EA201491452A1 - Антитела к asic1 и их применение - Google Patents
Антитела к asic1 и их применениеInfo
- Publication number
- EA201491452A1 EA201491452A1 EA201491452A EA201491452A EA201491452A1 EA 201491452 A1 EA201491452 A1 EA 201491452A1 EA 201491452 A EA201491452 A EA 201491452A EA 201491452 A EA201491452 A EA 201491452A EA 201491452 A1 EA201491452 A1 EA 201491452A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- antibodies
- asic1
- present
- cells expressing
- application
- Prior art date
Links
- 102100021624 Acid-sensing ion channel 1 Human genes 0.000 title 1
- 101710099904 Acid-sensing ion channel 1 Proteins 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 2
- 101000754290 Homo sapiens Acid-sensing ion channel 1 Proteins 0.000 abstract 1
- 108090000862 Ion Channels Proteins 0.000 abstract 1
- 102000004310 Ion Channels Human genes 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 102000048484 human ASIC1 Human genes 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
Abstract
Настоящее изобретение предлагает антитела и их антигенсвязывающие фрагменты, которые специфически связываются с клетками, экспрессирующими кислоточувствительный ионный канал 1 (ASIC1). В соответствии с некоторыми вариантами осуществления настоящего изобретения антитела ингибируют индуцируемые кислотами ASICl-опосредованные ионные токи в клетках, экспрессирующих человеческие ASIC1. Антитела настоящего изобретения применяются для лечения боли, включая боль, связанную с хирургическим вмешательством, различными заболеваниями и нарушениями.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261592837P | 2012-01-31 | 2012-01-31 | |
US61/592,837 | 2012-01-31 | ||
US201261644038P | 2012-05-08 | 2012-05-08 | |
US61/644,038 | 2012-05-08 | ||
US201261692925P | 2012-08-24 | 2012-08-24 | |
US61/692,925 | 2012-08-24 | ||
PCT/US2013/023784 WO2013116296A1 (en) | 2012-01-31 | 2013-01-30 | Anti-asic1 antibodies and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201491452A1 true EA201491452A1 (ru) | 2014-11-28 |
EA028647B1 EA028647B1 (ru) | 2017-12-29 |
Family
ID=47666522
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201491452A EA028647B1 (ru) | 2012-01-31 | 2013-01-30 | Антитела к asic1 и их применение |
Country Status (33)
Country | Link |
---|---|
US (3) | US9150648B2 (ru) |
EP (2) | EP3453723B1 (ru) |
JP (1) | JP6302844B2 (ru) |
KR (1) | KR102111941B1 (ru) |
CN (1) | CN104093738B (ru) |
AR (1) | AR089852A1 (ru) |
AU (1) | AU2013215254B2 (ru) |
CA (1) | CA2862332C (ru) |
CL (1) | CL2014002019A1 (ru) |
CO (1) | CO7020877A2 (ru) |
CY (2) | CY1121368T1 (ru) |
DK (2) | DK2809681T3 (ru) |
EA (1) | EA028647B1 (ru) |
ES (2) | ES2707599T3 (ru) |
HK (1) | HK1199269A1 (ru) |
HR (2) | HRP20211541T1 (ru) |
HU (2) | HUE042531T2 (ru) |
IL (2) | IL233410A0 (ru) |
IN (1) | IN2014CN04645A (ru) |
JO (1) | JO3547B1 (ru) |
LT (2) | LT2809681T (ru) |
MX (1) | MX358518B (ru) |
MY (1) | MY168748A (ru) |
NZ (1) | NZ626242A (ru) |
PH (1) | PH12014501613A1 (ru) |
PL (2) | PL3453723T3 (ru) |
PT (2) | PT3453723T (ru) |
RS (2) | RS62454B1 (ru) |
SG (1) | SG11201403222UA (ru) |
SI (2) | SI2809681T1 (ru) |
TW (1) | TWI591073B (ru) |
UY (1) | UY34603A (ru) |
WO (1) | WO2013116296A1 (ru) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LT2809681T (lt) | 2012-01-31 | 2019-02-11 | Regeneron Pharmaceuticals, Inc. | Antikūnai prieš asic1 ir jų panaudojimas |
MA39847A (fr) | 2014-04-15 | 2017-02-22 | Sorrento Therapeutics Inc | Protéines de liaison à l'antigène se liant à wisp1 |
KR20230145503A (ko) | 2014-05-16 | 2023-10-17 | 아블린쓰 엔.브이. | 개선된 면역글로불린 가변 도메인 |
