WO1990006110A1 - Treatment of obesity - Google Patents

Treatment of obesity Download PDF

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Publication number
WO1990006110A1
WO1990006110A1 PCT/GB1989/001383 GB8901383W WO9006110A1 WO 1990006110 A1 WO1990006110 A1 WO 1990006110A1 GB 8901383 W GB8901383 W GB 8901383W WO 9006110 A1 WO9006110 A1 WO 9006110A1
Authority
WO
WIPO (PCT)
Prior art keywords
cyclobutyl
chlorophenyl
obesity
treatment
group
Prior art date
Application number
PCT/GB1989/001383
Other languages
English (en)
French (fr)
Inventor
Monte Lee Scheinbaum
Original Assignee
The Boots Company Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23060006&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1990006110(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by The Boots Company Plc filed Critical The Boots Company Plc
Priority to AT89912801T priority Critical patent/ATE94385T1/de
Priority to KR1019900701628A priority patent/KR0164435B1/ko
Priority to JP2500580A priority patent/JPH06102622B2/ja
Publication of WO1990006110A1 publication Critical patent/WO1990006110A1/en
Priority to DK199001776A priority patent/DK175587B1/da
Priority to HK98105187A priority patent/HK1006002A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Definitions

  • This invention relates to the medical treatment of obesity.
  • a method of treating obesity in which a therapeutically effective amount of ,N-dimethyl-1 [1- (4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydro ⁇ chloride is administered in conjunction with a pharmaceutically acceptable diluent or carrier.
  • a particularly preferred form of this compound is ,N-dimethyl-1-[1 -( ⁇ -chlorophenyl)cyclobutyl]-3- methylbutylamine hydrochloride monohydrate (sibutramine hydrochloride) which is described in European Patent Application 230742.
  • the therapeutically active compound may be administered in any of the known pharmaceutical dosage forms for example solid dosage forms such as tablets or capsules or liquid dosage forms for example those forms intended for oral or parenteral administration.
  • the amount of the compound to be administered will depend on a number of factors including the age of the patient, the severity of the condition and the past medical history of the patient and always lies within the sound discretion of the administering physician but it is generally envisaged that the dosage of the compound to be administered will be in the range 0.1 to 50 mg preferably 1 to 30'mg per day given in one or more doses.
  • sibutramine hydrochloride The ability of sibutramine hydrochloride to cause weight reduction in humans has been demonstrated by the following trials.
  • a first group (Group 1) of 15 subjects were given 2.5 mg sibutramine hydrochloride per day for the first two weeks of the trial, followed by 5 mg sibutramine hydrochloride per day for the remaining four weeks of the trial.
  • the second group (Group 2) of 15 subjects were given 5 mg sibutramine hydrochloride per day for the first two weeks of the trial, followed by 10 mg sibutramine hydrochloride per day for the remaining four weeks of the trial.
  • the third group (Group 3) of 9 subjects were given a placebo containing no sibutramine hydrochloride.
  • the subjects were treated with a single dose of sibutramine hydrochloride or placebo taken each morning of the trial.
  • the weight of each subject was taken at the commencement of treatment and after six weeks.
  • the weight of each, subject (in kg) at the start and the change in weight (in kg) over the six week trial period is given in Table 1 below.
  • a first group (Group 1) of 26 subjects were treated with 10 mg of sibutramine hydrochloride per day for the first two weeks of the trial and then with 20 mg of sibutramine hydrochloride per day for a further period of four weeks.
  • the second group (Group 2) were given a placebo containing no sibutramine hydrochloride every day throughout the trial.
  • the subjects were treated with a single dose of sibutramine hydrochoride or placebo taken each morning of the trial.
  • the weight of each subject was taken at the commencement of the trial and after six weeks.
  • the weight of each subject (in kg) at the start and the change in weight (in kg) over the six week period are given below in Table 2.
  • a first group (Group 1) of 14 subjects were treated with 15 mg of sibutramine hydrochloride per day for the first two weeks of the trial and then with 30 mg of sibutramine hydrochloride for a further period of four weeks.
  • the second group (Group 2) were given a placebo containing no sibutramine hydrochloride every day throughout the trial.
  • the subjects were treated with a single dose of sibutramine hydrochloride or placebo taken each morning of the trial.
  • the weight of each subject was taken at the commencement of the trial and after six weeks.
  • the weight of each subject (in kg) at the start of the trial and the change in weight (in kg) over the six week period are given below in Table 3.

