DK175587B1 - Behandling af fedme - Google Patents
Behandling af fedme Download PDFInfo
- Publication number
- DK175587B1 DK175587B1 DK199001776A DK177690A DK175587B1 DK 175587 B1 DK175587 B1 DK 175587B1 DK 199001776 A DK199001776 A DK 199001776A DK 177690 A DK177690 A DK 177690A DK 175587 B1 DK175587 B1 DK 175587B1
- Authority
- DK
- Denmark
- Prior art keywords
- group
- weight
- trial
- weeks
- sibutramine hydrochloride
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
Claims (1)
- 2. Anvendelse af N,N-dimetyl-1-/1.- (4-klorfenyl) -cyklobu-tyl7-3-metylbutylamin-hydrokl°rid-monohydrat til fremstilling af et lægemiddel til behandling af fedme.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27724088A | 1988-11-29 | 1988-11-29 | |
US27724088 | 1988-11-29 | ||
PCT/GB1989/001383 WO1990006110A1 (en) | 1988-11-29 | 1989-11-21 | Treatment of obesity |
GB8901383 | 1989-11-21 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK177690D0 DK177690D0 (da) | 1990-07-26 |
DK177690A DK177690A (da) | 1990-09-13 |
DK175587B1 true DK175587B1 (da) | 2004-12-13 |
Family
ID=23060006
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK199001776A DK175587B1 (da) | 1988-11-29 | 1990-07-26 | Behandling af fedme |
Country Status (16)
Country | Link |
---|---|
US (1) | US5436272A (da) |
EP (1) | EP0397831B1 (da) |
JP (1) | JPH06102622B2 (da) |
KR (1) | KR0164435B1 (da) |
AU (1) | AU633529B2 (da) |
CA (1) | CA2003524C (da) |
DE (2) | DE19975039I2 (da) |
DK (1) | DK175587B1 (da) |
HK (1) | HK1006002A1 (da) |
IE (1) | IE61928B1 (da) |
IL (1) | IL92406A (da) |
LU (1) | LU90866I2 (da) |
NL (1) | NL300066I2 (da) |
PH (1) | PH26677A (da) |
WO (1) | WO1990006110A1 (da) |
ZA (1) | ZA899058B (da) |
Families Citing this family (100)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8531071D0 (en) * | 1985-12-17 | 1986-01-29 | Boots Co Plc | Therapeutic compound |
AU721924B2 (en) * | 1992-06-23 | 2000-07-20 | Sepracor, Inc. | Methods and compositions for treating depression and other disorders using optically pure (-) sibutramine |
WO1994000114A1 (en) * | 1992-06-23 | 1994-01-06 | Sepracor Inc. | Methods and compositions for treating depression and other disorders using optically pure (-) sibutramine |
GB9301192D0 (en) | 1993-06-09 | 1993-06-09 | Trott Francis W | Flower shaped mechanised table |
US5459164A (en) * | 1994-02-03 | 1995-10-17 | Boots Pharmaceuticals, Inc. | Medical treatment |
DE19518988A1 (de) * | 1995-05-29 | 1996-12-05 | Basf Ag | Verwendung arylsubstituierter Cyclobutylalkylamine zur Behandlung der Fettleibigkeit |
GB9619757D0 (en) | 1996-09-21 | 1996-11-06 | Knoll Ag | Chemical process |
GB9619961D0 (en) | 1996-09-25 | 1996-11-13 | Knoll Ag | Medical treatment |
GB9619962D0 (en) * | 1996-09-25 | 1996-11-13 | Knoll Ag | Medical treatment |
GB9727131D0 (en) | 1997-12-24 | 1998-02-25 | Knoll Ag | Therapeutic agents |
US6331571B1 (en) | 1998-08-24 | 2001-12-18 | Sepracor, Inc. | Methods of treating and preventing attention deficit disorders |
US6974838B2 (en) | 1998-08-24 | 2005-12-13 | Sepracor Inc. | Methods of treating or preventing pain using sibutramine metabolites |