SI3143042T1 (sl) * | 2014-05-16 | 2020-08-31 | Ablynx N.V. | Variabilne domene imunoglobulina |
CN105233286B (zh) * | 2015-09-10 | 2018-10-30 | 上海交通大学医学院 | 含酸敏感离子通道调控剂的制剂及其在治疗瘙痒中的用途 |
CN105713089B (zh) * | 2016-02-26 | 2019-08-06 | 上海科技大学 | 一种特异性抑制酸敏感离子通道i型的全人抗体 |
WO2018085441A1 (en) * | 2016-11-01 | 2018-05-11 | Berg Llc | Filamin b binding proteins and uses thereof |
US10941213B2 (en) * | 2018-01-26 | 2021-03-09 | Regeneron Pharmaceuticals, Inc. | Anti-TMPRSS2 antibodies and antigen-binding fragments |
CN114729034B (zh) * | 2019-06-04 | 2024-01-12 | 上海科技大学 | 亲和力成熟的抗ASIC1a抗体 |
CA3146566A1 (en) * | 2019-07-11 | 2021-01-14 | Memorial Sloan Kettering Cancer Center | Dll3-targeting antibodies and uses thereof |
US20230287107A1 (en) * | 2019-07-23 | 2023-09-14 | Shanghaitech University | Asic1 channel antagonist antibody |
WO2021050857A1 (en) * | 2019-09-13 | 2021-03-18 | Memorial Sloan-Kettering Cancer Center | Anti-cd371 antibodies and uses thereof |
WO2023019121A2 (en) * | 2021-08-09 | 2023-02-16 | Merck Patent Gmbh | Proteins that decouple t cell-mediated tumor cytotoxicity from release of pro-inflammatory cytokines |
WO2023034566A1 (en) * | 2021-09-02 | 2023-03-09 | Memorial Sloan-Kettering Cancer Center | Anti-dll3 antibodies and uses thereof |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2759373B1 (fr) | 1997-02-11 | 2001-05-04 | Centre Nat Rech Scient | Nouveau canal cationique neuronal de mammifere sensible a l'acidite, son clonage et ses applications |
ES2279583T3 (es) | 1997-10-29 | 2007-08-16 | Mcgill University | Adn que codifica para un canal ionico regulado por protones humano y usos del mismo. |
US6287859B1 (en) | 1998-08-05 | 2001-09-11 | Centre National De La Recherche | Identification, functional expression and chromosal localization of a sustained human proton-gated cation channel |
CA2304494A1 (en) | 2000-04-20 | 2001-10-20 | Philippe Seguela | A novel heteromultimeric ion channel receptor and uses thereof |
US6635432B1 (en) | 2000-04-25 | 2003-10-21 | University Of Iowa Research Foundation | Peptide potentiation of acid-sensory ion channel in pain |
US7132505B1 (en) | 2001-05-10 | 2006-11-07 | Centre National De La Recherche Scientifique - Cnrs | Polypeptide inhibiting a proton-gated Na+ channel, a nucleic acid coding for such polypeptide and a method of manufacturing an ASIC1a channel blocker |
CA2352702A1 (en) * | 2001-07-18 | 2003-01-18 | Philippe Seguela | Novel human proton gated ion channel |
AR039067A1 (es) | 2001-11-09 | 2005-02-09 | Pfizer Prod Inc | Anticuerpos para cd40 |
US20070197583A1 (en) | 2002-03-29 | 2007-08-23 | Welsh Michael J | Novel compositions and methods for modulation of the acid-sensing ion channel (ASIC) for the treatment of anxiety and drug addiction |
US20030186860A1 (en) | 2002-03-29 | 2003-10-02 | Welsh Michael J. | Novel compositions and methods for modulating the acid-sensing ion channel (ASIC) |
WO2003085089A2 (en) * | 2002-03-29 | 2003-10-16 | Schering Corporation | Human monoclonal antibodies to interleukin-5 and methods and compositions comprising same |
EP1667735A2 (en) * | 2003-09-11 | 2006-06-14 | The Uab Research Foundation | Inhibition of inward sodium currents in cancer |
WO2005074923A1 (en) | 2004-02-03 | 2005-08-18 | Agt Biosciences Limited | Methods and compositions |
JP2007530664A (ja) | 2004-03-30 | 2007-11-01 | ペインセプター ファーマ コーポレーション | ゲートイオンチャンネルを調節するための組成物及び方法 |
EP1740946B1 (en) | 2004-04-20 | 2013-11-06 | Genmab A/S | Human monoclonal antibodies against cd20 |
US7192500B2 (en) | 2004-04-30 | 2007-03-20 | Kimberly-Clark Worldwide, Inc. | Process for making a garment including an absorbent assembly |
