UY34603A - Anticuerpos anti-asic-1 y usos de los mismos - Google Patents

Anticuerpos anti-asic-1 y usos de los mismos

Info

Publication number
UY34603A
UY34603A UY34603A UY34603A UY34603A UY 34603 A UY34603 A UY 34603A UY 34603 A UY34603 A UY 34603A UY 34603 A UY34603 A UY 34603A UY 34603 A UY34603 A UY 34603A
Authority
UY
Uruguay
Prior art keywords
asic
antibodies
same
figura
hay
Prior art date
Application number
UY34603A
Other languages
English (en)
Spanish (es)
Inventor
Mcdonald Lynn
Gao Min
Marc R Morra
Nicole M Alessandri Haber
Michael L Lacroix-Fralish
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47666522&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY34603(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of UY34603A publication Critical patent/UY34603A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
UY34603A 2012-01-31 2013-01-31 Anticuerpos anti-asic-1 y usos de los mismos UY34603A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261592837P 2012-01-31 2012-01-31
US201261644038P 2012-05-08 2012-05-08
US201261692925P 2012-08-24 2012-08-24

Publications (1)

Publication Number Publication Date
UY34603A true UY34603A (es) 2013-07-31

Family

ID=47666522

Family Applications (1)

Application Number Title Priority Date Filing Date
UY34603A UY34603A (es) 2012-01-31 2013-01-31 Anticuerpos anti-asic-1 y usos de los mismos

Country Status (33)

Country Link
US (3) US9150648B2 (enExample)
EP (2) EP3453723B1 (enExample)
JP (1) JP6302844B2 (enExample)
KR (1) KR102111941B1 (enExample)
CN (1) CN104093738B (enExample)
AR (1) AR089852A1 (enExample)
AU (1) AU2013215254B2 (enExample)
CA (1) CA2862332C (enExample)
CL (1) CL2014002019A1 (enExample)
CO (1) CO7020877A2 (enExample)
CY (2) CY1121368T1 (enExample)
DK (2) DK3453723T3 (enExample)
EA (1) EA028647B1 (enExample)
ES (2) ES2707599T3 (enExample)
HR (2) HRP20190358T1 (enExample)
HU (2) HUE042531T2 (enExample)
IL (2) IL233410A0 (enExample)
IN (1) IN2014CN04645A (enExample)
JO (1) JO3547B1 (enExample)
LT (2) LT2809681T (enExample)
MX (1) MX358518B (enExample)
MY (1) MY168748A (enExample)
NZ (1) NZ626242A (enExample)
PH (1) PH12014501613A1 (enExample)
PL (2) PL2809681T3 (enExample)
PT (2) PT3453723T (enExample)
RS (2) RS58439B1 (enExample)
SG (1) SG11201403222UA (enExample)
SI (2) SI3453723T1 (enExample)
SM (1) SMT202100628T1 (enExample)
TW (1) TWI591073B (enExample)
UY (1) UY34603A (enExample)
WO (1) WO2013116296A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3453723T3 (da) 2012-01-31 2021-09-13 Regeneron Pharma Anti-ASIC1-antistoffer og anvendelser deraf
WO2015160858A2 (en) * 2014-04-15 2015-10-22 Sorrento Therapeutics, Inc. Antigen binding proteins that bind wisp1
KR20230145503A (ko) 2014-05-16 2023-10-17 아블린쓰 엔.브이. 개선된 면역글로불린 가변 도메인
KR20250099289A (ko) 2014-05-16 2025-07-01 아블린쓰 엔.브이. 개선된 면역글로불린 가변 도메인
CN105233286B (zh) * 2015-09-10 2018-10-30 上海交通大学医学院 含酸敏感离子通道调控剂的制剂及其在治疗瘙痒中的用途
CN105713089B (zh) * 2016-02-26 2019-08-06 上海科技大学 一种特异性抑制酸敏感离子通道i型的全人抗体
WO2018085441A1 (en) * 2016-11-01 2018-05-11 Berg Llc Filamin b binding proteins and uses thereof
CN111936517B (zh) * 2018-01-26 2025-04-18 瑞泽恩制药公司 抗tmprss2抗体和抗原结合片段
GB2598698B (en) * 2019-06-04 2024-09-18 Univ Shanghai Technology Affinity-maturated anti-ASICIa antibodies
US12441789B2 (en) * 2019-07-11 2025-10-14 Memorial Sloan Kettering Cancer Center DLL3-targeting antibodies and uses thereof
US20230287107A1 (en) * 2019-07-23 2023-09-14 Shanghaitech University Asic1 channel antagonist antibody
MX2022003074A (es) * 2019-09-13 2022-06-14 Memorial Sloan Kettering Cancer Center Anticuerpos anti-cd371, y usos de los mismos.
MX2024001808A (es) * 2021-08-09 2024-02-29 Merck Patent Gmbh Proteinas que desacoplan la citotoxicidad tumoral mediada por celulas t de la liberacion de citoquinas proinflamatorias.
AU2022337142A1 (en) * 2021-09-02 2024-03-07 Memorial Hospital For Cancer And Allied Diseases Anti-dll3 antibodies and uses thereof
CN119331085B (zh) * 2024-10-16 2025-03-14 中国科学院合肥物质科学研究院 沙贝冠状病毒广谱中和抗体及其应用