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PCT/GB1989/001383 1988-11-29 1989-11-21 Treatment of obesity WO1990006110A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AT89912801T ATE94385T1 (de) 1988-11-29 1989-11-21 Behandlung von obesitas.
KR1019900701628A KR0164435B1 (ko) 1988-11-29 1989-11-21 비만증 치료용 약제학적 조성물
JP2500580A JPH06102622B2 (ja) 1988-11-29 1989-11-21 肥満の治療
DK199001776A DK175587B1 (da) 1988-11-29 1990-07-26 Behandling af fedme
HK98105187A HK1006002A1 (en) 1988-11-29 1998-06-11 Treatment of obesity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27724088A 1988-11-29 1988-11-29
US277,240 1988-11-29

Publications (1)

Publication Number Publication Date
WO1990006110A1 true WO1990006110A1 (en) 1990-06-14

Family

ID=23060006

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1989/001383 WO1990006110A1 (en) 1988-11-29 1989-11-21 Treatment of obesity

Country Status (16)

Country Link
US (1) US5436272A (da)
EP (1) EP0397831B1 (da)
JP (1) JPH06102622B2 (da)
KR (1) KR0164435B1 (da)
AU (1) AU633529B2 (da)
CA (1) CA2003524C (da)
DE (2) DE19975039I2 (da)
DK (1) DK175587B1 (da)
HK (1) HK1006002A1 (da)
IE (1) IE61928B1 (da)
IL (1) IL92406A (da)
LU (1) LU90866I2 (da)
NL (1) NL300066I2 (da)
PH (1) PH26677A (da)
WO (1) WO1990006110A1 (da)
ZA (1) ZA899058B (da)

Cited By (30)

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US5068440A (en) * 1985-12-17 1991-11-26 Boots Company, Plc Process for the manufacture of N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate
WO1994000114A1 (en) * 1992-06-23 1994-01-06 Sepracor Inc. Methods and compositions for treating depression and other disorders using optically pure (-) sibutramine
US5459164A (en) * 1994-02-03 1995-10-17 Boots Pharmaceuticals, Inc. Medical treatment
WO1996038134A1 (de) * 1995-05-29 1996-12-05 Knoll Ag Verwendung arylsubstituierter cyclobutylalkylamine zur behandlung der fettleibigkeit
WO1998013033A1 (en) * 1996-09-25 1998-04-02 Knoll Aktiengesellschaft Medical treatment
AU721924B2 (en) * 1992-06-23 2000-07-20 Sepracor, Inc. Methods and compositions for treating depression and other disorders using optically pure (-) sibutramine
US6174925B1 (en) 1996-09-21 2001-01-16 Knoll Aktiengesellschaft Use of sibutramine analogues to prevent the development of diabetes
US6187820B1 (en) 1996-09-25 2001-02-13 Knoll Aktiengesellschaft Medical treatment to improve lipid levels
WO2001034140A1 (en) * 1999-11-06 2001-05-17 Abbott Gmbh & Co. Kg Pharmaceutical formulation
WO2001062341A2 (en) * 2000-02-22 2001-08-30 Knoll Gmbh Combination product for the treatment of obesity
US6331571B1 (en) 1998-08-24 2001-12-18 Sepracor, Inc. Methods of treating and preventing attention deficit disorders
EP1162966A1 (en) * 1999-03-19 2001-12-19 Knoll Pharmaceutical Company Weight loss after pregnancy
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EP1169029A1 (en) * 1999-03-19 2002-01-09 Knoll GmbH Method of treating sleep apnoea
US6339106B1 (en) 1999-08-11 2002-01-15 Sepracor, Inc. Methods and compositions for the treatment and prevention of sexual dysfunction
US6365632B1 (en) 1999-03-19 2002-04-02 Knoll Pharmaceuticals Company Treatment of orthostatic hypotension
US6372798B1 (en) 1999-03-19 2002-04-16 Knoll Pharmaceutical Company Treatment of hyperactivity disorders
US6376551B1 (en) 1999-03-19 2002-04-23 Knoll Pharmaceutical Company Treatment of chronic fatigue syndrome
US6376554B1 (en) 1999-03-19 2002-04-23 Knoll Pharmaceutical Company Method of treating sexual dysfunction
US6399826B1 (en) 1999-08-11 2002-06-04 Sepracor Inc. Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain
US6403650B1 (en) 1999-03-19 2002-06-11 Knoll Pharmaceutical Company Treatment of pulmonary hypertension
US6433020B1 (en) 1999-03-19 2002-08-13 Knoll Pharmaceutical Company Treatment of cardiovascular disease
US6441046B1 (en) 1999-03-19 2002-08-27 Abbott Gmbh & Co. Kg Control of metabolism
US6476078B2 (en) 1999-08-11 2002-11-05 Sepracor, Inc. Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction
US6610887B2 (en) 2001-04-13 2003-08-26 Sepracor Inc. Methods of preparing didesmethylsibutramine and other sibutramine derivatives
US6803387B1 (en) 1999-03-19 2004-10-12 Abbott Gmbh & Co. Kg Treatment of neuropathic pain or fibromyalgia
US6974838B2 (en) 1998-08-24 2005-12-13 Sepracor Inc. Methods of treating or preventing pain using sibutramine metabolites
US7148258B2 (en) 2000-10-04 2006-12-12 Aventis Pharma S.A. Combination of a CB1 receptor antagonist and of sibutramine, the pharmaceutical compositions comprising them and their use in the treatment of obesity
BG65170B1 (bg) * 1999-03-17 2007-05-31 Knoll Gmbh Използване на n-заместени производни на 1-[1-(4-хлорофенил)циклобутил]-3-метилбутиламин за производство на лекарство за лечение на разстройства при храненето
EP1328269B2 (fr) † 2000-10-04 2008-07-30 Aventis Pharma S.A. Association d'un antagoniste du recepteur cb1 et de la sibutramine pour le traitement de l'obesite