US6339106B1 (en) | 1999-08-11 | 2002-01-15 | Sepracor, Inc. | Methods and compositions for the treatment and prevention of sexual dysfunction |
US6476078B2 (en) * | 1999-08-11 | 2002-11-05 | Sepracor, Inc. | Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction |
US6046242A (en) * | 1998-11-27 | 2000-04-04 | Basf Aktiengesellschaft | Use of aryl-substituted cyclobutylalkylamines for treating urinary incontinence |
US6696495B2 (en) | 1998-12-02 | 2004-02-24 | Snowden Pharmaceuticals, Llc | Treatment of disorders secondary to organic impairments |
US6323242B1 (en) | 1998-12-02 | 2001-11-27 | Peter Sterling Mueller | Treatment of disorders secondary to organic impairments |
BG65170B1 (bg) * | 1999-03-17 | 2007-05-31 | Knoll Gmbh | Използване на n-заместени производни на 1-[1-(4-хлорофенил)циклобутил]-3-метилбутиламин за производство на лекарство за лечение на разстройства при храненето |
AU3894500A (en) | 1999-03-19 | 2000-10-09 | Knoll Pharmaceutical Company | Prevention of cardiovascular disease |
AU3757200A (en) | 1999-03-19 | 2000-10-09 | Knoll Gmbh | Treatment of pulmonary hypertension |
CN1161114C (zh) * | 1999-03-19 | 2004-08-11 | 艾博特股份有限两合公司 | 一种治疗睡眠障碍的化合物在制药中的用途 |
AU4014800A (en) * | 1999-03-19 | 2000-10-09 | Knoll Gmbh | Treatment of gallstones |
US6441046B1 (en) | 1999-03-19 | 2002-08-27 | Abbott Gmbh & Co. Kg | Control of metabolism |
US6372798B1 (en) | 1999-03-19 | 2002-04-16 | Knoll Pharmaceutical Company | Treatment of hyperactivity disorders |
WO2000056309A1 (en) | 1999-03-19 | 2000-09-28 | Knoll Pharmaceutical Company | Method of treating sexual dysfunction |
KR100432825B1 (ko) * | 1999-03-19 | 2004-05-24 | 애보트 게엠베하 운트 콤파니 카게 | 식이 장애 치료용 약제학적 조성물 |
AU3760600A (en) | 1999-03-19 | 2000-10-09 | Knoll Pharmaceutical Company | Treatment of orthostatic hypotension |
US6552087B1 (en) | 1999-03-19 | 2003-04-22 | Abbott Gmbh & Co. Kg | Therapeutic agent comprising (+)-sibutramine |
NZ514016A (en) * | 1999-03-19 | 2001-09-28 | Knoll Gmbh | Treatment of osteoarthritis |
JP2002539251A (ja) * | 1999-03-19 | 2002-11-19 | クノール・ゲー・エム・ベー・ハー | 治療薬に伴う体重増加を調節する方法 |
CN1352553A (zh) * | 1999-03-19 | 2002-06-05 | 克诺尔股份有限公司 | 怀孕后的减肥 |
AU3895300A (en) | 1999-03-19 | 2000-10-09 | Knoll Pharmaceutical Company | Treatment of chronic fatigue syndrome |
US6803387B1 (en) | 1999-03-19 | 2004-10-12 | Abbott Gmbh & Co. Kg | Treatment of neuropathic pain or fibromyalgia |
US6245782B1 (en) | 1999-05-17 | 2001-06-12 | Heartdrug Research L.L.C. | Methods of inhibiting platelet activation with selective serotonin reuptake inhibitors |
US6399826B1 (en) | 1999-08-11 | 2002-06-04 | Sepracor Inc. | Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain |
GB9926251D0 (en) * | 1999-11-06 | 2000-01-12 | Knoll Ag | Pharmaceutical formulation |
GB0004003D0 (en) * | 2000-02-22 | 2000-04-12 | Knoll Ag | Therapeutic agents |
AU2001282913A1 (en) * | 2000-09-08 | 2002-03-22 | Eli Lilly And Company | A method of treating weight gain associated with atypical antipsychotic use |