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2759373B1 (fr) 1997-02-11 2001-05-04 Centre Nat Rech Scient Nouveau canal cationique neuronal de mammifere sensible a l'acidite, son clonage et ses applications
DE69836591T2 (de) 1997-10-29 2007-09-20 Mcgill University, Montreal Dna kodierend für einen humanen protonenabhängigen ionenkanal und deren verwendungen
US6287859B1 (en) 1998-08-05 2001-09-11 Centre National De La Recherche Identification, functional expression and chromosal localization of a sustained human proton-gated cation channel
CA2304494A1 (en) 2000-04-20 2001-10-20 Philippe Seguela A novel heteromultimeric ion channel receptor and uses thereof
US6635432B1 (en) 2000-04-25 2003-10-21 University Of Iowa Research Foundation Peptide potentiation of acid-sensory ion channel in pain
US7132505B1 (en) 2001-05-10 2006-11-07 Centre National De La Recherche Scientifique - Cnrs Polypeptide inhibiting a proton-gated Na+ channel, a nucleic acid coding for such polypeptide and a method of manufacturing an ASIC1a channel blocker
CA2352702A1 (en) * 2001-07-18 2003-01-18 Philippe Seguela Novel human proton gated ion channel
AR039067A1 (es) 2001-11-09 2005-02-09 Pfizer Prod Inc Anticuerpos para cd40
CA2479927C (en) * 2002-03-29 2013-03-12 Schering Corporation Human monoclonal antibodies to interleukin-5 and methods and compositions comprising same
US20030186860A1 (en) 2002-03-29 2003-10-02 Welsh Michael J. Novel compositions and methods for modulating the acid-sensing ion channel (ASIC)
US20070197583A1 (en) 2002-03-29 2007-08-23 Welsh Michael J Novel compositions and methods for modulation of the acid-sensing ion channel (ASIC) for the treatment of anxiety and drug addiction
WO2005025518A2 (en) * 2003-09-11 2005-03-24 The Uab Research Foundation Inhibition of inward sodium currents in cancer
WO2005074923A1 (en) 2004-02-03 2005-08-18 Agt Biosciences Limited Methods and compositions
JP2007530664A (ja) 2004-03-30 2007-11-01 ペインセプター ファーマ コーポレーション ゲートイオンチャンネルを調節するための組成物及び方法
JP5848861B2 (ja) 2004-04-20 2016-01-27 ジェンマブ エー/エスGenmab A/S Cd20に対するヒトモノクローナル抗体
US7192500B2 (en) 2004-04-30 2007-03-20 Kimberly-Clark Worldwide, Inc. Process for making a garment including an absorbent assembly
US8030442B2 (en) 2004-09-16 2011-10-04 Morehouse School Of Medicine Treatment of injury to the brain by inhibition of acid sensing ion channels
CN105085678B (zh) * 2004-12-21 2019-05-07 阿斯利康公司 血管生成素-2的抗体及其应用
CA2604357C (en) * 2005-04-26 2012-01-17 Pfizer Inc. P-cadherin antibodies
JP5307708B2 (ja) 2006-06-02 2013-10-02 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒトil−6受容体に対する高親和性抗体
WO2008007648A1 (fr) * 2006-07-10 2008-01-17 Institute For Antibodies Co., Ltd. Procédé de classification d'antigène, procédé d'identification d'antigène, procédé d'obtention d' un ensemble d'antigènes ou d'anticorps, procédés de construction d'un panel d'anticorps, anticorps et ens
EP2043650A2 (en) 2006-07-14 2009-04-08 Medical Research Council Treatment for demyelinating disease
RU2448979C2 (ru) * 2006-12-14 2012-04-27 Ридженерон Фармасьютикалз, Инк. Антитела человека к дельта-подобному лиганду-4 человека
US7598039B2 (en) 2007-01-30 2009-10-06 Academia Sinica Treatment of insulin resistance
WO2008119360A1 (en) 2007-04-03 2008-10-09 ILEGUSAVNID, Genetics Resource Centre Minestry of Social Affairs and Health Amiloride sensitive sodium channels associated with panic disorders
WO2008134659A2 (en) * 2007-04-27 2008-11-06 Zymogenetics, Inc. Antagonists to il-17a, il-17f, and il-23p19 and methods of use
EP2853897A1 (en) * 2008-05-08 2015-04-01 University Of Utah Research Foundation Sensory receptors for chronic fatigue and pain and uses thereof
US20090291150A1 (en) 2008-05-21 2009-11-26 University Of Iowa Research Foundation Method and compositions for treating and preventing seizures by modulating acid-sensing ion channel activity
FR2932091B1 (fr) 2008-06-06 2012-12-28 Centre Nat Rech Scient Effets analgesiques de la toxine peptidique apetx2
JP2012508017A (ja) * 2008-11-07 2012-04-05 ファブラス エルエルシー 抗dll4抗体及びその使用
JO3672B1 (ar) * 2008-12-15 2020-08-27 Regeneron Pharma أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9).
US8926976B2 (en) * 2009-09-25 2015-01-06 Xoma Technology Ltd. Modulators
GB0922434D0 (en) * 2009-12-22 2010-02-03 Ucb Pharma Sa antibodies and fragments thereof
CN102234316B (zh) * 2010-05-07 2014-01-29 中国人民解放军军事医学科学院毒物药物研究所 具有增强酸感受离子通道1a电流作用的多肽及其用途
US9371383B2 (en) 2012-01-31 2016-06-21 Regeneron Pharmaceuticals, Inc. Anti-ASIC1 antibodies and uses thereof
DK3453723T3 (da) 2012-01-31 2021-09-13 Regeneron Pharma Anti-ASIC1-antistoffer og anvendelser deraf

