MX358518B - Anticuerpos anti - asic1 y usos de los mismos. - Google Patents

Anticuerpos anti - asic1 y usos de los mismos.

Info

Publication number
MX358518B
MX358518B MX2014008541A MX2014008541A MX358518B MX 358518 B MX358518 B MX 358518B MX 2014008541 A MX2014008541 A MX 2014008541A MX 2014008541 A MX2014008541 A MX 2014008541A MX 358518 B MX358518 B MX 358518B
Authority
MX
Mexico
Prior art keywords
asic1
antibodies
cells expressing
acid
asic1 antibodies
Prior art date
Application number
MX2014008541A
Other languages
English (en)
Other versions
MX2014008541A (es
Inventor
Macdonald Lynn
Gao Min
R Morra Marc
M Alessandri-Haber Nicole
L Lacroix-Fralish Michael
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47666522&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX358518(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2014008541A publication Critical patent/MX2014008541A/es
Publication of MX358518B publication Critical patent/MX358518B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La presente invención se refiere a anticuerpos y fragmentos de unión a antígeno de los mismos que se unen específicamente a células que expresan el canal sensible a ácido 1 (ASIC1). Según ciertas realizaciones de la invención, los anticuerpos inhiben las corrientes iónicas mediadas por ASICI inducidas por ácido en células que expresan ASIC1 humano. Los anticuerpos de la invención son útiles para el tratamiento del dolor, incluyendo dolor asociado a intervención quirúrgica y diversas enfermedades y trastornos.
MX2014008541A 2012-01-31 2013-01-30 Anticuerpos anti - asic1 y usos de los mismos. MX358518B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261592837P 2012-01-31 2012-01-31
US201261644038P 2012-05-08 2012-05-08
US201261692925P 2012-08-24 2012-08-24
PCT/US2013/023784 WO2013116296A1 (en) 2012-01-31 2013-01-30 Anti-asic1 antibodies and uses thereof

Publications (2)

Publication Number Publication Date
MX2014008541A MX2014008541A (es) 2014-10-24
MX358518B true MX358518B (es) 2018-08-24

Family

ID=47666522

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014008541A MX358518B (es) 2012-01-31 2013-01-30 Anticuerpos anti - asic1 y usos de los mismos.

Country Status (33)

Country Link
US (3) US9150648B2 (es)
EP (2) EP2809681B1 (es)
JP (1) JP6302844B2 (es)
KR (1) KR102111941B1 (es)
CN (1) CN104093738B (es)
AR (1) AR089852A1 (es)
AU (1) AU2013215254B2 (es)
CA (1) CA2862332C (es)
CL (1) CL2014002019A1 (es)
CO (1) CO7020877A2 (es)
CY (2) CY1121368T1 (es)
DK (2) DK2809681T3 (es)
EA (1) EA028647B1 (es)
ES (2) ES2886123T3 (es)
HK (1) HK1199269A1 (es)
HR (2) HRP20211541T1 (es)
HU (2) HUE042531T2 (es)
IL (2) IL233410A0 (es)
IN (1) IN2014CN04645A (es)
JO (1) JO3547B1 (es)
LT (2) LT3453723T (es)
MX (1) MX358518B (es)
MY (1) MY168748A (es)
NZ (1) NZ626242A (es)
PH (1) PH12014501613B1 (es)
PL (2) PL2809681T3 (es)
PT (2) PT2809681T (es)
RS (2) RS62454B1 (es)
SG (1) SG11201403222UA (es)
SI (2) SI3453723T1 (es)
TW (1) TWI591073B (es)
UY (1) UY34603A (es)
WO (1) WO2013116296A1 (es)