FR2814678B1 (fr) † | 2000-10-04 | 2002-12-20 | Aventis Pharma Sa | Association d'un antagoniste du recepteur cb1 et de sibutramine, les compositions pharmaceutiques les contenant et leur utilisation pour la traitement de l'obesite |
US20020091114A1 (en) | 2000-10-04 | 2002-07-11 | Odile Piot-Grosjean | Combination of a CB1 receptor antagonist and of sibutramine, the pharmaceutical compositions comprising them and their use in the treatment of obesity |
WO2002083631A1 (en) * | 2001-04-13 | 2002-10-24 | Sepracor Inc. | Methods of preparing didesmethylsibutramine and other sibutramine derivatives |
US20030139386A1 (en) * | 2001-12-21 | 2003-07-24 | Sophie Cote | Pharmaceutical compositions based on azetidine derivatives |
NZ534757A (en) * | 2002-03-12 | 2006-07-28 | Merck & Co Inc | Substituted amides |
US7105526B2 (en) | 2002-06-28 | 2006-09-12 | Banyu Pharmaceuticals Co., Ltd. | Benzimidazole derivatives |
US20040122033A1 (en) * | 2002-12-10 | 2004-06-24 | Nargund Ravi P. | Combination therapy for the treatment of obesity |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
US20050131074A1 (en) * | 2003-08-04 | 2005-06-16 | Beckman Kristen M. | Methods for treating metabolic syndrome |
CA2551037A1 (en) | 2003-09-22 | 2005-03-31 | Banyu Pharmaceutical Co., Ltd. | Novel piperidine derivative |
US20080125403A1 (en) | 2004-04-02 | 2008-05-29 | Merck & Co., Inc. | Method of Treating Men with Metabolic and Anthropometric Disorders |
JP2008526836A (ja) | 2005-01-06 | 2008-07-24 | シージェー チェイルジェダン コーポレーション | シブトラミンの無機酸塩 |
US7737155B2 (en) | 2005-05-17 | 2010-06-15 | Schering Corporation | Nitrogen-containing heterocyclic compounds and methods of use thereof |
RU2417985C2 (ru) | 2005-05-30 | 2011-05-10 | Баниу Фармасьютикал Ко., Лтд. | Новые производные пиперидина |
US20100216758A1 (en) | 2005-08-10 | 2010-08-26 | Makoto Ando | Pyridone Compounds |
JPWO2007024004A1 (ja) | 2005-08-24 | 2009-03-05 | 萬有製薬株式会社 | フェニルピリドン誘導体 |
EP1939194A4 (en) | 2005-09-07 | 2010-12-08 | Banyu Pharma Co Ltd | AROMATIC SUBSTITUTED BICYLIC PYRIDONE DERIVATIVE |
EP1938811A4 (en) * | 2005-09-22 | 2008-12-17 | Eisai R&D Man Co Ltd | MEDICAL COMPOSITION FOR THE TREATMENT OF BULAMINE AND BULAMIC DEPRESSIONS |
EP1940842B1 (en) | 2005-09-29 | 2012-05-30 | Merck Sharp & Dohme Corp. | Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators |
US8911751B2 (en) * | 2005-10-11 | 2014-12-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compositions for nasal delivery |
JP2009512715A (ja) | 2005-10-21 | 2009-03-26 | ノバルティス アクチエンゲゼルシャフト | レニン阻害剤と抗異脂肪血症剤および/または抗肥満症剤の組み合わせ |
CA2627139A1 (en) | 2005-10-27 | 2007-05-03 | Banyu Pharmaceutical Co., Ltd. | Novel benzoxathiin derivative |
EP1953165B1 (en) | 2005-11-10 | 2012-02-01 | Msd K.K. | Aza-substituted spiro derivative |
RU2477634C2 (ru) * | 2006-06-16 | 2013-03-20 | Теракос, Инк. | Лечение психологических состояний с применением антагонистов m1-мускариновых рецепторов |
US8748419B2 (en) | 2006-06-16 | 2014-06-10 | Theracos, Inc. | Treating obesity with muscarinic receptor M1 antagonists |
EP2063890A1 (en) | 2006-09-07 | 2009-06-03 | Nycomed GmbH | Combination treatment for diabetes mellitus |