US8030442B2 (en) | 2004-09-16 | 2011-10-04 | Morehouse School Of Medicine | Treatment of injury to the brain by inhibition of acid sensing ion channels |
AU2005319382B2 (en) * | 2004-12-21 | 2011-04-07 | Astrazeneca Ab | Antibodies directed to angiopoietin-2 and uses thereof |
AU2006238930B2 (en) * | 2005-04-26 | 2010-12-23 | Pfizer Inc. | P-cadherin antibodies |
ATE537190T1 (de) | 2006-06-02 | 2011-12-15 | Regeneron Pharma | Hochaffine antikörper gegen den humanen il-6- rezeptor |
EP2078732B1 (en) * | 2006-07-10 | 2015-09-16 | Fujita Health University | Method of identifying a candidate diagnostic or therapeutic antibody using flow cytometry |
US8618113B2 (en) | 2006-07-14 | 2013-12-31 | Medical Research Council | Treatment for demyelinating disease |
NO347649B1 (no) * | 2006-12-14 | 2024-02-12 | Regeneron Pharma | Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse. |
US7598039B2 (en) | 2007-01-30 | 2009-10-06 | Academia Sinica | Treatment of insulin resistance |
DK2137539T3 (da) | 2007-04-03 | 2011-01-24 | Ilegusavnid Genetics Resource Ct Minestry Of Social Affairs And Health | Amolorid følsomme calciumkanaler forbundet med paniklidelser |
CA2683145C (en) * | 2007-04-27 | 2018-06-12 | Katherine E. Lewis | Antagonists to il-17a, il-17f, and il-23p19 and methods of use |
EP2288922B1 (en) * | 2008-05-08 | 2016-08-17 | University of Utah Research Foundation | Sensory receptors for chronic fatigue and pain and uses thereof |
US20090291150A1 (en) | 2008-05-21 | 2009-11-26 | University Of Iowa Research Foundation | Method and compositions for treating and preventing seizures by modulating acid-sensing ion channel activity |
FR2932091B1 (fr) | 2008-06-06 | 2012-12-28 | Centre Nat Rech Scient | Effets analgesiques de la toxine peptidique apetx2 |
WO2010054007A1 (en) * | 2008-11-07 | 2010-05-14 | Fabrus Llc | Combinatorial antibody libraries and uses thereof |
JO3672B1 (ar) * | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
US8926976B2 (en) * | 2009-09-25 | 2015-01-06 | Xoma Technology Ltd. | Modulators |
GB0922434D0 (en) * | 2009-12-22 | 2010-02-03 | Ucb Pharma Sa | antibodies and fragments thereof |
CN102234316B (zh) * | 2010-05-07 | 2014-01-29 | 中国人民解放军军事医学科学院毒物药物研究所 | 具有增强酸感受离子通道1a电流作用的多肽及其用途 |
US9371383B2 (en) | 2012-01-31 | 2016-06-21 | Regeneron Pharmaceuticals, Inc. | Anti-ASIC1 antibodies and uses thereof |
LT2809681T (lt) | 2012-01-31 | 2019-02-11 | Regeneron Pharmaceuticals, Inc. | Antikūnai prieš asic1 ir jų panaudojimas |
-
2013
- 2013-01-30 LT LTEP13702876.7T patent/LT2809681T/lt unknown
- 2013-01-30 DK DK13702876.7T patent/DK2809681T3/en active
- 2013-01-30 RS RS20211284A patent/RS62454B1/sr unknown
- 2013-01-30 JO JOP/2013/0036A patent/JO3547B1/ar active
- 2013-01-30 JP JP2014554950A patent/JP6302844B2/ja active Active
- 2013-01-30 CA CA2862332A patent/CA2862332C/en active Active
- 2013-01-30 AU AU2013215254A patent/AU2013215254B2/en active Active
- 2013-01-30 HU HUE13702876A patent/HUE042531T2/hu unknown
- 2013-01-30 SG SG11201403222UA patent/SG11201403222UA/en unknown
- 2013-01-30 SI SI201331343T patent/SI2809681T1/sl unknown
- 2013-01-30 DK DK18201823.4T patent/DK3453723T3/da active
- 2013-01-30 PL PL18201823T patent/PL3453723T3/pl unknown
- 2013-01-30 HR HRP20211541TT patent/HRP20211541T1/hr unknown
- 2013-01-30 LT LTEP18201823.4T patent/LT3453723T/lt unknown
- 2013-01-30 MX MX2014008541A patent/MX358518B/es active IP Right Grant
- 2013-01-30 PT PT182018234T patent/PT3453723T/pt unknown
- 2013-01-30 EP EP18201823.4A patent/EP3453723B1/en active Active
- 2013-01-30 SI SI201331923T patent/SI3453723T1/sl unknown
- 2013-01-30 WO PCT/US2013/023784 patent/WO2013116296A1/en active Application Filing