Also Published As

Publication number Publication date
JO3547B1 (ar) 2020-07-05
KR102111941B1 (ko) 2020-05-18
TWI591073B (zh) 2017-07-11
EP3453723A3 (en) 2019-04-10
CA2862332C (en) 2021-05-18
ES2707599T3 (es) 2019-04-04
DK3453723T3 (da) 2021-09-13
CN104093738A (zh) 2014-10-08
HUE042531T2 (hu) 2019-07-29
IL233410A0 (en) 2014-08-31
MY168748A (en) 2018-11-30
PH12014501613B1 (en) 2014-10-13
TW201335182A (zh) 2013-09-01
BR112014018651A2 (pt) 2017-07-04
EA201491452A1 (ru) 2014-11-28
MX2014008541A (es) 2014-10-24
US20130195878A1 (en) 2013-08-01
PT3453723T (pt) 2021-09-07
CL2014002019A1 (es) 2015-01-16
KR20140125363A (ko) 2014-10-28
LT2809681T (lt) 2019-02-11
RS62454B1 (sr) 2021-11-30
JP2015508063A (ja) 2015-03-16
EP2809681B1 (en) 2018-12-05
US9150648B2 (en) 2015-10-06
CY1124778T1 (el) 2022-11-25
MX358518B (es) 2018-08-24
HUE056335T2 (hu) 2022-02-28
AU2013215254A1 (en) 2014-07-03
IL254416A0 (en) 2017-11-30
US10513557B2 (en) 2019-12-24
EP2809681A1 (en) 2014-12-10
PL3453723T3 (pl) 2022-01-03
IL254416B (en) 2018-03-29
HRP20190358T1 (hr) 2019-04-05
SG11201403222UA (en) 2014-07-30
CN104093738B (zh) 2018-05-18
SI3453723T1 (sl) 2021-11-30
CO7020877A2 (es) 2014-08-11
EA028647B1 (ru) 2017-12-29
CY1121368T1 (el) 2020-05-29
SI2809681T1 (sl) 2019-04-30
ES2886123T3 (es) 2021-12-16
IN2014CN04645A (enExample) 2015-09-18
RS58439B1 (sr) 2019-04-30
US20160002332A1 (en) 2016-01-07
AU2013215254B2 (en) 2017-08-31
LT3453723T (lt) 2021-09-10
NZ626242A (en) 2017-02-24
EP3453723A2 (en) 2019-03-13
JP6302844B2 (ja) 2018-03-28
CA2862332A1 (en) 2013-08-08
AR089852A1 (es) 2014-09-24
DK2809681T3 (en) 2019-03-11
SMT202100628T1 (it) 2022-01-10
PL2809681T3 (pl) 2019-05-31
HRP20211541T1 (hr) 2021-12-24
WO2013116296A1 (en) 2013-08-08
PH12014501613A1 (en) 2014-10-13
PT2809681T (pt) 2019-02-18
HK1199269A1 (en) 2015-06-26
EP3453723B1 (en) 2021-08-11
US20180222976A1 (en) 2018-08-09

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Effective date: 20220104