EP2066329B1 (en) | 2006-09-15 | 2017-09-06 | Reviva Pharmaceuticals, Inc. | Synthesis, methods of using, and compositions of cyclobutylmethylamines |
EP2083831B1 (en) | 2006-09-22 | 2013-12-25 | Merck Sharp & Dohme Corp. | Method of treatment using fatty acid synthesis inhibitors |
CA2664358A1 (en) | 2006-09-28 | 2008-04-03 | Banyu Pharmaceutical Co., Ltd. | Diarylketimine derivative |
KR20090127904A (ko) * | 2007-04-09 | 2009-12-14 | 싸이도우스 엘엘씨. | 스타틴과 항비만제의 복합물 |
US20080249156A1 (en) * | 2007-04-09 | 2008-10-09 | Palepu Nageswara R | Combinations of statins and anti-obesity agent and glitazones |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
MX2009013354A (es) | 2007-06-04 | 2010-07-06 | Univ Ben Gurion | Compuestos de triarilo y composiciones que los contienen. |
EA020466B1 (ru) | 2007-06-04 | 2014-11-28 | Синерджи Фармасьютикалз Инк. | Агонисты гуанилатциклазы, пригодные для лечения желудочно-кишечных нарушений, воспаления, рака и других заболеваний |
WO2009110510A1 (ja) | 2008-03-06 | 2009-09-11 | 萬有製薬株式会社 | アルキルアミノピリジン誘導体 |
JPWO2009119726A1 (ja) | 2008-03-28 | 2011-07-28 | Msd株式会社 | メラニン凝集ホルモン受容体拮抗作用を有するジアリールメチルアミド誘導体 |
CA2726917C (en) | 2008-06-04 | 2018-06-26 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
AU2009261248A1 (en) | 2008-06-19 | 2009-12-23 | Banyu Pharmaceutical Co., Ltd. | Spirodiamine-diarylketoxime derivative |
CA2730603C (en) | 2008-07-16 | 2019-09-24 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
JPWO2010013595A1 (ja) | 2008-07-30 | 2012-01-12 | Msd株式会社 | 5員−5員又は5員−6員縮環シクロアルキルアミン誘導体 |
CN102264228A (zh) | 2008-10-22 | 2011-11-30 | 默沙东公司 | 用于抗糖尿病药的新的环状苯并咪唑衍生物 |
US8329914B2 (en) | 2008-10-31 | 2012-12-11 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
WO2010065889A2 (en) * | 2008-12-06 | 2010-06-10 | Auspex Pharmaceutical | Cyclobutanemethanamine inhibitors of monomine reuptake |
US20110245209A1 (en) | 2008-12-16 | 2011-10-06 | Schering Corporation | Pyridopyrimidine derivatives and methods of use thereof |
US20110243940A1 (en) | 2008-12-16 | 2011-10-06 | Schering Corporation | Bicyclic pyranone derivatives and methods of use thereof |
WO2011106273A1 (en) | 2010-02-25 | 2011-09-01 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
WO2012003501A2 (en) | 2010-07-02 | 2012-01-05 | Reviva Pharmaceuticals, Inc. | Compositions, synthesis, and methods of using cycloalkylmethylamine derivatives |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
CA2826649C (en) | 2011-02-25 | 2016-07-26 | Merck Sharp & Dohme Corp. | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
US20140045746A1 (en) | 2012-08-02 | 2014-02-13 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
BR112015019836A2 (pt) | 2013-02-22 | 2017-07-18 | Merck Sharp & Dohme | composto, composição farmacêutica, e, uso de um composto |
US9650375B2 (en) | 2013-03-14 | 2017-05-16 | Merck Sharp & Dohme Corp. | Indole derivatives useful as anti-diabetic agents |
CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
CN113388007A (zh) | 2013-06-05 | 2021-09-14 | 博士医疗爱尔兰有限公司 | 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法 |
WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
