物用途
EP3044210A4 (en) * 2013-09-13 2017-03-15 Cortendo AB (publ) Novel cytochrome p450 inhibitors and their method of use

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GB9102997D0 (en) * 1991-02-13 1991-03-27 Pfizer Ltd Therapeutic agents
US6372770B1 (en) 1994-10-12 2002-04-16 Euro-Celtique, S.A. Benzoxazoles

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EP0330327A2 (en) * 1988-02-25 1989-08-30 Pfizer Limited Dihydropyridines, their preparation and their use as PAF-antagonists

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ES8401486A1 (es) * 1981-11-10 1983-12-01 Wellcome Found Un procedimiento para la preparacion de nuevos derivados de imidazo (4,5-c)piridina.
GB8822170D0 (en) * 1988-09-21 1988-10-26 Pfizer Ltd Therapeutic agents

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Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994004537A3 (en) * 1992-08-20 1994-10-27 Cytomed Inc Dual functional anti-inflammatory and immunosuppressive agents
WO1999058518A3 (en) * 1998-05-12 2000-01-20 American Home Prod Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6232322B1 (en) 1998-05-12 2001-05-15 American Home Products Corporation Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6369072B2 (en) 1998-05-12 2002-04-09 American Home Products Corporation Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6391897B2 (en) 1998-05-12 2002-05-21 American Home Products Corporation Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6310081B1 (en) 1999-05-10 2001-10-30 American Home Products Corporation Biphenyl sulfonyl aryl carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
US7507754B2 (en) 2003-01-29 2009-03-24 Asterand Uk Limited EP4 receptor antagonists
US7196089B2 (en) 2003-01-29 2007-03-27 Asterand Uk Limited EP4 receptor antagonists
US7528157B2 (en) 2003-01-29 2009-05-05 Asterand Uk Limited EP4 receptor antagonists
US7858644B2 (en) 2003-01-29 2010-12-28 Asterand Uk Limited EP4 receptor antagonists
US7417068B2 (en) 2003-10-16 2008-08-26 Asterand Uk Limited EP4 receptor antagonists
US7569602B2 (en) 2003-10-16 2009-08-04 Asterand Uk Limited Furan derivatives as EP4 receptor antagonists
EP3044210A4 (en) * 2013-09-13 2017-03-15 Cortendo AB (publ) Novel cytochrome p450 inhibitors and their method of use
US9725436B2 (en) 2013-09-13 2017-08-08 Cortendo Ab (Publ) Cytochrome P450 inhibitors and their method of use
CN105348182A (zh) * 2014-08-24 2016-02-24 复旦大学 2-烷氧基苯甲酰芳胺类化合物及其药物用途
WO2016029767A1 (zh) * 2014-08-24 2016-03-03 复旦大学 2-烷氧基苯甲酰芳胺类化合物及其药物用途

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AU642265B2 (en) 1993-10-14
EP0533695B1 (en) 1994-10-05
IE911553A1 (en) 1991-11-20
FI925053A7 (fi) 1992-11-06
NO924290L (no) 1992-11-06
BG97059A (bg) 1993-12-24
AP224A (en) 1992-10-27
AU7867191A (en) 1991-11-27
ATE112567T1 (de) 1994-10-15
FI925053A0 (fi) 1992-11-06
TW205549B (enrdf_load_stackoverflow) 1993-05-11
PT97616A (pt) 1992-03-31
NO924290D0 (no) 1992-11-06
FI925053L (fi) 1992-11-06
NZ238089A (en) 1992-10-28
DE69104481D1 (de) 1994-11-10
DE69104481T2 (de) 1995-02-09
IL98075A0 (en) 1992-06-21
MY105512A (en) 1994-10-31
MA22151A1 (fr) 1991-12-31
AP9100259A0 (en) 1991-07-31
CN1057839A (zh) 1992-01-15
PE26691A1 (es) 1991-10-21
GT199100031A (es) 1992-10-30
RO109450B1 (ro) 1995-02-28
HU9203496D0 (en) 1993-01-28
YU81191A (sh) 1994-06-10
EP0533695A1 (en) 1993-03-31
ZA913497B (en) 1992-12-30
DK0533695T3 (da) 1995-01-09
JPH0678340B2 (ja) 1994-10-05
HUT62894A (en) 1993-06-28
CA2080476A1 (en) 1991-11-10
BR9106433A (pt) 1993-05-04
JPH05505619A (ja) 1993-08-19
ES2061247T3 (es) 1994-12-01

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