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Cited By (47)

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US5068440A (en) * 1985-12-17 1991-11-26 Boots Company, Plc Process for the manufacture of N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate
WO1994000114A1 (en) * 1992-06-23 1994-01-06 Sepracor Inc. Methods and compositions for treating depression and other disorders using optically pure (-) sibutramine
AU721924B2 (en) * 1992-06-23 2000-07-20 Sepracor, Inc. Methods and compositions for treating depression and other disorders using optically pure (-) sibutramine
EP0814788A4 (en) * 1994-02-03 1999-05-06 Boots Pharma Inc IMPROVEMENT OF GLUCOSE TOLERANCE
EP0814788A1 (en) * 1994-02-03 1998-01-07 Boots Pharmaceuticals Inc. Improving glucose tolerance
US5942549A (en) * 1994-02-03 1999-08-24 Knoll Pharmaceutical Company Improving glucose tolerance
US5459164A (en) * 1994-02-03 1995-10-17 Boots Pharmaceuticals, Inc. Medical treatment
WO1996038134A1 (de) * 1995-05-29 1996-12-05 Knoll Ag Verwendung arylsubstituierter cyclobutylalkylamine zur behandlung der fettleibigkeit
US6127424A (en) * 1995-05-29 2000-10-03 Knoll Aktiengesesllschaft Aryl-substituted cyclobutylalkylamines for treating obesity
US6174925B1 (en) 1996-09-21 2001-01-16 Knoll Aktiengesellschaft Use of sibutramine analogues to prevent the development of diabetes
US6617360B1 (en) 1996-09-21 2003-09-09 Knoll Aktiengesellschaft Medical treatment
WO1998013033A1 (en) * 1996-09-25 1998-04-02 Knoll Aktiengesellschaft Medical treatment
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IL92406A (en) 1995-07-31
EP0397831B1 (en) 1993-09-15
NL300066I1 (nl) 2001-12-01
DE68909219D1 (de) 1993-10-21
EP0397831A1 (en) 1990-11-22
NL300066I2 (nl) 2002-06-03
CA2003524A1 (en) 1990-05-29
AU4620789A (en) 1990-06-26
JPH02503682A (ja) 1990-11-01
DK175587B1 (da) 2004-12-13
PH26677A (en) 1992-09-15
DK177690D0 (da) 1990-07-26
LU90866I2 (fr) 2002-02-18
KR0164435B1 (ko) 1999-01-15
DK177690A (da) 1990-09-13
HK1006002A1 (en) 1999-02-05
IE893690L (en) 1990-05-29
IE61928B1 (en) 1994-11-30
ZA899058B (en) 1990-08-29
US5436272A (en) 1995-07-25
AU633529B2 (en) 1993-02-04
CA2003524C (en) 1999-10-19
KR900701261A (ko) 1990-12-01
DE68909219T2 (de) 1994-01-13
JPH06102622B2 (ja) 1994-12-14
DE19975039I2 (de) 2000-03-30

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