US10111880B2 (en) | 2013-11-05 | 2018-10-30 | Ben-Gurion University Of The Negev Research And Development Authority | Compounds for the treatment of diabetes and disease complications arising from same |
EP3186242B1 (en) | 2014-08-29 | 2021-10-06 | Tes Pharma S.r.l. | Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase |
EP3526199B1 (en) | 2016-10-14 | 2022-04-13 | Tes Pharma S.r.l. | Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase |
US11072602B2 (en) | 2016-12-06 | 2021-07-27 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
EP3558298A4 (en) | 2016-12-20 | 2020-08-05 | Merck Sharp & Dohme Corp. | ANTIDIABETIC SPIROCHROMAN COMPOUNDS |
CN113302189A (zh) | 2018-11-20 | 2021-08-24 | Tes制药有限责任公司 | α-氨基-β-羧基己二烯二酸半醛去羧酶的抑制剂 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4443449A (en) * | 1981-04-06 | 1984-04-17 | The Boots Company Limited | Arylcyclobutylalkylamines and anti-depression composition and methods using same |
ZA821577B (en) * | 1981-04-06 | 1983-03-30 | Boots Co Plc | Therapeutic agents |
GB2184122B (en) * | 1985-12-17 | 1989-10-18 | Boots Co Plc | N,n-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methyl butylamine hydrochloride monohydrate |
GB8704777D0 (en) * | 1987-02-28 | 1987-04-01 | Boots Co Plc | Medical treatment |
-
1989
- 1989-11-17 IE IE369089A patent/IE61928B1/en not_active IP Right Cessation
- 1989-11-21 KR KR1019900701628A patent/KR0164435B1/ko not_active IP Right Cessation
- 1989-11-21 DE DE1999175039 patent/DE19975039I2/de active Active
- 1989-11-21 JP JP2500580A patent/JPH06102622B2/ja not_active Expired - Lifetime
- 1989-11-21 AU AU46207/89A patent/AU633529B2/en not_active Expired
- 1989-11-21 EP EP89912801A patent/EP0397831B1/en not_active Expired - Lifetime
- 1989-11-21 DE DE89912801T patent/DE68909219T2/de not_active Expired - Lifetime
- 1989-11-21 WO PCT/GB1989/001383 patent/WO1990006110A1/en active IP Right Grant
- 1989-11-21 CA CA002003524A patent/CA2003524C/en not_active Expired - Lifetime
- 1989-11-22 IL IL9240689A patent/IL92406A/en active Protection Beyond IP Right Term
- 1989-11-24 PH PH39593A patent/PH26677A/en unknown
- 1989-11-28 ZA ZA899058A patent/ZA899058B/xx unknown
-
1990
- 1990-07-26 DK DK199001776A patent/DK175587B1/da not_active IP Right Cessation
-
1992
- 1992-10-15 US US07/962,175 patent/US5436272A/en not_active Expired - Lifetime
-
1998
- 1998-06-11 HK HK98105187A patent/HK1006002A1/xx not_active IP Right Cessation
-
2001
- 2001-10-04 NL NL300066C patent/NL300066I2/nl unknown
- 2001-12-18 LU LU90866C patent/LU90866I2/fr unknown
Also Published As
Publication number | Publication date |
---|---|
IL92406A (en) | 1995-07-31 |
EP0397831B1 (en) | 1993-09-15 |
NL300066I1 (nl) | 2001-12-01 |
DE68909219D1 (de) | 1993-10-21 |
EP0397831A1 (en) | 1990-11-22 |
NL300066I2 (nl) | 2002-06-03 |
CA2003524A1 (en) | 1990-05-29 |
AU4620789A (en) | 1990-06-26 |
JPH02503682A (ja) | 1990-11-01 |
PH26677A (en) | 1992-09-15 |
DK177690D0 (da) | 1990-07-26 |
LU90866I2 (fr) | 2002-02-18 |
KR0164435B1 (ko) | 1999-01-15 |
DK177690A (da) | 1990-09-13 |
HK1006002A1 (en) | 1999-02-05 |
IE893690L (en) | 1990-05-29 |
IE61928B1 (en) | 1994-11-30 |
ZA899058B (en) | 1990-08-29 |