- 2013-01-30 EA EA201491452A patent/EA028647B1/ru not_active IP Right Cessation
- 2013-01-30 IN IN4645CHN2014 patent/IN2014CN04645A/en unknown
- 2013-01-30 CN CN201380007553.3A patent/CN104093738B/zh active Active
- 2013-01-30 PL PL13702876T patent/PL2809681T3/pl unknown
- 2013-01-30 ES ES13702876T patent/ES2707599T3/es active Active
- 2013-01-30 TW TW102103458A patent/TWI591073B/zh active
- 2013-01-30 PT PT13702876T patent/PT2809681T/pt unknown
- 2013-01-30 ES ES18201823T patent/ES2886123T3/es active Active
- 2013-01-30 MY MYPI2014001721A patent/MY168748A/en unknown
- 2013-01-30 KR KR1020147020682A patent/KR102111941B1/ko active IP Right Grant
- 2013-01-30 US US13/753,836 patent/US9150648B2/en active Active
- 2013-01-30 AR ARP130100280 patent/AR089852A1/es active IP Right Grant
- 2013-01-30 HU HUE18201823A patent/HUE056335T2/hu unknown
- 2013-01-30 RS RS20190287A patent/RS58439B1/sr unknown
- 2013-01-30 NZ NZ626242A patent/NZ626242A/en unknown
- 2013-01-30 EP EP13702876.7A patent/EP2809681B1/en active Active
- 2013-01-31 UY UY34603A patent/UY34603A/es not_active Application Discontinuation
-
2014
- 2014-06-26 IL IL233410A patent/IL233410A0/en unknown
- 2014-07-11 PH PH12014501613A patent/PH12014501613A1/en unknown
- 2014-07-25 CO CO14162499A patent/CO7020877A2/es unknown
- 2014-07-30 CL CL2014002019A patent/CL2014002019A1/es unknown
- 2014-12-23 HK HK14112815.2A patent/HK1199269A1/xx unknown
-
2015
- 2015-09-09 US US14/848,452 patent/US20160002332A1/en not_active Abandoned
-
2017
- 2017-09-11 IL IL254416A patent/IL254416B/en active IP Right Grant
- 2017-09-28 US US15/719,220 patent/US10513557B2/en active Active
-
2019
- 2019-02-22 HR HRP20190358TT patent/HRP20190358T1/hr unknown
- 2019-02-27 CY CY20191100246T patent/CY1121368T1/el unknown
-
2021
- 2021-11-09 CY CY20211100968T patent/CY1124778T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201491452A1 (ru) | Антитела к asic1 и их применение | |
CY1123256T1 (el) | Συζευγματα αντισωματος enanti-cmet δραστικης ουσιας και μεθοδοι για τη χρηση αυτων | |
EA201591762A1 (ru) | Человеческие антитела к grem1 | |
NZ743124A (en) | Antibodies targeting fc receptor-like 5 and methods of use | |
EA201890453A1 (ru) | Анти-angptl8 антитела и их применение | |
MX2015010749A (es) | Anticuerpos humanos para nav1.7. | |
MY185813A (en) | Factor xi antibodies and methods of use | |
EA202090031A3 (ru) | Человеческие антитела против gfr3 и способы их применения | |
EA201590085A1 (ru) | Антитела анти-egfr и их применение | |
BR112018068678A2 (pt) | anticorpos anti-mica | |
EA201590144A1 (ru) | Rspo3-связывающие агенты и их применение | |
EA201390506A1 (ru) | Полипептиды, которые связывают компонент с5 комплемента человека | |
EA201591611A1 (ru) | Конъюгаты антитело-лекарственное средство | |
WO2015009726A3 (en) | Medical uses of cd38 agonists | |
EA201070730A1 (ru) | Гуманизированные антитела, специфичные к фактору фон виллебранда | |
EA201592203A1 (ru) | Способы лечения таупатии | |
EA201690503A1 (ru) | Антитела | |
EA201290849A1 (ru) | Оптимизированные моноклональные антитела против ингибитора пути тканевого фактора (tfpi) | |
MX2015017853A (es) | Anticuerpos contra el receptor 1 de ldl oxidada tipo lectina de metodos de uso. | |
PH12015502829A1 (en) | Lectin-like oxidized ldl receptor1 antibodies and methods of use | |
EA201691220A1 (ru) | Способ для получения композиции пегилированных белков | |
MX2017001983A (es) | Agentes de union a proteina r-espondina 1 (rspo1) y usos de los mismos. | |
MA35863B1 (fr) | Anticorps anti-asic1 et leurs utilisations |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG TJ TM |