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NZ626242A (en) 2012-01-31 2017-02-24 Regeneron Pharma Anti-asic1 antibodies and uses thereof
CA2945498A1 (en) * 2014-04-15 2015-10-22 Sorrento Therapeutics, Inc. Antibody therapeutics that bind wisp1
HUE050007T2 (hu) 2014-05-16 2020-11-30 Ablynx Nv Immunglobulin variábilis domének
CN105233286B (zh) * 2015-09-10 2018-10-30 上海交通大学医学院 含酸敏感离子通道调控剂的制剂及其在治疗瘙痒中的用途
CN105713089B (zh) * 2016-02-26 2019-08-06 上海科技大学 一种特异性抑制酸敏感离子通道i型的全人抗体
WO2018085441A1 (en) * 2016-11-01 2018-05-11 Berg Llc Filamin b binding proteins and uses thereof
MD3638698T2 (ro) * 2018-01-26 2021-07-31 Regeneron Pharma Anticorpi anti-TMPRSS2 și fragmente de legare al antigenului
EP3980456A4 (en) * 2019-06-04 2023-01-18 Shanghaitech University AFFINITY MATURED ANTI-ASIC1A ANTIBODIES
MX2022000325A (es) * 2019-07-11 2022-03-25 Memorial Sloan Kettering Cancer Center Anticuerpos dirigidos contra dll3 y usos de los mismos.
GB2600333A (en) * 2019-07-23 2022-04-27 Univ Shanghai Technology ASICI channel antagonist antibody
AU2020346886A1 (en) * 2019-09-13 2022-04-14 Memorial Hospital For Cancer And Allied Diseases Anti-CD371 antibodies and uses thereof
IL310700A (en) * 2021-08-09 2024-04-01 Merck Patent Gmbh Proteins that uncouple cell-mediated tumor cytotoxicity from proinflammatory cytokine release
CN118159558A (zh) * 2021-09-02 2024-06-07 纪念斯隆-凯特琳癌症中心 抗dll3抗体和其用途

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US6287859B1 (en) 1998-08-05 2001-09-11 Centre National De La Recherche Identification, functional expression and chromosal localization of a sustained human proton-gated cation channel
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NZ626242A (en) 2012-01-31 2017-02-24 Regeneron Pharma Anti-asic1 antibodies and uses thereof

Also Published As

Publication number Publication date
TW201335182A (zh) 2013-09-01
EP3453723A2 (en) 2019-03-13
MY168748A (en) 2018-11-30
JP6302844B2 (ja) 2018-03-28
US20180222976A1 (en) 2018-08-09
EP3453723A3 (en) 2019-04-10
IL254416B (en) 2018-03-29
ES2707599T3 (es) 2019-04-04
JP2015508063A (ja) 2015-03-16
CN104093738A (zh) 2014-10-08
US20160002332A1 (en) 2016-01-07
MX2014008541A (es) 2014-10-24
PH12014501613A1 (en) 2014-10-13
IL233410A0 (en) 2014-08-31
PT2809681T (pt) 2019-02-18
CL2014002019A1 (es) 2015-01-16
AU2013215254A1 (en) 2014-07-03
CY1124778T1 (el) 2022-11-25
PH12014501613B1 (en) 2014-10-13
EP2809681A1 (en) 2014-12-10
PL3453723T3 (pl) 2022-01-03
TWI591073B (zh) 2017-07-11
HK1199269A1 (en) 2015-06-26
US20130195878A1 (en) 2013-08-01
SI3453723T1 (sl) 2021-11-30
EP3453723B1 (en) 2021-08-11
AR089852A1 (es) 2014-09-24
EA201491452A1 (ru) 2014-11-28
US10513557B2 (en) 2019-12-24
KR102111941B1 (ko) 2020-05-18
DK3453723T3 (da) 2021-09-13
SI2809681T1 (sl) 2019-04-30
RS58439B1 (sr) 2019-04-30
HUE042531T2 (hu) 2019-07-29
CN104093738B (zh) 2018-05-18
LT2809681T (lt) 2019-02-11
HUE056335T2 (hu) 2022-02-28
EP2809681B1 (en) 2018-12-05
CA2862332A1 (en) 2013-08-08
RS62454B1 (sr) 2021-11-30
ES2886123T3 (es) 2021-12-16
HRP20211541T1 (hr) 2021-12-24
BR112014018651A2 (pt) 2017-07-04
CA2862332C (en) 2021-05-18
PL2809681T3 (pl) 2019-05-31
JO3547B1 (ar) 2020-07-05
NZ626242A (en) 2017-02-24
US9150648B2 (en) 2015-10-06
PT3453723T (pt) 2021-09-07
AU2013215254B2 (en) 2017-08-31
KR20140125363A (ko) 2014-10-28
LT3453723T (lt) 2021-09-10
SG11201403222UA (en) 2014-07-30
UY34603A (es) 2013-07-31
CY1121368T1 (el) 2020-05-29
DK2809681T3 (en) 2019-03-11
IN2014CN04645A (es) 2015-09-18
IL254416A0 (en) 2017-11-30
WO2013116296A1 (en) 2013-08-08
HRP20190358T1 (hr) 2019-04-05
CO7020877A2 (es) 2014-08-11
EA028647B1 (ru) 2017-12-29

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