US5436272A (en) | 1995-07-25 |
AU633529B2 (en) | 1993-02-04 |
CA2003524C (en) | 1999-10-19 |
KR900701261A (ko) | 1990-12-01 |
DE68909219T2 (de) | 1994-01-13 |
JPH06102622B2 (ja) | 1994-12-14 |
WO1990006110A1 (en) | 1990-06-14 |
DE19975039I2 (de) | 2000-03-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK175587B1 (da) | Behandling af fedme | |
Hanotin et al. | Efficacy and tolerability of sibutramine in obese patients: a dose-ranging study | |
Espir et al. | Treatment of paroxysmal disorders in multiple sclerosis with carbamazepine (Tegretol) | |
US4507323A (en) | Treatment of psychosexual dysfunctions | |
Bagnall | The value of chloroquine in rheumatoid disease: a four-year study of continuous therapy | |
Rolland et al. | A new approach to the inhibition of puerperal lactation | |
US4435449A (en) | Treatment of minimal brain dysfunction (MBD) | |
US4438138A (en) | Reduction of cholesterol with meta-chloro α-t-butylaminopropiophenone | |
US5017575A (en) | Treatment of immunologically based disorders, specifically Crohn's disease | |
JPH09504798A (ja) | 早発性射精の治療におけるアルフゾシンまたはテラゾシンの使用 | |
IE851848L (en) | Propiophenone compound against sexual dysfunction | |
Dotevall et al. | Controlled clinical trial of mepiprazole in irritable bowel syndrome | |
Hollister et al. | Propranolol in withdrawal from opiates | |
US4315033A (en) | Method of treating menopausal symptoms | |
JP6042886B2 (ja) | 早漏症治療用の薬学組成物 | |
Carter et al. | Once‐Daily Propranolol for Hypertension: A Comparison of Regular‐Release, Long‐Acting, and Generic Formulations | |
Tuchman et al. | A comparison of Rauwolfia serpentina compounds, crude root, alseroxylon derivative, and single alkaloid, in the treatment of hypertension | |
Kagan et al. | Flufenamic acid and placebo compared in rheumatoid arthritis and osteoarthritis | |
Rab et al. | Double-blind multicentre isradipine dose-confirmation study in Pakistan | |
Lishner et al. | Analgesic effect of ceruletide compared with pentazocine in biliary and renal colic: a prospective, controlled, double-blind study | |
SU1713587A1 (ru) | Способ лечени радикулита | |
PSYCHOPHARMACOL—Baltimore | DOMESTIC ABSTRACTS | |
Gallant | Antidepressant overdose: symptoms and treatment | |
CN114632083A (zh) | 一种用于治疗感冒、咳嗽的复方制剂及制备方法 | |
Glazer et al. | A Double‐Blind Study of Oxprenolol Once and Twice Daily in Hypertensive Patients |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
CTFF | Application for supplementary protection certificate (spc) filed |
Spc suppl protection certif: CA 2005 00031 Filing date: 20050613 |
|
CTFW | Supplementary protection certificate (spc) withdrawn, refused or deemed withdrawn |
Spc suppl protection certif: CA 2005 00031 Filing date: 20050613 |
|
CTFF | Application for supplementary protection certificate (spc) filed |
Spc suppl protection certif: CA 2005 00030 Filing date: 20050613 Expiry date: 20140113 |
|
CTFG | Supplementary protection certificate (spc) issued |
Free format text: PRODUCT NAME: SIBUTRAMIN HYDROCHLORIDMONOHYDRAT Spc suppl protection certif: CA 2005 00030 Filing date: 20050613 |
|
PUP | Patent expired |